scholarly journals An Update on the Role of Leptin in the Immuno-Metabolism of Cartilage

2021 ◽  
Vol 22 (5) ◽  
pp. 2411
Author(s):  
Alfonso Cordero-Barreal ◽  
María González-Rodríguez ◽  
Clara Ruiz-Fernández ◽  
Djedjiga Ait Eldjoudi ◽  
Yousof Ramadan Farrag AbdElHafez ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Leptin Receptor ◽  
Cartilage Degeneration ◽  
Protective Effects ◽  
Cartilage Diseases ◽  
The One ◽  
Inflammatory Molecules ◽  
Leptin Expression ◽  
The Impact

Since its discovery in 1994, leptin has been considered as an adipokine with pleiotropic effects. In this review, we summarize the actual information about the impact of this hormone on cartilage metabolism and pathology. Leptin signalling depends on the interaction with leptin receptor LEPR, being the long isoform of the receptor (LEPRb) the one with more efficient intracellular signalling. Chondrocytes express the long isoform of the leptin receptor and in these cells, leptin signalling, alone or in combination with other molecules, induces the expression of pro-inflammatory molecules and cartilage degenerative enzymes. Leptin has been shown to increase the proliferation and activation of immune cells, increasing the severity of immune degenerative cartilage diseases. Leptin expression in serum and synovial fluid are related to degenerative diseases such as osteoarthritis (OA), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Inhibition of leptin signalling showed to have protective effects in these diseases showing the key role of leptin in cartilage degeneration.

scholarly journals Hypothyroidism Compromises Hypothalamic Leptin Signaling in Mice

2013 ◽  
Vol 27 (4) ◽  
pp. 586-597 ◽  
Author(s):  
Claudia Groba ◽  
Steffen Mayerl ◽  
Alies A. van Mullem ◽  
Theo J. Visser ◽  
Veerle M. Darras ◽  
...  
Keyword(s):  
Arcuate Nucleus ◽  
Leptin Receptor ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Double Knockout ◽  
Hypothalamic Arcuate Nucleus ◽  
The Central Nervous System ◽  
Leptin Expression ◽  
The Impact

Abstract The impact of thyroid hormone (TH) on metabolism and energy expenditure is well established, but the role of TH in regulating nutritional sensing, particularly in the central nervous system, is only poorly defined. Here, we studied the consequences of hypothyroidism on leptin production as well as leptin sensing in congenital hypothyroid TRH receptor 1 knockout (Trhr1 ko) mice and euthyroid control animals. Hypothyroid mice exhibited decreased circulating leptin levels due to a decrease in fat mass and reduced leptin expression in white adipose tissue. In neurons of the hypothalamic arcuate nucleus, hypothyroid mice showed increased leptin receptor Ob-R expression and decreased suppressor of cytokine signaling 3 transcript levels. In order to monitor putative changes in central leptin sensing, we generated hypothyroid and leptin-deficient animals by crossing hypothyroid Trhr1 ko mice with the leptin-deficient ob/ob mice. Hypothyroid Trhr1/ob double knockout mice showed a blunted response to leptin treatment with respect to body weight and food intake and exhibited a decreased activation of phospho-signal transducer and activator of transcription 3 as well as a up-regulation of suppressor of cytokine signaling 3 upon leptin treatment, particularly in the arcuate nucleus. These data indicate alterations in the intracellular processing of the leptin signal under hypothyroid conditions and thereby unravel a novel mode of action by which TH affects energy metabolism.

scholarly journals Estrogen Receptor and Vascular Aging

2021 ◽  
Vol 2 ◽  
Author(s):  
Morgane Davezac ◽  
Melissa Buscato ◽  
Rana Zahreddine ◽  
Patrick Lacolley ◽  
Daniel Henrion ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cardiovascular Diseases ◽  
Experimental Studies ◽  
Hormonal Treatment ◽  
Protective Effects ◽  
Age Related ◽  
Nuclear Receptor Family ◽  
The Impact ◽  
Receptor Family

Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. The arterial actions of estrogens, but also part of that of androgens through their aromatization into estrogens, are mediated by the estrogen receptor (ER)α and ERβ. ERs belong to the nuclear receptor family and act by transcriptional regulation in the nucleus, but also exert non-genomic/extranuclear actions. Beside the decline of estrogens at menopause, abnormalities in the expression and/or function of ERs in the tissues, and particularly in arteries, could contribute to the failure of classic estrogens to protect arteries during aging. Finally, we will discuss how recent insights in the mechanisms of action of ERα could contribute to optimize the hormonal treatment of the menopause.

scholarly journals How Will the Use of Technology in Translation and Testing Affect Language Learning?

2014 ◽  
Vol 8 (1) ◽  
pp. 22 ◽  
Author(s):  
David Michael Bourne
Keyword(s):  
Language Learning ◽  
Language Proficiency ◽  
Educational Institutions ◽  
Human Element ◽  
Use Of Technology ◽  
The One ◽  
Impact Of Technology ◽  
Age Range ◽  
The Impact

Technology has an ever increasing impact on how we work and live. Article adressed the issue of the impact of technology in two key areas of language learning. On the one side learners increasingly used technology to translate. Given this trend, was there any real need to learn a language. On the other side, educational institutions increasingly used technology to rate language proficiency. Given this trend, would the work of the teacher become less and less important. The survey was conducted by using quantitative method. The respondents’ age range was 18-25. There were 53 respondents, 35% were male and 65% were female. The instrument was a questionaire having 9 questions describing the students’ reliance on computer in translation. It can be concluded that learners of English indicate that they accept and welcome the role of technology in language learning, but there is a doubt that the role and participation of humans in the learning process will be completely replaced. The human element remains an important ingredient. (EE)

scholarly journals Inferring recent evolutionary changes in speech sounds

2021 ◽  
Vol 376 (1824) ◽  
Author(s):  
Steven Moran ◽  
Nicholas A. Lester ◽  
Eitan Grossman
Keyword(s):  
Language Contact ◽  
Language Evolution ◽  
Speech Sounds ◽  
Theme Issue ◽  
Short Term ◽  
The Past ◽  
Evolutionary Changes ◽  
The One ◽  
The Impact

In this paper, we investigate evolutionarily recent changes in the distributions of speech sounds in the world's languages. In particular, we explore the impact of language contact in the past two millennia on today's distributions. Based on three extensive databases of phonological inventories, we analyse the discrepancies between the distribution of speech sounds of ancient and reconstructed languages, on the one hand, and those in present-day languages, on the other. Furthermore, we analyse the degree to which the diffusion of speech sounds via language contact played a role in these discrepancies. We find evidence for substantive differences between ancient and present-day distributions, as well as for the important role of language contact in shaping these distributions over time. Moreover, our findings suggest that the distributions of speech sounds across geographic macro-areas were homogenized to an observable extent in recent millennia. Our findings suggest that what we call the Implicit Uniformitarian Hypothesis, at least with respect to the composition of phonological inventories, cannot be held uncritically. Linguists who would like to draw inferences about human language based on present-day cross-linguistic distributions must consider their theories in light of even short-term language evolution. This article is part of the theme issue ‘Reconstructing prehistoric languages’.

scholarly journals Energy Saving as an Important Factor in Ensuring Product Competitiveness

2021 ◽  
Vol 2 (48) ◽  
pp. 120-125
Author(s):  
O. P. Vashkiv ◽  
◽  
S. B. Smereka ◽  
Keyword(s):  
Energy Saving ◽  
Specific Energy Consumption ◽  
Environmental Standards ◽  
Manufacturing Enterprise ◽  
Research Results ◽  
Industrial Enterprises ◽  
The Face ◽  
The One ◽  
The Impact

The article is aimed at studying the features of energy saving at a manufacturing enterprise and establishing a cause-and-effect relationship between energy saving and product competitiveness. Due to analyzing and generalizing the research results of domestic and foreign scientists the views of researchers on the process of energy saving at a manufacturing enterprise are systematized; the growing role of energy saving in ensuring energy efficiency and, consequently, product competitiveness is established. The research results show that energy saving at an enterprise is one of its most important assets, the impact of which on the level of product competitiveness is becoming increasingly important in the face of the exacerbating energy and environmental crises. Energy saving, basically focusing on the intensification of production processes and use of energy and energy resources, on the one hand, reduces the level of specific energy consumption and, consequently, the price of the released product while maintaining or increasing its quality; on the other hand, it reduces the carbon loading on the environment, thus contributes to the growth of the company's image among its consumers and partners. Both components are the most important factors in ensuring product competitiveness. The development and implementation of energy saving measures at industrial enterprises, with regard to the industry-specific character of economic entities, market conditions, and the requirements of environmental standards can serve as prospects for further research

University Social Responsibility

2021 ◽  
pp. 230-241
Author(s):  
Doina Stratu-Strelet ◽  
Anna Karina López-Hernández ◽  
Vicente Guerola-Navarro ◽  
Hermenegildo Gil-Gómez ◽  
Raul Oltra-Badenes
Keyword(s):  
Knowledge Management ◽  
Private Sector ◽  
The Other ◽  
Public Private Partnerships ◽  
Market Strategy ◽  
Private Partnership ◽  
The One ◽  
Dissemination Of Results ◽  
The Impact

This chapter highlights the role of technology-based universities in public-private partnerships (PPP) to strengthen and deploy the digital single market strategy. Moreover, it analyzes how these collaboration channels have link knowledge management as a tool for sustainable collaboration. Given the need to establish collaboration channels with the private sector, according to Lee, it is critical to establish the impact of sharing sophisticated knowledge and partnering at the same time. This chapter wants to highlights two relevant aspects of PPP: on the one hand, the importance of integrating the participation of a technology-based university with three objectives: (1) the coordination, (2) the funding management, and (3) the dissemination of results; and the other hand, the participation private sector that is represented by agile agents capable to execute high-value actions for society. With the recognition of these values, the investment and interest of the projects under way are justified by public-private partnership.

Representations of the (woman) judge: Hercules, the little mermaid, and the vain and naked Emperor

Legal Studies ◽  
2002 ◽  
Vol 22 (4) ◽  
pp. 602-624 ◽  
Author(s):  
Erika Rackley
Keyword(s):  
Fairy Tale ◽  
The Other ◽  
Women Judges ◽  
Other Hand ◽  
The One ◽  
The Impact ◽  
Alternative Understanding ◽  
Woman Judge

This paper reconsiders images of the judge and, in particular, the position of the woman judge using fairy tale and myth. It begins by exploring the actuality of women's exclusion within the judiciary, traditional explanations for this and the impact of recent changes. It goes on to consider the image of the Herculean judge, arguing that whilst we may view him as an ideological construct, or even as a fairy tale, we routinely deny this to ourselves and to others. This both ensures the normative survival of Hercules and simultaneously constrains counter-images of judges, including that of the woman judge, who becomes almost a contradiction in terms, faced with the need to shed her difference and fit the fairy tale. Like the little mermaid, the woman judge must trade her voice for partial acceptance in the prince's world.This image of silencing which Andersen's tale so vividly captures highlights a paradox in current discourses of adjudication. On the one hand, women judges are viewed as desirable in order to broaden the range of perspectives on the bench, thus making the judiciary more representative; on the other hand, judges are supposed to be without perspective, thus suggesting there is little need for a representative judiciary. Feminists and other commentators negotiate their way uncomfortably through this territory, acknowledging a gender dimension to adjudication, but failing fully to confront its implications. This paper seeks to ‘undress’ the judge, to flush out images of adjudication which deter or prevent women from joining the judiciary and constrain their potential within it. It highlights both the role of the imagination in existing conceptions of adjudication and the increasing necessity for a re-imagined Hercules – an alternative understanding of the judge which women and other groups currently underrepresented on the bench can comfortably and constructively occupy.

scholarly journals The Role of Sexual Hormones on the Enteroinsular Axis

2019 ◽  
Vol 40 (4) ◽  
pp. 1152-1162 ◽  
Author(s):  
Sandra Handgraaf ◽  
Jacques Philippe
Keyword(s):  
Sex Hormones ◽  
Glucose Homeostasis ◽  
Fine Tuning ◽  
Protective Effects ◽  
Enteroinsular Axis ◽  
Sexual Hormones ◽  
The Impact ◽  
Potential Therapeutics

AbstractSex steroid estrogens, androgens, and progesterone, produced by the gonads, which have long been considered as endocrine glands, are implicated in sexual differentiation, puberty, and reproduction. However, the impact of sex hormones goes beyond these effects through their role on energy metabolism. Indeed, sex hormones are important physiological regulators of glucose homeostasis and, in particular, of the enteroinsular axis. In this review, we describe the roles of estrogens, androgens, and progesterone on glucose homeostasis through their effects on pancreatic α- and β-cells, as well as on enteroendocrine L-cells, and their implications in hormonal biosynthesis and secretion. The analysis of their mechanisms of action with the dissection of the receptors implicated in the several protective effects could provide some new aspects of the fine-tuning of hormonal secretion under the influence of the sex. This knowledge paves the way to the understanding of transgender physiology and new potential therapeutics in the field of type 2 diabetes.

Role of serum leptin levels and leptin receptor gene polymorphisms in systemic lupus erythematosus

2020 ◽  
Vol 39 (11) ◽  
pp. 3465-3472
Author(s):  
Abd EL-Moaty Ali Afifi ◽  
Reham M. Shaat ◽  
Ola Mohamed Gharbia ◽  
M. Elhanafy ◽  
Al Shimaa Goda Hasan
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Systemic Lupus ◽  
Serum Leptin ◽  
Receptor Gene Polymorphisms

scholarly journals The Role of Personality Factors in the Reduction of Intergroup Anxiety and Amelioration of Outgroup Attitudes via Intergroup Contact

2014 ◽  
Vol 28 (2) ◽  
pp. 180-192 ◽  
Author(s):  
Rhiannon N. Turner ◽  
Kristof Dhont ◽  
Miles Hewstone ◽  
Andrew Prestwich ◽  
Christiana Vonofakou
Keyword(s):  
Intergroup Contact ◽  
Openness To Experience ◽  
Prejudice Reduction ◽  
The Other ◽  
Personality Factors ◽  
Intergroup Anxiety ◽  
The One ◽  
The Impact ◽  
Potential Confound

Two studies investigated the role of personality factors in the amelioration of outgroup attitudes via intergroup contact. In study 1, the effect of extraversion on outgroup attitude operated via an increase in cross–group friendship, whereas openness to experience and agreeableness had a direct effect on outgroup attitude. In study 2, we included intergroup anxiety as a mediator explaining these relationships, and we ruled out ingroup friendship as a potential confound. We found that the relationships between openness to experience and agreeableness on the one hand and outgroup attitude on the other were mediated by reduced intergroup anxiety. In addition, the effect of extraversion on outgroup attitude operated via an increase in cross–group friendship that was in turn associated with lower levels of intergroup anxiety. Across both studies, the friendship–attitude relationship was stronger among those low in agreeableness and extraversion. We discuss the importance of integrating personality and situational approaches to prejudice reduction in optimizing the impact of contact–based interventions. Copyright © 2013 John Wiley & Sons, Ltd.

Sign in / Sign up

Export Citation Format

Share Document