scholarly journals CD200:CD200R Interactions and Their Importance in Immunoregulation

2021 ◽  
Vol 22 (4) ◽  
pp. 1602
Author(s):  
Katarzyna Kotwica-Mojzych ◽  
Barbara Jodłowska-Jędrych ◽  
Mariusz Mojzych
Keyword(s):  
Transplant Rejection ◽  
Large Body ◽  
Structural Constraints ◽  
Relative Importance ◽  
The Past ◽  
Naturally Occurring ◽  
Biochemical Level ◽  
Important Marker ◽  
Made In

The molecule CD200, described many years ago as a naturally occurring immunomodulatory agent, capable of regulating inflammation and transplant rejection, has attracted additional interest over the past years with the realization that it may also serve as an important marker for progressive malignancy. A large body of evidence also supports the hypothesis that this molecule can contribute to immunoregulation of, among other diseases, infection, autoimmune disease and allergy. New data have also come to light to characterize the receptors for CD200 (CD200R) and their potential mechanism(s) of action at the biochemical level, as well as the description of a novel natural antagonist of CD200, lacking the NH2-terminal region of the full-length molecule. Significant controversies exist concerning the relative importance of CD200 as a ligand for all reported CD200Rs. Nevertheless, some progress has been made in the identification of the structural constraints determining the interaction between CD200 and CD200R, and this information has in turn proved of use in developing novel small molecule agonists/antagonists of the interaction. The review below highlights many of these newer findings, and attempts to place them in the broad context of our understanding of the role of CD200-CD200R interactions in a variety of human diseases.

scholarly journals Naturally Occurring Anthraquinones: Chemistry and Therapeutic Potential in Autoimmune Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Shih-Chang Chien ◽  
Yueh-Chen Wu ◽  
Zeng-Weng Chen ◽  
Wen-Chin Yang
Keyword(s):  
Therapeutic Potential ◽  
Autoimmune Diabetes ◽  
Early Stage ◽  
Large Body ◽  
Autoimmune Disorder ◽  
Biological Properties ◽  
Naturally Occurring ◽  
New Strategy ◽  
Made In

Anthraquinones are a class of aromatic compounds with a 9,10-dioxoanthracene core. So far, 79 naturally occurring anthraquinones have been identified which include emodin, physcion, cascarin, catenarin, and rhein. A large body of literature has demonstrated that the naturally occurring anthraquinones possess a broad spectrum of bioactivities, such as cathartic, anticancer, anti-inflammatory, antimicrobial, diuretic, vasorelaxing, and phytoestrogen activities, suggesting their possible clinical application in many diseases. Despite the advances that have been made in understanding the chemistry and biology of the anthraquinones in recent years, research into their mechanisms of action and therapeutic potential in autoimmune disorders is still at an early stage. In this paper, we briefly introduce the etiology of autoimmune diabetes, an autoimmune disorder that affects as many as 10 million worldwide, and the role of chemotaxis in autoimmune diabetes. We then outline the chemical structure and biological properties of the naturally occurring anthraquinones and their derivatives with an emphasis on recent findings about their immune regulation. We discuss the structure and activity relationship, mode of action, and therapeutic potential of the anthraquinones in autoimmune diabetes, including a new strategy for the use of the anthraquinones in autoimmune diabetes.

The Role of Histones and Heparin in Sepsis: A Review

2021 ◽  
pp. 088506662199232
Author(s):  
Xiaojuan Zhang ◽  
Xin Li
Keyword(s):  
Septic Shock ◽  
Multiple Organ ◽  
Clinical Settings ◽  
The Past ◽  
Life Saving ◽  
Extracellular Histones ◽  
Sepsis And Septic Shock ◽  
Development And Management ◽  
Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

Ectomycorrhizae in the Agaricales and Gasteromycetes

1983 ◽  
Vol 61 (3) ◽  
pp. 909-916 ◽  
Author(s):  
Orson K. Miller Jr.
Keyword(s):  
Fruiting Body ◽  
Biological Role ◽  
Spore Morphology ◽  
Generic Level ◽  
Body Form ◽  
Ecological Conditions ◽  
Fungal Succession ◽  
The Past ◽  
Made In

Over the past decade much progress has been made in an effort to determine which fungi are mycorrhizal symbionts. It is now apparent that one ectomycorrhizal or ectendomycorrhizal host is often able to form mycorrhizae with a wide variety of higher fungi. Evidence is presented which supports the hypothesis that fungal succession occurs as the host matures. In addition, fungi which are normally ectomycorrhizal may sometimes form endomycorrhizae on different hosts or under altered ecological conditions. There has also been much evolution in fruiting-body form and mode of spore discharge especially under severe montane or desert conditions. As a result patterns are emerging in the Homobasidiomycetes at the order, family, and generic level in the evolution of the mycorrhizal habit. Spore morphology, habitat, and distribution are listed and discussed in relation to the biological role of the fungi.

The Role of Biography in Writing the History of Archaeology (1992)

2008 ◽  
Author(s):  
Douglas R. Givens
Keyword(s):  
No Value ◽  
History Of Archaeology ◽  
History Of Anthropology ◽  
Historical Evidence ◽  
Past Work ◽  
The Past ◽  
Institutional Influences ◽  
History Of ◽  
Made In

The history of any discipline involves the explanation of its past and how the past has influenced its development through time. Its ‘objects are events which have finished happening, and conditions no longer in existence. Only when they are no longer perceptible do they become objects of historical thought’ (Collingwood 1946: 233). Writing the history of archaeology involves the analysis of past events and of the contributions that individual archaeologists have made to its development through time. The roles of individuals in archaeology are best seen in biographical accounts of their labours and in the contributions to the discipline that they have made. In general, historians of archaeological science, who are interested in explaining the roles of the individuals in its development, must focus their attention on three important items. First, the most important item is evidence that something has occurred. If individuals’ contributions have no basis in truth and cannot be justified, then they are of no value to the historian of archaeology. Second, the historical picture of individuals’ lives and work must have defined boundaries in space and time. These provide the area of focus for study and description of individuals’ activities. Third, the efforts of individual practitioners must be couched within the intellectual climate in which they are made. Individuals’ contributions are not made in an intellectual vacuum, apart from collegial or institutional influences. Biography, as a tool for writing the history of archaeology, must embrace all of these requisites. For those engaged in explaining archaeology’s past, historical evidence of event and period provide the foundation upon which we can trace our science’s development. Studying and evaluating past work can be helpful in separating useful and outdated methodologies of the field and laboratory. Moreover, the study of the history of anthropology may give the anthropologist needed ‘distance from their own theoretical and methodological preoccupations’ (Darnell 1974: 2). What we see anthropology today as being is certainly not what the ultimate science of humankind will be in the future.

scholarly journals Sciences and audiences along the last century: the impact of Astronomy Education

2018 ◽  
Vol 13 (S349) ◽  
pp. 474-478
Author(s):  
Rosa M. Ros ◽  
Beatriz Garca
Keyword(s):  
Secondary Teachers ◽  
Astronomy Education ◽  
Interest In Science ◽  
The Past ◽  
The World ◽  
History Of ◽  
The Impact ◽  
Made In ◽  
Science Activities

AbstractJust as in the past, the development of the natural sciences and in particular of astronomy has changed the history of humanity. If we think about the role of our discipline into the future, it shows its enormous power in the field of education, owing to the possibility of awakening interest in science in very varied audiences. Within the framework of the enormous progress made in the technologies related to astronomy, many of them of daily use, the role of the astronomer in the era of Communications acquires fundamental importance.In this presentation, we will try to make a journey through the different ways of presenting astronomical topics for different audiences over the last 100 years. In turn, we will show some specific achievements, associated with education programmes of the discipline. We discuss the impact produced by proposals that are both rigorous in terms of content, and also appeal to the development of the human being in an integral manner, within the framework of citizen science activities.For this research, we have taken into account the uninterrupted development of the NASE programme, which has performed 112 courses in 24 countries throughout the world and in different languages. NASE has involved 4966 secondary teachers in the last eight years.

On Anticipatory Accounts

2019 ◽  
Vol 37 (1) ◽  
pp. 93-107
Author(s):  
Abigail Jane Mack
Keyword(s):  
Mental Health ◽  
Los Angeles ◽  
Mental Health Court ◽  
Judicial Decision ◽  
The Past ◽  
Present Experience ◽  
The Social ◽  
Social Belonging ◽  
Made In

Engaging an account of a judicial decision made in the Los Angeles Mental Health Court, this article interrogates the role of anticipation in the lived negotiation of moral, social and institutional orders. As Judge Samuel Benton recounts his attempt to let himself ‘emotionally off the hook’ in the wake of a patient’s suicide, anticipation emerges as: 1) an ordered, linear sequencing of events towards logical ends; 2) unsettled, temporally disjunctive engagements with the past in order to make sense of present experience and ambiguous futures; 3) existential negotiations of one’s potential morality and social belonging; and 4) distributed organization of information between people and across objects in order to elaborate present and future experience. These manifestations of anticipation reveal the social and temporal contingency and deep intersubjectivity of our negotiations with uncertainty in the unsettling process of becoming moral.

scholarly journals The role of CD154 in organ transplant rejection and acceptance

2001 ◽  
Vol 356 (1409) ◽  
pp. 691-702 ◽  
Author(s):  
Allan D. Kirk ◽  
Patrick J. Blair ◽  
Douglas K. Tadaki ◽  
He Xu ◽  
David M. Harlan
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Transplant Rejection ◽  
Critical Role ◽  
Organ Transplant ◽  
The Past ◽  
Costimulatory Signals ◽  
Intensive Investigation ◽  
Antigen Presenting

CD154 plays a critical role in determining the outcome of a transplanted organ. This simple statement is amply supported by experimental evidence demonstrating that anti–CD154 antibodies are potent inhibitors of allograft rejection in many rigorous transplant models. Unfortunately, despite intensive investigation over the past ten years, the precise mechanisms by which antibodies against CD154 exert their anti–rejection effects have remained less obvious. Though originally classified with reference to B–cell function, CD154–CD40 interactions have also been shown to be important in T cell–antigen–presenting cell interactions. Accordingly, CD154 has been classified as a T–cell co–stimulatory molecule. However, mounting data suggest that treatment with anti–CD154 antibodies does not simply block costimulatory signals, but rather that the antibodies appear to induce signalling in receptor–bearing T cells. Other data suggest that anti–CD154 effects may be mediated by endothelial cells and possibly even platelets. In fact, the current literature suggests that CD154 can either stimulate or attenuate an immune response, depending upon the model system under study. CD154 has secured a fundamental place in transplant biology and general immunology that will no doubt be the source of considerable investigation and therapeutic manipulation in the coming decade.

scholarly journals Disease conditions and subclinical infections of the platypus ( Ornithorhynchus anatinus )

1998 ◽  
Vol 353 (1372) ◽  
pp. 1093-1099 ◽  
Author(s):  
B. L. Munday ◽  
R. J. Whittington ◽  
N. J. Stewart
Keyword(s):  
Motor Vehicles ◽  
The Public ◽  
The Past ◽  
European Settlement ◽  
Ornithorhynchus Anatinus ◽  
The Subject ◽  
Intensive Investigation ◽  
Large Predators ◽  
Made In

Before the arrival of European settlers in Australia, the platypus, Ornithorhynchus anatinus , probably suffered from little disease. Among other things, European settlement has involved substantial environmental perturbation, introduction of large predators, introduction of motor vehicles and translocation of potential pathogens. As a result, platypuses are now killed by motor vehicles, dogs, foxes and discarded plastic litter. Information programmes targeting appropriate segments of the public would help reduce these unnecessary deaths. The enigmatic disease, ulcerative mycosis, caused by Mucor amphibiorum , has been the subject of scientific investigation in Tasmania for the past 15 years. The apparent recent acceleration in its spread has sounded a warning and more intensive investigation is warranted. The possibility that this pathogen has been translocated from subtropical to temperate Tasmania, Australia, with green tree frogs in banana shipments further emphasizes the role of humans in threatening the welfare of the platypus. Recommendations are made in relation to appropriate measures that could be taken to ameliorate disease and trauma in this species.

scholarly journals Aggregate Trends in Four Main Agricultural Regions in Egypt, 1964–1979

1988 ◽  
Vol 20 (2) ◽  
pp. 135-164 ◽  
Author(s):  
Hadi S. Esfahani
Keyword(s):  
Public Investment ◽  
Arable Land ◽  
Relative Importance ◽  
Investment Policies ◽  
Relative Prices ◽  
The Past ◽  
The Government ◽  
Egyptian Government ◽  
Agricultural Regions

In the past two decades, the rate of growth of agricultural output in Egypt has been quite low and, in particular, has fallen behind the country's population growth rate. Most observers seem to agree that despite certain natural constraints, such as limitation of arable land, the sector's performance could have been much better if the Egyptian government had chosen to pursue more supportive policies toward agriculture. There is, however, much less agreement over the specific policies that have been most responsible for the sector's past stagnation. Several recent studies have emphasized the role of price policies, pointing out that the government has taxed agriculture heavily by keeping the relative prices of most major crops quite low. Others, on the other hand, have held the government's investment policies responsible, arguing that the sector's resources have remained undeveloped because of insufficient public investment in research, extension, and infrastructure. While the debate over the relative importance of these sets of policies has generated a number of valuable contributions to the understanding of Egyptian agriculture, the past analyses of the sector's production system have not sufficed to settle the differences. One of the main problems is that, so far, most studies have concentrated on outputs and prices of individual crops and have thus failed to provide comprehensive analyses of the sector as a whole.

scholarly journals Myasthenia Gravis: A Review

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Annapurni Jayam Trouth ◽  
Alok Dabi ◽  
Noha Solieman ◽  
Mohankumar Kurukumbi ◽  
Janaki Kalyanam
Keyword(s):  
Myasthenia Gravis ◽  
Treatment Modalities ◽  
Initial Symptom ◽  
Significant Progress ◽  
The Past ◽  
The Us ◽  
Circulating Antibodies ◽  
New Treatment ◽  
Made In

Acquired myasthenia gravis is a relatively uncommon disorder, with prevalence rates that have increased to about 20 per 100,000 in the US population. This autoimmune disease is characterized by muscle weakness that fluctuates, worsening with exertion, and improving with rest. In about two-thirds of the patients, the involvement of extrinsic ocular muscle presents as the initial symptom, usually progressing to involve other bulbar muscles and limb musculature, resulting in generalized myasthenia gravis. Although the cause of the disorder is unknown, the role of circulating antibodies directed against the nicotinic acetylcholine receptor in its pathogenesis is well established. As this disorder is highly treatable, prompt recognition is crucial. During the past decade, significant progress has been made in our understanding of the disease, leading to new treatment modalities and a significant reduction in morbidity and mortality.

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