scholarly journals Endocrine Disruptors in Water and Their Effects on the Reproductive System

2020 ◽  
Vol 21 (6) ◽  
pp. 1929 ◽  
Author(s):  
Andressa Gonsioroski ◽  
Vasiliki E. Mourikes ◽  
Jodi A. Flaws
Keyword(s):  
Reproductive Health ◽  
Bisphenol A ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Disinfection Byproducts ◽  
Water Disinfection ◽  
Chemical Contamination ◽  
Therapeutic Drugs ◽  
Reproductive Effects ◽  
Endocrine Disrupting

Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility of non-human animals and humans. The source of chemical contamination in water is diverse, originating from byproducts formed during water disinfection processes, release from industry and livestock activity, or therapeutic drugs released into sewage. This review discusses the occurrence of EDCs in water such as disinfection byproducts, fluorinated compounds, bisphenol A, phthalates, pesticides, and estrogens, and it outlines their adverse reproductive effects in non-human animals and humans.

scholarly journals The effects of endocrine disrupting chemicals on the human organism

2017 ◽  
Vol 71 (0) ◽  
pp. 0-0
Author(s):  
Karolina Kulik-Kupka ◽  
Justyna Nowak ◽  
Ilona Korzonek-Szlacheta ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Bisphenol A ◽  
Polychlorinated Biphenyls ◽  
Sperm Count ◽  
Biological Fluids ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Food Storage ◽  
Human Organism ◽  
Human Beings ◽  
Endocrine Disrupting

The development of civilization has not only improved the quality of life, but it is also responsible for increasing environmental pollution. Between 80000-100000 previously unknown chemicals have been estimated to circulate in the air. They include substances known as endocrine disrupting chemicals (EDC). These substances can naturally be found in the environment and food, or are classified as pollutants. EDCs are said to change the functionality of the endocrine system and, in this way, exert an influence on other body functions. Substances such as bisphenol A, phthalates, polychlorinated biphenyls and dioxins are part of the endocrine disrupting chemicals. Some of these compounds (bisphenol A, phthalates) are used in the production of daily necessities like plastic food storage containers, bottles, perfumes, and shampoos. Endocrine disrupting chemicals accumulate in the adipose tissue and have been detected in biological fluids, namely serum, urine, breast milk and amniotic fluid. Exposure to EDC may cause many negative health effects. Bisphenol A, for example, can lead to diabetes, obesity, metabolic syndrome, cancer, or fertility disorders. Classified as carcinogens, phthalates can cause reduced sperm count and testosterone levels, as well as damage to the liver, kidneys and the heart. Dioxins have also been found to exhibit carcinogenic properties. Prenatal exposure to polychlorinated biphenyls (PCBs) has been linked to decreased IQ of offspring, among other problems. This article is a review of publications available on the medical databases such as Polish Medical Bibliography and PubMed-NCBI from the years 2005-2016, which covered endocrine disrupting chemicals and their influence on human beings.

scholarly journals Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

2020 ◽  
Vol 21 (9) ◽  
pp. 3215
Author(s):  
Majorie B. M. van Duursen ◽  
Julie Boberg ◽  
Sofie Christiansen ◽  
Lisa Connolly ◽  
Pauliina Damdimopoulou ◽  
...  
Keyword(s):  
Reproductive Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Test Methods ◽  
Incidence Rates ◽  
Chemical Safety ◽  
Embryonic And Fetal Development ◽  
Female Reproductive Health ◽  
Endocrine Disrupting ◽  
And Function

Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally.

Effect of Polyphosphate on Removal of Endocrine-Disrupting Chemicals of Nonylphenol and Bisphenol-A by Activated Carbons

2005 ◽  
Vol 40 (4) ◽  
pp. 484-490 ◽  
Author(s):  
Keun J. Choi ◽  
Sang G. Kim ◽  
Chang W. Kim ◽  
Seung H. Kim
Keyword(s):  
Activated Carbon ◽  
Bisphenol A ◽  
Surface Charge ◽  
Activated Carbons ◽  
Endocrine Disrupting Chemicals ◽  
Dipole Interaction ◽  
High Affinity ◽  
Calcium Polyphosphate ◽  
Endocrine Disrupting ◽  
Positively Charged

Abstract This study examined the effect of polyphosphate on removal of endocrine-disrupting chemicals (EDCs) such as nonylphenol and bisphenol-A by activated carbons. It was found that polyphosphate aided in the removal of nonylphenol and bisphenol- A. Polyphosphate reacted with nonylphenol, likely through dipole-dipole interaction, which then improved the nonylphenol removal. Calcium interfered with this reaction by causing competition. It was found that polyphosphate could accumulate on carbon while treating a river. The accumulated polyphosphate then aided nonylphenol removal. The extent of accumulation was dependent on the type of carbon. The accumulation occurred more extensively with the wood-based used carbon than with the coal-based used carbon due to the surface charge of the carbon. The negatively charged wood-based carbon attracted the positively charged calcium-polyphosphate complex more strongly than the uncharged coal-based carbon. The polyphosphate-coated activated carbon was also effective in nonylphenol removal. The effect was different depending on the type of carbon. Polyphosphate readily attached onto the wood-based carbon due to its high affinity for polyphosphate. The attached polyphosphate then improved the nonylphenol removal. However, the coating failed to attach polyphosphate onto the coal-based carbon. The nonylphenol removal performance of the coal-based carbon remained unchanged after the polyphosphate coating.

Environmental exposures to endocrine disrupting chemicals (EDCs) and their role in endometriosis: a systematic literature review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Diksha Sirohi ◽  
Ruqaiya Al Ramadhani ◽  
Luke D. Knibbs
Keyword(s):  
Bisphenol A ◽  
Phthalate Esters ◽  
Endocrine Disrupting Chemicals ◽  
Environmental Pollutants ◽  
Positive Association ◽  
Environmental Chemicals ◽  
Reproductive Age ◽  
Organochlorinated Pesticides ◽  
Endocrine Disrupting ◽  
The Relationship

AbstractPurposeEndocrine-related diseases and disorders are on the rise globally. Synthetically produced environmental chemicals (endocrine-disrupting chemicals (EDCs)) mimic hormones like oestrogen and alter signalling pathways. Endometriosis is an oestrogen-dependent condition, affecting 10–15% of women of the reproductive age, and has substantial impacts on the quality of life. The aetiology of endometriosis is believed to be multifactorial, ranging from genetic causes to immunologic dysfunction due to environmental exposure to EDCs. Hence, we undertook a systematic review and investigated the epidemiological evidence for an association between EDCs and the development of endometriosis. We also aimed to assess studies on the relationship between body concentration of EDCs and the severity of endometriosis.MethodFollowing PRISMA guidelines, a structured search of PubMed, Embase and Scopus was conducted (to July 2018). The included studies analysed the association between one or more EDCs and the prevalence of endometriosis. The types of EDCs, association and outcome, participant characteristics and confounding variables were extracted and analysed. Quality assessment was performed using standard criteria.ResultsIn total, 29 studies were included. Phthalate esters were positively associated with the prevalence of endometriosis. The majority (71%) of studies revealed a significant association between bisphenol A, organochlorinated environmental pollutants (dioxins, dioxin-like compounds, organochlorinated pesticides, polychlorinated biphenyls) and the prevalence of endometriosis. A positive association between copper, chromium and prevalence of endometriosis was demonstrated in one study only. Cadmium, lead and mercury were not associated with the prevalence of endometriosis. There were conflicting results for the association between nickel and endometriosis. The relationship of EDCs and severity of endometriosis was not established in the studies.ConclusionWe found some evidence to suggest an association between phthalate esters, bisphenol A, organochlorinated environmental pollutants and the prevalence of endometriosis. Disentangling these exposures from various other factors that affect endometriosis is complex, but an important topic for further research.

scholarly journals Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

2021 ◽  
Vol 22 (2) ◽  
pp. 933
Author(s):  
Maria E. Street ◽  
Karine Audouze ◽  
Juliette Legler ◽  
Hideko Sone ◽  
Paola Palanza
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Current Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Research Needs ◽  
Important Class ◽  
Testing Strategies ◽  
Endocrine Disrupting ◽  
Health And Disease

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

scholarly journals Metabolic syndrome and endocrine disrupting chemicals: exposure and health effects

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
E Haverinen ◽  
R Lange ◽  
H Tolonen
Keyword(s):  
Metabolic Syndrome ◽  
Bisphenol A ◽  
Health Effects ◽  
Endocrine Disrupting Chemicals ◽  
Positive Association ◽  
Human Biomonitoring ◽  
European Population ◽  
Priority Substances ◽  
Metabolic Disturbances ◽  
Endocrine Disrupting

Abstract Increasing prevalence of metabolic syndrome (MetS) is causing significant health burden among the European population. Current knowledge supports the notion that endocrine disrupting chemicals (EDCs) interfere with human metabolism and hormonal balance, contributing to the conventionally recognized life-style related risk factors for MetS. In relation to the Human biomonitoring initiative (HBM4EU) five priority substances (Bisphenol A, Per- and polyfluoroalkyl substances (PFASs), Phthalates, Cadmium and Arsenic) and their association with adverse metabolic health effects were examined. A methodological framework for scoping reviews was followed to increase consistency and transparency throughout the process. A literature review was conducted to identify epidemiological studies focusing on the association between MetS or its individual components and the five HBM4EU priority substances. Human biomonitoring studies have been able to present evidence supporting EDC exposure and development of individual MetS components; however the strength of the association varies between the components and EDCs. Most of the identified literature examined Bisphenol A and Phthalate exposure, usually targeting obesity, anthropometrics or glucose metabolism. Evidence suggests a positive association between Bisphenol A and Phthalate exposure and obesity-related components. The substance group of PFASs indicated weakest association, as the results were inconsistent and were suggestive only for a positive association with development of dyslipidaemia. Current evidence on metabolic disturbances and EDCs are inconclusive and fragmented, hence establishing harmonized and standardized human biomonitoring procedures among the European population are needed. Rigorous and ongoing human biomonitoring in combination with health monitoring could provide comprehensive information on EDC exposure and association of metabolic disturbances. Key messages EDC exposure is ubiquitous within European population, hence more human biomonitoring in combination with health surveys is needed to strengthen knowledge on human’s metabolic health. MetS is an increasing global health concern, which requires novel approaches to tackle the challenge.

scholarly journals Endocrine Disrupting Chemicals and Reproductive Health in Boys and Men

2021 ◽  
Vol 12 ◽  
Author(s):  
Wiwat Rodprasert ◽  
Jorma Toppari ◽  
Helena E. Virtanen
Keyword(s):  
Reproductive Health ◽  
Testicular Cancer ◽  
Semen Quality ◽  
Endocrine Disrupting Chemicals ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Sensitive Period ◽  
Testicular Development ◽  
Reproductive Disorders ◽  
Endocrine Disrupting

Male reproductive health has declined as indicated by increasing rates of cryptorchidism, i.e., undescended testis, poor semen quality, low serum testosterone level, and testicular cancer. Exposure to endocrine disrupting chemicals (EDCs) has been proposed to have a role in this finding. In utero exposure to antiandrogenic EDCs, particularly at a sensitive period of fetal testicular development, the so-called ‘masculinization programming window (MPW)’, can disturb testicular development and function. Low androgen effect during the MPW can cause both short- and long-term reproductive disorders. A concurrent exposure to EDCs may also affect testicular function or damage testicular cells. Evidence from animal studies supports the role of endocrine disrupting chemicals in development of male reproductive disorders. However, evidence from epidemiological studies is relatively mixed. In this article, we review the current literature that evaluated relationship between prenatal EDC exposures and anogenital distance, cryptorchidism, and congenital penile abnormality called hypospadias. We review also studies on the association between early life and postnatal EDC exposure and semen quality, hypothalamic-pituitary-gonadal axis hormone levels and testicular cancer.

scholarly journals Endocrine System and Endocrine Disrupting Chemicals(EDCs).

2001 ◽  
Vol 14 (1) ◽  
pp. 59-64
Author(s):  
R. Yoshiyuki Osamura ◽  
Toshiki Iwasaka ◽  
Shinobu Umemura
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Endocrine Disrupting
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