scholarly journals The Potential of Calcium/Phosphate Containing MAO Implanted in Bone Tissue Regeneration and Biological Characteristics

2021 ◽  
Vol 22 (9) ◽  
pp. 4706
Author(s):  
Shun-Yi Jian ◽  
Salim Levent Aktug ◽  
Hsuan-Ti Huang ◽  
Cheng-Jung Ho ◽  
Sung-Yen Lin ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Calcium Phosphate ◽  
Soft Tissues ◽  
Salt Spray ◽  
Surface Characteristics ◽  
Corrosion Current ◽  
Biological Properties ◽  
Bone Tissue Regeneration ◽  
Additional Surgery

Micro arc oxidation (MAO) is a prominent surface treatment to form bioceramic coating layers with beneficial physical, chemical, and biological properties on the metal substrates for biomaterial applications. In this study, MAO treatment has been performed to modify the surface characteristics of AZ31 Mg alloy to enhance the biocompatibility and corrosion resistance for implant applications by using an electrolytic mixture of Ca3(PO4)2 and C10H16N2O8 (EDTA) in the solutions. For this purpose, the calcium phosphate (Ca-P) containing thin film was successfully fabricated on the surface of the implant material. After in-vivo implantation into the rabbit bone for four weeks, the apparent growth of soft tissues and bone healing effects have been documented. The morphology, microstructure, chemical composition, and phase structures of the coating were identified by SEM, XPS, and XRD. The corrosion resistance of the coating was analyzed by polarization and salt spray test. The coatings consist of Ca-P compounds continuously have proliferation activity and show better corrosion resistance and lower roughness in comparison to mere MAO coated AZ31. The corrosion current density decreased to approximately 2.81 × 10−7 A/cm2 and roughness was reduced to 0.622 μm. Thus, based on the results, it was anticipated that the development of degradable materials and implants would be feasible using this method. This study aims to fabricate MAO coatings for orthopedic magnesium implants that can enhance bioactivity, biocompatibility, and prevent additional surgery and implant-related infections to be used in clinical applications.

scholarly journals A Review on the Enhancement of Calcium Phosphate Cement with Biological Materials in Bone Defect Healing

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3075
Author(s):  
Sok Kuan Wong ◽  
Yew Hoong Wong ◽  
Kok-Yong Chin ◽  
Soelaiman Ima-Nirwana
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Research Effort ◽  
Biological Materials ◽  
Biological Properties ◽  
Comprehensive Overview ◽  
Bone Defect Healing ◽  
Living Organisms

Calcium phosphate cement (CPC) is a promising material used in the treatment of bone defects due to its profitable features of self-setting capability, osteoconductivity, injectability, mouldability, and biocompatibility. However, the major limitations of CPC, such as the brittleness, lack of osteogenic property, and poor washout resistance, remain to be resolved. Thus, significant research effort has been committed to modify and reinforce CPC. The mixture of CPC with various biological materials, defined as the materials produced by living organisms, have been fabricated by researchers and their characteristics have been investigated in vitro and in vivo. This present review aimed to provide a comprehensive overview enabling the readers to compare the physical, mechanical, and biological properties of CPC upon the incorporation of different biological materials. By mixing the bone-related transcription factors, proteins, and/or polysaccharides with CPC, researchers have demonstrated that these combinations not only resolved the lack of mechanical strength and osteogenic effects of CPC but also further improve its own functional properties. However, exceptions were seen in CPC incorporated with certain proteins (such as elastin-like polypeptide and calcitonin gene-related peptide) as well as blood components. In conclusion, the addition of biological materials potentially improves CPC features, which vary depending on the types of materials embedded into it. The significant enhancement of CPC seen in vitro and in vivo requires further verification in human trials for its clinical application.

Effect of Sol-Gel Film on the Corrosion Resistance of Low Carbon Steel Plate

2020 ◽  
Vol 984 ◽  
pp. 43-50
Author(s):  
Hua Yuan Zhang ◽  
Can Wang ◽  
Bing Xue ◽  
Jing Luo
Keyword(s):  
Corrosion Resistance ◽  
Carbon Steel ◽  
Steel Plate ◽  
Salt Spray ◽  
Sol Gel ◽  
Low Carbon Steel ◽  
Corrosion Current ◽  
Neutral Salt ◽  
Low Carbon ◽  
Gel Film

To improve the corrosion resistance on Q235 low carbon steel, in this paper, tetraethyl orthosilicate (TEOS), N-dodecyl trimethoxysilane and γ-(2,3-epoxypropoxy) propytrimethoxysilane (KH560) were used to make organic-inorganic hybrid sol-gel film. Cross cut test adhesion method, neutral salt spray test, electrochemical test and film protective efficiency were taken to value the corrosion resistance property. The corrosion topography was studied by optical microscope. In addition, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) curves and equivalent electric circuit fitting were used to analyze the corrosion mechanism. The cross cut adhesion of sol-gel film can reach 1 class and the protection class can attain 5 class after 72 hours neutral salt spray test. According to the potentiodynamic polarization curve analysis, the corrosion potential of sol-gel film coating sample after 0.5 hours immersion was -0.46 V (vs. SCE) on the 0.1 Hz, and its corrosion current density was 4.74×10-7 A·cm-2. The corrosion potential of bare Q235 low carbon steel plate after 0.5 hours immersion was -0.78 V (vs. SCE) on the 0.1 Hz, and its corrosion current density was 4.75×10-6 A·cm-2. The impedance value on 0.1 Hz (|Z|0.1Hz) (1.27×106 Ω·cm2) of sol-gel film coating sample was more than three orders of magnitude higher than the value of the low carbon steel plate. Even dipping in 3.5 wt. % NaCl for 72 hours, the |Z|0.1Hz value of sol-gel coating sample was still one order of magnitude higher than the low carbon steel plate with 0.5 hours immersion. Sol-gel film with excellent adhesion can significantly improve the corrosion resistance of low carbon steel plate. Sol-gel film can increase the protection efficiency of low carbon steel plate by 90%.

Effects of potassium silicate on corrosion behavior of dacromet coating

2019 ◽  
Vol 66 (6) ◽  
pp. 819-826
Author(s):  
Khashayar Tabi ◽  
Mansour Farzam ◽  
Davood Zaarei
Keyword(s):  
Corrosion Resistance ◽  
Corrosion Behavior ◽  
Automobile Industry ◽  
Electrochemical Impedance ◽  
Salt Spray ◽  
Corrosion Current ◽  
Potassium Silicate ◽  
Coated Steel ◽  
Content Type ◽  
New Information

Purpose Potassium silicate sealer was applied on solvent-cleaned, acid-pickled, dacromet-coated steel to improve its corrosion resistance. The purpose of this paper is to study the corrosion behavior of dacromet-coated steel. Design/methodology/approach Potassium silicate sealer was applied on solvent-cleaned, acid-pickled, dacromet-coated steel to improve its corrosion resistance. Electrochemical impedance spectroscopy (EIS), potentiodynamic polarization, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and salt spray were carried out. SEM was used to study the morphological appearance of the surface. Findings The EIS behavior indicated that solvent-cleaned dacromet-coated steel sealed with potassium silicate showed that the corrosion current density was 2.664E − 5 A.cm2 which was reduced to 8.752E − 6 A.cm2 and the corrosion rate, which was 2.264E − 2 mm.year−1, was reduced to 7.438E − 3 mm.year−1 in NaCl 3.5 wt.per cent. EIS was used in NaCl 3.5 wt.%, and the Bode plot characteristics showed that the corrosion protection of solvent-cleaned, dacromet-coated steel was enhanced when sealed with potassium silicate. The EDS results of salt-sprayed, solvent-cleaned samples after 10 days indicated that the main corrosion products are composed of SiO2, ZnO and Al2O3. Research limitations/implications The detection of Li element in EDS was not possible because of the device limitation. Originality/value The current paper provides new information about the sealing properties of potassium silicate and its effects on the corrosion resistance of dacromet coating, which is widely used in many industries such as the automobile industry.

scholarly journals Calcium Phosphate Ceramics Can Prevent Bisphosphonate-Related Osteonecrosis of the Jaw

Materials ◽  
2020 ◽  
Vol 13 (8) ◽  
pp. 1955
Author(s):  
Siri Paulo ◽  
Mafalda Laranjo ◽  
Anabela Paula ◽  
Ana Margarida Abrantes ◽  
João Martins ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Calcium Phosphate ◽  
Tooth Extraction ◽  
Soft Tissues ◽  
Calcium Phosphates ◽  
Test Group ◽  
Osteonecrosis Of The Jaw ◽  
In Vivo Model ◽  
Calcium Phosphate Ceramics

Bisphosphonate-associated osteonecrosis of the jaw (BRONJ), a post-surgical non-healing wound condition, is one of the most common side effects in patients treated with nitrogen-containing bisphosphonates. Its physiopathology has been related with suppression of bone turnover, of soft tissue healing and infection. Biphasic calcium phosphates (BCP) are used as a drug delivery vehicle and as a bone substitute in surgical wounds. Due to their capacity to adsorb zoledronate, it was hypothesized these compounds might have a protective effect on the soft tissues in BRONJ wounds. To address this hypothesis, a reproducible in vivo model of BRONJ in Wistar rats was used. This model directly relates chronic bisphosphonate administration with the development of osteonecrosis of the jaw after tooth extraction. BCP granules were placed in the alveolus immediately after tooth extraction in the test group. The animals were evaluated through nuclear medicine, radiology, macroscopic observation, and histologic analysis. Encouragingly, calcium phosphate ceramics were able to limit zoledronate toxicity in vivo and to favor healing, which was evidenced by medical imaging (nuclear medicine and radiology), macroscopically, and through histology. The studied therapeutic option presented itself as a potential solution to prevent the development of maxillary osteonecrosis.

scholarly journals Surface Modification of Mg0.8Ca Alloy via Wollastonite Micro-Arc Coatings: Significant Improvement in Corrosion Resistance

Metals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 754
Author(s):  
Mariya B. Sedelnikova ◽  
Anna V. Ugodchikova ◽  
Tatiana V. Tolkacheva ◽  
Valentina V. Chebodaeva ◽  
Ivan A. Cluklhov ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Corrosion Current ◽  
Biological Properties ◽  
Mineralization Process ◽  
Corrosion Properties ◽  
Oxidation Method ◽  
Significant Difference ◽  
Structure Phase ◽  
Micro Arc Oxidation ◽  
Calcium Silicates

Biodegradable materials are currently attracting the attention of scientists as materials for implants in reconstructive medicine. At the same time, ceramics based on calcium silicates are promising materials for bone recovery, because Ca2+ and Si2+ ions are necessary for the mineralization process, and they take an active part in the formation of apatite. In the presented research, the protective silicate biocoatings on a Mg0.8Ca alloy were formed by means of the micro-arc oxidation method, and the study of their morphology, structure, phase composition, corrosion, and biological properties was carried out. Elongated crystals and pores were uniformly distributed over the surface of the coatings. The coated samples exhibited remarkable anti-corrosion properties in comparison with bare magnesium alloy because their corrosion current decreased 10 times, and their corrosion resistance increased almost 100 times. The coatings did not significantly affect the viability of the cells, even without the additional dilution of the extract, and were non-toxic according to ISO 10993-5: 2009. In this case, there was a significant difference in toxicity of the pure Mg0.8Ca alloy and the coated samples. Thus, the results demonstrated that the applied coatings significantly reduced the toxicity of the alloy.

Enhancing in vitro bioactivity and in vivo osteogenesis of organic–inorganic nanofibrous biocomposites with novel bioceramics

2014 ◽  
Vol 2 (37) ◽  
pp. 6293-6305 ◽  
Author(s):  
Tao Liu ◽  
Xinbo Ding ◽  
Dongzhi Lai ◽  
Yongwei Chen ◽  
Ridong Zhang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Biological Properties ◽  
Bone Tissue Regeneration ◽  
In Vitro Bioactivity ◽  
Physicochemical And Biological Properties

MGHA-introduced, an electrospun SF-based composite can exhibit improved physicochemical and biological properties to stimulate bone tissue regeneration and repair.

scholarly journals Bone Tissue Regeneration by Collagen Scaffolds with Different Calcium Phosphate Coatings: Amorphous Calcium Phosphate and Low-Crystalline Apatite

Materials ◽  
2021 ◽  
Vol 14 (19) ◽  
pp. 5860
Author(s):  
Syama Santhakumar ◽  
Ayako Oyane ◽  
Maki Nakamura ◽  
Yuto Yoshino ◽  
Mohammed Katib Alruwaili ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Amorphous Calcium Phosphate ◽  
Bone Tissue Regeneration ◽  
Apatite Coating ◽  
Low Crystalline ◽  
Mineralized Collagen

Surface-mineralized collagen sponges have attracted much attention as scaffolds for bone tissue engineering. Recently, we developed amorphous calcium phosphate (ACP) and low-crystalline apatite coating processes on collagen sponges. In the present study, we applied these coating processes to granular collagen sponges (referred to as Col) to compare the bone tissue regeneration capabilities of ACP-coated and apatite-coated Col (referred to as Col-ACP and Col-Ap, respectively) using a rat cranial bone defect model. According to micro-CT and histological analyses, Col-Ap enhanced bone tissue regeneration compared to Col, whereas Col-ACP did not. These results not only demonstrated the superior bone tissue regeneration capability of Col-Ap, but also indicated limitations of the in vitro simulated body fluid (SBF) test used in our previous study. Despite the apatite-forming ability of Col-ACP in SBF, it was ineffective in improving bone tissue regeneration in vivo, unlike Col-Ap, most likely due to the quick resorption of the ACP coating in the defect site. The present results clarified the importance of the coating stability in vivo and revealed that the low-crystalline apatite coating was more beneficial than the ACP coating in the fabrication of surface-mineralized collagen sponges for use as bone tissue engineering scaffolds.

Fabrication and Corrosion Properties of Electroplated Ni-Co-Cr Alloy Coatings

2013 ◽  
Vol 456 ◽  
pp. 438-441 ◽  
Author(s):  
Tian Yang ◽  
Cheng Zhang Peng ◽  
Lang Xiang ◽  
Huo Cao
Keyword(s):  
Corrosion Resistance ◽  
Salt Spray ◽  
Low Carbon Steel ◽  
Corrosion Current ◽  
Polarization Measurement ◽  
Neutral Salt ◽  
Low Carbon ◽  
X Ray Diffraction ◽  
Corrosion Properties ◽  
X Ray

The electroplated Ni-Co-Cr coatings were prepared on surface of a low carbon steel. The microstructure of the deposits were analyzed by scanning electron microscope (SEM) and X-ray diffraction (XRD), the corrosion resistance of the deposits was evaluated using neutral salt-spray test and polarization measurement. The results show that the deposits are a Co and Cr solid solution in Ni with a grain size of 6.9~10.6nm, were nearly free of corrosion after neutral salt-spray tested 100 hours. With chromium content increasing, the coatings exhibited higher corrosion potential and lower corrosion current, which revealed excellent corrosion resistance.

Bone regeneration strategy by different sized multichanneled biphasic calcium phosphate granules: In vivo evaluation in rabbit model

2018 ◽  
Vol 32 (10) ◽  
pp. 1406-1420 ◽  
Author(s):  
Mirana Taz ◽  
Sang Ho Bae ◽  
Hae Il Jung ◽  
Hyun-Deuk Cho ◽  
Byong-Taek Lee
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Rabbit Model ◽  
Morphological Characteristics ◽  
Confocal Imaging ◽  
Bone Tissue Regeneration ◽  
Micro Computed Tomography ◽  
In Vivo Evaluation

A variety of synthetic materials are currently in use as bone substitutes, among them a new calcium phosphate-based multichannel, cylindrical, granular bone substitute that is showing satisfactory biocompatibility and osteoconductivity in clinical applications. These cylindrical granules differ in their mechanical and morphological characteristics such as size, diameter, surface area, pore size, and porosity. The aim of this study is to investigate whether the sizes of these synthetic granules and the resultant inter-granular spaces formed by their filling critical-sized bone defects affect new bone formation characteristics and to determine the best formulations from these individual types by combining the granules in different proportions to optimize the bone tissue regeneration. We evaluated two types of multichanneled cylindrical granules, 1 mm and 3 mm in diameter, combined the granules in two different proportions (wt%), and compared their different mechanical, morphological, and in vitro and in vivo biocompatibility characteristics. We assessed in vitro biocompatibility and cytotoxicity using MC3T3-E1 osteoblast-like cells using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and confocal imaging. In vivo investigation in a rabbit model indicated that all four samples formed significantly better bone than the control after four weeks and eight weeks of implantation. Micro-computed tomography analysis showed more bone formation by the 1 mm cylindrical granules with 160 ± 10 µm channeled pore and 50% porosity than the other three samples ( p<.05), which we confirmed by histological analysis.

scholarly journals in situ Fabrication of Biological Chitosan and Gelatin-Based Hydrogels Loading Biphasic Calcium Phosphate Nanoparticles for Bone Tissue Regeneration

2019 ◽  
Vol 31 (5) ◽  
pp. 1062-1070
Author(s):  
Tien Thinh Nguyen ◽  
Chan Khon Huynh ◽  
Van Thu Le ◽  
Minh Dung Truong ◽  
Bach Long Giang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Biological Properties ◽  
Bone Tissue Regeneration ◽  
Nanocomposite Hydrogels ◽  
In Situ Fabrication ◽  
Marrow Mesenchymal Stem Cells ◽  
Calcium Phosphate Nanoparticles ◽  
Gelatin Derivative

Adjustably biodegradable materials have gained much attention in biomedical applications. Among of them, various hydrogel-based scaffolds have applied for regenerating soft and hard tissues. In this study, according to differently biological properties of gelatin or chitosan as well as biphasic calcium phosphate nanoparticles (BCPNPs), several injectable nanocomposite hydrogels (INgel) were enzymatically fabricated from a phenolic chitosan derivative (PCD), phenolic gelatin derivative (PGD) and BCPNPs. According the change of H2O2 concentration with follow-up the time, the in situ formation of INgel was varied from 35 to 80 s. The degradation rate of the nanocomposite materials significantly related to in presence of collagenase that expended from 3 days to over one month depending on amount of the formulated PCD. The BCPNPs-encapsulated PCD-PGD INgel enhanced mineralization in the simulated biofluid. Fluorescent cytotoxicity assay indicated that the INgel was fabricated from a higher amount of the PGD resulting in a significant proliferation of bone marrow mesenchymal stem cells. These preliminary results exhibited a great potential of the INgel for bone regeneration.

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