scholarly journals Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis

2020 ◽  
Vol 21 (8) ◽  
pp. 2703 ◽  
Author(s):  
Tommaso Gori
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Plaque Rupture ◽  
Nitric Oxide Donors ◽  
New Class ◽  
Amyl Nitrite ◽  
Treatment And Prevention ◽  
The Subject ◽  
Prevention Of Atherosclerosis ◽  
Nitric Oxide Pathway

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been the subject of a number of pharmacological approaches, particularly since when this elusive mediator was identified as one of the most important modulators of vascular homeostasis beyond vasomotion, including platelet function, inflammation, and atherogenesis. While having potent antianginal and antiischemic properties, however, nitric oxide donors are also not devoid of side effects, including the induction of tolerance, and, as shown in the last decade, of oxidative stress and endothelial dysfunction. In turn, endothelial dysfunction is itself felt to be involved in all stages of atherogenesis, from the development of fatty streaks to plaque rupture and thrombosis. In the present review, we summarize the agents that act on the nitric oxide pathway, with a particular focus on their potentially beneficial antiatherosclerotic and unwanted pro-atherosclerotic effects.

scholarly journals Endothelium and nitric oxide

Medicina ◽  
2008 ◽  
Vol 44 (7) ◽  
pp. 564 ◽  
Author(s):  
Vida Garalienė
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Blood Vessels ◽  
Leukocyte Adhesion ◽  
Endothelial Permeability ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Short Review ◽  
Isosorbide Mononitrate ◽  
Nitric Oxide Donors ◽  
Converting Enzyme Inhibitors

Studied nature of the “blood vessels relaxing factor” derived fromendotheliumthat was identified as nitric oxide caused intensive scientific research on nitric oxide regarding some aspects of its impact on human physiological and pathological processes. The objective of this short review is to discuss widely used (in the clinical practice) direct and indirect donors of nitric oxide and/or other agents, increasing nitric oxide concentration in human body, and their beneficial role for the prevention of atherosclerosis. Under physiological conditions, endotheliumregulates the tone of blood vessels, homeostasis of which is maintained by endotheliumgenerated vasoconstrictors and vasodilators. The most important vasodilator and the main substance produced by the endothelium is nitric oxide. The failure of synthesis and/or the lost of nitric oxide bioavailability is the major feature of endothelial dysfunction and key factor initiating progression of atherosclerosis. The endothelial dysfunction initiates the series of events, which stimulate and aggravate the course of atherosclerosis by increasing endothelial permeability, platelet aggregation, and leukocyte adhesion, and cytokine expression. Further, the review deals with the mechanisms of action of statins, angiotensin-converting enzyme inhibitors, L-arginine, direct nitric oxide donors (nitroglycerin, isosorbide mononitrate and isosorbide dinitrate), and indirect nitric oxide donors (phosphodiesterase-V inhibitors, KATP openers).

A new class of nitric oxide donors

2016 ◽  
Vol 86 (3) ◽  
pp. 158-163 ◽  
Author(s):  
S. M. Aldoshin ◽  
N. A. Sanina ◽  
M. I. Davydov ◽  
E. I. Chazov
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donors ◽  
New Class

O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

2017 ◽  
Vol 53 (36) ◽  
pp. 5059-5062 ◽  
Author(s):  
Chengfeng Bai ◽  
Rongfang Xue ◽  
Jianbing Wu ◽  
Tian Lv ◽  
Xiaojun Luo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donor ◽  
Nitric Oxide Donors ◽  
New Class

3c, a new nitric oxide donor activatable by GSH/GSTπ, exhibits both anti-proliferative and anti-metastatic activities against melanoma.

scholarly journals The Application of Nitric Oxide for Ocular Hypertension Treatment

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7306
Author(s):  
Binze Han ◽  
Maomao Song ◽  
Liping Li ◽  
Xinghuai Sun ◽  
Yuan Lei
Keyword(s):  
Nitric Oxide ◽  
Ocular Hypertension ◽  
Nitric Oxide Donors ◽  
Hypertension Treatment ◽  
Aqueous Humor Outflow ◽  
New Class ◽  
Pubmed Database ◽  
Main Pathway ◽  
Outflow Pathway ◽  
Outflow System

Despite of various therapeutic methods for treating ocular hypertension and glaucoma, it still remains the leading cause of irreversible blindness. Intraocular pressure (IOP) lowering is the most effective way to slow disease progression and prevent blindness. Among the ocular hypotensive drugs currently in use, only a couple act on the conventional outflow system, which is the main pathway for aqueous humor outflow and the major lesion site resulting in ocular hypertension. Nitric oxide (NO) is a commendable new class of glaucoma drugs that acts on the conventional outflow pathway. An increasing number of nitric oxide donors have been developed for glaucoma and ocular hypertension treatment. Here, we will review how NO lowers IOP and the types of nitric oxide donors that have been developed. And a brief analysis of the advantages and challenges associated with the application will be made. The literature used in this review is based on Pubmed database search using ‘nitric oxide’ and ‘glaucoma’ as key words.

scholarly journals On the nitroprussides, a new class of salts

1851 ◽  
Vol 5 ◽  
pp. 846-847 ◽  
Keyword(s):  
Nitric Oxide ◽  
Nitric Acid ◽  
Prussian Blue ◽  
New Class ◽  
Original Weight ◽  
The Subject ◽  
Green Precipitate ◽  
White Substance

When nitric acid is made to act on yellow prusside of potassium, in the proportion of one equivalent of acid for every equivalent of potassium present in the salt, the following reactions are observed. The salt dissolves in the acid with a dark red, almost black colour, a very little nitric oxide is evolved, which soon ceases, and is fol­lowed by a copious evolution of cyanogen mixed with nitrogen. The continued action of the acid causes the liquid to cease the usual reactions of red prusside of potassium; the addition of sulphate of iron now produces a slate-coloured instead of blue precipitate. On allowing the solution to cool, abundance of nitrate of potash cry­stallizes out, mixed with a little prussian blue, and about 5 percent, of the original weight of the salt, of a white granular substance, which is scarcely soluble in cold, and only very slightly so in boil­ing water. This white substance, on examination, proves to be the remarkable body oxamide , the production of which in an oxidising medium is highly singular. The dark red supernatant liquor, being neutralized with an alka­line carbonate, and boiled, deposits a green precipitate and yields a clear ruby-red solution. This solution furnishes the new class of salts, which is the subject of this paper. It may be evaporated to crystallization, and yields the nitroprusside of the base used in the neutralization.

scholarly journals Correction: O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma

2020 ◽  
Vol 56 (29) ◽  
pp. 4130-4131
Author(s):  
Chengfeng Bai ◽  
Rongfang Xue ◽  
Jianbing Wu ◽  
Tian Lv ◽  
Xiaojun Luo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donors ◽  
New Class

Correction for ‘O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma’ by Chengfeng Bai et al., Chem. Commun., 2017, 53, 5059–5062.

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