scholarly journals Dioxin and Related Compound Detection: Perspectives for Optical Monitoring

2019 ◽  
Vol 20 (11) ◽  
pp. 2671 ◽  
Author(s):  
Barbara Patrizi ◽  
Mario Siciliani de Cumis ◽  
Silvia Viciani ◽  
Francesco D’Amato
Keyword(s):  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Human Life ◽  
Endocrine System ◽  
Developmental Issues ◽  
Frequency Combs ◽  
Sensitivity And Selectivity ◽  
Short Time ◽  
The Impact ◽  
Related Compounds

Dioxins and related compounds are environmental xenobiotics that are dangerous to human life, due to the accumulation and persistence in the environment and in the food chain. Cancer, reproductive and developmental issues, and damage to the immune system and endocrine system are only a few examples of the impact of such substances in everyday life. For these reasons, it is fundamental to detect and monitor these molecules in biological samples. The consolidated technique for analytical evaluation is gas chromatography combined with high-resolution mass spectrometry. Nowadays, the development of mid-infrared optical components like broadband laser sources, optical frequency combs, high performance Fourier-transform infrared spectroscopy, and plasmonic sensors open the way to new techniques for detection and real time monitoring of these organic pollutants in gaseous or liquid phase, with sufficient sensitivity and selectivity, and in short time periods. In this review, we report the latest techniques for the detection of dioxins, furans and related compounds based on optical and spectroscopic methods, looking at future perspectives.

scholarly journals E-Government services in Moldova: Value and opportunities

2018 ◽  
Vol 325 ◽  
pp. 347-358
Author(s):  
Mihai Grecu ◽  
Ilie Costaş ◽  
Artus Reaboi
Keyword(s):  
High Performance ◽  
Electronic Government ◽  
Government Services ◽  
Telecommunications Infrastructure ◽  
Technology Changes ◽  
Multiple Levels ◽  
The Government ◽  
The One ◽  
Short Time ◽  
The Impact

Technological progress in ICT has created conditions for a new government paradigm - from a government that leads to a government providing services to society. Technology changes the nature of the connection between government and citizens: governance becomes more participatory and citizens' interests prevail. The impact of e-Government solutions is complex, on multiple levels, depending on the maturity of the models applied and the capacity of citizens and business to assimilate e-Government services. In a short time, electronic government services in Moldova have evolved from simple information services to integrated transactional services. On the one hand, this is due to high performance telecommunications infrastructure (broadband, 2G, 3G and 4G technology) and, on the other hand, to citizens' expectations that boosted recently and determined the government to accelerate the implementation of new e-services, increasingly complex and a better quality. The paper addresses the issue of e-Government services in terms of the value that it gives to the government and to citizens' lives and analyzes opportunities to develop e-Government services in the new technological and social realities.

scholarly journals The Impact of Covid-19 on the Macro Indicators: A Comparative Analysis for Oil, Gold, Exchange Rates and Wheat

2021 ◽  
Vol 9 (10) ◽  
pp. 48-63
Author(s):  
DILEK TEKER ◽  
E. Asena Deniz
Keyword(s):  
Human Life ◽  
Economic Life ◽  
Impact Response ◽  
Response Analysis ◽  
Economic Activities ◽  
Economic Sectors ◽  
Health Crisis ◽  
Short Time ◽  
The Impact ◽  
Adf Test

COVID-19, which occurred in Wuhan, China at the end of December 2019 and have affected the whole world, appears to have drastic effects on human health and economic stability. Economic activities related to global trade decreased with the spread of the epidemic and caused crisis both economically and financially. This virus, which is also a health crisis, has affected human life greatly due to uncertainty in the protection and treatment processes. Increasing numbers of cases and deaths negatively affect the economic progress globally and show that countries with intense epidemic are vulnerable. Not knowing how long the pandemic will last and how long economic activities will be restricted requires an economic precaution. If the pandemic is brought under control quickly, the return to normal economic life will happen quickly and thus all economic sectors, especially service sectors, will recover in a short time. If the process of controlling the pandemic is long, the destruction on economic growth and employment will be at higher levels. With the vaccine found, it is predicted that the normalization process will accelerate and the economy may recover. Increased studies examining the impact of the COVID-19 pandemic on financial markets and commodity markets will make it easier for both economists and financial actors in the future.  In this study, the relationship between the daily number of cases of COVID-19 and brent oil, gold, EUR / USD and wheat prices were examined. After the natural logarithm of our variables was applied, it was determined whether they were static or not. ARDL test, Impact-Response Analysis and Variance Decomposition were performed according to the determined lag lengths. According to the results, ARDL test was performed because our data was not stationary according to the ADF test and cointegration was not found among the data. As a result of impact response analysis, shocks lose their effect in a short time.

Chemical Fate of Photodegraded Diluted Bitumen in Seawater

2017 ◽  
Vol 2017 (1) ◽  
pp. 2286-2305 ◽  
Author(s):  
Zeyu Yang ◽  
Bruce P. Hollebone ◽  
Gong Zhang ◽  
Carl E. Brown ◽  
Chun Yang ◽  
...  
Keyword(s):  
Crude Oil ◽  
Oil Sands ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Degradation Process ◽  
Naphthenic Acids ◽  
Solar Irradiation ◽  
Chemical Compositions ◽  
Chemical Fate ◽  
The Impact

ABSTRACT2017-336: Diluted bitumen (dilbit), an oil sands product, may present new response challenges differing from conventional crude oil in terms of its potential environmental impacts. Simple naphthenic acids (NAs), a complex group of monocarboxylic acids, with a general formula CnH2n+zO2, may be present in the source bitumen or may be created by photolytic weathering. Knowing the composition and concentrations of NAs created during the photo-degradation process of dilbit will help understand the fate, behavior and toxicity of dilbit. In the present study, two diluted bitumen products, Cold Lake Blend (CLB) and Access Western Blend (AWB), were mixed with saltwater and irradiated with natural solar light (Ottawa, Canada, 45.4°N) over winter and summer seasons, to assess the impact of sunlight on the chemical fate of the dilbit. For comparison, a light, sweet crude oil was exposed under similar conditions. The samples were analyzed by high performance liquid chromatography-high resolution mass spectrometry to examine the molecular transformation of diluted bitumen by solar irradiation. The abundances of NAs in all three test oils increased significantly after 90 days of solar irradiation, strongly suggesting that polar NAs were formed by photolysis. Further, greater increases in NAs in the light crude were found than in the two dilbits. Similarly, the lighter oil had higher photolytic removal rates of petroleum hydrocarbons than the two dilbits. The concentrations of NAs in oils exposed during the summer were generally higher than those exposed in winter. During summer exposure, the abundance of total NAs increased up to the 30-day’s solar exposure, then fell again, indicating the transient nature of these compounds. However, net increases in polar NA compounds were observed for all the winter exposed samples. Greater increases were observed in the smaller NA compounds (average C-number decreased), also accompanied by an increase in saturation (average z-number decreased). These chemical changes strongly indicate the effect of sunlight on the potential behaviour, fate and effects of spilled oil, with creation of new resin group compounds and reduction of aromatics and saturates. These changes may affect the viscosity of the oil and its ability to uptake water. These chemical compositions also imply significant changes to the ecological effects of the oil following a spill when aged in sunlight.

scholarly journals Deciphering microbiome impacts on fungal-microalgal interaction in a marine environment using metabolomics

2021 ◽  
Author(s):  
Olivier Berry ◽  
Enora Briand ◽  
Alize Bagot ◽  
Maud Chaigne ◽  
Laurence Meslet-Cladiere ◽  
...  
Keyword(s):  
Marine Environment ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Chemical Interaction ◽  
Microbial Interactions ◽  
Fungal Mycelium ◽  
Physical Interaction ◽  
Associated Bacteria ◽  
Depth Analysis ◽  
The Impact

The comprehension of microbial interactions is one of the key challenges in microbial ecology. The present study focuses on studying the chemical interaction between the toxic dinoflagellate Prorocentrum lima PL4V strain and associated fungal strains (two Penicillium sp. strains and three Aspergillus sp) among which the Aspergillus pseudoglaucus strain MMS1589 was selected for further co-culture experiment. Such rarely studied interaction (fungal-microalgal) was explored in axenic and non-axenic conditions, in a dedicated microscale marine environment (hybrid solid/liquid conditions), to delineate specialized metabolome alteration in relation to the P. lima and A. pseudoglaucus co-culture in regard to the presence of their associated bacteria. Such alteration was monitored by high-performance liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS). In-depth analysis of the resulting data highlighted (1) the chemical modification associated to fungal-microalgal co-culture, and (2) the impact of associated bacteria in microalgal resilience to fungal interaction. Even if only a very low number of highlighted metabolites were fully characterised due to the poor chemical investigation of the studied species, a clear co-culture induction of the dinoflagellate toxins okadaic acid and dinophysistoxin 1 was observed. Such results highlight the importance to consider microalgal microbiome to study parameters regulating toxin production. Finally, a microscopic observation showed an unusual physical interaction between the fungal mycelium and the dinoflagellates.

scholarly journals The Bee Hemolymph Metabolome: A Window into the Impact of Viruses on Bumble Bees

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 600
Author(s):  
Luoluo Wang ◽  
Lieven Van Meulebroek ◽  
Lynn Vanhaecke ◽  
Guy Smagghe ◽  
Ivan Meeus
Keyword(s):  
Virus Infection ◽  
Viral Infection ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Virus Detection ◽  
Bumble Bees ◽  
Wild Bees ◽  
Bee Community ◽  
The Impact ◽  
Paralysis Virus

State-of-the-art virus detection technology has advanced a lot, yet technology to evaluate the impacts of viruses on bee physiology and health is basically lacking. However, such technology is sorely needed to understand how multi-host viruses can impact the composition of the bee community. Here, we evaluated the potential of hemolymph metabolites as biomarkers to identify the viral infection status in bees. A metabolomics strategy based on ultra-high-performance liquid chromatography coupled to high-resolution mass spectrometry was implemented. First, we constructed a predictive model for standardized bumble bees, in which non-infected bees were metabolically differentiated from an overt Israeli acute paralysis virus (IAPV) infection (R2Y = 0.993; Q2 = 0.906), as well as a covert slow bee paralysis virus (SBPV) infection (R2Y = 0.999; Q2 = 0.875). Second, two sets of potential biomarkers were identified, being descriptors for the metabolomic changes in the bee’s hemolymph following viral infection. Third, the biomarker sets were evaluated in a new dataset only containing wild bees and successfully discriminated virus infection versus non-virus infection with an AUC of 0.985. We concluded that screening hemolymph metabolite markers can underpin physiological changes linked to virus infection dynamics, opening promising avenues to identify, monitor, and predict the effects of virus infection in a bee community within a specific environment.

scholarly journals Metabolomic Signatures in Pediatric Crohn’s Disease Patients with Mild or Quiescent Disease Treated with Partial Enteral Nutrition: A Feasibility Study

2020 ◽  
pp. 247263032096914
Author(s):  
Jair Gonzalez Marques ◽  
Engy Shokry ◽  
Klara Frivolt ◽  
Katharina Julia Werkstetter ◽  
Annecarin Brückner ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Disease Activity ◽  
High Performance ◽  
Metabolic Response ◽  
High Resolution Mass Spectrometry ◽  
Intervention Group ◽  
Mild Disease ◽  
The Impact

Little is known about the metabolic response of pediatric Crohn’s disease (CD) patients to partial enteral nutrition (PEN) therapy and the impact of disease activity and inflammation. We analyzed plasma samples from a nonrandomized controlled intervention study investigating the effect of partial enteral nutrition (PEN) on bone health and growth throughout one year with untargeted metabolomics using high-performance liquid chromatography (HPLC) coupled with high-resolution mass spectrometry (HRMS). Thirty-four paired samples from two time points (baseline and 12 months) were analyzed. Patients (median age: 13.9 years, range: 7–18.9 years, 44% females) were in remission or had mild disease activity. The intervention group received a casein-based formula for 12 months, providing ~25% of estimated daily energy requirements. Sparse partial least squares discriminant analysis (splsda) was applied for group discrimination and identifying sources of variation to identify the impact of PEN. We also investigated the correlation of metabolites with inflammation markers, including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fecal calprotectin. After 12 months, our results show substantial difference between PEN and non-PEN groups in the metabolome of CD patients in remission or with mild disease activity. Inflammatory markers were associated with individual compounds and chemical classes such as isoprenoids and phospholipids. Identified compounds comprise metabolites produced by human or bacterial metabolism, as well as xenobiotics recognized as flavoring agents and environmental contaminants and their biotransformation products. Further longitudinal studies that also include patients with higher disease activity are warranted to evaluate the suitability of these metabolic biomarkers for predicting disease activity.

scholarly journals Global-Scale Metabolomic Profiling of Human Hair for Simultaneous Monitoring of Endogenous Metabolome, Short- and Long-Term Exposome

2021 ◽  
Vol 9 ◽  
Author(s):  
Ying Chen ◽  
Jian Guo ◽  
Shipei Xing ◽  
Huaxu Yu ◽  
Tao Huan
Keyword(s):  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
Global Scale ◽  
Short Term ◽  
Experimental Conditions ◽  
Hair Samples ◽  
Wide Range ◽  
Endogenous Metabolites ◽  
The Impact

Hair is a unique biological matrix that adsorbs short-term exposures (e. g., environmental contaminants and personal care products) on its surface and also embeds endogenous metabolites and long-term exposures in its matrix. In this work, we developed an untargeted metabolomics workflow to profile both temporal exposure chemicals and endogenous metabolites in the same hair sample. This analytical workflow begins with the extraction of short-term exposures from hair surfaces through washing. Further development of mechanical homogenization extracts endogenous metabolites and long-term exposures from the cleaned hair. Both solutions of hair wash and hair extract were analyzed using ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS)-based metabolomics for global-scale metabolic profiling. After analysis, raw data were processed using bioinformatic programs recently developed specifically for exposome research. Using optimized experimental conditions, we detected a total of 10,005 and 9,584 metabolic features from hair wash and extraction samples, respectively. Among them, 274 and 276 features can be definitively confirmed by MS2 spectral matching against spectral library, and an additional 3,356 and 3,079 features were tentatively confirmed as biotransformation metabolites. To demonstrate the performance of our hair metabolomics, we collected hair samples from three female volunteers and tested their hair metabolic changes before and after a 2-day exposure exercise. Our results show that 645 features from wash and 89 features from extract were significantly changed from the 2-day exposure. Altogether, this work provides a novel analytical approach to study the hair metabolome and exposome at a global scale, which can be implemented in a wide range of biological applications for a deeper understanding of the impact of environmental and genetic factors on human health.

Dietary Vitamin and Stability of Oral Anticoagulation: Proposal of a Diet with Constant Vitamin K1 Content

1997 ◽  
Vol 77 (03) ◽  
pp. 504-509 ◽  
Author(s):  
Sarah L Booth ◽  
Jacqueline M Charnley ◽  
James A Sadowski ◽  
Edward Saltzman ◽  
Edwin G Bovill ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Vitamin K ◽  
High Performance ◽  
Case Reports ◽  
Food Composition ◽  
Dietary Guidelines ◽  
Dietary Vitamin ◽  
Vitamin K1 ◽  
The Stability ◽  
The Impact

SummaryCase reports cited in Medline or Biological Abstracts (1966-1996) were reviewed to evaluate the impact of vitamin K1 dietary intake on the stability of anticoagulant control in patients using coumarin derivatives. Reported nutrient-drug interactions cannot always be explained by the vitamin K1 content of the food items. However, metabolic data indicate that a consistent dietary intake of vitamin K is important to attain a daily equilibrium in vitamin K status. We report a diet that provides a stable intake of vitamin K1, equivalent to the current U.S. Recommended Dietary Allowance, using food composition data derived from high-performance liquid chromatography. Inconsistencies in the published literature indicate that prospective clinical studies should be undertaken to clarify the putative dietary vitamin K1-coumarin interaction. The dietary guidelines reported here may be used in such studies.

Forms of physical activity of the elderly

2020 ◽  
Vol 18 (3) ◽  
pp. 221-228
Author(s):  
Piotr Czarnecki ◽  
◽  
Justyna Podgórska-Bednarz ◽  
Lidia Perenc ◽  
◽  
...  
Keyword(s):  
Physical Activity ◽  
Elderly People ◽  
Population Aging ◽  
Human Life ◽  
Good Health ◽  
The Elderly ◽  
Polish Society ◽  
Central Statistical ◽  
Key Phrases ◽  
The Impact

Introduction. Physical activity is known to be an important factor influencing health throughout human life. This issue has become crucial for public health due to the aging of the population in both developed and developing countries. Aim. is to present a literature review on the forms of physical activity undertaken by the elderly, as well as on issues related to physical activity and the population aging. Material and methods. The study was prepared on the basis of a review of Polish and foreign literature. The following databases and data sources were used: EBSCO, ScienceDirect and Google Scholar. An additional source of data were the websites of the Central Statistical Office. Strictly defined key phrases were used during the collection of literature. The work has been divided into thematic subsections on the aging of the society, the impact of physical activity on health and the main topic, i.e. forms of physical activity selected by the elderly. Analysis of the literature. The number of elderly people in Polish society has increased by almost 3.7 million over three decades. Therefore, an important topic is prophylaxis aimed at increasing the number of days in good health, largely covering the broadly understood activation of the elderly. The available data indicate that only 12% of elderly people undertake physical activity once a week. The most common form of spending free time actively is walking (as many as 73% of people in this population declare this form of physical activity in one of the presented studies). Conclusion. Organized forms of physical activity are undertaken much less frequently by the analyzed age group mainly due to financial limitations and limited availability of sports infrastructure.

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