scholarly journals Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

2020 ◽  
Vol 21 (10) ◽  
pp. 3641 ◽  
Author(s):  
Beatriz D. Cardoso ◽  
Ana Rita O. Rodrigues ◽  
Bernardo G. Almeida ◽  
Carlos O. Amorim ◽  
Vítor S. Amaral ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Natural Compound ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Pharmacological Properties ◽  
Magnesium Ferrite ◽  
Superparamagnetic Properties ◽  
Over Time

Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.

scholarly journals Magnetoliposomes Based on Shape Anisotropic Calcium/Magnesium Ferrite Nanoparticles as Nanocarriers for Doxorubicin

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1248
Author(s):  
Beatriz D. Cardoso ◽  
Ana Rita O. Rodrigues ◽  
Manuel Bañobre-López ◽  
Bernardo G. Almeida ◽  
Carlos O. Amorim ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Ferrite Nanoparticles ◽  
Individual Characteristics ◽  
Release Kinetic ◽  
Magnesium Ferrite ◽  
Promising Therapeutic Approach ◽  
The Individual

Multifunctional lipid nanocarriers are a promising therapeutic approach for controlled drug release in cancer therapy. Combining the widely used liposome structure with magnetic nanoparticles in magnetoliposomes allies, the advantages of using liposomes include the possibility to magnetically guide, selectively accumulate, and magnetically control the release of drugs on target. The effectiveness of these nanosystems is intrinsically related to the individual characteristics of the two main components—lipid formulation and magnetic nanoparticles—and their physicochemical combination. Herein, shape-anisotropic calcium-substituted magnesium ferrite nanoparticles (Ca0.25Mg0.75Fe2O4) were prepared for the first time, improving the magnetic properties of spherical counterparts. The nanoparticles revealed a superparamagnetic behavior, high saturation magnetization (50.07 emu/g at 300 K), and a large heating capacity. Furthermore, a new method for the synthesis of solid magnetoliposomes (SMLs) was developed to enhance their magnetic response. The manufacturing technicalities were optimized with different lipid compositions (DPPC, DPPC/Ch, and DPPC/DSPE-PEG) originating nanosystems with optimal sizes for biomedical applications (around or below 150 nm) and low polydispersity index. The high encapsulation efficiency of doxorubicin in these magnetoliposomes was proven, as well as the ability of the drug-loaded nanosystems to interact with cell membrane models and release DOX by fusion. SMLs revealed to reduce doxorubicin interaction with human serum albumin, contributing to a prolonged bioavailability of the drug upon systemic administration. Finally, the drug release kinetic assays revealed a preferable DOX release at hyperthermia temperatures (42 °C) and acidic conditions (pH = 5.5), indicating them as promising controlled release nanocarriers by either internal (pH) and external (alternate magnetic field) stimuli in cancer therapy.

scholarly journals Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review

2021 ◽  
Vol 2 (1) ◽  
pp. 51-60
Author(s):  
Mostafa Yusefi ◽  
Kamyar Shameli ◽  
Siti Nur Amalina Mohamad Sukri
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Tumor Type ◽  
Heating Efficiency ◽  
Heating Source ◽  
Hyperthermia Therapy

The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical characteristics of MNPs enhance their heating capability. In addition, heating efficiency is strongly associated with the amount of the applied magnetic field and frequency. The great efforts have offered promising preclinical trials of magnetic hyperthermia via MNPs as a smart nanoagent. MNPs are very appropriate to be considered as a heating source in MHT and prospective research in this field will lead to tackle the problems from chemotherapy and introduce promising therapeutic techniques and nanodrug formulations for remotely controlled drug release and anticancer effects. This mini-review aims to pinpoint synthesis and structural analysis of various magnetic nanoparticles examined for magnetic hyperthermia therapy and controlled drug release in cancer treatment.

scholarly journals Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Joseph C. Bear ◽  
P. Stephen Patrick ◽  
Alfred Casson ◽  
Paul Southern ◽  
Fang-Yu Lin ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Gi Tract

AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy

2002 ◽  
Vol 55 (1-2) ◽  
pp. 17-19 ◽  
Author(s):  
M Babincová ◽  
P Čičmanec ◽  
V Altanerová ◽  
Č Altaner ◽  
P Babinec
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Site Specific ◽  
Ac Magnetic Field

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica nanoparticles for potential controlled drug release and hyperthermia

RSC Advances ◽  
2015 ◽  
Vol 5 (29) ◽  
pp. 22365-22372 ◽  
Author(s):  
Yufang Zhu ◽  
Cuilian Tao
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Potential Temperature ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Temperature Controlled ◽  
Magnetic Mesoporous Silica

DNA-capped Fe3O4/SiO2 magnetic mesoporous silica (MMS) nanoparticles were developed for potential temperature controlled drug release and magnetic hyperthermia.

scholarly journals Combined Magnetoliposome Formation and Drug Loading in One Step for Efficient Alternating Current-Magnetic Field Remote-Controlled Drug Release

2020 ◽  
Vol 12 (4) ◽  
pp. 4295-4307 ◽  
Author(s):  
Maria Eugenia Fortes Brollo ◽  
Ana Domínguez-Bajo ◽  
Andrea Tabero ◽  
Vicente Domínguez-Arca ◽  
Victor Gisbert ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Alternating Current ◽  
One Step ◽  
Current Magnetic Field

scholarly journals Effect of manganese doping on the hyperthermic profile of ferrite nanoparticles using response surface methodology

RSC Advances ◽  
2021 ◽  
Vol 11 (28) ◽  
pp. 16942-16954
Author(s):  
Ruby Gupta ◽  
Ruchi Tomar ◽  
Suvankar Chakraverty ◽  
Deepika Sharma
Keyword(s):  
Magnetic Field ◽  
Response Surface Methodology ◽  
Cancer Therapy ◽  
Response Surface ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Alternating Magnetic Field ◽  
Magnetic Nanomaterials ◽  
Manganese Doping

Magnetic hyperthermia-based cancer therapy mediated by magnetic nanomaterials is a promising antitumoral nanotherapy, owning to its power to generate heat under the application of an alternating magnetic field.

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