scholarly journals Oxytocin Signaling Acts as a Marker for Environmental Stressors in Zebrafish

2021 ◽  
Vol 22 (14) ◽  
pp. 7459
Author(s):  
Hsin-Ju Chuang ◽  
Chun-Yung Chang ◽  
Huai-Ping Ho ◽  
Ming-Yi Chou
Keyword(s):  
Stress Responses ◽  
Behavioral Outcomes ◽  
Environmental Stressors ◽  
Adult Zebrafish ◽  
Peripheral Tissues ◽  
Stress Indicator ◽  
Oxytocin Receptors ◽  
And Behavior ◽  
The Brain ◽  
Insight Into

The oxytocin system plays a role in stress responses and behavior modulation. However, the effects of oxytocin signaling on stress adaptation remain unclear. Here, we demonstrated the roles of oxytocin signaling as a biomarker under stress conditions in the peripheral tissues (the gills) and central nervous system (the brain). All the environmental stressors downregulated the expression of oxytocin receptors in the gills, and the alteration of the expression of oxytocin receptors was also found in the brain after the acidic (AC) and high-ammonia (HA) treatments. The number of oxytocin neurons was increased after double-deionized (DI) treatment. By transgenic line, Tg(oxtl:EGFP), we also investigated the projections of oxytocin neurons and found oxytocin axon innervations in various nuclei that might regulate the anxiety levels and aggressiveness of adult zebrafish under different environmental stresses. The oxytocin system integrates physiological responses and behavioral outcomes to ensure environmental adaptation in adult zebrafish. Our study provides insight into oxytocin signaling as a stress indicator upon environmental stressors.

scholarly journals Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain

2016 ◽  
Vol 28 (4pt2) ◽  
pp. 1229-1243 ◽  
Author(s):  
Tiffany S. Doherty ◽  
Tania L. Roth
Keyword(s):  
Central Nervous System ◽  
Animal Models ◽  
Behavioral Outcomes ◽  
Adult Brain ◽  
Epigenetic Changes ◽  
Behavioral Deficits ◽  
The Central Nervous System ◽  
Brain And Behavior ◽  
And Behavior ◽  
The Brain

AbstractThe efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments.

scholarly journals Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior

2021 ◽  
Author(s):  
Ronald de Vlaming ◽  
Eric A.W. Slob ◽  
Philip R Jansen ◽  
Alain Dagher ◽  
Philipp D. Koellinger ◽  
...  
Keyword(s):  
Grey Matter ◽  
Behavioral Outcomes ◽  
Genetic Correlations ◽  
Brain Morphology ◽  
Grey Matter Volume ◽  
Behavioral Traits ◽  
And Behavior ◽  
The Brain ◽  
Genomic Relatedness ◽  
Shared Genetic

Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce multivariate genomic-relatedness restricted maximum likelihood (MGREML) and provide estimates of the heritability of grey-matter volume in 74 regions of interest (ROIs) in the brain. We map genetic correlations between these ROIs and health-relevant behavioral outcomes including intelligence. We find four genetically distinct clusters in the brain that are aligned with standard anatomical subdivision in neuroscience. Behavioral traits have distinct genetic correlations with brain morphology which suggests trait-specific relevance of ROIs.

scholarly journals Remodeling in the Prefrontal Cortex of a Brain-related to Higher Executive Functions in Adolescence: Its effects on Behavior

2021 ◽  
pp. 99-102
Author(s):  
Tin Moe Nwe ◽  
San San Aye ◽  
Khin Than Yee ◽  
Soe Lwin ◽  
Vidya Bhagat
Keyword(s):  
Prefrontal Cortex ◽  
Problem Behaviors ◽  
Independent Living ◽  
Behavioral Outcomes ◽  
Risky Behaviors ◽  
Developmental Trajectory ◽  
The Past ◽  
Brain Changes ◽  
The Brain ◽  
Insight Into

Adolescence is a critical stage of the developmental trajectory, where a child’s transition to independent living may result in healthy or unhealthy styles. During this period, it is easier to mend an individual as a healthy adult; at the same time, misguided children may enter into risky behaviors. The aim of the study to get an insight into changing brains of adolescents and their behavioral outcomes. The current review search engine proceeds with reviewing the literature in the past through electronic databases such as PubMed, Medline, and Scopus databases using keywords such as adolescent stage, the brain of teenagers, risk behaviors, reduction in gray matter in the prefrontal cortex. The current study reviewed and analyzed 20 articles. The reviewed articles would increase the awareness and insights regarding brain changes and their behavioral outcomes. This insightful information’s drawn out of the study may help professionals and parents who intervene the adolescent’s problem behaviors.

scholarly journals The Circadian Clock and Viral Infections

2020 ◽  
pp. 074873042096776
Author(s):  
Helene Borrmann ◽  
Jane A McKeating ◽  
Xiaodong Zhuang
Keyword(s):  
Circadian Clock ◽  
Clinical Evidence ◽  
Viral Infections ◽  
Peripheral Tissues ◽  
Antiviral Therapies ◽  
Regulatory Circuits ◽  
Fertile Ground ◽  
Central Clock ◽  
And Behavior ◽  
The Brain

The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections. These rhythms affect the pharmacokinetics and efficacy of therapeutic agents and vaccines. The core circadian regulatory circuits and clock-regulated host pathways provide fertile ground to identify novel antiviral therapies. An increased understanding of the role circadian systems play in regulating virus infection and the host response to the virus will inform our clinical management of these diseases. This review provides an overview of the experimental and clinical evidence reporting on the interplay between the circadian clock and viral infections, highlighting the importance of virus-clock research.

Review of Self-regulation of the Brain and Behavior.

1985 ◽  
Vol 30 (12) ◽  
pp. 999-999
Author(s):  
Gerald S. Wasserman
Keyword(s):  
Self Regulation ◽  
Brain And Behavior ◽  
And Behavior ◽  
The Brain

An Insight into Oligopeptide Transporter 3 (OPT3) family proteins

2020 ◽  
Vol 27 ◽  
Author(s):  
Fırat Kurt
Keyword(s):  
Stress Responses ◽  
Chelating Agent ◽  
Biological Processes ◽  
Biotic And Abiotic Stress ◽  
Oligopeptide Transporter ◽  
Binding Residues ◽  
Fe Homeostasis ◽  
Proteins Interactions ◽  
Insight Into ◽  
Selection Of

: Oligopeptide transporter 3 (OPT3) proteins are one of the subsets of OPT clade, yet little is known about these transporters. Therefore, homolog OPT3 proteins in several plant species were investigated and characterized using bioinformatical tools. Motif and co-expression analyses showed that OPT3 proteins may be involved in both biotic and abiotic stress responses as well as growth and developmental processes. AtOPT3 usually seemed to take part in Fe homeostasis whereas ZmOPT3 putatively interacted with proteins involved in various biological processes from plant defense system to stress responses. Glutathione (GSH), as a putative alternative chelating agent, was used in the AtOPT3 and ZmOPT3 docking analyses to identify their putative binding residues. The information given in this study will contribute to the understanding of OPT3 proteins’ interactions in various pathways and to the selection of potential ligands for OPT3s.

scholarly journals Functional Food—Consumer Motivations and Expectations

2021 ◽  
Vol 18 (10) ◽  
pp. 5327
Author(s):  
Kinga Topolska ◽  
Adam Florkiewicz ◽  
Agnieszka Filipiak-Florkiewicz
Keyword(s):  
Functional Food ◽  
Consumer Attitudes ◽  
Evidence Based ◽  
Nutritional Knowledge ◽  
Future Perspectives ◽  
Research Papers ◽  
Adequate Knowledge ◽  
Food Market ◽  
And Behavior ◽  
Insight Into

This review provides insight into consumer attitudes toward functional food (FF), with the purpose of better understanding the needs and behavior regarding this kind of product. A total of 47 articles were selected for this paper. The available studies from last 20 years differ according to the focus (awareness, attitudes, motivations, willingness, acceptance by consumers) and methodologies used. Several factors, including socio-demographic, cognitive and attitudinal ones, seem to be serve as the basis for the acceptance of functional products. The research papers showed that nutritional knowledge is the most important of these. Older people are more interested in functional products than younger consumers, because of their stronger belief in the health benefits of FF. Moreover, women are more open to compromise between taste and health properties. Claims concerning the disease preventative properties of FF are the most attractive for consumers. This review focuses also on future perspectives for the functional food market. Adequate knowledge and evidence-based communication seem to be the most promising ways to increase consumers’ interest in these kinds of products.

scholarly journals Can neuroscience help to understand narcissism? A systematic review of an emerging field

2021 ◽  
Vol 4 ◽  
Author(s):  
Emanuel Jauk ◽  
Philipp Kanske
Keyword(s):  
Systematic Review ◽  
Stress Responses ◽  
Interpersonal Functioning ◽  
Integrative Model ◽  
Experimental Investigations ◽  
Future Research ◽  
Pathological Narcissism ◽  
Ego Threat ◽  
Self Reports ◽  
And Behavior

Abstract Narcissism is a Janusian personality construct, associated with both grandiose self-assuredness and dominance, as well as vulnerable insecurity and reactivity. Central questions of intra- and interpersonal functioning in narcissism are still a matter of debate. Neuroscience could help to understand the paradoxical patterns of experience and behavior beyond the limitations of self-reports. We provide a systematic review of 34 neuroscience studies on grandiose, vulnerable, pathological narcissism, and Narcissistic Personality Disorder (NPD), spanning experimental investigations of intra- and interpersonal mechanisms, research on neurophysiological and neuroendocrine aspects of baseline function, and brain structural correlates. While neuroscience has scarcely directly studied vulnerable narcissism, grandiose narcissism is associated with heightened vigilance to ego threat and stress responses following ego threat, as well as heightened stress indicators in baseline measures. Such responses are not commonly observed in self-reports, highlighting the potential of neuroscience to augment our understanding of self-regulatory dynamics in narcissism. Interpersonal functioning is characterized by deficits in social–affective processes. Both involve altered activity within the salience network, pointing to a double dissociation regarding the expression of narcissism and self/other oriented situational focus. Findings are summarized in an integrative model providing testable hypotheses for future research along with methodological recommendations.

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