scholarly journals Three-Dimensional Nuclear Telomere Profiling as a Biomarker for Recurrence in Oligodendrogliomas: A Pilot Study

2020 ◽  
Vol 21 (22) ◽  
pp. 8539
Author(s):  
Macoura Gadji ◽  
Shubha Mathur ◽  
Brigitte Bélanger ◽  
Jaganmohan Reddy Jangamreddy ◽  
Josée Lamoureux ◽  
...  
Keyword(s):  
Pilot Study ◽  
Fluorescent In Situ Hybridization ◽  
Three Dimensional ◽  
Telomere Dysfunction ◽  
Short Term ◽  
Time To Recurrence ◽  
Potential Link ◽  
Touch Preparation

Mechanisms of recurrence in oligodendrogliomas are poorly understood. Recurrence might be driven by telomere dysfunction-mediated genomic instability. In a pilot study, we investigated ten patients with oligodendrogliomas at the time of diagnosis (first surgery) and after recurrence (second surgery) using three-dimensional nuclear telomere analysis performed with quantitative software TeloView® (Telo Genomics Corp, Toronto, Ontario, Canada). 1p/19q deletion status of each patient was determined by fluorescent in situ hybridization on touch preparation slides. We found that a very specific 3D telomeric profile was associated with two pathways of recurrence in oligodendrogliomas independent of their 1p/19q status: a first group of 8 patients displayed significantly different 3D telomere profiles between both surgeries (p < 0.0001). Their recurrence happened at a mean of 231.375 ± 117.42 days and a median time to progression (TTP) of 239 days, a period defined as short-term recurrence; and a second group of three patients displayed identical 3D telomere profiles between both surgery samples (p > 0.05). Their recurrence happened at a mean of 960.666 ± 86.19 days and a median TTP of 930 days, a period defined as long-term recurrence. Our results suggest a potential link between nuclear telomere architecture and telomere dysfunction with time to recurrence in oligodendrogliomas, independently of the 1p/19q status.

scholarly journals Remember like humans

2017 ◽  
Vol 14 (1) ◽  
pp. 172988141769231 ◽  
Author(s):  
Ning An ◽  
Shi-Ying Sun ◽  
Xiao-Guang Zhao ◽  
Zeng-Guang Hou
Keyword(s):  
Short Term Memory ◽  
Three Dimensional ◽  
Sensory Memory ◽  
Long Term Memory ◽  
Observation Model ◽  
Two Dimensional ◽  
Short Term ◽  
Term Memory ◽  
Memory Register

Visual tracking is a challenging computer vision task due to the significant observation changes of the target. By contrast, the tracking task is relatively easy for humans. In this article, we propose a tracker inspired by the cognitive psychological memory mechanism, which decomposes the tracking task into sensory memory register, short-term memory tracker, and long-term memory tracker like humans. The sensory memory register captures information with three-dimensional perception; the short-term memory tracker builds the highly plastic observation model via memory rehearsal; the long-term memory tracker builds the highly stable observation model via memory encoding and retrieval. With the cooperative models, the tracker can easily handle various tracking scenarios. In addition, an appearance-shape learning method is proposed to update the two-dimensional appearance model and three-dimensional shape model appropriately. Extensive experimental results on a large-scale benchmark data set demonstrate that the proposed method outperforms the state-of-the-art two-dimensional and three-dimensional trackers in terms of efficiency, accuracy, and robustness.

scholarly journals A study of long-term changes in Black Sea ecosystems based on data assimilation of remote measurements in a numerical model

2019 ◽  
Vol 46 (1) ◽  
pp. 58-69
Author(s):  
V. L. Dorofeev ◽  
L. I. Sukhikh
Keyword(s):  
Black Sea ◽  
Marine Ecosystem ◽  
Three Dimensional ◽  
The Black Sea ◽  
Regular Grid ◽  
Remote Measurements ◽  
Biogeochemical Parameters ◽  
Color Scanner

Herein, we present a simulation of the dynamics of Black Sea ecosystems using a three-dimensional interdisciplinary model that assimilates satellite color scanner measurements. Calculations were performed for the fifteen years from 1998 and a set of 3-d biogeochemical fields of the Black Sea were generated on a regular grid with a discreteness time of 1 day. Analyses of core biogeochemical parameters of the marine ecosystem were then performed. The qualities of received fields were evaluated using comparisons with existing data from in situ measurements.

Recall of Familiar Objects and Projected Color Photographs of Objects by Mentally Retarded Individuals of Comparable Mental Age

1976 ◽  
Vol 42 (1) ◽  
pp. 139-145
Author(s):  
Andrew L. Shotick ◽  
A. Bartow Ray ◽  
C. Lewis Addison
Keyword(s):  
Memory Span ◽  
Three Dimensional ◽  
Mentally Retarded ◽  
Short Term ◽  
Delayed Recall ◽  
Mental Age ◽  
Mentally Retarded Children ◽  
Cue Availability ◽  
Familiar Objects

The effects of cue-availability on short-term and long-term recall of 40 mentally retarded children were investigated. Subjects were chosen on the basis of comparable mental age (approximately 90 mo.) and randomly assigned to either an objects (high cues) group or slides (low cues) group. 52 familiar objects served as stimuli for the objects group and projected color photographs of the objects were presented to the slides group. In the short-term recall session the subjects were shown stimuli grouped into eight trials and asked to recall the names of the stimuli in each trial ten seconds after presentation. Delayed recall was obtained 48 hr. later in a free recall session. The objects group scored significantly higher than the slides group on memory span ( p < .01), short-term recall ( p < .001), and delayed recall ( p < .025). The facilitation of recall achieved by using three-dimensional stimuli was clearly demonstrated, and the relative degree of facilitation was comparable for both short- and long-term recall.

Differential Effects of Worry and Imagery After Exposure to a Stressful Stimulus: A Pilot Study

1995 ◽  
Vol 23 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Gillian Butler ◽  
Adrian Wells ◽  
Hilary Dewick
Keyword(s):  
Pilot Study ◽  
Emotional Processing ◽  
Long Term Effects ◽  
Short Term ◽  
Differential Effects ◽  
Short And Long Term ◽  
Intrusive Cognitions ◽  
Stressful Stimulus ◽  
Do So

Imagery appears to be associated with higher levels of anxiety than does worry. Borkovec has argued that worry could be a way of avoiding distressing imagery and the associated affect. Thus worry could suppress emotional activation, interfere with emotional processing, and contribute to the maintenance of anxiety. This hypothesis suggests that short and long-term effects of worrying after experiencing a distressing stimulus should differ from the effects of engaging in imagery. In the short term, imagery should maintain anxiety while worry should not do so, or should do so less. In the longer term, worry should be a less successful way of reducing anxiety associated with the stimulus than imagery, and should be followed by a greater number of intrusive cognitions (indicating the relative failure of emotional processing). These predictions were tested by asking subjects to worry, engage in imagery or “settle down” after watching a distressing video. The results were broadly consistent with the hypothesis. Other interpretations are also considered.

The Research of Statistic Prediction for Wave Loads Based on Three Dimensional Method

2013 ◽  
Author(s):  
Yihan Zhang ◽  
Huilong Ren ◽  
Hui Li ◽  
Xiaoyu Li
Keyword(s):  
Structural Strength ◽  
Wave Spectrum ◽  
Three Dimensional ◽  
Frequency Interval ◽  
Wave Loads ◽  
Short Term ◽  
Empirical Formulas ◽  
Strength Assessment ◽  
Term Prediction

The exact prediction of wave loads for ship or other marine structure is the key to its design and the assessment of structural strength, reliability and security. The short-term and long-term prediction of wave loads are always used in direct calculation for structural strength, fatigue strength assessment and so on based on spectral analysis method. In this paper, the numerical calculation method for statistic prediction is discussed firstly, including the Weibull distribution fitted method and the stack method. Further more, it is necessary to find a quick solution in order to improve the efficiency to compute the nonlinear equation in the second method. Then, some main factors that may influence the long-term or short-term prediction are discussed, such as wave spectrum, wave scatter diagram, incident wave angle interval and frequency interval. Finally, the wave loads prediction for a series of typical bulk carriers and oil tankers are calculated by the uniform predict method discussed above base on three dimensional wave loads calculation theory. The results showed that the method used in this paper can predict the statistic value of wave loads induced by irregular incident waves conveniently and efficiently. A rule to choose a series of uniform factors is confirmed for statistic prediction and some empirical formulas for long-term value of wave bending moment are concluded which are very useful in marine engineering.

Adaptation to calcium deprivation in the rat: effects of parathyroidectomy.

1977 ◽  
Vol 232 (3) ◽  
pp. E336
Author(s):  
J T Pento ◽  
L C Waite ◽  
P J Tracy ◽  
A D Kenny
Keyword(s):  
Adaptive Response ◽  
Calcium Transport ◽  
Parathyroid Tissue ◽  
Adaptation Period ◽  
Short Term ◽  
High Calcium

The role of parathyroid hormone (PTH) in the adaptive response in gut calcium transport to calcium deprivation has been studied in the rat using both the in vitro everted duodenal sac and the in situ ligated duodenal segment technique. Intact or parathyroidectomized (PTX) young rats were placed on a low calcium (0.01%) diet for 7-, 14-, or 21-day adaptation periods and compared with control rats maintained on a high calcium (1.5%) diet. Prior PTX (3 days before the start of the adaptation period) abolished the adaptive response (enhanced calcium transport) induced by calcium deprivation for a 7-day adaptation period, but did not abolish a response after a 21-day period. A 14-day adaptation period gave equivocal results. It is concluded that PTH appears to be necessary for short-term (7-day) adaptation, but not for long-term (21-day) adaptation to calcium deprivation. However, if accessory parathyroid tissue is present, the data could be interpreted differently: the essentiality of PTH for the adaptive response might be independent of the length of the adaptation period. The data also contribute to a possible resolution of the controversy concerning the involvement of PTH in the regulation of intestinal calcium transport in the rat.

Wear performance of selective laser melted Ti-6Al-4V alloy in situ modified with oxygen and boron

2019 ◽  
Vol 34 (01n03) ◽  
pp. 2040027
Author(s):  
Ben Jackson ◽  
Rob Torrens ◽  
Leandro Bolzoni ◽  
Fei Yang ◽  
Nigel Ross ◽  
...  
Keyword(s):  
Titanium Alloys ◽  
Saline Solution ◽  
Wear Properties ◽  
Short Term ◽  
Wear Performance ◽  
Three Body Abrasion ◽  
Three Body ◽  
Metal Additive

Titanium alloys have poor wear performance, with severe adhesive wear and three-body abrasion being dominant mechanisms. To extend the use of titanium to applications demanding better wear properties, modifications can be made to the alloys. This can include the addition of hard particulates or interstitial strengthening, by increasing the oxygen or nitrogen content. The metal additive manufacturing process of selective laser melting (SLM) has been shown to enable manufacture of these modified titanium alloys in situ. In this study, small amounts of boron and titanium dioxide powders were added to Ti-6Al-4V (Ti64) and processed using SLM. To compare wear performance of these modified materials, reciprocating pin on plate tests in brine solution were performed. Increased oxygen content increased the hardness of the material, which reduced wear. The presence of boron increased wear in the short term but reduced the long-term wear rate. Incorporating of oxygen and boron has been shown to improve the saline solution wear properties of Ti64 against silicon nitride.

scholarly journals New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: a Pilot Short-Term Follow-Up Study with Adult Patients

2015 ◽  
Vol 60 (2) ◽  
pp. 833-837 ◽  
Author(s):  
María Gabriela Álvarez ◽  
Yolanda Hernández ◽  
Graciela Bertocchi ◽  
Marisa Fernández ◽  
Bruno Lococo ◽  
...  
Keyword(s):  
Pilot Study ◽  
Adverse Effects ◽  
Liver Enzymes ◽  
Main Criterion ◽  
Short Term ◽  
Follow Up Study ◽  
End Of Treatment ◽  
Chronic Chagas Disease

ABSTRACTThere is a clinical need to test new schemes of benznidazole administration that are expected to be at least as effective as the current therapeutic scheme but safer. This study assessed a new scheme of benznidazole administration in chronic Chagas disease patients. A pilot study with intermittent doses of benznidazole at 5 mg/kg/day in two daily doses every 5 days for a total of 60 days was designed. The main criterion of response was the comparison of quantitative PCR (qPCR) findings prior to and 1 week after the end of treatment. The safety profile was assessed by the rate of suspensions and severity of adverse effects. Twenty patients were analyzed for safety, while qPCR was tested for 17 of them. The average age was 43 ± 7.9 years; 55% were female. Sixty-five percent of treated subjects showed detectable qPCR results prior to treatment of 1.45 (0.63 to 2.81) and 2.1 (1.18 to 2.78) parasitic equivalents per milliliter of blood (par.eq/ml) for kinetoplastic DNA (kDNA) qPCR and nuclear repetitive sequence satellite DNA (SatDNA) qPCR, respectively. One patient showed detectable PCR at the end of treatment (1/17), corresponding to 6% treatment failure, compared with 11/17 (65%) patients pretreatment (P= 0.01). Adverse effects were present in 10/20 (50%) patients, but in only one case was treatment suspended. Eight patients showed mild adverse effects, whereas moderate reactions with increased liver enzymes were observed in two patients. The main accomplishment of this pilot study is the promising low rate of treatment suspension. Intermittent administration of benznidazole emerges a new potential therapeutic scheme, the efficacy of which should be confirmed by long-term assessment posttreatment.

scholarly journals Short Term Versus Long Term Catheterization after Urogenital Prolapse Surgery

2012 ◽  
Vol 3 (2) ◽  
pp. 41-43
Author(s):  
Farzana Rabee Choudhury ◽  
Maliha Rashid ◽  
Ratu Rumana ◽  
ABM Zakir Uddin ◽  
Nilufar Nasrin Ava
Keyword(s):  
Genital Prolapse ◽  
Cross Sectional Study ◽  
Prolapse Surgery ◽  
Case Group ◽  
Short Term ◽  
Cross Sectional ◽  
Medical College ◽  
Better Than

Background: Genital prolapse is a common gynaecological problem in developing country like Bangladesh.Objectives: The aim of this study was to evaluate the advantages of short term catheterization in comparison to long term catheterization after genital prolapse surgery. Methodology: This was a prospective analytical cross sectional study being carried out from 1st July 2005 to 30th July 2006 in the Department of Gynaecology & Obstetrics of Sir Salimullah Medical College & Mitford Hospital. A total of 200 patients undergoing genital prolapse surgery were selected for this study. Patients were divided into two groups. In short term catheterization group the urinary catheter was withdrawal within one day after surgery and in the short term catheterization group the catheter was remained in situ for 5 days after surgery. Result: Positive urine culture was found in 16% in long term catheterization group compared with 6% in short term group (P=0.02). Mean duration of hospital stay was 6.98 days in long term catheterization group and 4.68 days in short term catheterization group (P<0.01). Residual volume was more than 200 ml and need for re-catheterization occurred in 3% in group whereas it was 10% in case group (P=0.04). Conclusion: This study permits to conclude that short term catheterization is better than long term catheterization. J Shaheed Suhrawardy Med Coll, 2011;3 (2): 41-43 DOI: http://dx.doi.org/10.3329/jssmc.v3i2.12077

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