scholarly journals Nuclear Receptors, Ligands and the Mammalian B Cell

2020 ◽  
Vol 21 (14) ◽  
pp. 4997
Author(s):  
Bart G. Jones ◽  
Rhiannon R. Penkert ◽  
Sherri L. Surman ◽  
Robert E. Sealy ◽  
Julia L. Hurwitz
Keyword(s):  
B Cell ◽  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Cell Function ◽  
Receptor Ligands ◽  
Cell Responses ◽  
Cell Genome ◽  
Ligand Regulation ◽  
Nuclear Receptor Ligands ◽  
Pathogen Clearance

Questions concerning the influences of nuclear receptors and their ligands on mammalian B cells are vast in number. Here, we briefly review the effects of nuclear receptor ligands, including estrogen and vitamins, on immunoglobulin production and protection from infectious diseases. We describe nuclear receptor interactions with the B cell genome and the potential mechanisms of gene regulation. Attention to the nuclear receptor/ligand regulation of B cell function may help optimize B cell responses, improve pathogen clearance, and prevent damaging responses toward inert- and self-antigens.

scholarly journals Research Resource: Comparative Nuclear Receptor Atlas: Basal and Activated Peritoneal B-1 and B-2 Cells

2011 ◽  
Vol 25 (3) ◽  
pp. 529-545 ◽  
Author(s):  
Cody J. Diehl ◽  
Grant D. Barish ◽  
Michael Downes ◽  
Meng-Yun Chou ◽  
Sven Heinz ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Lupus Erythematosus ◽  
Cell Function ◽  
Cell Lineage ◽  
Primary Source ◽  
Receptor Expression ◽  
Marginal Zone B Cells

Abstract Naïve murine B cells are typically divided into three subsets based on functional and phenotypic characteristics: innate-like B-1 and marginal zone B cells vs. adaptive B-2 cells, also known as follicular or conventional B cells. B-1 cells, the innate-immune-like component of the B cell lineage are the primary source of natural antibodies and have been shown to modulate autoimmune diseases, human B-cell leukemias, and inflammatory disorders such as atherosclerosis. On the other hand, B-2 cells are the principal mediators of the adaptive humoral immune response and represent an important pharmacological target for various conditions including rheumatoid arthritis, lupus erythematosus, and lymphomas. Using the resources of the Nuclear Receptor Signaling Atlas program, we used quantitative real-time PCR to assess the complement of the 49 murine nuclear receptor superfamily expressed in quiescent and toll-like receptor (TLR)-stimulated peritoneal B-1 and B-2 cells. We report the expression of 24 nuclear receptors in basal B-1 cells and 25 nuclear receptors in basal B-2 cells, with, in some cases, dramatic changes in response to TLR 4 or TLR 2/1 stimulation. Comparative nuclear receptor profiling between B-1 and peritoneal B-2 cells reveals a highly concordant expression pattern, albeit at quantitatively dissimilar levels. We also found that splenic B cells express 23 nuclear receptors. This catalog of nuclear receptor expression in B-1 and B-2 cells provides data to be used to better understand the specific roles of nuclear receptors in B cell function, chronic inflammation, and autoimmune disease.

Author response for "Dysregulation in B cell responses and T follicular helper cell function in ADA2 deficiency patients"

2020 ◽  
Author(s):  
Francesca Schena ◽  
Federica Penco ◽  
Stefano Volpi ◽  
Claudia Pastorino ◽  
Roberta Caorsi ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Function ◽  
Author Response ◽  
Helper Cell ◽  
Cell Responses ◽  
Follicular Helper ◽  
T Follicular Helper Cell ◽  
B Cell Responses

scholarly journals Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors

2018 ◽  
Vol 8 (3) ◽  
pp. 1554967 ◽  
Author(s):  
Raffaella Fontana ◽  
Laura Raccosta ◽  
Lucrezia Rovati ◽  
Knut R. Steffensen ◽  
Aida Paniccia ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nuclear Receptor ◽  
Receptor Ligands ◽  
Nuclear Receptor Ligands

Reporter cell lines are useful tools for monitoring biological activity of nuclear receptor ligands

Luminescence ◽  
2001 ◽  
Vol 16 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Patrick Balaguer ◽  
Anne-Marie Boussioux ◽  
Ediz Demirpence ◽  
Jean-Claude Nicolas
Keyword(s):  
Biological Activity ◽  
Cell Lines ◽  
Nuclear Receptor ◽  
Receptor Ligands ◽  
Reporter Cell ◽  
Nuclear Receptor Ligands
Sign in / Sign up

Export Citation Format

Share Document