scholarly journals Comparative Study of Silk-Based Magnetic Materials: Effect of Magnetic Particle Types on the Protein Structure and Biomaterial Properties

2020 ◽  
Vol 21 (20) ◽  
pp. 7583
Author(s):  
Ye Xue ◽  
Samuel Lofland ◽  
Xiao Hu
Keyword(s):  
Magnetic Particle ◽  
Barium Hexaferrite ◽  
Silk Protein ◽  
Mri Imaging ◽  
Magnetic Composites ◽  
Coordination Bonding ◽  
Magnetite Fe3o4 ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Β Sheet

This study investigates combining the good biocompatibility and flexibility of silk protein with three types of widely used magnetic nanoparticles to comparatively explore their structures, properties and potential applications in the sustainability and biomaterial fields. The secondary structure of silk protein was quantitatively studied by infrared spectroscopy. It was found that magnetite (Fe3O4) and barium hexaferrite (BaFe12O19) can prohibit β-sheet crystal due to strong coordination bonding between Fe3+ ions and carboxylate ions on silk fibroin chains where cobalt particles showed minimal effect. This was confirmed by thermal analysis, where a high temperature degradation peak was found above 640 °C in both Fe3O4 and BaFe12O19 samples. This was consistent with the magnetization studies that indicated that part of the Fe in the Fe3O4 and BaFe12O19 was no longer magnetic in the composite, presumably forming new phases. All three types of magnetic composites films maintained high magnetization, showing potential applications in MRI imaging, tissue regeneration, magnetic hyperthermia and controlled drug delivery in the future.

scholarly journals Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 906
Author(s):  
Le Minh Tu Phan ◽  
Thuy Anh Thu Vo ◽  
Thi Xoan Hoang ◽  
Sungbo Cho
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
High Light ◽  
Conversion Materials ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Biomedical Field ◽  
Hydrogel Composites ◽  
Material Fabrication ◽  
Biomedical Fields

Recently, photothermal therapy (PTT) has emerged as one of the most promising biomedical strategies for different areas in the biomedical field owing to its superior advantages, such as being noninvasive, target-specific and having fewer side effects. Graphene-based hydrogels (GGels), which have excellent mechanical and optical properties, high light-to-heat conversion efficiency and good biocompatibility, have been intensively exploited as potential photothermal conversion materials. This comprehensive review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine. The latest advances in the synthesis strategies, unique properties and potential applications of photothermal-responsive GGel nanocomposites in biomedical fields are introduced in detail. This review aims to provide a better understanding of the current progress in GGel material fabrication, photothermal properties and potential PTT-based biomedical applications, thereby aiding in more research efforts to facilitate the further advancement of photothermal biomedicine.

scholarly journals Optical Imaging of Magnetic Particle Cluster Oscillation and Rotation in Glycerol

2021 ◽  
Vol 7 (5) ◽  
pp. 82
Author(s):  
River Gassen ◽  
Dennis Thompkins ◽  
Austin Routt ◽  
Philippe Jones ◽  
Meghan Smith ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Magnetic Particle ◽  
Barium Hexaferrite ◽  
Optical Microscope ◽  
Simplified Model ◽  
Particle Cluster ◽  
Average Deviation ◽  
Cross Sectional

Magnetic particles have been evaluated for their biomedical applications as a drug delivery system to treat asthma and other lung diseases. In this study, ferromagnetic barium hexaferrite (BaFe12O19) and iron oxide (Fe3O4) particles were suspended in water or glycerol, as glycerol can be 1000 times more viscous than water. The particle concentration was 2.50 mg/mL for BaFe12O19 particle clusters and 1.00 mg/mL for Fe3O4 particle clusters. The magnetic particle cluster cross-sectional area ranged from 15 to 1000 μμm2, and the particle cluster diameter ranged from 5 to 45 μμm. The magnetic particle clusters were exposed to oscillating or rotating magnetic fields and imaged with an optical microscope. The oscillation frequency of the applied magnetic fields, which was created by homemade wire spools inserted into an optical microscope, ranged from 10 to 180 Hz. The magnetic field magnitudes varied from 0.25 to 9 mT. The minimum magnetic field required for particle cluster rotation or oscillation in glycerol was experimentally measured at different frequencies. The results are in qualitative agreement with a simplified model for single-domain magnetic particles, with an average deviation from the model of 1.7 ± 1.3. The observed difference may be accounted for by the fact that our simplified model does not include effects on particle cluster motion caused by randomly oriented domains in multi-domain magnetic particle clusters, irregular particle cluster size, or magnetic anisotropy, among other effects.

scholarly journals Synthesis and Characterization of Super Paramagnetic Magnetite Nanoparticles for Drug Delivery Application

2018 ◽  
Vol 7 (2.19) ◽  
pp. 87
Author(s):  
D BALAJ ◽  
C SARALA RUBI ◽  
N G. RENGANATHAN
Keyword(s):  
Drug Delivery ◽  
Magnetite Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Biomedical Application ◽  
Synthesis And Characterization ◽  
Xrd Pattern ◽  
Magnetite Fe3o4 ◽  
Tumor Hyperthermia ◽  
Potential Applications

Attractive nanoparticles have been broadly considered on account of their potential applications as complexity operators in attractive reverberation imaging (MRI) of tumors, cell and DNA partition, attractively guided medication conveyance, tumor hyperthermia. Among the attractive oxides, magnetite nanoparticles are most appropriate because of their low danger and great attractive properties which may be used in drug delivery. Magnetite nanoparticles were synthesized using FeCl3 and FeSO4 as precursors and characterized for size and shape using non-contact AFM.  The formation of magnetite was confirmed by XRD pattern. The elemental composition of the obtained phase was determined using EDAX. In this work, we are aiming to develop drug loaded biopolymer Magnetite nanoparticles for biomedical application. Our main objective is to synthesize and characterize Magnetite (Fe3O4) nanoparticles.  

scholarly journals A Versatile AIE Fluorogen with Selective Reactivity to Primary Amines for Monitoring Amination, Protein Labeling and Mitochondrial Staining

2021 ◽  
Author(s):  
Xinyuan He ◽  
Huilin Xie ◽  
Lianrui Hu ◽  
Pengchao Liu ◽  
Changhuo Xu ◽  
...  
Keyword(s):  
Fast Response ◽  
Molecular Engineering ◽  
Protein Labeling ◽  
Primary Amines ◽  
Probe Design ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Selective Reactivity ◽  
Mitochondrial Staining ◽  
Wide Potential

Specific bioconjugation for native primary amines is highly valuable for both chemistry and biomedical research. Despite all the efforts, scientists lack a proper strategy to achieve high selectivity for primary amines, not to mention the requirement of fast response for real applications. Herein, in this work, we report a chromone-based aggregation-induced emission (AIE) fluorogen called CMVMN as a self-reporting bioconjugation reagent for selective primary amine identification, and its applications for monitoring bioprocesses of amination and protein labeling. CMVMN is AIE-active and is capable of solid-state sensing. Thus, its electrospun films are manufactured for visualization of amine diffusion and leakage process. CMVMN also shows good biocompatibility and potential mitochondria-staining ability, which provides new insight for organelle-staining probe design. Combined with its facile synthesis and good reversibility, CMVMN not only shows wide potential applications in biology, but also offers new possibilities for molecular engineering.

ONE-STEP SYNTHESIS OF BIOCOMPATIBLE CHITOSAN/NaGdF4:Eu3+ NANOCOMPOSITE WITH FLUORESCENT AND MAGNETIC PROPERTIES FOR BIOIMAGING

NANO ◽  
2014 ◽  
Vol 09 (01) ◽  
pp. 1450007 ◽  
Author(s):  
HUI LI ◽  
CHUANXI WANG ◽  
YINGNAN JIANG ◽  
ZHANCHEN CUI ◽  
QUAN LIN
Keyword(s):  
Hexagonal Phase ◽  
Mri Contrast Agent ◽  
Uniform Size ◽  
Mri Contrast ◽  
Potential Applications ◽  
One Step ◽  
Ft Ir ◽  
Good Biocompatibility ◽  
Amine Groups ◽  
Magnetic Resonance Imaging Mri

Lanthanide-doped luminescent nanoscale materials have great potential applications in biological researches. Herein, we reported a novel and mild method for one-step synthesis of chitosan/ NaGdF 4: Eu 3+ nanocomposites. The luminescent Eu 3+ ions and magnetic resonance imaging (MRI) contrast agent Gd 3+ ions were incorporated to these biocompatible nanocomposites. The resultant nanocomposites exhibited strong fluorescence and attractive magnetic features. The nanocomposites also have pure hexagonal phase with uniform size of about 65 nm. FT-IR spectra revealed that these nanocomposites were successfully coated by hydrophilic chitosan, whose amine groups conferred the nanocomposites excellent dispensability in aqueous solution. Besides, the MTT assay and laser confocal microscopy images have confirmed the good biocompatibility of the nanocomposites. These results indicated that the as-prepared nanocomposites could be used as an excellent targeted imaging agent in biological fields.

scholarly journals Preparation and Photocatalytic Activity of Magnetic Fe3O4/SiO2/TiO2Composites

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Rijing Wang ◽  
Xiaohong Wang ◽  
Xiaoguang Xi ◽  
Ruanbing Hu ◽  
Guohua Jiang
Keyword(s):  
Electron Microscopy ◽  
Sol Gel ◽  
Separation And Purification ◽  
X Ray Diffraction ◽  
Magnetic Composites ◽  
X Ray ◽  
Structure And Morphology ◽  
Transmission Electron ◽  
Potential Applications ◽  
Ft Ir

A simple sol-gel method was used to prepare magnetic Fe3O4/SiO2/TiO2composites with core-shell structure. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and transmission electron microscopy (TEM) have been applied to investigate the structure and morphology of the resultant composites. The obtained composites showed excellent magnetism and higher photodegradation ability than pure TiO2. The photocatalytic mechanism was also discussed. The magnetic composites should be extended to various potential applications, such as photodegradation, catalysis, separation, and purification processes.

scholarly journals Graphitic carbon nitride quantum dots: Synthesis and applications

2021 ◽  
pp. 58-73
Author(s):  
Dang Dinh Khoi
Keyword(s):  
Quantum Dots ◽  
Carbon Nitride ◽  
Structural Features ◽  
Graphitic Carbon ◽  
Synthetic Methods ◽  
Graphitic Carbon Nitride ◽  
Vast Number ◽  
Future Challenges ◽  
Potential Applications ◽  
Good Biocompatibility

Graphitic-carbon nitride quantum dots (g-CNQDs), a rising star in the carbon nitride family, has shown great potential in many fields including chemical and biomedical applications due to their good biocompatibility, stable fluorescence, high quantum yield, and nontoxicity. For this reason, enormous efforts have been devoted to optimizing synthetic methods and structures of g-CNQDs to discover the inner properties and structural features in the intriguing system. Also, a vast number of studies have been pursued to discuss the potential applications of g-CNQDs in chemical and biomedical areas. In this review, recent advances in synthesis and applications of g-CNQDs were summarized and the future challenges as well as opportunities of these g-CNQDs in the chemical and biomedical fields will be highlighted.

scholarly journals Synthesis and Characterization Nanomagnetite by Co-precipitation

2019 ◽  
Vol 2 (2) ◽  
pp. 90
Author(s):  
Rahimah Rahimah ◽  
Ahmad Fadli ◽  
Yelmida Yelmida ◽  
Nurfajriani Nurfajriani ◽  
Zakwan Zakwan
Keyword(s):  
Retention Time ◽  
Drug Carrier ◽  
Precipitation Method ◽  
Effect Of Temperature ◽  
Xrd Pattern ◽  
Magnetite Fe3o4 ◽  
Low Toxicity ◽  
Magnetite Particles ◽  
Good Biocompatibility ◽  
Co Precipitation

Magnetite (Fe3O4) nanoparticles becomes a new innovation that gets attention of biomedicine scientists. Magnetite can be applied to cancer treatment as a drug carrier because it’s good biocompatibility and very low toxicity. The aim of this study was to determine the effect of temperature and retention time on the magnetite particle characteristics prepared by co-precipitation method. The first, FeCl3 and FeCl2 with 2:1 mole ratio were reacted with 10% NH4OH at 40 - 80°C temperatures during 1 – 30 minutes in a beaker glass. Subsequently, the precipitate was separated using filter paper and it dried into air oven at 100°C. The characteristic of obtained magnetite powder were determined using XRD and SEM. From XRD pattern indicates that magnetite formed at all temperatures with crystallite diameter in the range of 7-13 nm. The SEM results indicate the agglomeration of the magnetite particles with size in the range of 1.37 to 1.72 μm. In the other hand, the higher of temperature and retention time will make the agglomeration of the particles become more uniform. The increasing of temperature and the retention time will increase the magnetite crystallinity level.

scholarly journals Ion effects on the conformation and dynamics of repetitive domains of a spider silk protein: implications for solubility and β-sheet formation

2019 ◽  
Vol 55 (66) ◽  
pp. 9761-9764 ◽  
Author(s):  
Nur Alia Oktaviani ◽  
Akimasa Matsugami ◽  
Fumiaki Hayashi ◽  
Keiji Numata
Keyword(s):  
Hydrogen Bond ◽  
Molecular Interactions ◽  
Spider Silk ◽  
Silk Protein ◽  
Hydrogen Bond Interactions ◽  
Spider Silk Protein ◽  
Ion Effects ◽  
Β Sheet ◽  
Chaotropic Ions

Chaotropic ions prevent molecular interactions of a spider silk protein, which are required to maintain the solubility, while kosmotropic ions promote hydrogen bond interactions, which are a prerequisite for β-sheet formation.

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