scholarly journals Proteinuria Is Associated with the Development of Crohn’s Disease: A Nationwide Population-Based Study

2021 ◽  
Vol 10 (4) ◽  
pp. 799
Author(s):  
Seona Park ◽  
Hyun Jung Lee ◽  
Kyung-Do Han ◽  
Hosim Soh ◽  
Jung Min Moon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
National Health ◽  
Population Based ◽  
Health Examination ◽  
Dipstick Test ◽  
Population Based Study ◽  
Urine Dipstick ◽  
The Impact

Background and Aims: The impact of proteinuria and its severity on the incidence of inflammatory bowel disease (IBD) has not yet been studied. We aimed to determine the association between proteinuria measured by urine dipstick tests and the development of IBD. Methods: This nationwide population-based study was conducted using the Korean National Health Insurance Service (NHIS) database. A total of 9,917,400 people aged 20 years or older who had undergone a national health examination conducted by the NHIS in 2009 were followed up until 2017. The study population was classified into four groups—negative, trace, 1+, and ≥ 2+—according to the degree of proteinuria measured by the urine dipstick test. The primary endpoint was newly diagnosed IBD, Crohn’s disease (CD), or ulcerative colitis (UC) during the follow-up period. Results: Compared with the dipstick-negative group, the incidence of CD significantly increased according to the degree of proteinuria (adjusted hazard ratio [aHR] with 95% confidence interval [CI], 1.01 [0.703–1.451], 1.515 [1.058–2.162], and 2.053 [1.301–3.24] in the trace, 1+, and ≥ 2+ dipstick groups, respectively; p for trend 0.007). However, there was no significant difference in the incidence of UC according to the degree of proteinuria (aHR with 95% CI, 1.12 [0.949–1.323], 0.947 [0.764–1.174], and 1.009 [0.741–1.373] in the trace, 1+, and ≥ 2+ dipstick groups, respectively; p for trend 0.722). In the subgroup analysis, dipstick-positive proteinuria independently increased the incidence of CD regardless of the subgroup. However, dipstick-positive proteinuria was associated with the risk of UC in those with diabetes mellitus and not in those without diabetes mellitus (aHR, 1.527 vs. 0.846; interaction p-value 0.004). The risk of CD was increased or decreased according to proteinuria changes but not associated with the risk of UC. Conclusion: Proteinuria, measured by the dipstick test, is strongly associated with the development of CD.

scholarly journals P780 Proteinuria is associated with the development of Crohn’s disease: a nationwide population-based study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S618-S618
Author(s):  
J S Kim ◽  
S Park ◽  
H J Lee ◽  
H Soh ◽  
J M Moon ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Health Insurance ◽  
Crohn's Disease ◽  
National Health ◽  
Population Based ◽  
Health Examination ◽  
Dipstick Test ◽  
Urine Dipstick ◽  
Urine Dipstick Test ◽  
The Impact

Abstract Background Proteinuria has been identified as a sign of systemic endothelial dysfunction and chronic inflammation, and associated with the development of several systemic inflammatory diseases. However, the impact of proteinuria and its severity on the incidence of inflammatory bowel disease (IBD) has not been studied yet. The aim of this study was to determine the association between proteinuria measured by urine dipstick test and the development of IBD. Methods We conducted a nationwide population-based cohort study using claims data from the National Health Insurance (NHI) database, a mandatory health insurance programme covering about 97% of the Korean population. A total of 9,917,400 people aged 20 years or older who had undergone a national health examination conducted by NHI in 2009 were followed until 2017. The study population was classified into four groups, negative, trace, 1+, and ≥2+, depending on the degree of proteinuria measured by urine dipstick test. The primary endpoint was the newly diagnosed IBD, Crohn’s disease (CD) or ulcerative colitis (UC) during the follow-up period, which was detected by both ICD-10 (K50 and K51) and the rare intractable disease registration programme codes which provide co-payment reduction of up to 90% in South Korea. Results The incidence of CD significantly increased according to the degree of proteinuria (adjusted hazard ratio [aHR] with 95% confidence interval [CI], 1.01(0.703–1.451), 1.515(1.058–2.162), and 2.053(1.301–3.24) in trace, 1+, and ≥2+ dipstick groups, respectively) as compared with the dipstick-negative group. However, there was no significant difference in the incidence of UC among the degrees of proteinuria (aHR with 95% CI, 1.12(0.949–1.323), 0.947(0.764–1.174), 1.009(0.741–1.373 in trace, 1+, and ≥2+ dipstick groups, respectively). In subgroup analysis, dipstick-positive proteinuria independently increased the incidence of CD regardless of subgroups. However, in the development of UC, dipstick-positive proteinuria increased the risk of UC in those with diabetes mellitus (DM), but not in those without DM (aHR, 1.527 vs. 0.846; interaction p-value 0.004). Conclusion Proteinuria, measured by dipstick test, may be associated with the development of CD.

Risk of fracture in Crohn's disease: A population-based study

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
E LOFTUSJR ◽  
C CROWSON ◽  
W SANDBORN ◽  
W TREAMINE ◽  
W OFALLON ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Population Based ◽  
Population Based Study ◽  
Risk Of Fracture

scholarly journals New Insights Into the Genetic Basis for Variation in Crohn's Disease (CD) Phenotype in a Population-Based Study

2011 ◽  
Vol 140 (5) ◽  
pp. S-783
Author(s):  
John D. Ryan ◽  
Mark S. Silverberg ◽  
Wei Xu ◽  
John R. Walker ◽  
Lesley A. Graff ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genetic Basis ◽  
Population Based ◽  
Population Based Study
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