scholarly journals Insight on Solution Plasma in Aqueous Solution and Their Application in Modification of Chitin and Chitosan

2021 ◽  
Vol 22 (9) ◽  
pp. 4308
Author(s):  
Chayanaphat Chokradjaroen ◽  
Jiangqi Niu ◽  
Gasidit Panomsuwan ◽  
Nagahiro Saito
Keyword(s):  
Aqueous Solutions ◽  
Atmospheric Pressure ◽  
Scientific Progress ◽  
Biological Properties ◽  
Environmental Concerns ◽  
Plasma Process ◽  
Renewable Materials ◽  
Chemical Structures ◽  
Chitin And Chitosan ◽  
Insight Into

Sustainability and environmental concerns have persuaded researchers to explore renewable materials, such as nature-derived polysaccharides, and add value by changing chemical structures with the aim to possess specific properties, like biological properties. Meanwhile, finding methods and strategies that can lower hazardous chemicals, simplify production steps, reduce time consumption, and acquire high-purified products is an important task that requires attention. To break through these issues, electrical discharging in aqueous solutions at atmospheric pressure and room temperature, referred to as the “solution plasma process”, has been introduced as a novel process for modification of nature-derived polysaccharides like chitin and chitosan. This review reveals insight into the electrical discharge in aqueous solutions and scientific progress on their application in a modification of chitin and chitosan, including degradation and deacetylation. The influencing parameters in the plasma process are intensively explained in order to provide a guideline for the modification of not only chitin and chitosan but also other nature-derived polysaccharides, aiming to address economic aspects and environmental concerns.

Studies on Chitosan Extraction and Its Biomedical Properties

2020 ◽  
Vol 3 (2) ◽  
pp. 69
Author(s):  
Alef Mustafa ◽  
Rodica Sîrbu
Keyword(s):  
Aqueous Solutions ◽  
Biological Properties ◽  
Raw Material ◽  
Biological Macromolecules ◽  
The Novel ◽  
Potential Applications ◽  
Chitin And Chitosan

Chitin and chitosan are natural biopolymers that are included in the novel families of biological macromolecules. Chitosan its the main derivative of chitin, and research upon the characteristics and properties of these molecules has become increasingly evident and important. It was reported that the main and potential applications of these polymers as well as their derivatives are more than 200. These applications include biomedicine, pharmacy, agriculture, biotechnology, cosmetics. In the last years, especially in the pharmaceutical and medical fields chitosan has received considerable attentions as a functional, renewable, nontoxic and biodegradable biopolymer for diverse applications. The recent efforts of the scientists concentrated on the methods of preparation of chitin from raw material, on processing chitosan, as well as on the chemical and biological properties that help increase solubility in aqueous solutions.

PubChem and ChEMBL Beyond Lipinski

2019 ◽  
Author(s):  
Jean-Louis Reymond ◽  
Mahendra Awale ◽  
Daniel Probst ◽  
Alice Capecchi
Keyword(s):  
Nearest Neighbor ◽  
Molecular Shape ◽  
Biological Properties ◽  
Web Based ◽  
Large Molecules ◽  
Interactive Tools ◽  
Small Molecule Drugs ◽  
Pubchem Database ◽  
Nearest Neighbor Searches ◽  
Insight Into

<p>Seven million of the currently 94 million entries in the PubChem database break at least one of the four Lipinski constraints for oral bioavailability, 183,185 of which are also found in the ChEMBL database. These non-Lipinski PubChem (NLP) and ChEMBL (NLC) subsets are interesting because they contain new modalities that can display biological properties not accessible to small molecule drugs. Unfortunately, the current search tools in PubChem and ChEMBL are designed for small molecules and are not well suited to explore these subsets, which therefore remain poorly appreciated. Herein we report MXFP (macromolecule extended atom-pair fingerprint), a 217-D fingerprint tailored to analyze large molecules in terms of molecular shape and pharmacophores. We implement MXFP in two web-based applications, the first one to visualize NLP and NLC interactively using Faerun (http://faerun.gdb.tools/), the second one to perform MXFP nearest neighbor searches in NLP (http://similaritysearch.gdb.tools/). We show that these tools provide a meaningful insight into the diversity of large molecules in NLP and NLC. The interactive tools presented here are publicly available at http://gdb.unibe.ch and can be used freely to explore and better understand the diversity of non-Lipinski molecules in PubChem and ChEMBL.</p>

Synthesis, Characterization and Thermal Degradation of Some New 3,5-dimethyl Pyrazole Derivatives

2017 ◽  
Vol 68 (2) ◽  
pp. 317-322
Author(s):  
Anca Mihaela Mocanu ◽  
Constantin Luca ◽  
Alina Costina Luca
Keyword(s):  
Thermal Degradation ◽  
Degradation Mechanism ◽  
New Products ◽  
Analysis Data ◽  
Biological Properties ◽  
Elemental Analysis Data ◽  
Ftir Analysis ◽  
Spectral Measurements ◽  
Chemical Structures ◽  
And Storage

The purpose of this research is to synthetize, characterize and thermal degradation of new heterolytic derivates with potential biological properties. The derivates synthesis was done by obtaining new molecules with pyralozone structure which combine two pharmacophore entities: the amidosulfonyl-R1,R2 phenoxyacetil with the 3,5-dimethyl pyrazole which can have potential biological properties. The synthesis stages of the new products are presented as well as the elemental analysis data and IR, 1H-NMR spectral measurements made for elucidating the chemical structures and thermostability study which makes evident the temperature range proper for their use and storage. The obtained results were indicative of a good correlation of the structure with the thermal stability as estimated by means of the initial degradation temperatures as well as with the degradation mechanism by means of the TG-FTIR analysis.

Chitosan in Biomedical Engineering: A Critical Review

2019 ◽  
Vol 14 (2) ◽  
pp. 93-116 ◽  
Author(s):  
Shabnam Mohebbi ◽  
Mojtaba Nasiri Nezhad ◽  
Payam Zarrintaj ◽  
Seyed Hassan Jafari ◽  
Saman Seyed Gholizadeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Biomedical Engineering ◽  
Biological Properties ◽  
Advanced Materials ◽  
Comprehensive Overview ◽  
Chemical Structures ◽  
Bio Imaging ◽  
Significant Attention ◽  
Unique Chemical

Biomedical engineering seeks to enhance the quality of life by developing advanced materials and technologies. Chitosan-based biomaterials have attracted significant attention because of having unique chemical structures with desired biocompatibility and biodegradability, which play different roles in membranes, sponges and scaffolds, along with promising biological properties such as biocompatibility, biodegradability and non-toxicity. Therefore, chitosan derivatives have been widely used in a vast variety of uses, chiefly pharmaceuticals and biomedical engineering. It is attempted here to draw a comprehensive overview of chitosan emerging applications in medicine, tissue engineering, drug delivery, gene therapy, cancer therapy, ophthalmology, dentistry, bio-imaging, bio-sensing and diagnosis. The use of Stem Cells (SCs) has given an interesting feature to the use of chitosan so that regenerative medicine and therapeutic methods have benefited from chitosan-based platforms. Plenty of the most recent discussions with stimulating ideas in this field are covered that could hopefully serve as hints for more developed works in biomedical engineering.

scholarly journals Formation of Amphiphilic Molecules from the Most Common Marine Polysaccharides, toward a Sustainable Alternative?

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4445
Author(s):  
Tiphaine Wong ◽  
Lorette Brault ◽  
Eric Gasparotto ◽  
Romuald Vallée ◽  
Pierre-Yves Morvan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Carboxylic Acid ◽  
Bioactive Compounds ◽  
Biological Properties ◽  
Cross Linking ◽  
Structural Modifications ◽  
Chemical Structures ◽  
Amphiphilic Molecules

Marine polysaccharides are part of the huge seaweeds resources and present many applications for several industries. In order to widen their potential as additives or bioactive compounds, some structural modifications have been studied. Among them, simple hydrophobization reactions have been developed in order to yield to grafted polysaccharides bearing acyl-, aryl-, alkyl-, and alkenyl-groups or fatty acid chains. The resulting polymers are able to present modified physicochemical and/or biological properties of interest in the current pharmaceutical, cosmetics, or food fields. This review covers the chemical structures of the main marine polysaccharides, and then focuses on their structural modifications, and especially on hydrophobization reactions mainly esterification, acylation, alkylation, amidation, or even cross-linking reaction on native hydroxyl-, amine, or carboxylic acid functions. Finally, the question of the necessary requirement for more sustainable processes around these structural modulations of marine polysaccharides is addressed, considering the development of greener technologies applied to traditional polysaccharides.

Adsorption of imidazolium-based ionic liquids with different chemical structures onto various resins from aqueous solutions

RSC Advances ◽  
2015 ◽  
Vol 5 (52) ◽  
pp. 41352-41358 ◽  
Author(s):  
Luyang Li ◽  
Yu Wang ◽  
Xinhua Qi
Keyword(s):  
Ionic Liquids ◽  
Aqueous Solutions ◽  
Adsorption Behavior ◽  
Chemical Structures

The adsorption behavior of a series of imidazolium-based ionic liquids with different chemical structures onto various resins was investigated.

scholarly journals Mono- and multilayers of molecular spoked carbazole wheels on graphite

2014 ◽  
Vol 10 ◽  
pp. 2783-2788 ◽  
Author(s):  
Stefan-S Jester ◽  
A Vikas Aggarwal ◽  
Daniel Kalle ◽  
Sigurd Höger
Keyword(s):  
Octanoic Acid ◽  
Pyrolytic Graphite ◽  
Self Assembled Monolayers ◽  
Scanning Tunneling ◽  
Tunneling Microscopy ◽  
Chemical Structures ◽  
Rigid Objects ◽  
Assembled Monolayers ◽  
Stm Images ◽  
Insight Into

Self-assembled monolayers of a molecular spoked wheel (a shape-persistent macrocycle with an intraannular spoke/hub system) and its synthetic precursor are investigated by scanning tunneling microscopy (STM) at the liquid/solid interface of 1-octanoic acid and highly oriented pyrolytic graphite. The submolecularly resolved STM images reveal that the molecules indeed behave as more or less rigid objects of certain sizes and shapes – depending on their chemical structures. In addition, the images provide insight into the multilayer growth of the molecular spoked wheels (MSWs), where the first adlayer acts as a template for the commensurate adsorption of molecules in the second layer.

THE ADSORPTION OF ALIPHATIC ACIDS ON ACTIVATED CHARCOALS

1947 ◽  
Vol 25b (5) ◽  
pp. 440-448 ◽  
Author(s):  
R. U. Lemieux ◽  
J. L. Morrison
Keyword(s):  
Aqueous Solutions ◽  
Activation Process ◽  
Aliphatic Acids ◽  
Surface Areas ◽  
Insight Into

The adsorptions of acetic, propionic, butyric, and valeric acids from aqueous solutions on a series of coconut charcoals of different degrees of activation were determined. For purposes of interpretation the numbers of millimoles adsorbed per gram of charcoal were compared for pairs of acids. Unimolecular adsorption of the acids is indicated. Surface areas of the charcoal series were estimated. They range from 130 to 625 sq. m. per gm. of charcoal, depending on the adsorbate used and the degree of activation of the charcoal. Some insight into the activation process is given.

scholarly journals New Sesterterpenes from Marine  Sponges from the Tropical Waters of the  Kingdom of Tonga

2021 ◽  
Author(s):  
◽  
Taitusi Taufa
Keyword(s):  
Biological Activities ◽  
Screening Method ◽  
Biological Properties ◽  
Geometric Isomer ◽  
Marine Sponges ◽  
Ring Closure ◽  
Substitution Pattern ◽  
Methyl Group ◽  
Structure Activity ◽  
Insight Into

<p>Over the course of this study, various species of Tongan marine sponges were investigated using an NMR-based screening method and has resulted in the discovery of three new sesterterpenes and 11 known compounds. Examination of the sponge Fascaplysinopsis sp. resulted in the isolation of two novel sesterterpenes, isoluffariellolide (46) and 1-O-methylisoluffariellolide (47). Compounds 46 and 47 share the same backbone pattern as the known luffariellolide (45) and 25-Omethylluffariellolide (107) respectively, and differ only in the substitution pattern of the butenolide rings. Isoluffariellolide (46) was found to be approximately six times less cytotoxic than 1-O-methylisoluffariellolide (47). Interestingly, these results suggested that the 1-O-methyl group in compound 47 plays an important role in the cytotoxicity of the compound. Secothorectolide (49), a new ring-opened and geometric isomer of the known compound thorectolide (48), was obtained from a sponge of the order Dictyoceratida. This ring closure and opening relationship was also observed between manoalide (109) and secomanoalide (110), as well as luffariellins A (141) and B (142). Despite the different carbon skeleton, the functional groups in 141 and 142 are similar with those in 109 and 110, respectively, and not surprisingly the biological properties are almost identical. The biological activities of compounds 48 and 49 were almost the same, which would give an insight into the structure-activity relationship (SAR) between these types of compounds.</p>

scholarly journals New Sesterterpenes from Marine  Sponges from the Tropical Waters of the  Kingdom of Tonga

2021 ◽  
Author(s):  
◽  
Taitusi Taufa
Keyword(s):  
Biological Activities ◽  
Screening Method ◽  
Biological Properties ◽  
Geometric Isomer ◽  
Marine Sponges ◽  
Ring Closure ◽  
Substitution Pattern ◽  
Methyl Group ◽  
Structure Activity ◽  
Insight Into

<p>Over the course of this study, various species of Tongan marine sponges were investigated using an NMR-based screening method and has resulted in the discovery of three new sesterterpenes and 11 known compounds. Examination of the sponge Fascaplysinopsis sp. resulted in the isolation of two novel sesterterpenes, isoluffariellolide (46) and 1-O-methylisoluffariellolide (47). Compounds 46 and 47 share the same backbone pattern as the known luffariellolide (45) and 25-Omethylluffariellolide (107) respectively, and differ only in the substitution pattern of the butenolide rings. Isoluffariellolide (46) was found to be approximately six times less cytotoxic than 1-O-methylisoluffariellolide (47). Interestingly, these results suggested that the 1-O-methyl group in compound 47 plays an important role in the cytotoxicity of the compound. Secothorectolide (49), a new ring-opened and geometric isomer of the known compound thorectolide (48), was obtained from a sponge of the order Dictyoceratida. This ring closure and opening relationship was also observed between manoalide (109) and secomanoalide (110), as well as luffariellins A (141) and B (142). Despite the different carbon skeleton, the functional groups in 141 and 142 are similar with those in 109 and 110, respectively, and not surprisingly the biological properties are almost identical. The biological activities of compounds 48 and 49 were almost the same, which would give an insight into the structure-activity relationship (SAR) between these types of compounds.</p>

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