scholarly journals Polycystic Ovary Syndrome: Familiar to Millions?

2020 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Johannes Ott
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Psychological Consequences ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
High Prevalence ◽  
Basic Characteristics

Often, articles about polycystic ovary syndrome (PCOS) start with information about the condition’s high prevalence, the basic characteristics that define this endocrine disorder, and the manifold somatic and/or psychological consequences [...]

High prevalence of multimorbidity in overweight and obese women with Polycystic Ovary Syndrome (PCOS)

2017 ◽  
Author(s):  
Hamidreza Mani ◽  
Yogini Chudasama ◽  
Danielle Bodicoat ◽  
Miles Levy ◽  
Laura Gray ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
High Prevalence

Preliminary indication of a high prevalence of polycystic ovary syndrome in indigenous Australian women

2002 ◽  
Vol 16 (6) ◽  
pp. 443-446 ◽  
Author(s):  
S. R. Davis ◽  
S. Knight ◽  
V. White ◽  
C. Claridge ◽  
B. J. Davis ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Indigenous Australian ◽  
High Prevalence

scholarly journals Pregnancy-related outcomes for women with polycystic ovary syndrome

2017 ◽  
Vol 13 (3) ◽  
pp. 89-97 ◽  
Author(s):  
Rose McDonnell ◽  
Roger J Hart
Keyword(s):  
Health Care ◽  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Congenital Anomalies ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Short Term ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Hypertensive Disorders

The polycystic ovary syndrome is a common endocrine disorder that has profound implications for women throughout their reproductive years. A diagnosis of polycystic ovary syndrome is associated with reproductive challenges including a difficulty in conceiving as well as the pregnancy-related complications of miscarriage, hypertensive disorders, gestational diabetes and prematurity. Consequently, polycystic ovary syndrome has profound implications for women and their offspring with regard to reproductive function in the short term and in the longer term the risk of chronic illness and congenital anomalies, and health care resources should be directed accordingly to mitigate against these risks.

scholarly journals Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome

2020 ◽  
Vol 41 (4) ◽  
pp. 538-576 ◽  
Author(s):  
Elisabet Stener-Victorin ◽  
Vasantha Padmanabhan ◽  
Kirsty A Walters ◽  
Rebecca E Campbell ◽  
Anna Benrick ◽  
...  
Keyword(s):  
Animal Models ◽  
Polycystic Ovary Syndrome ◽  
Genetic Manipulation ◽  
Polycystic Ovary ◽  
Developmental Origins ◽  
Metabolic Dysfunction ◽  
Ovary Syndrome ◽  
Naturally Occurring ◽  
High Prevalence

Abstract More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its high prevalence, PCOS and its accompanying morbidities are likely underdiagnosed, averaging > 2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is an urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females.

scholarly journals High Prevalence of the Polycystic Ovary Syndrome and Hirsutism in Women with Type 1 Diabetes Mellitus1

2000 ◽  
Vol 85 (11) ◽  
pp. 4182-4187 ◽  
Author(s):  
Héctor F. Escobar-Morreale ◽  
Belén Roldán ◽  
Raquel Barrio ◽  
Milagros Alonso ◽  
José Sancho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Type 1 Diabetes Mellitus ◽  
Polycystic Ovary ◽  
Normal Serum ◽  
Ovary Syndrome ◽  
Menstrual Dysfunction ◽  
High Prevalence

The current recommendation for strict metabolic control of type 1 diabetes mellitus requires the administration of supraphysiological doses of insulin, which might result in insulin-mediated stimulation of androgen synthesis, as occurs in insulin-resistant states. At present, the prevalence of hyperandrogenic disorders in women with type 1 diabetes mellitus is unknown. Eighty-five women with type 1 diabetes mellitus were evaluated for symptoms and signs of hyperandrogenism. In 68 of the patients, several serum androgen and hormone concentrations were measured. The polycystic ovary syndrome (PCOS) was defined by the presence of menstrual dysfunction, together with clinical and/or biochemical evidence of hyperandrogenism, and exclusion of other etiologies. Eighteen healthy women, menstruating regularly, served as controls for the androgenic profiles. Thirty-three patients (38.8%) presented hyperandrogenic disorders (16 had PCOS, and 17 had hirsutism without menstrual dysfunction). Type 1 diabetic patients with PCOS presented increased serum total and free testosterone concentrations, and serum androstenedione levels, but had normal serum sex hormone-binding globulin and dehydroepiandrosterone-sulfate levels. Hirsute type 1 diabetic women without menstrual dysfunction presented normal serum androgen levels. There were no significant differences between hyperandrogenic and nonhyperandrogenic type 1 diabetes mellitus women in clinical variables such as the duration of diabetes, age at diagnosis of diabetes, conventional or intensive insulin therapy, mean daily insulin dosage, or metabolic control. In conclusion, women with type 1 diabetes mellitus have a high prevalence of hyperandrogenic disorders, including PCOS and hirsutism.

scholarly journals High Prevalence of Metabolic Syndrome in First-Degree Male Relatives of Women with Polycystic Ovary Syndrome Is Related to High Rates of Obesity

2009 ◽  
Vol 94 (11) ◽  
pp. 4361-4366 ◽  
Author(s):  
Andrea D. Coviello ◽  
Susan Sam ◽  
Richard S. Legro ◽  
Andrea Dunaif
Keyword(s):  
Metabolic Syndrome ◽  
General Population ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Nhanes Iii ◽  
Total Testosterone ◽  
Nutrition Survey ◽  
Male Population ◽  
Ovary Syndrome ◽  
High Prevalence

Context: Women with polycystic ovary syndrome (PCOS) have twice the risk for metabolic syndrome (MetS) compared to women from the general population. Mothers and sisters of affected women also have an increased prevalence of MetS. Objective: The aim of the study was to determine the prevalence of MetS in fathers and brothers of women with PCOS compared to men from the general population. Design and Setting: We conducted a cross-sectional observational study at academic medical centers. Participants: A total of 211 fathers and 58 brothers of women with PCOS were studied and compared to 1153 and 582 Third National Health and Nutrition Survey (NHANES III) men of similar age and race/ethnicity, respectively. Main Outcome Measure: We measured MetS prevalence. Results: The prevalence of MetS was increased in fathers (42 vs. 32%; P = 0.006) and brothers (22 vs. 9%; P = 0.001) compared to NHANES III men. Fathers and brothers had higher body mass index (BMI) than NHANES III men (P < 0.0001). MetS rates were similar in fathers and brothers compared to NHANES III groups after adjusting for BMI. Total testosterone was inversely related to MetS in both fathers and brothers, but this relationship was also accounted for by the higher BMI in male relatives. Conclusion: Male relatives of women with PCOS had increased prevalence rates of MetS and obesity compared to the general U.S. male population from NHANES III. In contrast to women with PCOS and their female relatives, the higher prevalence of MetS in male relatives was accounted for by elevated BMI. These findings suggest that the high rates of MetS in male relatives of women with PCOS are related to higher rates of obesity than the general population. The high prevalence of metabolic syndrome in first degree male relatives of women affected by PCOS compared to similar men in the NHANES III population is attributable to higher rates of obesity than the general population.

scholarly journals Understanding Polycystic Ovary Syndrome: A Multifactorial Endocrine Disorder

2021 ◽  
Author(s):  
Surankita Sukul ◽  
Pushkal Sinduvadi Ramesh ◽  
Narahari Agasti
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Genetic Markers ◽  
Polycystic Ovary ◽  
Association Studies ◽  
Reproductive Age ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Genome Wide

Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting a significant population of women of reproductive age group worldwide. Due to the complex pathophysiology and overlapping symptoms, this disorder is often difficult to diagnose. Genome-wide association studies have identified several new risk loci and candidate genes for PCOS. However, currently, there are no standard genetic markers for PCOS susceptibility testing owing to the inconsistent findings. Despite the advent of the genomic era, the challenge to identify and pinpoint the heritable genetic basis of PCOS still exists. This mini-review explores the basic definition and phenotypes of PCOS, the different criteria for the diagnosis, the incidence, gestational complications associated with it, the basis of genetic heritability, and the influence of various gene polymorphisms. Also, this review briefly summarises the reports of genome-wide association studies conducted to identify candidate genetic markers to aid in understanding the complex pathophysiology of PCOS.

scholarly journals Endometrium and polycystic ovary syndrome

2018 ◽  
Vol 67 (4) ◽  
pp. 60-66
Author(s):  
Pavel P Yakovlev ◽  
Igor Yu Kogan
Keyword(s):  
Endometrial Cancer ◽  
Polycystic Ovary Syndrome ◽  
Pregnancy Outcomes ◽  
Polycystic Ovary ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Ovary Syndrome ◽  
Endocrine Disorder ◽  
Increased Risk ◽  
Adverse Pregnancy

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Patients with PCOS present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS is inconsistently associated adverse pregnancy outcomes and an increased risk of endometrial cancer. The purpose of this review is to systematize the available data on endometrial dysfunction associated with PCOS. (For citation: Yakovlev PP, Kogan IYu. Endometrium and polycystic ovary syndrome. Journal of Obstetrics and Women’s Diseases. 2018;67(4):60-66. doi: 10.17816/JOWD67460-66).

Sign in / Sign up

Export Citation Format

Share Document