scholarly journals The Antihypertensive Effect of Quercetin in Young Spontaneously Hypertensive Rats; Role of Arachidonic Acid Metabolism

2020 ◽  
Vol 21 (18) ◽  
pp. 6554
Author(s):  
Fawzy Elbarbry ◽  
Khaled Abdelkawy ◽  
Nicholas Moshirian ◽  
Ahmed M. Abdel-Megied
Keyword(s):  
Blood Pressure ◽  
Arachidonic Acid ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Arachidonic Acid Metabolism ◽  
High Dose ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Treatment Groups ◽  
Pressure Lowering

Hypertension affects almost 50% of the adult American population. Metabolites of arachidonic acid (AA) in the kidney play an important role in blood pressure regulation. The present study investigates the blood pressure-lowering potential of quercetin (QR), a naturally occurring polyphenol, and examines its correlation to the modulation of AA metabolism. Spontaneously hypertensive rats (SHR) were randomly divided into four groups. Treatment groups were administered QR in drinking water at concentrations of 10, 30, and 60 mg/L. Blood pressure was monitored at seven-day intervals. After a total of seven weeks of treatment, rats were killed and kidney tissues were collected to examine the activity of the two major enzymes involved in AA metabolism in the kidney, namely cytochrome P450 (CYP)4A and soluble epoxide hydrolase (sEH). Medium- and high-dose QR resisted the rise in blood pressure observed in the untreated SHR and significantly inhibited the activity of the CYP4A enzyme in renal cortical microsomes. The activity of the sEH enzyme in renal cortical cytosols was significantly inhibited only by the high QR dose. Our data not only demonstrate the antihypertensive effect of QR, but also provide a novel mechanism for its underlying cardioprotective properties.

Blood-pressure lowering efficacy of winged bean seed hydrolysate in spontaneously hypertensive rats, peptide characterization and a toxicity study in Sprague-Dawley rats

2018 ◽  
Vol 9 (3) ◽  
pp. 1657-1671 ◽  
Author(s):  
Shyan Yea Chay ◽  
Annas Salleh ◽  
Nor Fazila Sulaiman ◽  
Najib Zainal Abidin ◽  
Mohamad Ariff Hanafi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Good Manufacturing Practice ◽  
Reduce Blood Pressure ◽  
Winged Bean ◽  
Bean Seed ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Lowering

Winged bean seed hydrolysate is found to reduce blood pressure in spontaneously hypertensive rats. Peptide of non-Current Good Manufacturing Practice grade demonstrates toxicity and is not suitable for testing in animals.

scholarly journals Piper sarmentosum Leaves Aqueous Extract Attenuates Vascular Endothelial Dysfunction in Spontaneously Hypertensive Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Fatimatuzzahra Hashim Fauzy ◽  
Maizura Mohd Zainudin ◽  
Hidayatul Radziah Ismawi ◽  
Taher F. T. Elshami
Keyword(s):  
Blood Pressure ◽  
Aqueous Extract ◽  
Spontaneously Hypertensive Rats ◽  
Positive Control ◽  
No Production ◽  
Hypertensive Rats ◽  
Traditional Use ◽  
Spontaneously Hypertensive ◽  
Treatment Groups ◽  
Endothelin System

Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures (P<0.05) of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level (P<0.05) and reduced endothelin-1 (ET-1) level (P<0.05) in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production.

Partial Replacement of Sodium by Potassium in the Diet Restores Impaired Noradrenaline Inactivation and Lowers Blood Pressure in Stroke-Prone Spontaneously Hypertensive Rats

1981 ◽  
Vol 61 (s7) ◽  
pp. 69s-71s ◽  
Author(s):  
R. Dietz ◽  
A. Schömig ◽  
W. Rascher ◽  
R. Strasser ◽  
U. Ganten ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dietary Intake ◽  
Spontaneously Hypertensive Rats ◽  
Partial Replacement ◽  
Hypertensive Rats ◽  
Blood Pressure Lowering Effect ◽  
Spontaneously Hypertensive ◽  
Pressure Lowering ◽  
Metabolism Of Noradrenaline ◽  
Inactivation Of Noradrenaline

1. Partial replacement of sodium by potassium in the diet attenuates the rise in blood pressure in stroke-prone spontaneously hypertensive rats (SHR-SP). 2. The blood pressure-lowering effect of potassium cannot be ascribed to a reduction in intravascular volume. 3. The increased dietary intake of potassium leads to a reduced stimulation of the sympathoneuronal and sympathoadrenal system by cold compared with the response of sodium-loaded rats. 4. The impaired inactivation of noradrenaline observed in sodium-loaded SHR-SP is improved in SHR-SP on a potassium-substituted diet. 5. It is concluded that changes in dietary intake of sodium and potassium modulate sympathetic activity and the metabolism of noradrenaline, both of which are related to the development of hypertension in SHR-SP.

scholarly journals Antihypertensive Effect of Radix Paeoniae Alba in Spontaneously Hypertensive Rats and Excessive Alcohol Intake and High Fat Diet Induced Hypertensive Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Chen Su-Hong ◽  
Chen Qi ◽  
Li Bo ◽  
Gao Jian-Li ◽  
Su Jie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Fat Diet ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Hdl Cholesterol ◽  
High Fat ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Excessive Alcohol ◽  
Radix Paeoniae Alba

Radix Paeoniae Alba (Baishao, RPA) has long been used in traditional Chinese medicine formulation to treat hypertension by repression the hyperfunction of liver. However, whether the RPA itself has the antihypertensive effect or not is seldom studied. This study was to evaluate the protective effect of RPA on hypertensive rats. Alcohol in conjunction with a high fat diet- (ACHFD-) induced hypertensive rats and spontaneously hypertensive rats (SHR) was constantly received either RPA extract (25 or 75 mg/kg) or captopril (15 mg/kg) all along the experiments. As a result, RPA extract (75 mg/kg) could significantly reduce systolic blood pressure of both ACHFD-induced hypertensive rats and SHR after 9-week or 4-week treatment. In ACHFD-induced hypertensive rats, the blood pressure was significantly increased and the lipid profiles in serum including triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly deteriorated. Also, hepatic damage was manifested by a significant increase in alanine transaminase (ALT) and aspartate transaminase (AST) in serum. The RPA extract significantly reversed these parameters, which revealed that it could alleviate the liver damage of rats. In SHR, our result suggested that the antihypertensive active of RPA extract may be related to its effect on regulating serum nitric oxide (NO) and endothelin (ET) levels.

Abstract P760: Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Fabricio Simao ◽  
Jian Guan ◽  
Allen Clermont ◽  
Loc-Duyen Pham ◽  
Tuna Ustunkaya ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intracerebral Hemorrhage ◽  
Spontaneously Hypertensive Rats ◽  
High Salt ◽  
Plasma Kallikrein ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Blood Pressure Lowering ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Lowering

Introduction: Hypertension is a leading risk factor for spontaneous intracerebral hemorrhage. Plasma Kallikrein (PKa) has been implicated in contributing to hemorrhage following thrombolytic therapy, however, its role in spontaneous intracerebral hemorrhage is currently not available. This report investigates the role of PKa on hemorrhage and hypertension in stroke-prone spontaneously hypertensive rats (SHRSP). Methods: SHRSP were fed with a high salt containing stroke-prone diet to increase blood pressure and induce spontaneous intracerebral hemorrhage. The roles of PKa on blood pressure, intracerebral hemorrhage, and survival in SHRSP were examined in rats receiving a PKa inhibitor (BPCCB) or plasma prekallikrein antisense oligonucleotide (PK ASO) compared with rats receiving control ASO. Effects on PKa on the proteolytic cleavage of atrial natriuretic peptide (ANP) were analyzed by tandem mass spectrometry. Results: PKa activity in plasma was increased by 29% in SHRSP on high salt diet compared with control rats. Cleaved kininogen, a substrate for PKa, was 2-fold greater in SHRSP plasma during stroke compared with SHRSP without stroke symptoms. Systemic administration of BPCCB or PK ASO to SHRSP reduced intracerebral hemorrhage (Fig. 1A) and blood pressure (Fig. 1B), and improved neurological function and survival when compared with rats receiving control ASO. Since PKa inhibition was associated with reduced blood pressure in hypertensive rats, we investigated the effects of PKa on the cleavage of ANP. Incubation of PKa with ANP resulted in the generation fragment ANP 5-28 , which displayed reduced effects on blood pressure lowering compared with full length ANP. Conclusions: PKa contributes to increased blood pressure in SHRSP, which is associated with intracerebral hemorrhage and reduced survival. PKa-mediated cleavage of ANP reduces its blood pressure lowering effects and thereby may contribute to hypertension-induced intracerebral hemorrhage.

Blood pressure lowering effects of Australian canola protein hydrolysates in spontaneously hypertensive rats

2014 ◽  
Vol 55 ◽  
pp. 281-287 ◽  
Author(s):  
Adeola M. Alashi ◽  
Christopher L. Blanchard ◽  
Rodney J. Mailer ◽  
Samson O. Agboola ◽  
Andrew J. Mawson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Protein Hydrolysates ◽  
Blood Pressure Lowering ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Lowering ◽  
Canola Protein
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