scholarly journals Beneficial Effects of Soybean-Derived Bioactive Peptides

2021 ◽  
Vol 22 (16) ◽  
pp. 8570
Author(s):  
Il-Sup Kim ◽  
Woong-Suk Yang ◽  
Cheorl-Ho Kim

Peptides present in foods are involved in nutritional functions by supplying amino acids; sensory functions related to taste or solubility, emulsification, etc.; and bioregulatory functions in various physiological activities. In particular, peptides have a wide range of physiological functions, including as anticancer agents and in lowering blood pressure and serum cholesterol levels, enhancing immunity, and promoting calcium absorption. Soy protein can be partially hydrolyzed enzymatically to physiologically active soy (or soybean) peptides (SPs), which not only exert physiological functions but also help amino acid absorption in the body and reduce bitterness by hydrolyzing hydrophobic amino acids from the C- or N-terminus of soy proteins. They also possess significant gel-forming, emulsifying, and foaming abilities. SPs are expected to be able to prevent and treat atherosclerosis by inhibiting the reabsorption of bile acids in the digestive system, thereby reducing blood cholesterol, low-density lipoprotein, and fat levels. In addition, soy contains blood pressure-lowering peptides that inhibit angiotensin-I converting enzyme activity and antithrombotic peptides that inhibit platelet aggregation, as well as anticancer, antioxidative, antimicrobial, immunoregulatory, opiate-like, hypocholesterolemic, and antihypertensive activities. In animal models, neuroprotective and cognitive capacity as well as cardiovascular activity have been reported. SPs also inhibit chronic kidney disease and tumor cell growth by regulating the expression of genes associated with apoptosis, inflammation, cell cycle arrest, invasion, and metastasis. Recently, various functions of soybeans, including their physiologically active functions, have been applied to health-oriented foods, functional foods, pharmaceuticals, and cosmetics. This review introduces some current results on the role of bioactive peptides found in soybeans related to health functions.

Author(s):  
Marjan Mahdavi Roshan ◽  
Arsalan Salari ◽  
Sogol Emaminejad ◽  
Shirin Parvinroo ◽  
Asieh Ashouri ◽  
...  

High blood pressure, diabetes, hyperlipidemia and obesity are risk factors for cardiovascular diseases. With regard to the significant role of a healthy diet in the prevention and even treatment of diseases together with the high cost and side effects of drugs, finding foods effective in the treatment of metabolic disorders has been widely considered. This study aimed to evaluate the effect of oxymel – an Iranian traditional syrup with vinegar base – on cardiovascular risk indicators in obese and overweight people. Candidates were selected based on a set of inclusion criteria and were divided into two groups of control and test. The control group received 250 cc of water, while the test group received 250 cc water containing 30 cc of the oxymel for 30 days. Anthropometric and biochemical indicators were measured at the beginning and end of the study. The results showed that there were no significant changes in the body mass index, waist circumference, hip circumference, waist to hip ratio, HDL, LDL, Triglycerides, systolic and diastolic blood pressure, and blood glucose level. However, weight (P = 0.053) and cholesterol (P = 0.083) decreased relatively significantly in the test group compared to the control group. This study shows that consumption of oxymel has positive cardiovascular effects such as lowering the blood cholesterol level and can contribute to weight loss; however, studies with a larger sample size are recommended.


Author(s):  
A. V. Fominykh ◽  
V. G. Chyumakov ◽  
N. A. Kovshova ◽  
D. P. Ezdin ◽  
M. N. Kostomakhin

Humic drugs have a wide range of biological activity, affecting the metabolic processes in the body of animals and humans. Humins play a vital role in protecting the intestine from infections and favorably affect its functions, have the potential to suppress mold and bacterial growth, and reduce the level of toxins. When goats received humic substances they had higher milk yields, while significantly reducing total blood cholesterol. Sodium humate administered to broiler chickens increases the live weight by an average of 5–7 % and the livability of poultry by 3–5 %. The influence of humic acid on the quality of laying and egg quality in Japanese quails has been studied. The implementation of socio-economic and environmental programs of the agro-industrial complex provides for the improvement of technologies and technical means for the production of compound feed and protein-mineral vitamin additives for farm animals and poultry. The purpose of the research was to select a vacuum evaporation plant to increase the concentration of humic gel. It has been found that to increase the concentration of humic gel, it is advisable to use a vacuum evaporation plant with an ejector and a steam condenser. Methods for calculating the parameters of the ejector and the pressure reduction process in a vacuum evaporation unit have been developed. The dependences obtained to study the correlation between the area and the diameter of the nozzle water-air ejector, mass flow inject air, water pressure before the working nozzle, pressure inject air, density of the working water, pressure after the ejector, pressure of saturated steam, working temperature of water, temperature inject air, pressure reduction time.


Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mark Lemstra

Few community-based obesity reduction programs have been evaluated. After 153 community consultations, the city of Moose Jaw, Saskatchewan, Canada decided to initiate a free comprehensive program. The initiative included 71 letters of support from the Mayor, every family physician, cardiologist and internist in the city and every relevant community group including the Heart and Stroke Foundation, the Canadian Cancer Society and the Public Health Agency of Canada. The objective was to promote strong adherence while positively influencing a wide range of physical and mental health variables measured through objective assessment or validated surveys. The only inclusion criteria was that the individuals must be obese adults (BMI >30). Participants were requested to sign-up with a “buddy” who was also obese and identify three family members or friends to sign a social support contract. During the initial 12 weeks, each individual received 60 group exercise sessions, 12 group cognitive behaviour therapy sessions and 12 group dietary sessions with licensed professionals. During the second 12 week period, maintenance therapy included 12 group exercise sessions. To date, 243 people have been referred with 229 starting. Among those who started, 183 completed the program (79.9%) while 15 quit for medical reasons and 31 quit for personal reasons. Mean objective reductions included 31.0 pounds of body fat, 3.9 percent body fat, 2.9 inches from the waist, 2.3 inches from the hip, blood cholesterol by 0.5 mmol/L, systolic blood pressure by 5.9 mmHg and diastolic blood pressure by 3.2 mmHg (all p<.000). There were no changes in blood sugar levels. There was also statistically significant differences in aerobic fitness, self-report health, quality of life measured by SF-36 and depressed mood measured by CES-D (all p<.000). An independent risk factor for not completing the program was not having a family member or friend sign a social support contract (OR 2.91; 95% CI 1.01-8.34, p=.047). Education level was a confounder. Comprehensive obesity reduction programs can be effective when there is extensive consultation at the community level and social support at the individual level.


2018 ◽  
Vol 7 (3.3) ◽  
pp. 114 ◽  
Author(s):  
Satyanarayana Nimmala ◽  
Y Ramadevi ◽  
B Ashwin Kumar

Every tissue of human body needs energy and oxygen for its livelihood. In order to supply energy and oxygen, the heart pumps the blood around the body. When heart pushes the blood against the walls of arteries, it creates some pressure inside the arteries, called as blood pressure. If this pressure is more than the certain level we treat it as high blood pressure (HBP). Nowadays HBP is a silent killer of many across the globe. So here we proposed a new data-driven computational model to predict HBP. Blood Pressure (BP) may be elevated because of many changes such as physical and emotional. In the proposed model we have considered AAA++ (age, anger level, anxiety level, obesity (+), blood cholesterol (+)), for experimental analysis. Our model initially calculates the correlation coefficient (CC) between each risk factor and class label attribute. Then based on the impact of each risk factor value and CC, it assigns the corresponding weight to it. Then proposed model uses risk factor value and its weight to predict whether person becomes a victim of HBP or not. We have used real-time data set for experimental analysis. It consists of 1000 records, which are collected from Doctor C, a Medical Diagnostic center, Hyderabad, India. 


Author(s):  
Shweta Parwe

Obesity is a serious health condition that can lead to an earlier death. A variety of medical problems, including high blood pressure, heart problems, diabetes, sleep apnea, depression and arthritis, have been  associated with being overweight. An individual who is 30% heavier than his or her ideal weight (determined by standard medical and insurance data) is considered obese. Niruha Basti is one of the most important and commonly used therapies    having wide range of therapeutic action. Niruha Basti is one which eradicates dosha (Humors) from the body, increases strength of the body and has Achintya shakti (unpredictable effects) Gomutra has Tikshna, Ushna, Laghu Virya: Ushna Vipaka: Katu having Kaphavata Shamaka and Used as Deepana, Lekhana, Pachana, Anulomana, Malshodhak Amapachana, it is also used in Virechana and Basti have predominance of Vayu and Agni Mahabhuta. So by means of such properties have a negative impact on Kaphavridhi and Medovridhi.


Food systems ◽  
2021 ◽  
Vol 4 (3) ◽  
pp. 190-196
Author(s):  
A. S. Knyazeva ◽  
D. A. Utyanov ◽  
A. V. Kulikovskii ◽  
A. A. Kurzova

Food products undergo a wide range of chemical changes during their processing and storage. As a result of such reactions, both new chemical compounds and optical isomerization of compounds already present in the composition can be formed. The second case concerns the formation of D-enantiomers of amino acids from their L-forms. D-forms of amino acids not only have no biological value for the body, but also often have a negative effect on the human body due to the impossibility of metabolizing them and, as a consequence, their accumulation in the body. The aim of the work was to study the quantitative content of D-isomers of amino acids in milk that passed the ultra-pasteurization process and dairy products based on bacterial starter culture. The research results showed that in both cases of the considered technological methods, amino acid isomerization occurs. The highest degree of isomerization was observed in kefir samples relative to other samples. However, from the results obtained, it is not possible to estimate which amino acid is most susceptible to the racemization process, since different samples contained different D-isomers of amino acids. The smallest amount of D-isomers is found in milk that has not undergone any industrial processing. Studies have shown that technological processing of milk inevitably leads to the formation of D-isomers of amino acids, and this, in turn, at least reduces the nutritional and biological value of the product, which makes it necessary to conduct deeper studies in this direction to establish the most important factors in the process of racemization of amino acids in food products.


Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1738 ◽  
Author(s):  
Subhadeep Chakrabarti ◽  
Snigdha Guha ◽  
Kaustav Majumder

Recent scientific evidence suggests that food proteins not only serve as nutrients, but can also modulate the body’s physiological functions. These physiological functions are primarily regulated by some peptides that are encrypted in the native protein sequences. These bioactive peptides can exert health beneficial properties and thus are considered as a lead compound for the development of nutraceuticals or functional foods. In the past few decades, a wide range of food-derived bioactive peptide sequences have been identified, with multiple health beneficial activities. However, the commercial application of these bioactive peptides has been delayed because of the absence of appropriate and scalable production methods, proper exploration of the mechanisms of action, high gastro-intestinal digestibility, variable absorption rate, and the lack of well-designed clinical trials to provide the substantial evidence for potential health claims. This review article discusses the current techniques, challenges of the current bioactive peptide production techniques, the oral use and gastrointestinal bioavailability of these food-derived bioactive peptides, and the overall regulatory environment.


2020 ◽  
Vol 6 (1) ◽  
pp. 43-55
Author(s):  
A. I. Andriyanov ◽  
E. V. Kravchenko ◽  
S. G. Kuz’min ◽  
L. P. Lazarenko ◽  
O. G. Korosteleva ◽  
...  

At present time, the compliance of energy costs and the chemical composition of foods in the daily diet with physiological needs of the body gains a particular relevance. Particular attention is paid to the use of functional food products - special products intended for systematic use by all age groups of a healthy population. Functional nutrition compensates for the deficiency of essential amino acids, polyunsaturated fatty acids (PUFA), vitamins, macro- and microelements, etc., as well as protects the body from the effects of pesticides and herbicides, antibiotics, dyes and preservatives, widely used in conventional products, and is used to strengthen health and prevent diseases caused by deficiencies in traditional nutrition. Such diseases include: obesity, non-insulin-dependent diabetes mellitus, hypertension, atherosclerosis, mental depression and others. In some professional groups, for example, in military athletes, the use of functional foods has been practiced for a long time. Currently, a fairly wide range of this group of products has been developed and is being produced. When developing a functional product, environmentally friendly raw materials of animal and vegetable origin, biologically active additives that improve functional and consumer qualities should be used. The high content of amino acids, proteins, carbohydrates, minerals, vitamins and other necessary biologically active substances, as well as good organoleptic characteristics and high consumer properties justify the feasibility of including functional products in the diet of military personnel, whose professional activity is characterized by high physical activity, requiring maximum use of functional resources organism. At the same time, military personnel are capable of completing official tasks at the limit of their physical capabilities, while maintaining relatively constant biochemical constants of the internal environment of the body. The information presented in the paper will be useful to the logistics and medical service specialists of the Russian Army and Navy and will serve as the basis for further development of the direction for the use of functional products for feeding military personnel.


2021 ◽  
Author(s):  
Volkan Gelen ◽  
Abdulsamed Kükürt ◽  
Emin Şengül ◽  
Hacı Ahmet Devecı

Adipose tissue (AT) in the body plays a very important role in the regulation of energy metabolism. AT regulates energy metabolism by secreting adipokines. Some of the adipokines released are vaspin, resistin, adiponectin, visfatin and omentin, and leptin. In addition to regulating energy metabolism, leptin plays a role in the regulation of many physiological functions of the body such as regulation of blood pressure, inflammation, nutrition, appetite, insulin and glucose metabolism, lipid metabolism, coagulation, and apoptosis. Among all these physiological functions, the relationship between leptin, oxidative stress, and apoptosis has gained great importance recently due to its therapeutic effect in various types of cancer. For this reason, in this study, the release of leptin, its cellular effects and its effect on oxidative stress, and apoptosis are discussed in line with current information.


2020 ◽  
Vol 7 (1) ◽  
pp. 116-122
Author(s):  
Susanti Susanti ◽  
Caturia Sasti Sulistyana

Salah satu gangguan kesehatan yang banyak dialami oleh lansia adalah pada sistem kardiovaskuler yaitu hipertensi. Pada berbagai posisi akan menghasilkan tekanan darah yang bervariasi. Penelitian ini bertujuan untuk mengetahui hasil pengukuran tekanan darah pada lansia yang menderita hipertensi antara posisi duduk dan posisi berdiri. Penelitian ini dilaksanakan di RW 06 Kelurahan Bongkaran Sejahtera Kecamatan Pabean Cantian Surabaya pada 27 Januari 2018. Metode pada penelitian  yaitu  pra eksperimental dengan tipe one group pre post test design dengan pendekatan cross sectional. Sampel penelitian ditentukan secara total sampling yang berjumlah 50 orang. Data dianalisa menggunakan  uji  Wilcoxon Signed Ranks Test. Hasil penelitian menunjukan terdapat pengaruh posisi tubuh  terhadap tekanan darah. Hasil penelitian yang diperoleh sebagai berikut: tekanan darah yang diukur pada saat duduk sebesar 29 orang (58%) dikategorikan Hipertensi Derajat 1, sedangkan posisi berdiri sebesar 20 orang (34%) dikategorikan Hipertensi Derajat 2. Hasil uji Wilcoxon Signed Ranks Test menunjukkan bahwa terdapat perbedaan yang bermakna antara posisi duduk dan posisi berdiri dengan nilai p = 0,000 < α =0,05. Kecepatan denyut jantung akan meningkat pada posisi duduk karena jantung memompa darah akan lebih keras sehingga melawan gaya gravitasi. Hal ini membuat tekanan darah cenderung stabil.. Pengukuran tekanan darah dapat dilakukan pada  posisi tubuh yang lain dengan perbedaan waktu istirahat, dan berikan interval waktu dalam melakukan pengukuran tekanan darah. One of the many health problems experienced by the elderly is the cardiovascular system, that is hypertension. Blood pressure varies in a wide range of circumstances, one of which is the change in position. The purpose of this research is to know the results of the measurement of the blood pressure between sitting position and standing position on the elderly who suffer from hypertension. This research was carried out in the prosperous Village 06 RW Bongkaran Sejahtera Kecamatan Pabean Cantian Surabaya on 27 January 2018. Research on the methods of experimental type with pre eksperiment one group pre post test design with cross sectional approach. Sample determined in simple random sampling of 50 people. The data were analyzed using the Wilcoxon Signed Ranks test. The results showed there are. influence of the position of the body against blood pressure. The research results obtained the following data: blood pressure sitting of 29 people (58%) categorized Hypertension Degrees 1, while a sitting position by 20 people (34%) categorized Hypertension Degrees 2. Test results Wilcoxon Signed Ranks Test showed that there were significant differences between the positions of sitting and standing position with a value of p = 0.000<α = 0.05. Seated position makes blood pressure tend to be stable. Working the heart in a sitting position, in pumping blood will be harder because it opposes the gravitational force so that the heart rate increases. Blood pressure measurement can be done a variety of positions, the time difference break, as well as to provide an interval of time in doing the measurement of blood pressure.


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