scholarly journals Combining Magnetic Resonance Imaging with Systemic Monocyte Evaluation for the Implementation of GBM Management

2021 ◽  
Vol 22 (7) ◽  
pp. 3797
Author(s):  
Carolina Giordano ◽  
Giovanni Sabatino ◽  
Simona Romano ◽  
Giuseppe Maria Della Pepa ◽  
Martina Tufano ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Flow Cytometry ◽  
Magnetic Resonance ◽  
Macrophage Polarization ◽  
Residual Tumor ◽  
Surgical Removal ◽  
Resonance Imaging ◽  
Flow Cytometry Data ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnostic Modalities

Magnetic resonance imaging (MRI) is the gold standard for glioblastoma (GBM) patient evaluation. Additional non-invasive diagnostic modalities are needed. GBM is heavily infiltrated with tumor-associated macrophages (TAMs) that can be found in peripheral blood. FKBP51s supports alternative-macrophage polarization. Herein, we assessed FKBP51s expression in circulating monocytes from 14 GBM patients. The M2 monocyte phenotype was investigated by qPCR and flow cytometry using antibodies against PD-L1, CD163, FKBP51s, and CD14. MRI assessed morphologic features of the tumors that were aligned to flow cytometry data. PD-L1 expression on circulating monocytes correlated with MRI tumor necrosis score. A wider expansion in circulating CD163/monocytes was measured. These monocytes resulted in a dramatic decrease in patients with an MRI diagnosis of complete but not partial surgical removal of the tumor. Importantly, in patients with residual tumor, most of the peripheral monocytes that in the preoperative stage were CD163/FKBP51s− had turned into CD163/FKBP51s+. After Stupp therapy, CD163/FKBP51s+ monocytes were almost absent in a case of pseudoprogression, while two patients with stable or true disease progression showed sustained levels in such circulating monocytes. Our work provides preliminary but meaningful and novel results that deserve to be confirmed in a larger patient cohort, in support of potential usefulness in GBM monitoring of CD163/FKBP51s/CD14 immunophenotype in adjunct to MRI.

Technology Assessment in Different Nations and Lessons from a Cross-Sectional Survey of Magnetic Resonance Imaging (MRI) Diffusion

1985 ◽  
Vol 1 (3) ◽  
pp. 515-536 ◽  
Author(s):  
Paul F. Gross
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cost Effectiveness ◽  
Magnetic Resonance ◽  
Medical Technology ◽  
Resonance Imaging ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnostic Modalities ◽  
Made In

Magnetic resonance imaging (MRI) is a rapidly evolving medical technology which has become widely diffused before comprehensive assessment of its safety, efficacy, cost-effectiveness, and relative cost-effectiveness compared with diagnostic modalities that it seems most likely to replace could be made. In early 1982 there were fewer than ten units worldwide. In August 1984, there were about 150 units and the figure will be closer to 300 by the end of 1985.

scholarly journals Assessing Response to Radiation Therapy Treatment of Bone Metastases: Short-Term Followup of Radiation Therapy Treatment of Bone Metastases with Diffusion-Weighted Magnetic Resonance Imaging

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Salvatore Cappabianca ◽  
Raffaella Capasso ◽  
Fabrizio Urraro ◽  
Andrea Izzo ◽  
Antonio Raucci ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Radiation Therapy ◽  
Magnetic Resonance ◽  
Bone Metastases ◽  
Residual Tumor ◽  
Response To Therapy ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Magnetic Resonance Imaging Mri ◽  
Therapy Treatment

This study examined the usefulness of diffusion-weighted (DW) Magnetic Resonance Imaging (MRI) in monitoring bone metastases response to radiation therapy in 15 oligometastatic patients. For each metastasis, both mean apparent diffusion coefficient (ADC) changes and high b-value DW metastasis/muscle signal intensity ratio (SIR) variations were evaluated at 30 ± 5 days and 60 ± 7 days after the end of treatment. On baseline DW-MRI, all bone metastases were hyperintense and had signal intensities higher than normal bone marrow on calculated ADC maps. At follow-up evaluations, 4 patterns of response were identified: (I) decreased high b-value DW SIR associated with increased mean ADC (83.3% of cases); (II) increased mean ADC with no change of high b-value DW SIR (10% of cases); (III) decreased both high b-value DW SIR and mean ADC (3.3% of cases); (IV) a reduction in mean ADC associated with an increase in high b-value DW SIR compared to pretreatment values (3.3% of cases). Patterns (I) and (II) suggested a good response to therapy; pattern (III) was classified as indeterminate, while pattern (IV) was suggestive of disease progression. This pattern approach may represent a useful tool in the differentiation between treatment-induced necrosis and highly cellular residual tumor.

Magnetic resonance imaging and ultrasound for prediction of residual tumor size in early breast cancer within the ADAPT subtrials

2020 ◽  
Author(s):  
Monika Graeser ◽  
Simone Schrading ◽  
Oleg Gluz ◽  
Kevin Strobel ◽  
Christopher Herzog ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Size ◽  
Residual Tumor ◽  
Resonance Imaging ◽  
Predictive Values ◽  
Cancer Subtypes ◽  
Magnetic Resonance Imaging Mri ◽  
Imaging Performance

Abstract Background: Prediction of histological tumor size by post-neoadjuvant therapy (NAT) ultrasound and magnetic resonance imaging (MRI) was evaluated in different breast cancer subtypes.Methods: Imaging was performed after 12-week NAT in patients enrolled into three neoadjuvant WSG ADAPT subtrials. Imaging performance for prediction of tumor size was analyzed across increasing size ranges (≤10, ≤20 and ≤30 mm) and summarized using positive (PPV) and negative predictive values (NPV).Results: 248 and 588 patients had MRI and ultrasound, respectively. Tumor size was over- or underestimated by <10 mm in 4.4% and 21.8% of patients by MRI and in 10.2% and 15.8% by ultrasound. Overall, PPV (correctly predicted tumor size ≤10, ≤20 or ≤30 mm) of MRI and ultrasound increased from 0.61 and 0.72 for ≤10 mm tumors to 0.88 and 0.96 for ≤30 mm tumors; NPV (correctly predicted tumor size >10, >20 or >30 mm) decreased from 0.89 and 0.74 to 0.69 and 0.22. Across all tumor size ranges, ultrasound demonstrated higher PPV than MRI in HR+/HER2+ tumors while both methods had a similarly low PPV in HR-/HER2- and HR-/HER2+ tumors. MRI had a higher NPV than ultrasound with the exception of HR-/HER2- tumors measuring ≤10 and ≤20 mm where both methods had similar NPV. Conclusions: Ultrasound is less likely than MRI to underestimate the size of HR+/HER2+ tumors while MRI is associated with a lower risk to overestimate the size of HR+/HER2+ and HR-/HER2+ tumors. These findings may help to select the most optimal imaging approach for planning surgery after NAT. Trial registration: Clinicaltrials.gov, NCT01815242 (registration March 21, 2013, NCT01817452 (registration March 25, 2013), NCT01779206 (registration January 30, 2013).

Magnetic resonance imaging and brainstem auditory evoked responses in the diagnosis of cerebellar cortical degeneration in american staffordshire terriers

2013 ◽  
Vol 61 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Miłosława Kwiatkowska ◽  
Andrzej Pomianowski ◽  
Zbigniew Adamiak ◽  
Aneta Bocheńska
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Evoked Responses ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Auditory Evoked Responses ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnostic Modalities ◽  
The Right ◽  
Cerebellar Cortical Degeneration

The aim of the study was to determine the diagnostic usefulness of magnetic resonance imaging (MRI) and brainstem auditory evoked responses (BAER) in dogs suspected of having cerebellar cortical degeneration (CCD). In the years 2009–2011, six dogs with suspected CCD were examined. Both MRI and BAER examinations revealed abnormalities in all dogs (100%). By MRI, T2-weighted midsagittal images revealed an increased amount of cerebrospinal fluid (CSF) surrounding the cerebellum within the sulci of the folia in all dogs (100%). In 4 out of the 6 dogs (66.66%), cerebellar hypoplasia was more visible in the region of the dorsal cerebellar lobules. In 5 out of the 6 dogs (83.33%), the fourth ventricle was enlarged. In our studies, the brain to cerebellum ratio evaluated on the midsagittal image was 11.93%, in comparison to 14.9% in normal dogs. By BAER examination, the amplitude of the first and second waves was diminished and III–V interlatency was prolonged in 5 out of the 6 dogs (83.33%). In one out of the 6 dogs (16.67%), only the III–V interlatency was prolonged. In one dog (16.67%), somato-nervous deafness in the left ear was detected, whereas in the right ear the III–V interlatency was prolonged. MRI of the cerebellum is a reliable method for the antemortem diagnosis of CCD in American Staffordshire terriers, as is BAER examination. BAER is an objective diagnostic tool, which — along with other diagnostic modalities — can be helpful in the assessment, management and follow-up of dogs with cerebellar abiotrophy. It proved to be useful in determining the severity of neurological lesions in comparison to MRI findings, as well as in assessing the prognosis.

Magnetic Resonance Imaging in the Diagnosis and Treatment of Lhermitte-Duclos Disease (Dysplastic Gangliocytoma of the Cerebellum)

Neurosurgery ◽  
1988 ◽  
Vol 23 (2) ◽  
pp. 240-245 ◽  
Author(s):  
Ralph F. Reeder ◽  
Richard L. Saunders ◽  
David W. Roberts ◽  
Jonathan D. Fratkin ◽  
Laurence D. Cromwell
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Probability ◽  
Residual Tumor ◽  
Resonance Imaging ◽  
Dysplastic Gangliocytoma ◽  
First Case ◽  
Clinically Significant ◽  
Magnetic Resonance Imaging Mri ◽  
Significant Mass

ABSTRACT Lhermitte-Duclos disease is a rare disorder characterized by a slowly enlarging mass lesion in the cerebellum. The pathophysiology of the disease is poorly understood, but recent reports have suggested that a clinically significant mass may recur many years after total gross removal of the tumor. Computed tomography and angiography have been relatively insensitive in imaging the tumor either at presentation or during the postoperative period. The authors present three patients with histologically proven Lhermitte-Duclos disease who have undergone magnetic resonance imaging (MRI). In the first case, preoperative T1- and T2-weighted images clearly demonstrated the location and extent of the lesion, which was verified at operation. In the other two cases, only postoperative images were obtained. These demonstrated the extent of residual tumor and indicate a high probability of lesion expansion during periods of 4 and 10 years, respectively. We conclude that MRI is an important tool in both the diagnosis and the treatment of patients with Lhermitte-Duclos disease.

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