scholarly journals PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity

2019 ◽  
Vol 20 (9) ◽  
pp. 2121 ◽  
Author(s):  
Jastrzebska ◽  
Mellea ◽  
Salerno ◽  
Grzes ◽  
Siergiejczyk ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biofilm Formation ◽  
Ring Opening ◽  
Antibacterial Properties ◽  
Multidrug Resistant ◽  
Bacterial Biofilm ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Ring Opening Reaction

We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation.

Releasable antimicrobial polymer-silk coatings for combating multidrug-resistant bacteria

2021 ◽  
Author(s):  
Erna Wulandari ◽  
Rachel Budhisatria ◽  
Alexander H. Soeriyadi ◽  
Mark Willcox ◽  
Cyrille Boyer ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biofilm Formation ◽  
Multidrug Resistant ◽  
Bacterial Biofilm ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Antimicrobial Polymers ◽  
Planktonic Bacteria

Controlled release of synthetic cationic antimicrobial polymers from silk-based coating for preventing bacterial biofilm formation on the surface and for killing planktonic bacteria cells.

scholarly journals Antibacterial Activity of Moroccan Zantaz Honey and the Influence of Its Physicochemical Parameters Using Chemometric Tools

2021 ◽  
Vol 11 (10) ◽  
pp. 4675
Author(s):  
Youssef Elamine ◽  
Hamada Imtara ◽  
Maria Graça Miguel ◽  
Ofélia Anjos ◽  
Letícia M. Estevinho ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Principal Component ◽  
Physicochemical Characteristics ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Coumaric Acid ◽  
Atlas Mountains ◽  
Methyl Syringate ◽  
Chemometric Tools

The emergence of multidrug-resistant bacteria has prompted the development of alternative therapies, including the use of natural products with antibacterial properties. The antibacterial properties of Zantaz honey produced in the Moroccan Atlas Mountains against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus was evaluated and analyzed using chemometric tools. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) against S. aureus were the lowest (112.5 ± 54.5 mg/mL), revealing that this species was most sensitive to Zantaz honey. P. aeruginosa showed an intermediate sensitivity (MIC= 118.75 ± 51.9 mg/mL), while E. coli was the most resistant to treatment (MIC = 175 ± 61.2 mg/mL). Content of monosaccharides, certain minerals, and phenolic compounds correlated with antibacterial activity (p < 0.05). Principal component analysis of physicochemical characteristics and antibacterial activity indicated that the parameters most associated with antibacterial activity were color, acidity, and content of melanoidins, fructose, epicatechin, methyl syringate, 4-coumaric acid, and 3-coumaric acid.

scholarly journals The Antibacterial Activity of Human Amniotic Membrane against Multidrug-Resistant Bacteria Associated with Urinary Tract Infections: New Insights from Normal and Cancerous Urothelial Models

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 218
Author(s):  
Taja Železnik Ramuta ◽  
Larisa Tratnjek ◽  
Aleksandar Janev ◽  
Katja Seme ◽  
Marjanca Starčič Erjavec ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Amniotic Membrane ◽  
Multidrug Resistant ◽  
Basic Knowledge ◽  
Resistant Bacteria ◽  
Human Amniotic Membrane ◽  
Multidrug Resistant Bacteria ◽  
Tract Infections

Urinary tract infections (UTIs) represent a serious global health issue, especially due to emerging multidrug-resistant UTI-causing bacteria. Recently, we showed that the human amniotic membrane (hAM) could be a candidate for treatments and prevention of UPEC and Staphylococcus aureus infections. However, its role against multidrug-resistant bacteria, namely methicillin-resistant S. aureus (MRSA), extended-spectrum beta-lactamases (ESBL) producing Escherichia coli and Klebsiella pneumoniae, vancomycin-resistant Enterococci (VRE), carbapenem-resistant Acinetobacter baumannii, and Pseudomonas aeruginosa has not yet been thoroughly explored. Here, we demonstrate for the first time that the hAM homogenate had antibacterial activity against 7 out of 11 tested multidrug-resistant strains, the greatest effect was on MRSA. Using novel approaches, its activity against MRSA was further evaluated in a complex microenvironment of normal and cancerous urinary bladder urothelia. Even short-term incubation in hAM homogenate significantly decreased the number of bacteria in MRSA-infected urothelial models, while it did not affect the viability, number, and ultrastructure of urothelial cells. The hAM patches had no antibacterial activity against any of the tested strains, which further exposes the importance of the hAM preparation. Our study substantially contributes to basic knowledge on the antibacterial activity of hAM and reveals its potential to be used as an antibacterial agent against multidrug-resistant bacteria.

scholarly journals Effects of Experimental Agents Containing Tannic Acid or Chitosan on the Bacterial Biofilm Formation in Situ

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1315
Author(s):  
Anton Schestakow ◽  
Matthias Hannig
Keyword(s):  
Hydrochloric Acid ◽  
Tannic Acid ◽  
Biofilm Formation ◽  
Antibacterial Properties ◽  
Positive Control ◽  
Bacterial Biofilm ◽  
Dental Biofilm ◽  
Acid Ph ◽  
Bovine Enamel

Chitosan and tannic acid are known for their antibacterial properties. In the present in-situ study, their antibacterial and anti-adherent effects on biofilm formation on enamel were investigated. Six subjects carried upper jaw splints with bovine enamel specimens, allowing in-situ biofilm formation. During the two-day trial, subjects rinsed with experimental solutions that contained either chitosan, tannic acid (pH = 2.5), tannic acid (pH = 7) or hydrochloric acid. Water served as the negative and chlorhexidine as the positive control. Rinsing occurred four or five times following two different rinsing protocols to investigate both the immediate and long-lasting effects. After 48 h of intraoral exposure, the dental plaque was stained with LIVE/DEAD® BacLight, and fluorescence micrographs were evaluated by using the software ImageJ. The results were verified by scanning electron microscopy. Rinsing with chitosan resulted in little immediate antibacterial and anti-adherent effects but failed to show any long-lasting effect, while rinsing with tannic acid resulted in strong immediate and long-lasting effects. Except for a slightly lower antibacterial effect, the neutral solution of tannic acid was as good as the acidic solution. Hydrochloric acid showed neither an antibacterial nor an anti-adherent effect on dental biofilm formation. Experimental solutions containing tannic acid are promising anti-biofilm agents, irrespective of the pH values of the solutions. Chitosan, on the other hand, was not able to prevent biofilm formation.

Stalobacin: Discovery of Novel Lipopeptide Antibiotics with Potent Antibacterial Activity against Multidrug-Resistant Bacteria

2020 ◽  
Vol 63 (11) ◽  
pp. 6090-6095 ◽  
Author(s):  
Kouhei Matsui ◽  
Yukiko Kan ◽  
Junko Kikuchi ◽  
Keisuke Matsushima ◽  
Miki Takemura ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Lipopeptide Antibiotics

scholarly journals Antibacterial Activity of the Non-Cytotoxic Peptide (p-BthTX-I)2 and Its Serum Degradation Product against Multidrug-Resistant Bacteria

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1898 ◽  
Author(s):  
Norival Santos-Filho ◽  
Rafaela Fernandes ◽  
Bruna Sgardioli ◽  
Matheus Ramos ◽  
Julia Piccoli ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Degradation Product ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Cytotoxic Peptide

Antibacterial activity of Limonium brasiliense (Baicuru) against multidrug-resistant bacteria using a statistical mixture design

2017 ◽  
Vol 198 ◽  
pp. 313-323 ◽  
Author(s):  
Andressa Blainski ◽  
Barbara Gionco ◽  
Admilton G. Oliveira ◽  
Galdino Andrade ◽  
Ieda S. Scarminio ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Mixture Design ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Statistical Mixture

scholarly journals Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria

2014 ◽  
Vol 178 ◽  
pp. 84-91 ◽  
Author(s):  
David J. Sanabria-Ríos ◽  
Yaritza Rivera-Torres ◽  
Gamalier Maldonado-Domínguez ◽  
Idializ Domínguez ◽  
Camille Ríos ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria
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