scholarly journals Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment

2020 ◽  
Vol 21 (22) ◽  
pp. 8605 ◽  
Author(s):  
Montserrat Colilla ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Bacterial Infection ◽  
Silica Nanoparticles ◽  
Bacterial Infections ◽  
Mesoporous Silica Nanoparticles ◽  
Antimicrobial Treatment ◽  
Stimuli Responsive ◽  
Comprehensive Description ◽  
Infection Treatment ◽  
External Stimuli

The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.

Smart mesoporous silica nanoparticles for controlled-release drug delivery

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Mahdi Karimi ◽  
Hamed Mirshekari ◽  
Masoumeh Aliakbari ◽  
Parham Sahandi-Zangabad ◽  
Michael R. Hamblin
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
High Capacity ◽  
Bioactive Molecules ◽  
Stimuli Responsive ◽  
Release Drug ◽  
Stimulus Responsive ◽  
External Stimuli

AbstractStimuli-responsive controlled-release nanocarriers are promising vehicles for delivery of bioactive molecules that can minimize side effects and maximize efficiency. The release of the drug occurs when the nanocarrier is triggered by an internal or external stimulus. Mesoporous silica nanoparticles (MSN) can have drugs and bioactive cargos loaded into the high-capacity pores, and their release can be triggered by activation of a variety of stimulus-responsive molecular “gatekeepers” or “nanovalves.” In this mini-review, we discuss the basic concepts of MSN in targeted drug-release systems and cover different stimulus-responsive gatekeepers. Internal stimuli include redox, enzymes, and pH, while external stimuli include light, ultrasound, and magnetic fields, and temperature can either be internal or external.

scholarly journals Nanoantibiotics Based in Mesoporous Silica Nanoparticles: New Formulations for Bacterial Infection Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2033
Author(s):  
Elena Álvarez ◽  
Blanca González ◽  
Daniel Lozano ◽  
Antonio L. Doadrio ◽  
Montserrat Colilla ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Materials ◽  
Mesoporous Silica Nanoparticles ◽  
Chemical Properties ◽  
Future Application ◽  
General Context ◽  
Stimuli Responsive ◽  
Infection Treatment

This review focuses on the design of mesoporous silica nanoparticles for infection treatment. Written within a general context of contributions in the field, this manuscript highlights the major scientific achievements accomplished by professor Vallet-Regí’s research group in the field of silica-based mesoporous materials for drug delivery. The aim is to bring out her pivotal role on the envisage of a new era of nanoantibiotics by using a deep knowledge on mesoporous materials as drug delivery systems and by applying cutting-edge technologies to design and engineer advanced nanoweapons to fight infection. This review has been divided in two main sections: the first part overviews the influence of the textural and chemical properties of silica-based mesoporous materials on the loading and release of antibiotic molecules, depending on the host–guest interactions. Furthermore, this section also remarks on the potential of molecular modelling in the design and comprehension of the performance of these release systems. The second part describes the more recent advances in the use of mesoporous silica nanoparticles as versatile nanoplatforms for the development of novel targeted and stimuli-responsive antimicrobial nanoformulations for future application in personalized infection therapies.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

scholarly journals Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Daniel Pedraza ◽  
Jaime Díez ◽  
Isabel Izquierdo-Barba ◽  
Montserrat Colilla ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Chemical Properties ◽  
Bone Infection ◽  
Bacterial Biofilm ◽  
Functionalized Mesoporous Silica ◽  
Transmission Electron ◽  
Infection Treatment ◽  
Physical And Chemical

AbstractThis manuscript reports an effective new alternative for the management of bone infection by the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also denoted as “nanoantibiotic”, consists in mesoporous silica nanoparticles (MSNs) loaded with an antimicrobial agent (levofloxacin, LEVO) and externally functionalized with N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (DAMO) as targeting agent. This amine functionalization provides MSNs of positive charges, which improves the affinity towards the negatively charged bacteria wall and biofilm. Physical and chemical properties of the nanoantibiotic were studied using different characterization techniques, including Xray diffraction (XRD), transmission electron microscopy (TEM), N

Stimuli-responsive flexible Lewis pair-modified nanoparticles for fluorescence imaging

2020 ◽  
Vol 56 (44) ◽  
pp. 5981-5984
Author(s):  
Nicole E. Arsenault ◽  
Kathleen T. Downey ◽  
Michael O. Wolf
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fluorescence Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Water Concentration ◽  
Stimuli Responsive ◽  
Biologically Relevant

Environment-responsive fluorophores are attached to mesoporous silica nanoparticles that can be used for sensing water concentration around biologically-relevant substrates.

scholarly journals Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

2019 ◽  
Vol 16 (4) ◽  
pp. 415-439 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
Blanca González ◽  
Miguel Manzano ◽  
Isabel Izquierdo-Barba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive
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