scholarly journals Intervertebral Disc Nucleus Repair: Hype or Hope?

2019 ◽  
Vol 20 (15) ◽  
pp. 3622 ◽  
Author(s):  
Gauri Tendulkar ◽  
Tao Chen ◽  
Sabrina Ehnert ◽  
Hans-Peter Kaps ◽  
Andreas K Nüssler
Keyword(s):  
Growth Factors ◽  
Intervertebral Disc ◽  
Spinal Fusion ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Chronic Back Pain ◽  
Underlying Disease ◽  
Tissue Integration ◽  
Disc Repair ◽  
Intervertebral Disc Repair

Chronic back pain is a common disability, which is often accredited to intervertebral disc degeneration. Gold standard interventions such as spinal fusion, which are mainly designed to mechanically seal the defect, frequently fail to restore the native biomechanics. Moreover, artificial implants have limited success as a repair strategy, as they do not alter the underlying disease and fail to promote tissue integration and subsequent native biomechanics. The reported high rates of spinal fusion and artificial disc implant failure have pushed intervertebral disc degeneration research in recent years towards repair strategies. Intervertebral disc repair utilizing principles of tissue engineering should theoretically be successful, overcoming the inadequacies of artificial implants. For instance, advances in the development of scaffolds aided with cells and growth factors have opened up new possibilities for repair strategies. However, none has reached the stage of clinical trials in humans. In this review, we describe the hitches encountered in the musculoskeletal field and summarize recent advances in designing tissue-engineered constructs for promoting nucleus pulposus repair. Additionally, the review focuses on the effect of biomaterial aided with cells and growth factors on achieving effective functional reparative potency, highlighting the ways to enhance the efficacy of these treatments.

The Influence of Axial Compression on the Cellular and Mechanical Function of Spinal Tissues; Emphasis on The Nucleus Pulposus and Annulus Fibrosus

2021 ◽  
Author(s):  
John McMorran ◽  
Diane Gregory
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Axial Compression ◽  
Disc Degeneration ◽  
Annulus Fibrosus ◽  
Intervertebral Disc Degeneration ◽  
Chronic Back Pain ◽  
Physiological State ◽  
Movement Pattern ◽  
Mechanical Function

Abstract In light of the correlation between chronic back pain and intervertebral disc degeneration, this literature review seeks to illustrate the importance of the hydraulic response across the nucleus pulposus- annulus fibrosus interface, by synthesizing current information regarding injurious biomechanics of the spine, stemming from axial compression. Damage to vertebrae, endplates, the nucleus pulposus, and the annulus fibrosus, can all arise from axial compression, depending on the segment's posture, the manner in which it is loaded, and the physiological state of tissue. Therefore, this movement pattern was selected to illustrate the importance of the bracing effect of a pressurized nucleus pulposus on the annulus fibrosus, and how injuries interrupting support to the annulus fibrosus may contribute to intervertebral disc degeneration.

Growth Factors and Treatment of Intervertebral Disc Degeneration

Spine ◽  
2004 ◽  
Vol 29 (23) ◽  
pp. 2757-2769 ◽  
Author(s):  
Koichi Masuda ◽  
Theodore R. Oegema ◽  
Howard S. An
Keyword(s):  
Growth Factors ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration

scholarly journals Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Emanuel J. Novais ◽  
Victoria A. Tran ◽  
Shira N. Johnston ◽  
Kayla R. Darris ◽  
Alex J. Roupas ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Chronic Back Pain ◽  
The Elderly ◽  
Term Treatment ◽  
Specific Effects ◽  
Long Term Treatment ◽  
Age Dependent

AbstractIntervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combination (D + Q) to prevent an age-dependent progression of disc degeneration in mice. We treated C57BL/6 mice beginning at 6, 14, and 18 months of age, and analyzed them at 23 months of age. Interestingly, 6- and 14-month D + Q cohorts show lower incidences of degeneration, and the treatment results in a significant decrease in senescence markers p16INK4a, p19ARF, and SASP molecules IL-6 and MMP13. Treatment also preserves cell viability, phenotype, and matrix content. Although transcriptomic analysis shows disc compartment-specific effects of the treatment, cell death and cytokine response pathways are commonly modulated across tissue types. Results suggest that senolytics may provide an attractive strategy to mitigating age-dependent disc degeneration.

scholarly journals Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

2021 ◽  
Author(s):  
Makarand Risbud ◽  
Emanuel Novais ◽  
Victoria Tran ◽  
Kayla Darris ◽  
Alex Roupas ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Chronic Back Pain ◽  
The Elderly ◽  
Term Treatment ◽  
Specific Effects ◽  
Novel Approach ◽  
Long Term Treatment ◽  
Age Dependent

Abstract Intervertebral disc degeneration is highly prevalent within the elderly population and is a leading cause of chronic back pain and disability. Due to the link between disc degeneration and senescence, we explored the ability of the Dasatinib and Quercetin drug combination (D + Q) to prevent an age-dependent progression of disc degeneration in mice. We treated C57BL/6 mice beginning at 6, 14, and 18 months of age, and analyzed them at 23 months of age. Interestingly, 6- and 14-month D + Q cohorts showed lower incidences of degeneration, and the treatment resulted in a significant decrease in senescent markers p16INK4a, p19ARF, and SASP molecules IL-1β, and IL-6. Treated animals also showed preserved cell viability, phenotype, and matrix content. Although transcriptomic analysis showed disc compartment-specific effects of the treatment, cell death and cytokine response pathways were commonly modulated across tissue types. Results suggest that senolytics may provide a novel approach to mitigating age-dependent disc degeneration.

scholarly journals The Use of Stem Cells in the Treatment of Intervertebral Disc Degeneration

2016 ◽  
Vol 71 (5) ◽  
pp. 359-366
Author(s):  
V. A. Byvaltsev ◽  
I. A. Stepanov ◽  
L. A. Bardonova ◽  
E. G. Belykh
Keyword(s):  
Stem Cells ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Molecular Mechanisms ◽  
Experimental Studies ◽  
Spinal Pain ◽  
Underlying Disease ◽  
Current Data ◽  
Bone Marrow Tissue

The paper presents a review of current data on the use of stem cells in the treatment of intervertebral disc degeneration. Acute spinal pain is often a consequence of the pathology affecting the intervertebral disc. Many applied therapeutic techniques do not provide effective results as expected because most of them address symptoms, but do not treat the underlying disease. We have outlined current findings on the molecular mechanisms of intervertebral disc degeneration, analyzed international experimental studies demonstrating the feasibility of a stem cell therapy for intervertebral disc degeneration. The conducted studies reported on the clinical application of mesenchymal stem cells or stem cells derived from adipose, synovium, and bone marrow tissue. The most pressing and undetermined issues that require further experimental and clinical studies are indicated and defined in the article.

scholarly journals Growth Factors and Anticatabolic Substances for Prevention and Management of Intervertebral Disc Degeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-9
Author(s):  
Umile Giuseppe Longo ◽  
Stefano Petrillo ◽  
Edoardo Franceschetti ◽  
Nicola Maffulli ◽  
Vincenzo Denaro
Keyword(s):  
Growth Factors ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Annulus Fibrosus ◽  
Intervertebral Disc Degeneration ◽  
Surgical Intervention ◽  
Treatment Strategies ◽  
Clinical Applications ◽  
Ivd Degeneration

Intervertebral disc (IVD) degeneration is frequent, appearing from the second decade of life and progressing with age. Conservative management often fails, and patients with IVD degeneration may need surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably effective. Biological strategies aim to prevent and manage IVD degeneration, improving the function and anabolic and reparative capabilities of the nucleus pulposus and annulus fibrosus cells and inhibiting matrix degradation. At present, clinical applications are still in their infancy. Further studies are required to clarify the role of growth factors and anticatabolic substances for prevention and management of intervertebral disc degeneration.

Synergistic Effect of Combined Growth Factors in Porcine Intervertebral Disc Degeneration

2013 ◽  
Vol 54 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Hongsik Cho ◽  
Sangmin Lee ◽  
Sang-Hyug Park ◽  
Jinsong Huang ◽  
Karen A. Hasty ◽  
...  
Keyword(s):  
Growth Factors ◽  
Synergistic Effect ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration

Synergistic Effect of Combined Growth Factors in porcine intervertebral disc degeneration

2013 ◽  
pp. 130213063818006
Author(s):  
Hongsik Cho ◽  
Sangmin Lee ◽  
Sang-Hyug Park ◽  
Jinsong Huang ◽  
Karen A Hasty ◽  
...  
Keyword(s):  
Growth Factors ◽  
Synergistic Effect ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration
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