scholarly journals Solid Target System with In-Situ Target Dissolution

Instruments ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. 14 ◽  
Author(s):  
William Z. Gelbart ◽  
Richard R. Johnson
Keyword(s):  
Target Material ◽  
Incident Beam ◽  
Chemistry Laboratory ◽  
Target System ◽  
Beam Power ◽  
New Approach ◽  
Target Station ◽  
Production Target ◽  
Design Construction

A significant number of medical radioisotopes use solid, often metallic, parent materials.These materials are deposited on a substrate to facilitate the cooling and handling of the targetduring placing, irradiation, and processing. The processing requires the transfer of the target to aprocessing area outside the irradiation area. In this new approach the target is processed at theirradiation site for liquid only transport of the irradiated target material to the processing area. Thedesign features common to higher energy production target systems are included in the targetstation. The target is inclined at 14 degrees to the beam direction. The system has been designed toaccept an incident beam of 15 to 16 mm diameter and a beam power between 2 and 5 kW. Thermalmodeling is presented for targets of metals and compounds. A cassette of five or 10 preparedtargets is housed at the target station as well as a target dissolution assembly. Only the dissolvedtarget material is transported to the chemistry laboratory so that the design does not requireadditional irradiation area penetrations. This work presents the design, construction, and modelingdetails of the assembly. A full performance characterization will be reported after the unit is movedto a cyclotron facility for beam related measurements.

scholarly journals Neuroimmune Response Mediated by Cytokines in Natural Scrapie after Chronic Dexamethasone Treatment

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 204
Author(s):  
Isabel M. Guijarro ◽  
Moisés Garcés ◽  
Pol Andrés-Benito ◽  
Belén Marín ◽  
Alicia Otero ◽  
...  
Keyword(s):  
Prion Diseases ◽  
Global Approach ◽  
Profile Data ◽  
Dexamethasone Treatment ◽  
New Approach ◽  
Complex Interactions ◽  
Natural Scrapie ◽  
Anti Inflammatory

The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Additionally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.

scholarly journals An Unconventional Field Mapping Application: A Complete Opensource Workflow Solution Applied to Lithological Mapping of the Coatings of Cultural Heritage

2021 ◽  
Vol 10 (6) ◽  
pp. 357
Author(s):  
Niccolò Iandelli ◽  
Massimo Coli ◽  
Tessa Donigaglia ◽  
Anna Livia Ciuffreda
Keyword(s):  
Cultural Heritage ◽  
Coating Materials ◽  
Historical Building ◽  
New Approach ◽  
Photo Interpretation ◽  
Organization Management ◽  
Field Mapping ◽  
Lithological Mapping ◽  
Entire Amount

The conservation of a primary importance historical building requires organization, management, continuous updating, comparison, and visualization of a large amount of data of different nature and origin. In relation to these aspects the use of a GIS brings various advantages including single and univocal management of the entire amount of existing data in a relational, dynamic, updatable and queryable way. The integration of a mobile solution permits the updating of the dataset and checking on site all information. The workflow presented uses opensource solutions, desktop and mobile, which allows the creation of an unconventional lithological Field Mapping activity: starting from photo interpretation and in situ survey, all the coating materials (stone, etc.) of some monuments of primary historical and cultural interest have been mapped (i.e., Duomo di Firenze, Duomo di Prato). The product can be considered as a lithological cartography, vertically oriented, processed by field surveys, geognostic surveys and photo interpretation. All combined to create a “lithological” mapping of the coatings of the various monuments; the advantage is a new approach for conservation and restoration of Cultural Heritage. The proposed workflow involves a mobile solution, opensource, that allows the verification and management of the database in the field.

scholarly journals Non-dispersive UV Absorption Spectroscopy: A Promising New Approach for in-situ Detection of Sulfur Dioxide

2019 ◽  
Vol 7 ◽  
Author(s):  
Jan-Lukas Tirpitz ◽  
Denis Pöhler ◽  
Nicole Bobrowski ◽  
Bruce Christenson ◽  
Julian Rüdiger ◽  
...  
Keyword(s):  
Sulfur Dioxide ◽  
Absorption Spectroscopy ◽  
Uv Absorption ◽  
New Approach ◽  
Uv Absorption Spectroscopy ◽  
In Situ Detection

A new approach to arylhydrazides via the reaction of the Mitsunobu reagent with arynes: further application to access diverse nitrogen-containing heterocycles in one pot

2017 ◽  
Vol 4 (8) ◽  
pp. 1636-1639 ◽  
Author(s):  
Bin Cheng ◽  
Bian Bao ◽  
Yanhe Chen ◽  
Ning Wang ◽  
Yun Li ◽  
...  
Keyword(s):  
One Pot ◽  
New Approach ◽  
Mild Conditions ◽  
Highly Active ◽  
Active Intermediates

A new route to arylhydrazides involving the reaction of two highly active intermediates, the 1,3-zwitterion generated in situ from the Mitsunobu reagent and arynes, under mild conditions has been developed.

scholarly journals Imaging the Polymorphic Transformation in a Single Cu6Sn5 Grain in a Solder Joint

Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2229 ◽  
Author(s):  
Flora Somidin ◽  
Hiroshi Maeno ◽  
Xuan Tran ◽  
Stuart D. McDonald ◽  
Mohd Mohd Salleh ◽  
...  
Keyword(s):  
Solder Joint ◽  
Polymorphic Transformation ◽  
Structural Evolution ◽  
Real Space ◽  
Transformation Behavior ◽  
New Approach ◽  
Transmission Electron ◽  
Contrast Pattern ◽  
In Situ Observations

In-situ observations of the polymorphic transformation in a single targeted Cu6Sn5 grain constrained between Sn-0.7 wt % Cu solder and Cu-Cu3Sn phases and the associated structural evolution during a solid-state thermal cycle were achieved via a high-voltage transmission electron microscope (HV-TEM) technique. Here, we show that the monoclinic η′-Cu6Sn5 superlattice reflections appear in the hexagonal η-Cu6Sn5 diffraction pattern upon cooling to isothermal 140 °C from 210 °C. The in-situ real space imaging shows that the η′-Cu6Sn5 contrast pattern is initiated at the grain boundary. This method demonstrates a new approach for further understanding the polymorphic transformation behavior on a real solder joint.

Experimental Validation of an Identification Procedure of Soil Profile Characteristics from Free Field Acceleration Records

2012 ◽  
Vol 3 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Z. Harichane ◽  
H. Afra ◽  
R. Bahar
Keyword(s):  
Soil Profile ◽  
Damping Ratio ◽  
Linear Optimization ◽  
Free Field ◽  
Unit Weight ◽  
New Approach ◽  
Theoretical Function ◽  
Minimization Technique ◽  
Profile Characteristics

In this paper, a new approach for soil profile characterization is validated. The soil characteristics are calculated by fitting the theoretical amplification functions to those obtained experimentally. The identified characteristics have been observed to agree well with those obtained by in situ and laboratory tests. This new approach uses system identification theory and free field records. It is based on formulation of theoretical soil amplification function for two sites in terms of the different parameters of the soil profile layers (thickness, damping ratio, shear wave velocity and unit weight). The theoretical function is smoothed according to the experimental data (spectral ratios) by means of the least squares minimization technique. The function parameters are determined by solving, numerically, a non linear optimization problem. In this approach, soil profile characteristics of two sites can be identified simultaneously, from only a single soil acceleration record at free surface of each site without need of bedrock or outcropping acceleration records. Strong ground motions data recorded during the Boumerdes earthquake (Algeria) of May 21, 2003, are used for the validation.

scholarly journals Interfacial Adhesion and Mechanical Properties of PET Fabric/PVC Composites Enhanced by SiO2/Tributyl Citrate Hybrid Sizing

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 898
Author(s):  
Dandan Pu ◽  
Fuyao Liu ◽  
Yubing Dong ◽  
Qingqing Ni ◽  
Yaqin Fu
Keyword(s):  
Interfacial Adhesion ◽  
Ethylene Terephthalate ◽  
Sio2 Nanoparticles ◽  
New Approach ◽  
Pet Fabric ◽  
Poly Ethylene Terephthalate ◽  
Wide Range ◽  
Peeling Strength ◽  
Poly Ethylene

Poly(ethylene terephthalate) (PET) fabric-reinforced polyvinyl chloride (PVC) composites have a wide range of applications, but the interface bonding of PET fabric/PVC composites has remained a challenge. In this work, a new in-situ SiO2/tributyl citrate sizing agent was synthesized according to the principle of “similar compatibility.” The developed sizing agent was used as a PET surface modifier to enhance the interfacial performance of PET fabric/PVC composites. The morphology and structure of the PET filaments, the wettability and tensile properties of the PET fabric, the interfacial adhesion, and the tensile and tearing properties of the PET fabric/PVC composites were investigated. Experimental results showed that many SiO2 nanoparticles were scattered on the surface of the modified PET filaments. Moreover, the surface roughness of the modified PET filaments remarkably increased in comparison with that of the untreated PET filaments. The contact angle of the modified PET filaments was also smaller than that of the untreated ones. The peeling strength of the modified PET fabrics/PVC composites was 0.663 N/mm, which increased by 62.50% in comparison with the peeling strength of the untreated ones (0.408 N/mm). This work provides a new approach to the surface modification of PET and improves the properties of PET fabric/PVC composites.

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