scholarly journals Differential Disrupting Effects of Prolonged Low-Dose Exposure to Dichlorodiphenyltrichloroethane on Androgen and Estrogen Production in Males

2021 ◽  
Vol 22 (6) ◽  
pp. 3155
Author(s):  
Nataliya V. Yaglova ◽  
Dibakhan A. Tsomartova ◽  
Sergey S. Obernikhin ◽  
Valentin V. Yaglov ◽  
Svetlana V. Nazimova ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Low Dose ◽  
Serum Levels ◽  
Sex Steroid ◽  
Postnatal Exposure ◽  
Hormone Production ◽  
Sex Steroid Hormone ◽  
Testosterone Production ◽  
Estrogen Production ◽  
Male Wistar Rats

Dichlorodiphenyltrichloroethane (DDT) is the most widespread, persistent pollutant and endocrine disruptor on the planet. Although DDT has been found to block androgen receptors, the effects of its low-dose exposure in different periods of ontogeny on the male reproductive system remain unclear. We evaluate sex steroid hormone production in the pubertal period and after maturation in male Wistar rats exposed to low doses of o,p’-DDT, either during prenatal and postnatal development or postnatal development alone. Prenatally and postnatally exposed rats exhibit lower testosterone production and increased estradiol and estriol serum levels after maturation, associated with the delayed growth of gonads. Postnatally exposed rats demonstrate accelerated growth of gonads and higher testosterone production in the pubertal period. In contrast to the previous group, they do not present raised estradiol production. All of the exposed animals exhibit a reduced conversion of progesterone to 17OH-progesterone after sexual maturation, which indicates putative attenuation of sex steroid production. Thus, the study reveals age-dependent outcomes of low-dose exposure to DDT. Prenatal onset of exposure results in the later onset of androgen production and the enhanced conversion of androgens to estrogens after puberty, while postnatal exposure induces the earlier onset of androgen secretion.

Clinically insignificant improvement of prostate cancer prediction by addition of sex steroid hormones and SHBG serum levels to serum PSA, fPSA%, and age in a screening setting

2012 ◽  
Vol 11 (2) ◽  
Author(s):  
Isabel Heidegger ◽  
Marina Popovscaia ◽  
Reinhold Ramoner ◽  
Georg Schäfer ◽  
Birgit Stenzel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Steroid Hormones ◽  
Specific Antigen ◽  
Free Testosterone ◽  
Serum Levels ◽  
Sex Hormone Binding Globulin ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Cancer Prediction ◽  
Free Psa

AbstractVarious findings implicate sex hormones in prostate growth and development and also in prostate carcinogenesis. We investigated if addition of sex steroid hormone and sex hormone binding globulin (SHBG) serum levels to standard risk assessment parameters [prostate-specific antigen (PSA), free PSA percentage (fPSA%), and age] improves prostate cancer prediction in a PSA screening setting. Steroid hormones testosterone (T), free testosterone (fT), and estradiol (E2), and binding protein SHBG levels were measured in 762 men undergoing prostate biopsy due to suspect PSA serum levels. Prostate cancer was diagnosed in 286 (37.5%) of these men. Our data confirmed that PSA (mean BE=5.09; mean CA=6.05; p=1.24×10

scholarly journals Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work – the HORMONIT study

2021 ◽  
Author(s):  
Barbara N Harding ◽  
Gemma Castaño-Vinyals ◽  
Anna Palomar-Cros ◽  
Kyriaki Papantoniou ◽  
Ana Espinosa ◽  
...  
Keyword(s):  
Shift Work ◽  
Steroid Hormone ◽  
Night Shift ◽  
Sex Steroid ◽  
Hormone Production ◽  
Night Shift Work ◽  
Sex Steroid Hormone

scholarly journals Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression

2021 ◽  
Vol 22 (12) ◽  
pp. 6324
Author(s):  
Nataliya V. Yaglova ◽  
Sergey S. Obernikhin ◽  
Dibakhan A. Tsomartova ◽  
Svetlana V. Nazimova ◽  
Valentin V. Yaglov ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Low Dose ◽  
Organic Pollutant ◽  
Endocrine Disrupting Chemicals ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Hormone Production ◽  
Functional Changes ◽  
And Function ◽  
The Impact

Dichlorodiphenyltrichloroethane (DDT) is a persistent organic pollutant and one of the most widespread endocrine disrupting chemicals. The impact of low-dose exposure to DDT on the morphogenesis of the adrenal gland is still poorly understood. The development and function of zona glomerulosa in rats has been found to be associated with changes in the expression of the transcription factor Oct4 (Octamer 4), which is the most important player in cell pluripotency. The aim of the study was to investigate the morphogenesis and function of rat adrenal zona glomerulosa in rats exposed to low doses of DDT during prenatal and postnatal development and to determine the possible role of Oct4 in DDT-mediated structural and functional changes. The DDT-exposed rats demonstrated slower development and lower functional activity of the zona glomerulosa during the pubertal period associated with higher expression of Oct4. Further, accelerated growth and restoration of hormone production was associated with, firstly, a decrease in Oct4 expressing cells and secondly, the loss of the inverse relationship between basal aldosterone levels and the number of Oct4 expressing cells. Thus, the transcriptional factor Oct4 exhibited an altered pattern of expression in the DDT-exposed rats during postnatal development. The results of the study uncover a novel putative mechanism by which low doses of DDT disrupt the development of adrenal zona glomerulosa.

scholarly journals Characterization of cutaneous sex steroid hormone production through analysis of skin secretions

2021 ◽  
Author(s):  
Juliana L Pineider ◽  
Kaitlyn Eckert ◽  
Jeffrey G A McDonald ◽  
Tamia A Harris-Tryon
Keyword(s):  
Steroid Hormone ◽  
Skin Surface ◽  
Sex Steroid ◽  
Anatomical Site ◽  
Hormone Production ◽  
Eligibility Criteria ◽  
Sex Steroid Hormone ◽  
Eccrine Glands ◽  
Liquid Chromatography Tandem Mass ◽  
Skin Secretions

Importance: Systemic sex steroid hormone aberrations often manifest in skin disease. The sebaceous, apocrine, and eccrine glands all play an important role in the response and production of these hormones in the skin. However, our ability to quantify hormonal secretions at the skin surface is limited. Objective: Our study aims to characterize the hormonal landscape of the skin at different anatomical sites and between the sexes through analysis of skin secretions. Design: In this observational pilot study, we collected skin secretions from twelve male and ten female control subjects using commercially available, Sebutape®, from the antecubital fossa, forehead, back, and axilla. We then developed a method to extract and quantify the amount of sex steroid hormones from these secretions through liquid chromatography tandem mass spectrometry (LC-MS/MS). Setting: Outpatient clinic. Participants: 34 participants were enrolled in the study, with 22 participants meeting criteria. Eligibility criteria included age of 18 to 40 and BMI between 15-35. Exclusion criteria included participants outside the ages of 18 to 40, use of antibiotics in the last 6 months, history of hormonal aberrations or chronic skin disorders, and use of hormone altering medications (except oral contraception). Results: Our study detected anatomical site differences most notably in elevated dehydroepiandrosterone in the axilla and androstenedione in the forehead. Several hormonal differences were also detected between male and females consistent with known systemic hormone differences between the sexes. Conclusions: We developed a method to quantify the hormonal levels in skin secretions using Sebutape®. Our approach found that hormonal composition varies based on sex and anatomical site. Additional studies will need to be completed to determine relevant hormonal shifts in clinical skin conditions.

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