scholarly journals Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

2020 ◽  
Vol 21 (6) ◽  
pp. 1979 ◽  
Author(s):  
Katarzyna Niemirowicz-Laskowska ◽  
Joanna Mystkowska ◽  
Dawid Łysik ◽  
Sylwia Chmielewska ◽  
Grażyna Tokajuk ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Artificial Saliva ◽  
Antimicrobial Properties ◽  
Core Shell ◽  
Oral Microbiota ◽  
Oral Dryness ◽  
Systemic Factors ◽  
Saliva Substitutes

Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential to assure proper oral microbiota growth. Due to numerous extra- and intra-systemic factors, there are many disorders of its secretion, leading to oral dryness. Saliva substitutes used in such situations must meet many demands. This study was design to evaluate the effect of core-shell magnetic nanoparticles (MNPs) adding (gold-coated and aminosilane-coated nanoparticles NPs) on antimicrobial (microorganism adhesion, biofilm formation), rheological (viscosity, viscoelasticity) and physicochemical (pH, surface tension, conductivity) properties of three commercially available saliva formulations. Upon the addition of NPs (20 µg/mL), antibacterial activity of artificial saliva was found to increase against tested microorganisms by 20% to 50%. NPs, especially gold-coated ones, decrease the adhesion of Gram-positive and fungal cells by 65% and Gram-negative bacteria cells by 45%. Moreover, the addition of NPs strengthened the antimicrobial properties of tested artificial saliva, without influencing their rheological and physicochemical properties, which stay within the range characterizing the natural saliva collected from healthy subjects.

Magneto-Structural and Antimicrobial Properties of Sodium Doped Lanthanum Manganite Magnetic Nanoparticles for Biomedical Applications: Influence of Silica Coating

2018 ◽  
Vol 37 ◽  
pp. 117-127 ◽  
Author(s):  
Cyril O. Ehi-Eromosele ◽  
J.A.O. Olugbuyiro ◽  
A. Edobor-Osoh ◽  
A.A. Adebisi ◽  
O.A. Bamgboye ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Magnetic Nanoparticles ◽  
Structural Properties ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Antimicrobial Properties ◽  
Silica Coating ◽  
Coated Sample ◽  
Lanthanum Manganites ◽  
Doped Lanthanum Manganites

Coating of magnetic nanoparticles (MNPs) is usually a requirement prior to their utilization in biomedical applications. However, coating can influence the magneto-structural properties of MNPs thereby imparting their applications. The present work highlights the combustion synthesis of Na-doped lanthanum manganites (LNMO) and the influence of silica coatings on the magneto-structural properties, colloidal stability and antimicrobial properties of LNMO MNPs with their biomedical applications in mind. The crystalline perovskite structure was the same both for the bare and silica coated LNMO samples while there was a slight increase in crystallite size after coating. The FTIR spectral analysis, reduction in agglomeration of the particles and the elemental composition of the coated nanoparticles confirmed the presence of silica. The magnetization values of 34 emu/g and 29 emu/g recorded for bare and coated LNMO samples, respectively show that LNMO MNPs retained its ferromagnetic behaviour after silica coating. The pH dependent zeta potentials of the coated sample is-22.20 mV at pH 7.4 (physiological pH) and-18 mV at pH 5.0 (cell endosomal pH). Generally, silica coating reduced the antibacterial activity of the sample except forBacillussppwhere the antibacterial activity was the same with the bare sample. These results showed that while silica coating had marginal effect on the crystalline structure, size and magnetization of LNMO MNPs, it reduced the antibacterial activity of LNMO MNPs and enhanced greatly the colloidal stability of LNMO nanoparticles. Keywords: Na-doped lanthanum manganites, Silica coating, magnetic nanoparticles, biomedical applications, antimicrobial properties, colloidal stability

scholarly journals Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia

2019 ◽  
Vol 20 (13) ◽  
pp. 3199 ◽  
Author(s):  
Dawid Łysik ◽  
Katarzyna Niemirowicz-Laskowska ◽  
Robert Bucki ◽  
Grażyna Tokajuk ◽  
Joanna Mystkowska
Keyword(s):  
Salivary Gland ◽  
Artificial Saliva ◽  
Antimicrobial Properties ◽  
Antimicrobial Effect ◽  
Biological Properties ◽  
Dry Mouth ◽  
Disease Condition ◽  
Saliva Substitutes ◽  
Salivary Substitutes ◽  
Qualitative Changes

The chronic sensation of a dry mouth is a disease condition called xerostomia and affects a large part of the population. Xerostomia is associated with decreased secretion, or more often, qualitative changes in saliva proteins and immunoglobulin concentrations that develop as a result of salivary gland dysfunction. Several reasons causing dry mouth were described, and usually, they include taking medications, diseases or radiotherapy. In some situations, when it is difficult to use salivary stimulants or salivary gland damage is irreversible, the only option might seem to be saliva substitutes. The paper presents the most important aspects considering saliva preparations. The rheological and lubricating properties and the reconstruction of the complex saliva structure has been the main purpose of research. The biological properties of saliva preparations were also widely discussed. As part of the work, the antimicrobial effect of three commercial saliva preparations was tested. Finally, inadequate antimicrobial properties against the strains isolated from the oral cavity were demonstrated. The development of salivary substitutes, in particular, the improvement of antimicrobial properties, can be achieved using nanotechnology, including drug delivery systems containing nanocarriers.

scholarly journals Efficacy of BioXtra Spray and Mouthwash in Patients with Radiation-induced Xerostomia: A Randomized Clinical Trial

2014 ◽  
Vol 3 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Mahin Bakhshi ◽  
Soheila Manifar ◽  
Nemat Azizi ◽  
Samira Basir Shabestari ◽  
Abbas Hossein Mardi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Artificial Saliva ◽  
Medical Sciences ◽  
Oral Dryness ◽  
Saliva Substitutes ◽  
Radiation Induced ◽  
Level Of Significance ◽  
Mouth Wash ◽  
Patients Acceptance

ABSTRACT Aim Xerostomia is an important complication following radiotherapy for head and neck regions producing serious discomfort for patients. Symptomatic treatments for the disease include strict oral hygiene and use of artificial saliva substitutes. The present study compared the efficacy of BioXtra spray and mouthwash in the relief of radiotherapy-induced xerostomia in patients referred to Imam Khomeini Hospital, Tehran University of Medical Sciences. Materials and methods In a cross-over randomized clinical trial, BioXtra spray and mouth wash were used by 20 patients for 2 weeks with a 1 week wash-out period. The ease of application and the patients’ acceptance of the products were obtained using 100 mm visual analog scale (VAS) and dichotomous scales. We used SPSS version. 18.0 to analyze our data considering level of significance less than 0.05. Results Both forms of BioXtra showed similar effect in reducing oral dryness and its complications. The mean VAS was 33.2 for spray and 34.5 for mouthwash. Majority of our patients reported improvements in xerostomia after using spray (85%) and mouthwash (70%), respectively. The patients’ acceptance of both modalities was similar and they showed equal tendency to continue the treatments. No significant differences in symptoms relief as well as judgment of the regimens were found between groups. Conclusion BioXtra spray and mouthwash are similarly effective in reducing the symptoms of postradiotherapy xerostomia. How to cite this article Bakhshi M, Manifar S, Azizi N, Shabestari SB, Mardi AH, Shirinbak I, Mehdipour A. Efficacy of BioXtra Spray and Mouthwash in Patients with Radiationinduced Xerostomia: A Randomized Clinical Trial. Int J Experiment Dent Sci 2014;3(1):19-23.

scholarly journals Investigating spin coupling across a three-dimensional interface in core/shell magnetic nanoparticles

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
C. Kons ◽  
Manh-Huong Phan ◽  
Hariharan Srikanth ◽  
D. A. Arena ◽  
Zohreh Nemati ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Three Dimensional ◽  
Spin Coupling ◽  
Core Shell

scholarly journals An In Vitro Study on the Antimicrobial Properties of Essential Oil Modified Resin Composite against Oral Pathogens

Materials ◽  
2020 ◽  
Vol 13 (19) ◽  
pp. 4383
Author(s):  
Barbara Lapinska ◽  
Aleksandra Szram ◽  
Beata Zarzycka ◽  
Janina Grzegorczyk ◽  
Louis Hardan ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Resin Composite ◽  
Antimicrobial Properties ◽  
In Vitro Study ◽  
Diffusion Method ◽  
Oral Pathogens

Modifying the composition of dental restorative materials with antimicrobial agents might induce their antibacterial potential against cariogenic bacteria, e.g., S.mutans and L.acidophilus, as well as antifungal effect on C.albicans that are major oral pathogens. Essential oils (EOs) are widely known for antimicrobial activity and are successfully used in dental industry. The study aimed at evaluating antibacterial and antifungal activity of EOs and composite resin material (CR) modified with EO against oral pathogens. Ten EOs (i.e., anise, cinnamon, citronella, clove, geranium, lavender, limette, mint, rosemary thyme) were tested using agar diffusion method. Cinnamon and thyme EOs showed significantly highest antibacterial activity against S.mutans and L.acidophilus among all tested EOs. Anise and limette EOs showed no antibacterial activity against S.mutans. All tested EOs exhibited antifungal activity against C.albicans, whereas cinnamon EO showed significantly highest and limette EO significantly lowest activity. Next, 1, 2 or 5 µL of cinnamon EO was introduced into 2 g of CR and microbiologically tested. The modified CR showed higher antimicrobial activity in comparison to unmodified one. CR containing 2 µL of EO showed the best antimicrobial properties against S.mutans and C.albicans, while CR modified with 1 µL of EO showed the best antimicrobial properties against L.acidophilus.

scholarly journals Magneto-Optical Characteristics of Streptavidin-Coated Fe3O4@Au Core-Shell Nanoparticles for Potential Applications on Biomedical Assays

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chin-Wei Lin ◽  
Jian-Ming Chen ◽  
You-Jun Lin ◽  
Ling-Wei Chao ◽  
Sin-Yi Wei ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Faraday Effect ◽  
Au Nanoparticles ◽  
Optical Characteristics ◽  
Enzyme Linked Immunosorbent Assay ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Time Resolved ◽  
Biotechnology Research ◽  
Core Shell Nanoparticles

Abstract Recently, gold-coated magnetic nanoparticles have drawn the interest of researchers due to their unique magneto-plasmonic characteristics. Previous research has found that the magneto-optical Faraday effect of gold-coated magnetic nanoparticles can be effectively enhanced because of the surface plasmon resonance of the gold shell. Furthermore, gold-coated magnetic nanoparticles are ideal for biomedical applications because of their high stability and biocompatibility. In this work, we synthesized Fe3O4@Au core-shell nanoparticles and coated streptavidin (STA) on the surface. Streptavidin is a protein which can selectively bind to biotin with a strong affinity. STA is widely used in biotechnology research including enzyme-linked immunosorbent assay (ELISA), time-resolved immunofluorescence (TRFIA), biosensors, and targeted pharmaceuticals. The Faraday magneto-optical characteristics of the biofunctionalized Fe3O4@Au nanoparticles were measured and studied. We showed that the streptavidin-coated Fe3O4@Au nanoparticles still possessed the enhanced magneto-optical Faraday effect. As a result, the possibility of using biofunctionalized Fe3O4@Au nanoparticles for magneto-optical biomedical assays should be explored.

The Rheology of Saliva

1987 ◽  
Vol 66 (1_suppl) ◽  
pp. 660-666 ◽  
Author(s):  
W. H. Schwarz
Keyword(s):  
Salivary Gland ◽  
Rheological Properties ◽  
Medical Management ◽  
Artificial Saliva ◽  
Salivary Gland Dysfunction ◽  
Shear Dependent Viscosity ◽  
Saliva Analysis ◽  
Whole Saliva ◽  
Saliva Substitutes ◽  
Dependent Viscosity

The rheology of saliva affects the coating and lubrication of oral surfaces and the consistency of ingested foods. Salivary gland dysfunction can cause tissue damage and dysphagia. Therefore, we have considered the problem of designing a synthetic saliva for medical management. Also, we have measured certain rheological properties [shear-dependent viscosity η (k)] and the frequency-dependent moduli [G′(f) and η′(f)] of normal stimulated whole saliva. Analysis of the rheological data and consideration of requirements for using artificial saliva have resulted in a better understanding of the rheological functions of natural saliva and the desirable characteristics of synthetic saliva. In addition, we have measured rheological properties of two commercial saliva substitutes for comparison.

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