scholarly journals Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior

2020 ◽  
Vol 21 (15) ◽  
pp. 5478 ◽  
Author(s):  
Valentina S. Rumanova ◽  
Monika Okuliarova ◽  
Michal Zeman
Keyword(s):  
Circadian Rhythms ◽  
Light Level ◽  
Constant Light ◽  
Signal Molecules ◽  
Light At Night ◽  
Circadian Control ◽  
Dim Light ◽  
Underlying Mechanisms ◽  
And Behavior ◽  
Light:Dark Cycle

The disruption of circadian rhythms by environmental conditions can induce alterations in body homeostasis, from behavior to metabolism. The light:dark cycle is the most reliable environmental agent, which entrains circadian rhythms, although its credibility has decreased because of the extensive use of artificial light at night. Light pollution can compromise performance and health, but underlying mechanisms are not fully understood. The present review assesses the consequences induced by constant light (LL) in comparison with dim light at night (dLAN) on the circadian control of metabolism and behavior in rodents, since such an approach can identify the key mechanisms of chronodisruption. Data suggest that the effects of LL are more pronounced compared to dLAN and are directly related to the light level and duration of exposure. Dim LAN reduces nocturnal melatonin levels, similarly to LL, but the consequences on the rhythms of corticosterone and behavioral traits are not uniform and an improved quantification of the disrupted rhythms is needed. Metabolism is under strong circadian control and its disruption can lead to various pathologies. Moreover, metabolism is not only an output, but some metabolites and peripheral signal molecules can feedback on the circadian clockwork and either stabilize or amplify its desynchronization.

Effect of chronic dim-light-at-night exposure on sleep EEG and behavior in young and aged mice

2017 ◽  
Vol 40 ◽  
pp. e76
Author(s):  
M. Panagiotou ◽  
J.H. Meijer ◽  
T. de Boer
Keyword(s):  
Sleep Eeg ◽  
Light At Night ◽  
Aged Mice ◽  
Dim Light ◽  
And Behavior

Dim light at night attenuates circadian rhythms in the cardiovascular system and suppresses melatonin in rats

Life Sciences ◽  
2019 ◽  
Vol 231 ◽  
pp. 116568 ◽  
Author(s):  
Lubos Molcan ◽  
Hana Sutovska ◽  
Monika Okuliarova ◽  
Tomas Senko ◽  
Lucia Krskova ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Cardiovascular System ◽  
Light At Night ◽  
Dim Light

Acute dim light at night increases body mass, alters metabolism, and shifts core body temperature circadian rhythms

2014 ◽  
Vol 31 (8) ◽  
pp. 917-925 ◽  
Author(s):  
Jeremy C. Borniger ◽  
Santosh K. Maurya ◽  
Muthu Periasamy ◽  
Randy J. Nelson
Keyword(s):  
Body Temperature ◽  
Circadian Rhythms ◽  
Body Mass ◽  
Core Body Temperature ◽  
Light At Night ◽  
Dim Light ◽  
And Shifts ◽  
Core Body

scholarly journals Dim Light at Night Disrupts Molecular Circadian Rhythms and Increases Body Weight

2013 ◽  
Vol 28 (4) ◽  
pp. 262-271 ◽  
Author(s):  
Laura K. Fonken ◽  
Taryn G. Aubrecht ◽  
O. Hecmarie Meléndez-Fernández ◽  
Zachary M. Weil ◽  
Randy J. Nelson
Keyword(s):  
Body Weight ◽  
Circadian Rhythms ◽  
Light At Night ◽  
Dim Light

scholarly journals Light Pollution and Cancer

2020 ◽  
Vol 21 (24) ◽  
pp. 9360
Author(s):  
William H. Walker ◽  
Jacob R. Bumgarner ◽  
James C. Walton ◽  
Jennifer A. Liu ◽  
O. Hecmarie Meléndez-Fernández ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Metabolic Disorders ◽  
Clock Genes ◽  
Science Literature ◽  
Light At Night ◽  
Clock System ◽  
Industrialized Nations ◽  
Circadian Organization ◽  
And Behavior ◽  
Improve Health

For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metabolic disorders, and mood disorders. Within this review, we present a brief overview of the molecular circadian clock system and the importance of maintaining fidelity to bright days and dark nights. We describe the interrelation between core clock genes and the cell cycle, as well as the contribution of clock genes to oncogenesis. Next, we review the clinical implications of disrupted circadian rhythms on cancer, followed by a section on the foundational science literature on the effects of light at night and cancer. Finally, we provide some strategies for mitigation of disrupted circadian rhythms to improve health.

scholarly journals Impacts of home lighting on human health

2021 ◽  
Vol 53 (5) ◽  
pp. 453-475
Author(s):  
C Ticleanu
Keyword(s):  
Energy Efficiency ◽  
Circadian Rhythms ◽  
Human Health ◽  
Electromagnetic Fields ◽  
Good Health ◽  
Sleep Patterns ◽  
Light At Night ◽  
Night Time ◽  
Potential Health ◽  
Areas Of Concern

Typical home lighting practice is mainly centred on visual aspects to enable safe movement between spaces, flexibility in multiuse spaces, a sense of aesthetics and energy efficiency. Whilst lighting impacts on the health of residents have not received similar consideration, this area is gaining increasing interest. This is even more important and actual in the context of the recent pandemic where people have been working or studying from home. A combination of bright daytime light and night-time darkness is essential for circadian entrainment and maintenance of a regular daily sleep–wake cycle, whereas exposure to light at night can negatively impact circadian rhythms and sleep patterns and ultimately lead to potential health problems. Additionally, lighting also has the potential to affect health through associated effects such as flicker, glare, optical hazards or electromagnetic fields. This article discusses the main areas of concern related to home lighting and outlines general recommendations to limit detrimental effects and contribute to good health.

scholarly journals Divergent Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies

Diseases ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 18
Author(s):  
Rüdiger Hardeland
Keyword(s):  
Phase Response Curve ◽  
Sleep Onset ◽  
Melatonin Receptors ◽  
Duration Of Action ◽  
Circadian Oscillators ◽  
Protective Actions ◽  
Circadian Control ◽  
Dim Light ◽  
Poor Individual ◽  
Specific Phase

Melatonin has been used preclinically and clinically for different purposes. Some applications are related to readjustment of circadian oscillators, others use doses that exceed the saturation of melatonin receptors MT1 and MT2 and are unsuitable for chronobiological purposes. Conditions are outlined for appropriately applying melatonin as a chronobiotic or for protective actions at elevated levels. Circadian readjustments require doses in the lower mg range, according to receptor affinities. However, this needs consideration of the phase response curve, which contains a silent zone, a delay part, a transition point and an advance part. Notably, the dim light melatonin onset (DLMO) is found in the silent zone. In this specific phase, melatonin can induce sleep onset, but does not shift the circadian master clock. Although sleep onset is also under circadian control, sleep and circadian susceptibility are dissociated at this point. Other limits of soporific effects concern dose, duration of action and poor individual responses. The use of high melatonin doses, up to several hundred mg, for purposes of antioxidative and anti-inflammatory protection, especially in sepsis and viral diseases, have to be seen in the context of melatonin’s tissue levels, its formation in mitochondria, and detoxification of free radicals.

scholarly journals Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation

2017 ◽  
Vol 28 (6) ◽  
pp. 834-842 ◽  
Author(s):  
Amol Chaudhari ◽  
Richa Gupta ◽  
Sonal Patel ◽  
Nikkhil Velingkaar ◽  
Roman Kondratov
Keyword(s):  
Circadian Rhythms ◽  
Circadian Clock ◽  
Skeletal Muscles ◽  
Cancer Metabolism ◽  
Reduced Body ◽  
Circadian Control ◽  
Cell Growth And Proliferation ◽  
Deficient Mice ◽  
Igf Signaling

Insulin-like growth factor (IGF) signaling plays an important role in cell growth and proliferation and is implicated in regulation of cancer, metabolism, and aging. Here we report that IGF-1 level in blood and IGF-1 signaling demonstrates circadian rhythms. Circadian control occurs through cryptochromes (CRYs)—transcriptional repressors and components of the circadian clock. IGF-1 rhythms are disrupted in Cry-deficient mice, and IGF-1 level is reduced by 80% in these mice, which leads to reduced IGF signaling. In agreement, Cry-deficient mice have reduced body (∼30% reduction) and organ size. Down-regulation of IGF-1 upon Cry deficiency correlates with reduced Igf-1 mRNA expression in the liver and skeletal muscles. Igf-1 transcription is regulated through growth hormone–induced, JAK2 kinase–mediated phosphorylation of transcriptional factor STAT5B. The phosphorylation of STAT5B on the JAK2-dependent Y699 site is significantly reduced in the liver and skeletal muscles of Cry-deficient mice. At the same time, phosphorylation of JAK2 kinase was not reduced upon Cry deficiency, which places CRY activity downstream from JAK2. Thus CRYs link the circadian clock and JAK-STAT signaling through control of STAT5B phosphorylation, which provides the mechanism for circadian rhythms in IGF signaling in vivo.

Sign in / Sign up

Export Citation Format

Share Document