scholarly journals Correction: Santos, J., et al. Proteomic Analysis of Cyclic Ketamine Compounds Ability to Induce Neural Differentiation in Human Adult Mesenchymal Stem Cells. International Journal of Molecular Sciences 2019, 20, 523

2019 ◽  
Vol 20 (14) ◽  
pp. 3542
Author(s):  
Jerran Santos ◽  
Bruce Kenneth Milthorpe ◽  
Matthew Paul Padula
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Proteomic Analysis ◽  
Neural Differentiation ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells

The authors wish to make the following corrections to this paper [...]

Limited Ca2+ and PKA-pathway dependent neurogenic differentiation of human adult mesenchymal stem cells as compared to fetal neuronal stem cells

2010 ◽  
Vol 316 (2) ◽  
pp. 216-231 ◽  
Author(s):  
Guilherme Lepski ◽  
Cinthia Elim Jannes ◽  
Jaroslaw Maciaczyk ◽  
Anna Papazoglou ◽  
Alexander T. Mehlhorn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neurogenic Differentiation ◽  
Neuronal Stem Cells ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells ◽  
Pka Pathway

scholarly journals Induction of Neurotrophin Expression via Human Adult Mesenchymal Stem Cells: Implication for Cell Therapy in Neurodegenerative Diseases

2007 ◽  
Vol 16 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Federica Pisati ◽  
Patrizia Bossolasco ◽  
Mirella Meregalli ◽  
Lidia Cova ◽  
Marzia Belicchi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Neurodegenerative Diseases ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells

scholarly journals Differentiation of human adult mesenchymal stem cells in chondrocytes for cartilage engineering

2012 ◽  
Vol 20 ◽  
pp. S278 ◽  
Author(s):  
D. Ollitrault ◽  
F. Legendre ◽  
T. Gomez-Leduc ◽  
M. Hervieu ◽  
M. Bouyoucef ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Engineering ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells

O.1 Pre-clinical studies with human adult mesenchymal stem-cells: What have we learned?

2011 ◽  
Vol 21 (9-10) ◽  
pp. 640
Author(s):  
M. Zatz ◽  
N.M. Vieira ◽  
M. Valadares ◽  
M. Secco ◽  
E. Zucconi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Clinical Studies ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells

scholarly journals Valproic Acid Promotes Early Neural Differentiation in Adult Mesenchymal Stem Cells Through Protein Signalling Pathways

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 619 ◽  
Author(s):  
Jerran Santos ◽  
Thibaut Hubert ◽  
Bruce K Milthorpe
Keyword(s):  
Stem Cells ◽  
Valproic Acid ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Neural Differentiation ◽  
Clinical Applications ◽  
Janus Kinase ◽  
Fibroblast Growth Factor 21 ◽  
Neural Cells ◽  
Adult Mesenchymal Stem Cells

Regenerative medicine is a rapidly expanding area in research and clinical applications. Therapies involving the use of small molecule chemicals aim to simplify the creation of specific drugs for clinical applications. Adult mesenchymal stem cells have recently shown the capacity to differentiate into several cell types applicable for regenerative medicine (specifically neural cells, using chemicals). Valproic acid was an ideal candidate due to its clinical stability. It has been implicated in the induction of neural differentiation; however, the mechanism and the downstream events were not known. In this study, we showed that using valproic acid on adult mesenchymal stem cells induced neural differentiation within 24 h by upregulating the expression of suppressor of cytokine signaling 5 (SOCS5) and Fibroblast growth factor 21 (FGF21), without increasing the potential death rate of the cells. Through this, the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is downregulated, and the mitogen-activated protein kinase (MAPK) cascade is activated. The bioinformatics analyses revealed the expression of several neuro-specific proteins as well as a range of functional and structural proteins involved in the formation and development of the neural cells.

scholarly journals Multipotent Potential of Human Adult Mesenchymal Stem Cells

2018 ◽  
Vol 04 (02) ◽  
Author(s):  
Quratulain Yousaf ◽  
Amna Tirmzi ◽  
Saman Ahsan ◽  
Amber Afroz
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Adult ◽  
Adult Mesenchymal Stem Cells
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