scholarly journals Gender Predilection in Sporadic Parathyroid Adenomas

2020 ◽  
Vol 21 (8) ◽  
pp. 2964
Author(s):  
Maria P. Yavropoulou ◽  
Athanasios D. Anastasilakis ◽  
Argyro Panagiotakou ◽  
Evanthia Kassi ◽  
Polyzois Makras
Keyword(s):  
Primary Hyperparathyroidism ◽  
Sex Hormones ◽  
Clinical Presentation ◽  
Parathyroid Adenomas ◽  
Non Coding Rnas ◽  
And Gender ◽  
Gender Specific ◽  
Potential Use ◽  
Specific Management

Primary hyperparathyroidism is a common endocrinopathy that is mainly caused by benign parathyroid adenomas. The frequency, clinical presentation and complications of the disease show significant differences between genders, with the majority of cases being reported in postmenopausal women. Due to this gender predilection, several studies have investigated the role of sex hormones in the pathogenesis of the disease and their potential use as targets for optimal and gender-specific management. Epigenetic mechanisms that regulate gene transcription may also contribute to these differences between genders. In this review, we outline what is currently known regarding the role of sex hormones and the recent data on the role of non-coding RNAs in the differences between genders in primary hyperparathyroidism due to sporadic parathyroid adenomas.

scholarly journals SAT-LB65 A Rare Existence

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jiselle Aimee Yaplito Bedia ◽  
Maria Honolina S Gomez
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Clinical Presentation ◽  
Renal Involvement ◽  
Preoperative Imaging ◽  
Biochemical Screening ◽  
Central Target ◽  
Target Organs ◽  
Postoperative Hypoparathyroidism ◽  
Parathyroid Adenomas

Abstract Primary hyperparathyroidism is a common endocrine disorder of metabolism usually due to a parathyroid adenoma. Although, the clinical presentation of primary hyperparathyroidism has changed from Albright’s description of a disease of bones and stones, the central target organs affected by this disorder continue to be the skeleton and kidneys. With the advent of routine biochemical screening, the typical diagnosis of primary hyperparathyroidism is no longer accompanied by overt skeletal and renal involvement. Majority of the cases of primary hyperparathyroidism are due to parathyroid adenomas. Giant glands were defined as greater than the 95th percentile, characterized as glands weighing > 3.5 grams. This present case in a 54-year old female is a rare case of primary hyperparathyroidism secondary to a giant parathyroid adenoma measuring 10.7 x 8.0 x 40.0 cm and weighing 145 grams, the largest giant parathyroid adenoma reported to date, with co-existent silent thymoma, multinodular goiter and osteosclerosis of the vertebral spine, metaphorically known as the “rugger-jersey spine”. The association between thymoma and parathyroid adenoma is rare, and only 3 cases have been reported in the literature. We characterized the correlation of preoperative imaging, intraoperative location, and postoperative course, including significant postoperative hypoparathyroidism, as compared to other patients with PHPT to determine whether giant adenomas represent a clinical entity with distinct clinical characteristics. Keywords: primary hyperparathyroidism, giant parathyroid adenoma, rugger-jersey spine, thymoma Abbreviation PHPT Primary hyperparathyroidism

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

2019 ◽  
Vol 133 (1) ◽  
pp. 23-40 ◽  
Author(s):  
Silvia Lorente-Cebrián ◽  
Pedro González-Muniesa ◽  
Fermín I. Milagro ◽  
J. Alfredo Martínez
Keyword(s):  
Adipose Tissue ◽  
Current Knowledge ◽  
Metabolic Effects ◽  
Protein Coding ◽  
Non Coding Rnas ◽  
Potential Impact ◽  
Dietary Strategies ◽  
Potential Use

AbstractObesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2 diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation and related to white adipose tissue (WAT) dysfunction. Enlargement of WAT is associated with a transcriptional alteration of coding and non-coding RNAs (ncRNAs). For many years, big efforts have focused on understanding protein-coding RNAs and their involvement in the regulation of adipocyte physiology and subsequent role in obesity. However, diverse findings have suggested that a dysfunctional adipocyte phenotype in obesity might be also dependent on specific alterations in the expression pattern of ncRNAs, such as miRNAs. The aim of this review is to update current knowledge on the physiological roles of miRNAs and other ncRNAs in adipose tissue function and their potential impact on obesity. Therefore, we examined their regulatory role on specific WAT features: adipogenesis, adipokine secretion, inflammation, glucose metabolism, lipolysis, lipogenesis, hypoxia and WAT browning. MiRNAs can be released to body fluids and can be transported (free or inside microvesicles) to other organs, where they might trigger metabolic effects in distant tissues, thus opening new possibilities to a potential use of miRNAs as biomarkers for diagnosis, prognosis, and personalisation of obesity treatment. Understanding the role of miRNAs also opens the possibility of using these molecules on individualised dietary strategies for precision weight management. MiRNAs should be envisaged as a future therapeutic approach given that miRNA levels could be modulated by synthetic molecules (f.i. miRNA mimics and inhibitors) and/or specific nutrients or bioactive compounds.

The catecholamine response to spaceflight: role of diet and gender

2001 ◽  
Vol 281 (3) ◽  
pp. E500-E506 ◽  
Author(s):  
T. P. Stein ◽  
C. E. Wade
Keyword(s):  
Sexual Dimorphism ◽  
Catecholamine Excretion ◽  
Specific Effects ◽  
Catecholamine Response ◽  
Fluid Shifts ◽  
Response To Stress ◽  
And Gender ◽  
Gender Specific ◽  
Do So

Compared with men, women appear to have a decreased sympathetic nervous system (SNS) response to stress. The two manifestations where the sexual dimorphism has been the most pronounced involve the response of the SNS to fluid shifts and fuel metabolism during exercise. The objectives of this study were to investigate whether a similar sexual dimorphism was found in the response to spaceflight. To do so, we compared catecholamine excretion by male and female astronauts from two similar shuttle missions, Spacelab Life Sciences 1 (SLS1, 1991) and 2 (SLS2, 1993) for evidence of sexual dimorphism. To evaluate the variability of the catecholamine response in men, we compared catecholamine excretion from the two SLS missions against the 1996 Life and Microgravity Sciences Mission (LMS) and the 1973 Skylab missions. Results: No gender- or mission-dependent changes were found with epinephrine. Separating out the SLS1/2 data by gender shows that norepinephrine excretion was essentially unchanged with spaceflight in women (98 ± 10%; n = 3) and substantially decreased with the men (41 ± 9%; n= 4, P < 0.05). Data are a percentage of mean preflight value ± SE. Comparisons among males demonstrated significant mission effects on norepinephrine excretion. After flight, there was a transient increase in norepinephrine but no evidence of any gender-specific effects. We conclude that norepinephrine excretion during spaceflight is both mission and gender dependent. Men show the greater response, with at least three factors being involved, a response to microgravity, energy balance, and the ratio of carbohydrate to fat in the diet.

The Role of Gender-specific Cytokine Pathways as Drug Targets and Gender- specific Biomarkers in Personalized Cancer Therapy

2017 ◽  
Vol 18 (4) ◽  
pp. 485-495 ◽  
Author(s):  
Anna Berghella ◽  
Ida Contasta ◽  
Roberto Lattanzio ◽  
Giancarlo Gregorio ◽  
Irma Campitelli ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Targets ◽  
And Gender ◽  
Personalized Cancer Therapy ◽  
Personalized Cancer ◽  
Gender Specific

scholarly journals Dominant and Gender-Specific Tendencies in the Use of Discourse Markers: Insights from EFL Learners

2017 ◽  
Vol 7 (2) ◽  
pp. 1 ◽  
Author(s):  
Mahboobeh Tavakoli ◽  
Amin Karimnia
Keyword(s):  
English Language ◽  
Discourse Markers ◽  
The Other ◽  
Chi Square ◽  
Male And Female ◽  
Efl Learners ◽  
Chi Square Test ◽  
And Gender ◽  
Gender Specific

This study followed two objectives: it primarily investigated the types of discourse markers (DMs) used in thespoken language of Iranian advanced EFL learners, and then explored the possible impact of gender on theparticipants’ use of DMs. To this end, 40 male and female EFL learners selected from an English language instituteparticipated in this study. The data were gathered through class observations. The researchers used Fraser’staxonomy of DMs and Fung’s category of interpersonal DMs as the theoretical framework of the study. To analyzethe data descriptive and inferential statistics were used. Results of the frequency test revealed that “and” was themost commonly used elaborative DM, whereas “but” was the most frequent contrastive DM. “Because” and “by theway” were respectively the only reason and topic-related DMs used by the participants, while “sure” was the mostfrequent interpersonal DM. In addition, results of the chi-square test revealed that learners significantly employedinterpersonal DMs more than the other sub-classes of DMs. Concerning the role of gender in the use of DMs, resultsdemonstrated that females significantly used more DMs compared with the males.

scholarly journals Primary hyperparathyroidism: epidemiology, clinical features, diagnostic tools and current management

2015 ◽  
Vol 9 (4) ◽  
pp. 330
Author(s):  
Andrea Percivale ◽  
Paola Gnerre ◽  
Giulio Damonte ◽  
Sandra Buscaglia ◽  
Mario Monachesi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Surgical Treatment ◽  
Primary Hyperparathyroidism ◽  
Clinical Presentation ◽  
Definitive Treatment ◽  
Diagnostic Tools ◽  
Current Management ◽  
Knowledge Based ◽  
Relevant Role

Primary hyperparathyroidism (PHPT) is a clinical condition characterized by overactive parathyroid gland secretion of parathyroid hormone with concurrent alteration of the phosphocalcemic metabolism. We present a literature review on primary hyperparathyroidism addressing key on clinical presentation, causes, medical and surgical treatment at the best of our knowledge. Based on this review we confirm the role of serum calcium and serum level examination, as well as we define the definitive treatment for PHPT being parathyroidectomy. In case of contraindication for surgery, medical treatment can play a relevant role.

scholarly journals Sex Hormones in Lymphedema

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 530
Author(s):  
Florent Morfoisse ◽  
Audrey Zamora ◽  
Emmanuelle Marchaud ◽  
Manon Nougue ◽  
Leila H. Diallo ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Interstitial Fluid ◽  
Vascular System ◽  
Trigger Factor ◽  
Secondary Lymphedema ◽  
Primary Lymphedema ◽  
And Gender ◽  
After Cancer ◽  
Estrogen Receptor Antagonists

Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return resulting in swelling of the extremities and accumulation of undrained interstitial fluid/lymph that results in fibrosis and adipose tissue deposition in the limb. Whereas it is clearly established that primary lymphedema is sex-linked with an average ratio of one male for three females, the role of female hormones, in particular estrogens, has been poorly explored. In addition, secondary lymphedema in Western countries affects mainly women who developed the pathology after breast cancer and undergo through hormone therapy up to five years after cancer surgery. Although lymphadenectomy is identified as a trigger factor, the effect of co-morbidities associated to lymphedema remains elusive, in particular, estrogen receptor antagonists or aromatase inhibitors. In addition, the role of sex hormones and gender has been poorly investigated in the etiology of the pathology. Therefore, this review aims to recapitulate the effect of sex hormones on the physiology of the lymphatic system and to investigate whetherhormone therapy could promote a lymphatic dysfunction leading to lymphedema.

scholarly journals Sex and gender in asthma

2021 ◽  
Vol 30 (162) ◽  
pp. 210067
Author(s):  
Nowrin U. Chowdhury ◽  
Vamsi P. Guntur ◽  
Dawn C. Newcomb ◽  
Michael E. Wechsler
Keyword(s):  
Sex Differences ◽  
Environmental Factors ◽  
Sex Hormones ◽  
Therapeutic Response ◽  
Clinical Manifestations ◽  
Sex And Gender ◽  
Asthma Incidence ◽  
And Gender ◽  
Incidence Prevalence

Asthma is a heterogenous disease, and its prevalence and severity are different in males versus females through various ages. As children, boys have an increased prevalence of asthma. As adults, women have an increased prevalence and severity of asthma. Sex hormones, genetic and epigenetic variations, social and environmental factors, and responses to asthma therapeutics are important factors in the sex differences observed in asthma incidence, prevalence and severity. For women, fluctuations in sex hormone levels during puberty, the menstrual cycle and pregnancy are associated with asthma pathogenesis. Further, sex differences in gene expression and epigenetic modifications and responses to environmental factors, including SARS-CoV-2 infections, are associated with differences in asthma incidence, prevalence and symptoms. We review the role of sex hormones, genetics and epigenetics, and their interactions with the environment in the clinical manifestations and therapeutic response of asthma.

Sign in / Sign up

Export Citation Format

Share Document