scholarly journals Hydrogel-Encapsulated Mesoporous Silica-Coated Gold Nanoshells for Smart Drug Delivery

2019 ◽  
Vol 20 (14) ◽  
pp. 3422 ◽  
Author(s):  
Bo Sang Kim ◽  
Yi-Ting Chen ◽  
Pannaree Srinoi ◽  
Maria D. Marquez ◽  
T. Randall Lee
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Near Infrared ◽  
Sio2 Nanoparticles ◽  
Sio2 Layer ◽  
Therapeutic Drug ◽  
Core Shell ◽  
Silica Layer ◽  
Gold Nanoshell ◽  
Shell Composite

A “smart” core@shell composite nanoparticle (NP) having dual-response mechanisms (i.e., temperature and light) was synthesized, and its efficacy in the loading and release of small molecules was explored. These core@shell NPs are composed of an optically active gold nanoshell (GNS) core and a mesoporous (m-) silica layer (m-SiO2). The GNS@m-SiO2 nanoparticles are further encapsulated within a thermo-responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel (PNIPAM-co-AA). The multi-responsive composite NPs were designed to create thermally and optically modulated drug-delivery vehicles with a m-SiO2 layer providing additional non-collapsible space for drug storage. The influence of the m-SiO2 layer on the efficacy of loading and release of methylene blue, which serves as a model for a small-molecule therapeutic drug, was evaluated. The “smart” core@shell composite NPs having a m-SiO2 layer demonstrated an improved capacity to load and release small molecules compared to the corresponding NPs with no m-SiO2 shell. Additionally, an efficient response by the composite NPs was successfully induced by the thermal energy generated from the gold nanoshell core upon exposure to near infrared (NIR) stimulation.

scholarly journals Near-Infrared Light-Responsive Core–Shell Nanogels for Targeted Drug Delivery

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 5094-5099 ◽  
Author(s):  
Huaizhi Kang ◽  
Anna Carolina Trondoli ◽  
Guizhi Zhu ◽  
Yan Chen ◽  
Ya-Jen Chang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Core Shell ◽  
Near Infrared Light ◽  
Targeted Drug

scholarly journals Highly Red Light-Emitting Erbium- and Lutetium-Doped Core-Shell Upconverting Nanoparticles Surface-Modified with PEG-Folic Acid/TCPP for Suppressing Cervical Cancer HeLa Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1102
Author(s):  
Kyungseop Lim ◽  
Hwang Kyung Kim ◽  
Xuan Thien Le ◽  
Nguyen Thi Nguyen ◽  
Eun Seong Lee ◽  
...  
Keyword(s):  
Folic Acid ◽  
Hela Cells ◽  
Near Infrared ◽  
Red Light ◽  
Three Dimensional ◽  
Green Light ◽  
Core Shell ◽  
Silica Layer ◽  
Light Emitting ◽  
Surface Modified

Photodynamic therapy (PDT) combined with upconverting nanoparticles (UCNPs) are viewed together as an effective method of ablating tumors. After absorbing highly tissue-penetrating near-infrared (NIR) light, UCNPs emit a shorter wavelength light (~660 nm) suitable for PDT. In this study, we designed and prepared highly red fluorescence-emitting silica-coated core-shell upconverting nanoparticles modified with polyethylene glycol (PEG5k)-folic acid and tetrakis(4-carboxyphenyl)porphyrin (TCPP) (UCNPs@SiO2-NH2@FA/PEG/TCPP) as an efficient photodynamic agent for killing tumor cells. The UCNPs consisted of two simple lanthanides, erbium and lutetium, as the core and shell, respectively. The unique core-shell combination enabled the UCNPs to emit red light without green light. TCPP, folic acid, and PEG were conjugated to the outer silica layer of UCNPs as a photosensitizing agent, a ligand for tumor attachment, and a dispersing stabilizer, respectively. The prepared UCNPs of ~50 nm diameter and −34.5 mV surface potential absorbed 808 nm light and emitted ~660 nm red light. Most notably, these UCNPs were physically well dispersed and stable in the aqueous phase due to PEG attachment and were able to generate singlet oxygen (1O2) with a high efficacy. The HeLa cells were treated with each UCNP sample (0, 1, 5, 10, 20, 30 μg/mL as a free TCPP). The results showed that the combination of UCNPs@SiO2-NH2@FA/PEG/TCPP and the 808 nm laser was significantly cytotoxic to HeLa cells, almost to the same degree as naïve TCPP plus the 660 nm laser based on MTT and Live/Dead assays. Furthermore, the UCNPs@SiO2-NH2@FA/PEG/TCPP was well internalized into HeLa cells and three-dimensional HeLa spheroids, presumably due to the surface folic acid and small size in conjunction with endocytosis and the nonspecific uptake. We believe that our UCNPs@SiO2-NH2@FA/PEG/TCPP will serve as a new platform for highly efficient and deep-penetrating photodynamic agents suitable for various tumor treatments.

NIR light responsive core–shell nanocontainers for drug delivery

2015 ◽  
Vol 3 (35) ◽  
pp. 7046-7054 ◽  
Author(s):  
Liru Cui ◽  
Feng Zhang ◽  
Qian Wang ◽  
Huiming Lin ◽  
Chunyu Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Potential Application ◽  
Near Infrared ◽  
Core Shell ◽  
Nir Light ◽  
Good Biocompatibility

A novel near infrared (NIR)-triggered drug delivery nanocomposite (DOX-UCNP@mSiO2@α-CD, 70 nm in size) has been successfully constructed. The good biocompatibility, fast uptake and NIR light-sensitive cytotoxicity make the potential application for cancer therapy.

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