scholarly journals Synergistic or Additive Pharmacological Interactions between Magnoflorine and Cisplatin in Human Cancer Cells of Different Histological Origin

2020 ◽  
Vol 21 (8) ◽  
pp. 2848 ◽  
Author(s):  
Estera Okon ◽  
Jarogniew J. Luszczki ◽  
Wirginia Kukula-Koch ◽  
Marta Halasa ◽  
Agata Jarzab ◽  
...  
Keyword(s):  
Chemotherapy Regimen ◽  
Human Cancer ◽  
Combined Therapy ◽  
Fixed Ratio ◽  
Human Breast ◽  
Aporphine Alkaloid ◽  
Pharmacological Interaction ◽  
Human Cancer Cells ◽  
Proliferative Effect ◽  
Pharmacological Interactions

Magnoflorine is an aporphine alkaloid present in plant species belonging to the Berberidaceae, Magnoliaceae, Menispermaceae, or Papaveraceae botanical families. The interest of magnoflorine has increased recently due to its multiplicity of pharmacological properties. The aim of this study was the analysis of combined anti-proliferative effect of magnoflorine and cisplatin and the assessment of drug–drug pharmacological interaction between these agents using isobolographic method in MDA-MB-468 human breast, NCIH1299 lung, TE671 rhabdomyosarcoma, or T98G glioblastoma cancer cell lines. Magnoflorine in combination with cisplatin at a fixed ratio of 1:1 augmented their anticancer action and yielded synergistic or additive pharmacological interactions by means of isobolographic method, therefore combined therapy using these two active agents can be a promising chemotherapy regimen in the treatment of some types of breast, lung, rhabdomyosarcoma, and glioblastoma cancers.

Study on anti-proliferative effect of benzoxathiole derivatives through inactivation of NF-κB in human cancer cells

2012 ◽  
Vol 22 (14) ◽  
pp. 4523-4527 ◽  
Author(s):  
Eeda Venkateswararao ◽  
Hoang Le Tuan Anh ◽  
Vinay K. Sharma ◽  
Ki-Cheul Lee ◽  
Niti Sharma ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Proliferative Effect

scholarly journals A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 628 ◽  
Author(s):  
Li ◽  
Xi ◽  
Ma ◽  
Chen ◽  
Zhou ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Membranes ◽  
Human Cancer ◽  
Antimicrobial Effect ◽  
Human Cell Line ◽  
Haemolytic Activity ◽  
Human Cancer Cells ◽  
Proliferative Effect ◽  
Lysine Residues ◽  
Normal Human Cell

A novel dermaseptin peptide, dermaseptin-PT9 (DPT9), was isolated and identified from Phyllomedusa tarsius by the combination of molecular cloning and LC-MS analysis. Chemically synthesised DPT9 was broadly effective against the tested microorganisms through the disruption of cell membranes and showed weak haemolytic activity towards horse erythrocytes. It also exhibited anti-proliferative effect against various human cancer cells. Moreover, an analogue with enhanced cationicity, K8, 23-DPT9, in which Asp8 and Glu23 were substituted by lysine residues, had a markedly increased antimicrobial effect against all tested microorganisms and disrupted microbial cell membranes. This analogue also showed no haemolysis at its effective antimicrobial concentrations. In addition, K8, 23-DPT9 displayed an enhanced anti-proliferative effect against cancer cells, while displayed weak activity against the normal human cell line, HMEC-1.

scholarly journals Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together

2021 ◽  
Vol 22 (10) ◽  
pp. 5184
Author(s):  
Anna Wawruszak ◽  
Jarogniew Luszczki ◽  
Marta Halasa ◽  
Estera Okon ◽  
Sebastian Landor ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitors ◽  
Combined Therapy ◽  
Fixed Ratio ◽  
Activity Level ◽  
Mcf7 Cells ◽  
Pharmacological Interaction ◽  
Isobolographic Analysis ◽  
Anti Cancer ◽  
Luminal Type

Histone deacetylase inhibitors (HDIs) are promising anti-cancer agents that inhibit proliferation of many types of cancer cells including breast carcinoma (BC) cells. In the present study, we investigated the influence of the Notch1 activity level on the pharmacological interaction between cisplatin (CDDP) and two HDIs, valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA, vorinostat), in luminal-like BC cells. The type of drug–drug interaction between CDDP and HDIs was determined by isobolographic analysis. MCF7 cells were genetically modified to express differential levels of Notch1 activity. The cytotoxic effect of SAHA or VPA was higher on cells with decreased Notch1 activity and lower for cells with increased Notch1 activity than native BC cells. The isobolographic analysis demonstrated that combinations of CDDP with SAHA or VPA at a fixed ratio of 1:1 exerted additive or additive with tendency toward synergism interactions. Therefore, treatment of CDDP with HDIs could be used to optimize a combined therapy based on CDDP against Notch1-altered luminal BC. In conclusion, the combined therapy of HDIs and CDDP may be a promising therapeutic tool in the treatment of luminal-type BC with altered Notch1 activity.

scholarly journals Identification and Characterization of the Caspase-Mediated Apoptotic Activity of Teucrium mascatense and an Isolated Compound in Human Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 977 ◽  
Author(s):  
Neena Panicker ◽  
Sameera Balhamar ◽  
Shaima Akhlaq ◽  
Mohammed Qureshi ◽  
Tania Rizvi ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Apoptotic Cell ◽  
Human Cancer ◽  
Annexin V ◽  
Dependent Manner ◽  
Human Cancer Cells ◽  
Cell Death Pathways ◽  
Proliferative Effect ◽  
Mcf 7

Plants of the genus Teucrium (Lamiaceae or Labiatae family) are known historically for their medicinal value. Here, we identify and characterize the anticancer potential of T. mascatense and its active compound, IM60, in human cancer cells. The anti-proliferative effect of a T. mascatense methanol extract and its various fractions were analyzed in MCF-7 and HeLa cells in a dose- and time dependent manner. The dichloromethane fraction (TMDF) was observed to be the most effective with cytotoxicity against a more expanded series of cell lines, including MDA-MB-231. A time and dose-dependent toxicity profile was also observed for IM60; it could induce rapid cell death (within 3 h) in MCF-7 cells. Activation of caspases and PARP, hallmarks of apoptotic cell death pathways, following treatment with TMDF was demonstrated using western blot analysis. Inversion of the phosphatidylserine phospholipid from the inner to the outer membrane was confirmed by annexin V staining that was inhibited by the classical apoptosis inhibitor, Z-VAK-FMK. Changes in cell rounding, shrinkage, and detachment from other cells following treatment with TMDF and IM60 also supported these findings. Finally, the potential of TMDF and IM60 to induce enzymatic activity of caspases was also demonstrated in MCF-7 cells. This study, thus, not only characterizes the anticancer potential of T. mascatense, but also identifies a lead terpenoid, IM60, with the potential to activate anticancer cell death pathways in human cancer cells.

scholarly journals OBSERVATIONS ON THE RELATION OF THE VIRUS CAUSING RABBIT PAPILLOMAS TO THE CANCERS DERIVING THEREFROM

1936 ◽  
Vol 64 (3) ◽  
pp. 401-424 ◽  
Author(s):  
Peyton Rous ◽  
J. W. Beard ◽  
John G. Kidd
Keyword(s):  
Cancer Cells ◽  
Squamous Cell ◽  
Human Cancer ◽  
Subcutaneous Tissue ◽  
Human Breast ◽  
Carcinogenic Activity ◽  
Local Conditions ◽  
Voluntary Muscle ◽  
Human Cancer Cells ◽  
The Way

The papillomas caused by the Shope virus sometimes grow down spontaneously into the subcutaneous tissue and extend along the lymphatics in the same way as do many cancers of the human breast. They may even invade the voluntary muscle under such circumstances, taking on an aspect suggestive of squamous cell carcinomatosis, but ultimately they differentiate in the way characteristic of the papilloma. Slight operative interferences with papillomas may be followed by a development of secondary nodules in the lungs. These result from cell emboli, and the same local conditions determine their fate as are effective in the case of emboli composed of human cancer cells. The virus-induced papilloma is not only a neoplasm in its immediate aspect and habit but sometimes one that verges upon malignancy. The tumors, including the cancers, which eventually derive from it in favorable hosts, are representative of more than a mere enhancement of the activity of the growth. They develop within a relatively brief period of time but only after the papilloma has grown for a long while; and they are morphologically various whereas the parent tumor is remarkably constant in its form. Some of the new growths differ but little from the papilloma, however, even when possessed of the ability to metastasize, and many continue to be influenced by the virus. The Shope virus is heavily conditioned in its carcinogenic activity, yet it is the nearest cause for cancer now known.

Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells

2014 ◽  
Vol 22 (13) ◽  
pp. 3386-3392 ◽  
Author(s):  
Eeda Venkateswararao ◽  
Vinay K. Sharma ◽  
Jieun Yun ◽  
Youngsoo Kim ◽  
Sang-Hun Jung
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Chalcone Derivatives ◽  
Human Cancer Cells ◽  
Proliferative Effect

Stattic enhances the anti-proliferative effect of docetaxel via the Bax/Bcl-2/cyclin B axis in human cancer cells

2018 ◽  
Vol 69 ◽  
pp. 188-196 ◽  
Author(s):  
Jamal Mohammadian ◽  
Ommoleila Molavi ◽  
Mohammad Bagher Pirouzpanah ◽  
Ali Akbar Rahim Rahimi ◽  
Nasser Samadi
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cyclin B ◽  
Human Cancer Cells ◽  
Proliferative Effect
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