scholarly journals QSAR Study of p56lck Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MLR and GA-PLS

2008 ◽  
Vol 9 (9) ◽  
pp. 1876-1892 ◽  
Author(s):  
Afshin Fassihi ◽  
Razieh Sabet
Keyword(s):  
Tyrosine Kinase ◽  
Inhibitory Activity ◽  
Protein Tyrosine Kinase ◽  
Qsar Study ◽  
Protein Tyrosine ◽  
Kinase Inhibitory Activity

New Cytotoxic Bisindole Alkaloids with Protein Tyrosine Kinase Inhibitory Activity from a Myxomycete Lycogala epidendrum.

ChemInform ◽  
2005 ◽  
Vol 36 (42) ◽  
Author(s):  
Takahiro Hosoya ◽  
Yukinori Yamamoto ◽  
Yoshimasa Uehara ◽  
Masahiko Hayashi ◽  
Kanki Komiyama ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Inhibitory Activity ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
Kinase Inhibitory Activity

scholarly journals Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

Molecules ◽  
2011 ◽  
Vol 16 (6) ◽  
pp. 4897-4911 ◽  
Author(s):  
Fei Lang Zheng ◽  
Shu Rong Ban ◽  
Xiu E Feng ◽  
Cheng Xiao Zhao ◽  
Wenhan Lin ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Inhibitory Activity ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
Kinase Inhibitory Activity ◽  
Vitro Protein

New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum

2005 ◽  
Vol 15 (11) ◽  
pp. 2776-2780 ◽  
Author(s):  
Takahiro Hosoya ◽  
Yukinori Yamamoto ◽  
Yoshimasa Uehara ◽  
Masahiko Hayashi ◽  
Kanki Komiyama ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Inhibitory Activity ◽  
Protein Tyrosine Kinase ◽  
Protein Tyrosine ◽  
Kinase Inhibitory Activity

scholarly journals 4D-QSAR Study of p56IckProtein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MCET Method

2011 ◽  
Vol 32 (12) ◽  
pp. 4352-4360 ◽  
Author(s):  
Hayriye Yilmaz ◽  
Yahya Guzel ◽  
Zulbiye Onal ◽  
Gokce Altiparmak ◽  
Safak Ozhan Kocakaya
Keyword(s):  
Tyrosine Kinase ◽  
Inhibitory Activity ◽  
Qsar Study ◽  
Kinase Inhibitory Activity

Protein-tyrosine Kinase p72 syk Is Activated by Platelet Activating Factor in Platelets

1994 ◽  
Vol 72 (06) ◽  
pp. 937-941 ◽  
Author(s):  
Karim Rezaul ◽  
Shigeru Yanagi ◽  
Kiyonao Sada ◽  
Takanobu Taniguchi ◽  
Hirohei Yamamura
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Phosphorylation ◽  
Protein Tyrosine Kinase ◽  
Kinase Inhibitor ◽  
Critical Role ◽  
Platelet Activating Factor ◽  
Kinase Assay ◽  
Potential Candidate ◽  
Protein Tyrosine ◽  
Induced Aggregation

SummaryIt has been demonstrated that activation of platelets by platelet-activating factor (PAF) results in a dramatic increase in tyrosine phosphorylation of several cellular proteins. We report here that p72 syk is a potential candidate for the protein-tyrosine phosphorylation following PAF stimulation in porcine platelets. Immunoprecipitation kinase assay revealed that PAF stimulation resulted in a rapid activation of p72 syk which peaked at 10 s. The level of activation was found to be dose dependent and could be completely inhibited by the PAF receptor antagonist, CV3988. Phosphorylation at the tyrosine residues of p72 syk coincided with activation of yllsyk. Pretreatment of platelets with aspirin and apyrase did not affect PAF induced activation of p72 syk .Furthermore, genistein, a potent protein-tyrosine-kinase inhibitor, diminished PAF-induced p72 syk activation and Ca2+ mobilization as well as platelet aggregation. These results suggest that p72 syk may play a critical role in PAF-induced aggregation, possibly through regulation of Ca2+ mobilization.

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