scholarly journals The Role of Exosomes in Pancreatic Cancer

2019 ◽  
Vol 20 (18) ◽  
pp. 4332 ◽  
Author(s):  
Bin Lan ◽  
Siyuan Zeng ◽  
Robert Grützmann ◽  
Christian Pilarsky
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Treatment ◽  
Cancer Progression ◽  
Membrane Vesicles ◽  
Drug Carriers ◽  
Potential Mechanism ◽  
Response To Chemotherapy ◽  
The World ◽  
Potential Applications

Pancreatic cancer remains one of the deadliest cancers in the world, as a consequence of late diagnosis, early metastasis and limited response to chemotherapy, under which conditions the potential mechanism of pancreatic cancer progression requires further study. Exosomes are membrane vesicles which are important in the progression, metastasis and chemoresistance in pancreatic cancer. Additionally, they have been verified to be potential as biomarkers, targets and drug carriers for pancreatic cancer treatment. Thus, studying the role of exosomes in pancreatic cancer is significant. This paper focuses on the role of exosomes in the proliferation, metastasis and chemoresistance, as well as their potential applications for pancreatic cancer.

scholarly journals Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ameneh Jafari ◽  
Mostafa Rezaei-Tavirani ◽  
Behrouz Farhadihosseinabadi ◽  
Hakimeh Zali ◽  
Hassan Niknejad
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Treatment ◽  
Cancer Progression ◽  
Adult Stem Cells ◽  
Treatment Modalities ◽  
Human Amniotic Membrane ◽  
Amniotic Mesenchymal Stem Cells ◽  
Growth And Aging

AbstractCancer is a leading cause of death in both developed and developing countries, and because of population growth and aging, it is a growing medical burden worldwide. With robust development in medicine, the use of stem cells has opened new treatment modalities in cancer therapy. In adult stem cells, mesenchymal stem cells (MSCs) are showing rising promise in cancer treatment due to their unique properties. Among different sources of MSCs, human amniotic fluid/membrane is an attractive and suitable reservoir. There are conflicting opinions about the role of human amniotic membrane/fluid mesenchymal stem cells (hAMSCS/hAFMSCs) in cancer, as some studies demonstrating the anticancer effects of these cells and others suggesting their progressive effects on cancer. This review focuses on recent findings about the role of hAMSCs/hAFMSCs in cancer treatment and summarizes the suppressing as well as promoting effects of these cells on cancer progression and underling mechanisms.

scholarly journals Abstract 2679: Role of TH2 cells in pancreatic cancer progression

2021 ◽  
Author(s):  
Aftab Alam ◽  
Maulasri Bhatta ◽  
Parker Denz ◽  
Eric Levanduski ◽  
Prasenjit Dey
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression ◽  
Th2 Cells

Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies

2014 ◽  
Vol 40 (4) ◽  
pp. 513-522 ◽  
Author(s):  
K. Sideras ◽  
H. Braat ◽  
J. Kwekkeboom ◽  
C.H. van Eijck ◽  
M.P. Peppelenbosch ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune System ◽  
Cancer Progression ◽  
Treatment Strategies

Role of miRNA and cancer stem cells in chemoresistance and pancreatic cancer treatment

2012 ◽  
Vol 9 (12) ◽  
pp. 1443-1447 ◽  
Author(s):  
Michael Danquah ◽  
Saurabh Singh ◽  
Stephen W Behrman ◽  
Ram I Mahato
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cancer Treatment

scholarly journals Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1933
Author(s):  
Sathish Sundar Dhilip Kumar ◽  
Heidi Abrahamse
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Targeting Therapy ◽  
Potential Applications ◽  
Carrier Molecule ◽  
Novel Material ◽  
Potential Benefits ◽  
Targeted Photodynamic Therapy

In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

scholarly journals Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Chiara Bazzichetto ◽  
Fabiana Conciatori ◽  
Italia Falcone ◽  
Francesco Cognetti ◽  
Michele Milella ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Progression ◽  
Cancer Progression ◽  
Epidemiological Data ◽  
Tumor Stroma ◽  
Cytokine Network ◽  
Pharmacological Response ◽  
Wide Range ◽  
Clinical Models

Cytokines are a family of soluble factors (Growth Factors (GFs), chemokines, angiogenic factors, and interferons), which regulate a wide range of mechanisms in both physiological and pathological conditions, such as tumor cell growth and progression, angiogenesis, and metastasis. In recent years, the growing interest in developing new cancer targeted therapies has been accompanied by the effort to characterize Tumor Microenvironment (TME) and Tumor-Stroma Interactions (TSI). The connection between tumor and stroma is now well established and, in the last decade, evidence from genetic, pharmacological, and epidemiological data supported the importance of microenvironment in tumor progression. However, several of the mechanisms behind TSI and their implication in tumor progression remain still unclear and it is crucial to establish their potential in determining pharmacological response. Many studies have demonstrated that cytokines network can profoundly affect TME, thus displaying potential therapeutic efficacy in both preclinical and clinical models. The goal of this review is to give an overview of the most relevant cytokines involved in colorectal and pancreatic cancer progression and their implication in drug response.

The Role of Stromal Components in Pancreatic Cancer Progression

2016 ◽  
Vol 16 (9) ◽  
pp. 1117-1124 ◽  
Author(s):  
Mengdan Xu ◽  
Binhua P. Zhou ◽  
Min Tao ◽  
Jingyi Liu ◽  
Wei Li
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Progression

Imidazolidine Derivatives in Cancer Research: What is known?

2021 ◽  
Vol 21 ◽  
Author(s):  
Auvani Antunes da Silva Júnior ◽  
Marina Galdino da Rocha Pitta ◽  
Mardonny Bruno de Oliveira Chagas ◽  
Moacyr Jesus Barreto de Melo Rêgo ◽  
Michelle Melgarejo da Rosa ◽  
...  
Keyword(s):  
Cancer Research ◽  
Cancer Treatment ◽  
Cause Of Death ◽  
Cancer Progression ◽  
Open Issues

: Even though cancer is the second leading cause of death globally, a number of open issues persist in cancer treatment, despite the achievements of the field. This review aims at discussing the fundamental role of Imidazolidine derivatives in the industry of cancer treatment. Compelling data from 1996 to 2021 will introduce Imidazolidine derivatives as a relevant tool to modulate cancer progression.

EP-1244: The role of chemoradiotherapy in pancreatic cancer treatment: institutional experience

2014 ◽  
Vol 111 ◽  
pp. S70
Author(s):  
M.M Victoria De Torres ◽  
T.G. Tamara Garcia ◽  
I.J. Ignacio Juez ◽  
B.L. Blanca Ludeña ◽  
D.G. David Gutierrez ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Treatment ◽  
Institutional Experience

M1286 Role of CA 19-9 As a Prognosis Factor Before and After Pancreatic Cancer Treatment

2009 ◽  
Vol 136 (5) ◽  
pp. A-390
Author(s):  
Youn Joo Kim ◽  
Joo Kyung Park ◽  
Ki Young Yang ◽  
Jeong Kyun Seo ◽  
Yong-Tae Kim ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Treatment ◽  
Prognosis Factor ◽  
Before And After
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