scholarly journals Biomineralization of Collagen-Based Materials for Hard Tissue Repair

2021 ◽  
Vol 22 (2) ◽  
pp. 944
Author(s):  
Le Yu ◽  
Mei Wei
Keyword(s):  
Small Molecules ◽  
Bone Regeneration ◽  
Tissue Repair ◽  
Building Blocks ◽  
Future Trend ◽  
Collagen Fibrils ◽  
Size Exclusion ◽  
Hard Tissue ◽  
Dentin Mineralization ◽  
Tooth Repair

Hydroxyapatite (HA) reinforced collagen fibrils serve as the basic building blocks of natural bone and dentin. Mineralization of collagen fibrils play an essential role in ensuring the structural and mechanical functionalities of hard tissues such as bone and dentin. Biomineralization of collagen can be divided into intrafibrillar and extrafibrillar mineralization in terms of HA distribution relative to collagen fibrils. Intrafibrillar mineralization is termed when HA minerals are incorporated within the gap zone of collagen fibrils, while extrafibrillar mineralization refers to the minerals that are formed on the surface of collagen fibrils. However, the mechanisms resulting in these two types of mineralization still remain debatable. In this review, the evolution of both classical and non-classical biomineralization theories is summarized. Different intrafibrillar mineralization mechanisms, including polymer induced liquid precursor (PILP), capillary action, electrostatic attraction, size exclusion, Gibbs-Donnan equilibrium, and interfacial energy guided theories, are discussed. Exemplary strategies to induce biomimetic intrafibrillar mineralization using non-collagenous proteins (NCPs), polymer analogs, small molecules, and fluidic shear stress are discussed, and recent applications of mineralized collagen fibers for bone regeneration and dentin repair are included. Finally, conclusions are drawn on these proposed mechanisms, and the future trend of collagen-based materials for bone regeneration and tooth repair is speculated.

Regulation of Angiogenesis and Bone Regeneration with Natural and Synthetic Small Molecules

2013 ◽  
Vol 19 (19) ◽  
pp. 3403-3419 ◽  
Author(s):  
Claire E. Segar ◽  
Molly E. Ogle ◽  
Edward A. Botchwey
Keyword(s):  
Small Molecules ◽  
Bone Regeneration ◽  
Natural And Synthetic

From molecules to macrostructures: recent development of bioinspired hard tissue repair

2017 ◽  
Vol 5 (8) ◽  
pp. 1435-1449 ◽  
Author(s):  
Chunmei Ding ◽  
Zhuoxin Chen ◽  
Jianshu Li
Keyword(s):  
Tissue Repair ◽  
Hard Tissue

This review summarizes the bioinspired strategies for hard tissue repair, ranging from molecule-induced mineralization, to microscale assembly to macroscaffold fabrication.

scholarly journals Synthesis of sp3-rich scaffolds for molecular libraries through complexity-generating cascade reactions

2016 ◽  
Vol 14 (21) ◽  
pp. 4943-4946 ◽  
Author(s):  
T. Flagstad ◽  
G. Min ◽  
K. Bonnet ◽  
R. Morgentin ◽  
D. Roche ◽  
...  
Keyword(s):  
Small Molecules ◽  
Building Blocks ◽  
Cascade Reactions ◽  
Efficient Strategy ◽  
Molecular Libraries

An efficient strategy for the synthesis of complex small molecules from simple building blocks is presented.

Soft and hard tissue repair

2008 ◽  
pp. 87-109
Author(s):  
Stephen Young ◽  
Melissa Calvin
Keyword(s):  
Tissue Repair ◽  
Hard Tissue

scholarly journals Rapid approach to complex boronic acids

2019 ◽  
Vol 5 (7) ◽  
pp. eaaw4607 ◽  
Author(s):  
Constantinos G. Neochoritis ◽  
Shabnam Shaabani ◽  
Maryam Ahmadianmoghaddam ◽  
Tryfon Zarganes-Tzitzikas ◽  
Li Gao ◽  
...  
Keyword(s):  
Small Molecules ◽  
Boronic Acid ◽  
Multicomponent Reactions ◽  
Chemical Space ◽  
Building Blocks ◽  
Acid Synthesis ◽  
Success Rates ◽  
Boronic Acid Derivatives ◽  
Low Coverage ◽  
Target Synthesis

The compatibility of free boronic acid building blocks in multicomponent reactions to readily create large libraries of diverse and complex small molecules was investigated. Traditionally, boronic acid synthesis is sequential, synthetically demanding, and time-consuming, which leads to high target synthesis times and low coverage of the boronic acid chemical space. We have performed the synthesis of large libraries of boronic acid derivatives based on multiple chemistries and building blocks using acoustic dispensing technology. The synthesis was performed on a nanomole scale with high synthesis success rates. The discovery of a protease inhibitor underscores the usefulness of the approach. Our acoustic dispensing–enabled chemistry paves the way to highly accelerated synthesis and miniaturized reaction scouting, allowing access to unprecedented boronic acid libraries.

scholarly journals A review of protein adsorption on bioceramics

2012 ◽  
Vol 2 (3) ◽  
pp. 259-277 ◽  
Author(s):  
Kefeng Wang ◽  
Changchun Zhou ◽  
Youliang Hong ◽  
Xingdong Zhang
Keyword(s):  
Tissue Regeneration ◽  
Protein Interactions ◽  
Tissue Repair ◽  
Cellular Response ◽  
Biological Activities ◽  
Biological Mechanisms ◽  
Hard Tissue ◽  
Coated Layer ◽  
Sense And Respond

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic–protein interactions.

Bioactive Composite Coating on Titanium Implants for Hard Tissue Repair

2007 ◽  
Vol 334-335 ◽  
pp. 1249-1252 ◽  
Author(s):  
Jin Ming Wu ◽  
Min Wang ◽  
Akiyoshi Osaka
Keyword(s):  
Composite Coating ◽  
Low Temperatures ◽  
Tissue Repair ◽  
Body Fluid ◽  
Titanium Implants ◽  
Apatite Formation ◽  
Hard Tissue ◽  
Layer Composite ◽  
Titania Layer ◽  
Hydrolysis Of

A bioactive composite coating consisting of one layer of titania and one layer of apatite was formed on Ti substrate. The first layer of crystalline titania was deposited on Ti at low temperatures either through oxidation of Ti by hydrogen peroxide solution or through hydrolysis of TiF4 or TiCl4 solution. It was shown that the crystalline titania, either in the form of anatase or rutile, induced formation of the second layer of apatite in a simulated body fluid. However, the trace elements in the titania layer affected greatly apatite formation. The Cl incorporated in the titania layer did not hinder apatite formation while F did. The two-layer composite coating should enhance bonding of Ti implants to bone tissue.

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