scholarly journals Congenitally Malformed Hearts: Aspects of Teaching and Research Involving Medical Students

2021 ◽  
Vol 8 (4) ◽  
pp. 34
Author(s):  
Catherine C. Pickin ◽  
James Castle ◽  
Vibha Shaji ◽  
Adeolu Banjoko ◽  
Aimee-Louise Chambault ◽  
...  
Keyword(s):  
Congenital Heart ◽  
Right Aortic Arch ◽  
Clinical Anatomy ◽  
Research Projects ◽  
Detailed Understanding ◽  
Segmental Analysis ◽  
The University ◽  
Congenitally Corrected Transposition ◽  
Sequential Segmental Analysis ◽  
Corrected Transposition

To appreciate congenital heart disease fully, a detailed understanding of the anatomical presentation, as well as the physiology, is required. This is often introduced at an advanced stage of training. Professor Anderson has been influential in the Clinical Anatomy Intercalated BSc programme at the University of Birmingham, in particular in his teaching on Sequential Segmental Analysis. This article describes the experiences of the latest cohort of students on this programme, who undertook varying research projects using the Birmingham Cardiac Archive, with the guidance of Professor Anderson. The projects outlined include various aspects of isomerism, encompassing both the cardiac and abdominal manifestations, as well as details of congenitally corrected transposition of the great arteries and prenatally diagnosed right aortic arch and double arch. These studies all aimed to increase the knowledge base of their respective cardiac malformations and provide a basis for further research.

Galectin-3 plasma levels in adult congenital heart disease and the pressure overloaded right ventricle: reason matters

2020 ◽  
Vol 14 (13) ◽  
pp. 1197-1205
Author(s):  
Ewa Kowalik ◽  
Beata Kuśmierczyk-Droszcz ◽  
Anna Klisiewicz ◽  
Aleksandra Wróbel ◽  
Anna Lutyńska ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Adult Congenital Heart Disease ◽  
Clinical Status ◽  
Pressure Overload ◽  
Cross Sectional ◽  
Galectin 3 ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Aim: To assess galectin-3 (Gal-3) levels and their relationship with clinical status and right ventricular (RV) performance in adults with RV pressure overload of various mechanisms due to congenital heart disease. Materials & methods: A cross-sectional study was conducted. Patients underwent clinical examination, blood testing and transthoracic echocardiography. Results: The study included 63 patients with congenitally corrected transposition of the great arteries, 41 patients with Eisenmenger syndrome and 20 healthy controls. Gal-3 concentrations were higher in patients compared with controls (7.83 vs 6.11 ng/ml; p = 0.002). Biomarker levels correlated with age, New York Health Association class, N-terminal probrain natriuretic peptide and RV function only in congenitally corrected transposition of the great arteries patients. Conclusion: Gal-3 profile in congenital heart disease patients and pressure-overloaded RV differs according to the cause of pressure overload.

Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis

2019 ◽  
Vol 42 (6) ◽  
pp. 321-322
Author(s):  
Radi Wieloch ◽  
Nihat Firat Sipahi ◽  
Udo Boeken ◽  
Alexander Albert ◽  
Payam Akhyari ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
Situs Inversus ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Situs Inversus Totalis ◽  
Clinical Scenario ◽  
Assist Device ◽  
Ventricular Assist ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Congenitally corrected transposition of the great arteries and situs inversus totalis are rare congenital anomalies. While congenital heart diseases affect about 0.75%–0.9% of newborns, less than 1% of them have congenitally corrected transposition of the great arteries. Meanwhile, the incidence of situs inversus totalis is about 0.01%. This is a case report of a patient with congenitally corrected transposition of the great arteries and situs inversus totalis who was supported with a ventricular assist device, resulting in a challenging clinical scenario.

scholarly journals Atrial Fibrillation-Induced Cardiac Shock: First Manifestation of a Congenitally Corrected Transposition of the Great Arteries in a 45-Year-Old Man

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
M. Graf ◽  
M. Zaczkiewicz ◽  
J. Torzewski ◽  
O. Zimmermann
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Acute Heart Failure ◽  
Congenital Heart Defect ◽  
Congenital Heart ◽  
Prior History ◽  
Heart Defect ◽  
Cardiac Shock ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Background.The congenitally corrected transposition of the great arteries (L-TGA) is a very rare congenital heart defect, which often remains undetected for several decades of life.Case Presentation.We report on a 45-year-old man without prior history of heart disease, presenting with cardiac shock related to a first episode of tachycardic atrial fibrillation. The diagnostic work-up identified a L-TGA as the underlying cause for acute heart failure.Discussion.L-TGA is a very rare congenital heart defect, which is characterized by an atrioventricular as well as a ventriculoarterial discordance. By this means, the physiological sequence of pulmonary and systemic circulation is still maintained. On the basis of an ongoing strain of the right ventricle, which has to carry the burden of the systemic blood pressure, after more than four decades without symptoms, acute heart failure was triggered by a tachycardic atrial fibrillation.

scholarly journals Anaesthetic management of a case of congenitally corrected transposition of great arteries for non cardiac surgery: A case report

2021 ◽  
Vol 8 (2) ◽  
pp. 341-344
Author(s):  
Heena D Pahuja ◽  
Charuta P Gadkari ◽  
Neha G Wakode ◽  
Anjali R Bhure
Keyword(s):  
Cardiac Surgery ◽  
Congenital Heart ◽  
Heart Diseases ◽  
Anaesthetic Management ◽  
Left Ventricular ◽  
Complex Congenital Heart Disease ◽  
Associated Anomalies ◽  
Transposition Of Great Arteries ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Congenitally corrected transposition of the great arteries (CCTGA) is a rare form of congenital heart diseases, present with or without associated anomalies. It is a complex congenital heart disease with both atrioventricular and ventriculoarterial discordance. Such patients tend to develop systemic ventricular dysfuction with the stress of surgery. Patients with CCTGA are usually diagnosed at early stages of life due to associated anomalies, but they may even remain asymptomatic till later decades of their life. Literature search revealed very few reported cases of anaesthetic management of such high risk cases for non cardiac surgery. These patients have the tendency to develop cardiac dysrhythmias and left ventricular failure during intraoperative and postoperative period. We report anaesthetic management of a case of a 24 years old male with the congenitally corrected transposition of great arteries(CCTGA) who was operated for fracture left distal radius and ulna and right sided galeazzi fracture.

Morphology and classification

2011 ◽  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Rational Approach ◽  
Complex Congenital Heart Disease ◽  
Segmental Analysis ◽  
Anatomy And Physiology ◽  
Sequential Segmental Analysis

Introduction 4Physiological classification 4Sequential segmental analysis 6Atrial arrangement 8The classification and description of complex congenital heart disease is important to the understanding of the anatomy and physiology of the conditions.1,2 It can appear intimidating; an overview to a rational approach is described here....

scholarly journals Ventricular fibrillation in congenitally corrected transposition of great arteries treated with pacing: a case report

2019 ◽  
Author(s):  
Lei Zhang ◽  
Hongyang Liu ◽  
Qilin Wan ◽  
Xinqiang Han
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Ventricular Function ◽  
Congenital Heart ◽  
Ventricular Rate ◽  
Ventricular Tachyarrhythmias ◽  
Open Communication ◽  
History Of ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Abstract Background Congenitally corrected transposition of the great arteries (CCTGA) is a rare form of congenital heart disease which may present with sudden death from malignant arrhythmias including complete heart block and ventricular tachyarrhythmias as late complications. Only few cases about ventricular tachyarrhythmias, usually in those with markedly depressed systemic ventricular function, have been reported. Case summary A 26-year-old woman with a known history of CCTGA presented to the emergency department with palpitations and breathlessness for 3–4 weeks and worsening symptoms for 8 h. She had a history of ventricular septal defect repair 14 years ago. Her initial presentation electrocardiogram demonstrated high degree atrioventricular block with a ventricular rate of 44 b.p.m. She had two episodes of complete syncope during this hospitalization, both required external defibrillation due to documented bradycardia-dependent ventricular fibrillations. Her two-dimensional echocardiography study confirmed the diagnosis of CCTGA with preserved systolic ventricular function. She underwent urgent temporal pacing wire placement with a paced ventricular rate at 90 b.p.m. Having thoroughly reviewed the arrhythmia events and discussed with the patient about the option of defibrillator vs. pacemaker therapy a decision was made upon her request for dual-chamber pacemaker implantation. She was discharged home uneventfully 3 days after hospital presentation and has been physically active at 3-, 6-, and 9-month follow-ups. Discussion Our case illustrates the individualized clinical decision making in choosing device therapy for a rare congenital heart disease presented with malignant arrhythmia. Careful history taking, open communication, and closely planned long-term follow-up will be essential in caring for such patients.

scholarly journals EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Echocardiographic assessment of transposition of the great arteries and congenitally corrected transposition of the great arteries

2019 ◽  
Vol 6 (4) ◽  
pp. R107-R119 ◽  
Author(s):  
Meryl S Cohen ◽  
Luc L Mertens
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Sequential Analysis ◽  
Associated Lesions ◽  
Echocardiographic Assessment ◽  
Operative Assessment ◽  
Residual Lesions ◽  
Congenitally Corrected Transposition ◽  
Corrected Transposition

Echocardiographic assessment of patients with transposition of the great arteries and congenitally corrected transposition requires awareness of the morphology and commonly associated lesions. The pre-operative echocardiography should include a full segmental and sequential analysis. Post-operative assessment is not possible without awareness of the type of surgical procedure performed and consists of assessing surgical connections and residual lesions.

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