scholarly journals Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease

2020 ◽  
Vol 21 (18) ◽  
pp. 6924
Author(s):  
Molly Easter ◽  
Seth Bollenbecker ◽  
Jarrod W. Barnes ◽  
Stefanie Krick
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Nutrient Sensing ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Telomere Attrition ◽  
Global Epidemic ◽  
Novel Treatment Strategies

Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the third leading cause of death worldwide. COPD is characterized by chronic airway inflammation, loss of alveolar-capillary units, and progressive decline in lung function. Major risk factors for COPD are cigarette smoking and aging. COPD-associated pathomechanisms include multiple aging pathways such as telomere attrition, epigenetic alterations, altered nutrient sensing, mitochondrial dysfunction, cell senescence, stem cell exhaustion and chronic inflammation. In this review, we will highlight the current literature that focuses on the role of age and aging-associated signaling pathways as well as their impact on current treatment strategies in the pathogenesis of COPD. Furthermore, we will discuss established and experimental COPD treatments including senolytic and anti-aging therapies and their potential use as novel treatment strategies in COPD.

scholarly journals Update on Clinical Inflammometry for the Management of Airway Diseases

2013 ◽  
Vol 20 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Parameswaran Nair
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Airway Inflammation ◽  
Pulmonary Disease ◽  
Treatment Strategies ◽  
Chronic Obstructive ◽  
Central Feature ◽  
Obstructive Pulmonary Disease ◽  
Cell Counts ◽  
Airway Diseases ◽  
Anti Inflammatory

Airway inflammation is a central feature of many airway diseases such as asthma, chronic bronchitis, bronchiectasis and chronic cough; therefore, it is only logical that it is measured to optimize its treatment. However, most treatment recommendations, including the use of anti-inflammatory therapies such as corticosteroids, are based on assessments of only airflow and symptoms. Over the past 10 years, methods have been developed to assess airway inflammation relatively noninvasively. Quantitative cell counts in sputum and the fraction of exhaled nitric oxide are the most validated tests. Judicious use of currently available drugs, such as corticosteroids, bronchodilators and antibiotics, and other anti-inflammatory therapies guided by sputum eosinophil and neutrophil counts, have been demonstrated to decrease exacerbations of asthma and chronic obstructive pulmonary disease, ameliorate cough, improve quality of life in patients with these diseases and is cost effective compared with treatment strategies based on guidelines that do not incorporate these measurements. Thus, it is unfortunate that this is not used more widely in the management of airway diseases, particularly in patients with severe asthma and chronic obstructive pulmonary disease who experience frequent exacerbations.

scholarly journals Blinded to Their Own Daily Sufferings: the Lived Experience of Patients With Chronic Obstructive Pulmonary Disease in Ethiopia

2020 ◽  
Author(s):  
Mulugeta Tamire ◽  
Aschalew Worku ◽  
Adamu Addissie ◽  
Samuel Ayele ◽  
Tewodros Haile ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Treatment Strategies ◽  
Religious Life ◽  
Community Support ◽  
Male Participant ◽  
Female Participant ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Abstract Background: Worldwide, chronic obstructive pulmonary disease (COPD) continues to be an important contributor to morbidity, mortality and health-care costs. In Ethiopia, the physical, financial, emotional, social and religious life of patients living with COPD is poorly understood, information crucial for physicians in developing treatment strategies and government agencies in planning community support services. This study, the first of its kind, was designed to initiate understanding of the personal burden of living with COPD in Ethiopia.Methods: This was a qualitative research study using a phenomenographic approach. Twelve recruited COPD patients underwent in-depth interviews using a semi-structured open-ended interview guide. All audio-records were transcribed verbatim and translated to English for analysis using Atlas.ti software.Results: There were seven men and five women, whose ages ranged from 45 to 78 years. One male participant was a former smoker and one female participant had second-hand cigarette exposure. All 12 participants were unaware of their COPD diagnosis despite experiencing chronic symptoms of cough and shortness of breath, unresponsive to treatment, which affected their physical, financial, emotional, social and religious life. In addition, all participants attempted a variety of coping strategies to deal with their respiratory disease and many were optimistic about their future living with the disease. Conclusions: The findings of this study indicate an urgent need for improved awareness, diagnosis and treatment of COPD patients to lessen the burden of those living with the disease and more judiciously, utilize available resources in Ethiopia.

scholarly journals Two-Step Laparoscopic Surgery for a Patient with Synchronous Double Cancer of the Colon and Stomach Accompanied by Severe Chronic Obstructive Pulmonary Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Kazuhito Yajima ◽  
Shin-Ichi Kosugi ◽  
Yosuke Kano ◽  
Takaaki Hanyu ◽  
Hiroshi Ichikawa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Laparoscopic Surgery ◽  
Pulmonary Disease ◽  
Treatment Strategies ◽  
Forced Expiratory Volume ◽  
Pulmonary Complications ◽  
Chronic Obstructive ◽  
Double Cancer ◽  
D3 Lymphadenectomy ◽  
Obstructive Pulmonary Disease

Laparoscopic treatment strategies for synchronous intra-abdominal malignancies have not yet been standardized. We report a successful case of two-step laparoscopic surgery for synchronous double cancer of the colon and stomach accompanied by severe chronic obstructive pulmonary disease (COPD). A 66-year-old man with COPD was diagnosed as having advanced colon cancer and early gastric cancer. On admission, he could not go upstairs (Grade III according to the Hugh-Jones classification) and his forced expiratory volume in 1 second was 600 mL (35.9%). The patient initially underwent laparoscopy-assisted sigmoidectomy with D3 lymphadenectomy, followed by laparoscopy-assisted distal gastrectomy with D1 lymphadenectomy 68 days later. The patient's each postoperative course was uneventful with no pulmonary complications, and the patient was discharged 9 and 11 days after the first and second operations, respectively. The present case demonstrates that two-step laparoscopic surgery may be a safe and feasible surgical procedure for high-risk patients with synchronous intra-abdominal malignancies.

scholarly journals Treatment strategies after acute exacerbations of chronic obstructive pulmonary disease: Impact on mortality

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208847 ◽  
Author(s):  
Fernando Casas-Mendez ◽  
Maria Jose Abadías ◽  
Oriol Yuguero ◽  
Ignasi Bardés ◽  
Ferran Barbé ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Treatment Strategies ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Acute Exacerbations ◽  
Disease Impact

scholarly journals Updated view on the treatment of chronic obstructive pulmonary disease in Korea

2021 ◽  
Vol 64 (3) ◽  
pp. 225-231
Author(s):  
Deog Kyeom Kim ◽  
Chin Kook Rhee
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Clinical Practice ◽  
Medical Treatment ◽  
Pulmonary Disease ◽  
Treatment Strategies ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Clinical Benefits ◽  
Long Acting

Chronic obstructive pulmonary disease (COPD) is prevalent (13.4% in the population above the age of 40) but less recognized by patients and physicians in Korea. The definition and treatment strategies of COPD have changed with the accumulation of evidence, and the Korean COPD guidelines recommended by the Korean Academy of Tuberculosis and Respiratory Disease have also been updated. This review will cover some important points, that should be considered in the management of stable COPD in clinical practice. COPD is a treatable disease and earlier detection should be emphasized to achieve better clinical benefits in the mild stages. In addition, etiologies other than smoking are critical in the development of COPD. Medical treatment strategies have been updated focusing on the role of long-acting bronchodilators and the updated Korean COPD guidelines include specific Korean situations in the management of COPD.

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