scholarly journals The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder

2019 ◽  
Vol 20 (9) ◽  
pp. 2115 ◽  
Author(s):  
Piranavie Srikantha ◽  
M. Hasan Mohajeri
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Structural Changes ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Gut Health ◽  
Autistic Children ◽  
Bacterial Metabolites ◽  
Autistic People ◽  
Gastrointestinal Problems

New research points to a possible link between autism spectrum disorder (ASD) and the gut microbiota as many autistic children have co-occurring gastrointestinal problems. This review focuses on specific alterations of gut microbiota mostly observed in autistic patients. Particularly, the mechanisms through which such alterations may trigger the production of the bacterial metabolites, or leaky gut in autistic people are described. Various altered metabolite levels were observed in the blood and urine of autistic children, many of which were of bacterial origin such as short chain fatty acids (SCFAs), indoles and lipopolysaccharides (LPS). A less integrative gut-blood-barrier is abundant in autistic individuals. This explains the leakage of bacterial metabolites into the patients, triggering new body responses or an altered metabolism. Some other co-occurring symptoms such as mitochondrial dysfunction, oxidative stress in cells, altered tight junctions in the blood-brain barrier and structural changes in the cortex, hippocampus, amygdala and cerebellum were also detected. Moreover, this paper suggests that ASD is associated with an unbalanced gut microbiota (dysbiosis). Although the cause-effect relationship between ASD and gut microbiota is not yet well established, the consumption of specific probiotics may represent a side-effect free tool to re-establish gut homeostasis and promote gut health. The diagnostic and therapeutic value of bacterial-derived compounds as new possible biomarkers, associated with perturbation in the phenylalanine metabolism, as well as potential therapeutic strategies will be discussed.

scholarly journals Microbiota-Gut-Brain-Axis and Autism Spectrum Disorders

2018 ◽  
Author(s):  
Piranavie Srikantha ◽  
M. Hasan Mohajeri
Keyword(s):  
Gut Microbiota ◽  
Structural Changes ◽  
Short Chain Fatty Acids ◽  
Autism Spectrum ◽  
Gut Health ◽  
Autistic Children ◽  
Bacterial Metabolites ◽  
Autistic People ◽  
Gastrointestinal Problems ◽  
New Biomarkers

New research points to a possible link between Autism Spectrum Disorder and the gut microbiota as many autistic children have co-occurring gastrointestinal problems. This review focuses on specific alterations of gut microbiota mostly observed in autistic patients. Particularly, the mechanisms through which such alterations may trigger the production of the bacterial metabolites or leaky gut in autistic people are described. Various altered metabolite levels were observed in autistic children, many of those were of bacterial origin such as short chain fatty acids (SCFAs), indoles and lipopolysaccharides. A less integrative gut-blood-barrier is abundant in autistic individuals. This explains the leakage of bacterial metabolites into the patients triggering new body responses or altered metabolism. Some other co-occurring symptoms such as mitochondrial dysfunction, oxidative stress in the cells, altered tight junctions in the blood brain barrier and structural changes in cortex, hippocampus, amygdala and cerebellum were detected. Moreover, this paper suggests that autism is associated with an unbalanced gut microbiota (dysbiosis). Although the cause-effect relationship between autism and gut microbiota is not yet well established, consumption of specific probiotics may represent a powerful tool to re-establish gut homeostasis and promote gut health. Diagnostic and therapeutic value of new biomarkers leading to the perturbation in the phenylalanine metabolism will be discussed.

scholarly journals The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Laila Al-Ayadhi ◽  
Naima Zayed ◽  
Ramesa Shafi Bhat ◽  
Nadine M. S. Moubayed ◽  
May N. Al-Muammar ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Main Body ◽  
Leaky Gut ◽  
Gut Health ◽  
Blood Brain ◽  
Gastrointestinal Problems ◽  
Brain Barriers

Abstract Background Innovative research highlighted the probable connection between autism spectrum disorder (ASD) and gut microbiota as many autistic individuals have gastrointestinal problems as co-morbidities. This review emphasizes the role of altered gut microbiota observed frequently in autistic patients, and the mechanisms through which such alterations may trigger leaky gut. Main body Different bacterial metabolite levels in the blood and urine of autistic children, such as short-chain fatty acids, lipopolysaccharides, beta-cresol, and bacterial toxins, were reviewed. Moreover, the importance of selected proteins, among which are calprotectin, zonulin, and lysozyme, were discussed as biomarkers for the early detection of leaky gut as an etiological mechanism of ASD through the less integrative gut–blood–brain barriers. Disrupted gut–blood–brain barriers can explain the leakage of bacterial metabolites in these patients. Conclusion Although the cause-to-effect relationship between ASD and altered gut microbiota is not yet well understood, this review shows that with the consumption of specific diets, definite probiotics may represent a noninvasive tool to reestablish healthy gut microbiota and stimulate gut health. The diagnostic and therapeutic value of intestinal proteins and bacterial-derived compounds as new possible biomarkers, as well as potential therapeutic targets, are discussed.

scholarly journals The Brain-Gut-Microbiome System: Pathways and Implications for Autism Spectrum Disorder

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4497
Author(s):  
Michelle A. Chernikova ◽  
Genesis D. Flores ◽  
Emily Kilroy ◽  
Jennifer S. Labus ◽  
Emeran A. Mayer ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Preclinical Research ◽  
Gastrointestinal Problems ◽  
The Brain

Gastrointestinal dysfunction is one of the most prevalent physiological symptoms of autism spectrum disorder (ASD). A growing body of largely preclinical research suggests that dysbiotic gut microbiota may modulate brain function and social behavior, yet little is known about the mechanisms that underlie these relationships and how they may influence the pathogenesis or severity of ASD. While various genetic and environmental risk factors have been implicated in ASD, this review aims to provide an overview of studies elucidating the mechanisms by which gut microbiota, associated metabolites, and the brain interact to influence behavior and ASD development, in at least a subgroup of individuals with gastrointestinal problems. Specifically, we review the brain-gut-microbiome system and discuss findings from current animal and human studies as they relate to social-behavioral and neurological impairments in ASD, microbiota-targeted therapies (i.e., probiotics, fecal microbiota transplantation) in ASD, and how microbiota may influence the brain at molecular, structural, and functional levels, with a particular interest in social and emotion-related brain networks. A deeper understanding of microbiome-brain-behavior interactions has the potential to inform new therapies aimed at modulating this system and alleviating both behavioral and physiological symptomatology in individuals with ASD.

scholarly journals The Efficacy of the Gluten-Free Casein-Free Diet for Moroccan Autistic Children

2018 ◽  
Vol 6 (3) ◽  
pp. 734-741 ◽  
Author(s):  
AFAF HAFID ◽  
AHMED OMAR TOUHAMI AHAMI
Keyword(s):  
Autism Spectrum Disorder ◽  
Rating Scale ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Essential Elements ◽  
Spectrum Disorder ◽  
Gluten Free ◽  
Autistic Children ◽  
Gastrointestinal Problems ◽  
Urinary Peptides

The aims of this study are to verify the efficiency of gluten-free casein-free diet for children with autism spectrum disorder and to evaluate its impact on their nutritional profiles.30 children with autism spectrum disorder, between 6 and 12 years old, had been identified for the study. An analysis of biological matrixes was performed to detect the level of urinary peptides and essential elements. A gluten-free casein-free diet was administered for children with high urinary peptides level during one year, quarterly followed-up. The scale of autism was assessed by the “Childhood Autism Rating Scale” questionnaire. The findings, before the gluten-free casein-free diet, show that 20 children had high levels of urinary peptides and unnatural essential elements concentrations. At the end of the sixth diet month, the results show a large decrease in essential elements concentrations for the majority of children. After identifying these deficiencies, the diet was modified and fortified in a way that made it a supervised diet. We could, then, decrease the urinary peptides level for 40% of children, improve essential elements concentrations for 30% and decrease the autism severity for 30% of them. Our study has shown that only autistic children that present both very high urinary peptide and gastrointestinal problems respond positively to a gluten-free casein-free diet. This type of died should not therefore be systematic administered to all autistic children. On the other hand, the elimination diets run risk of having deficiencies which makes the supervision of a specialist required.

scholarly journals Wearable-Sensors-Based Platform for Gesture Recognition of Autism Spectrum Disorder Children Using Machine Learning Algorithms

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3319
Author(s):  
Uzma Abid Siddiqui ◽  
Farman Ullah ◽  
Asif Iqbal ◽  
Ajmal Khan ◽  
Rehmat Ullah ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gesture Recognition ◽  
Cross Validation ◽  
Wearable Sensors ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Machine Learning Algorithms ◽  
Spectrum Disorder ◽  
Autistic Children ◽  
Autistic People

Autistic people face many challenges in various aspects of daily life such as social skills, repetitive behaviors, speech, and verbal communication. They feel hesitant to talk with others. The signs of autism vary from one individual to another, with a range from mild to severe. Autistic children use fewer communicative gestures compared with typically developing children (TD). With time, the parents may learn their gestures and understand what is occurring in their child’s mind. However, it is difficult for other people to understand their gestures. In this paper, we propose a wearable-sensors-based platform to recognize autistic gestures using various classification techniques. The proposed system defines, monitors, and classifies the gestures of the individuals. We propose using wearable sensors that transmit their data using a Bluetooth interface to a data acquisition and classification server. A dataset of 24 gestures is created by 10 autistic children performing each gesture about 10 times. Time- and frequency-domain features are extracted from the sensors’ data, which are classified using k-nearest neighbor (KNN), decision tree, neural network, and random forest models. The main objective of this work is to develop a wearable-sensor-based IoT platform for gesture recognition in children with autism spectrum disorder (ASD). We achieve an accuracy of about 91% with most of the classifiers using dataset cross-validation and leave-one-person-out cross-validation.

Development of Neural Structure and Function in Autism Spectrum Disorder: Potential Implications for Learning Language

2020 ◽  
Vol 29 (4) ◽  
pp. 1783-1797
Author(s):  
Kelly L. Coburn ◽  
Diane L. Williams
Keyword(s):  
Autism Spectrum Disorder ◽  
Language Development ◽  
Diffusion Tensor ◽  
Autism Spectrum ◽  
Language Intervention ◽  
Spectrum Disorder ◽  
Autistic Children ◽  
Neural Structure ◽  
Complex Information ◽  
And Function

Purpose Neurodevelopmental processes that begin during gestation and continue throughout childhood typically support language development. Understanding these processes can help us to understand the disruptions to language that occur in neurodevelopmental conditions, such as autism spectrum disorder (ASD). Method For this tutorial, we conducted a focused literature review on typical postnatal brain development and structural and functional magnetic resonance imaging, diffusion tensor imaging, magnetoencephalography, and electroencephalography studies of the neurodevelopmental differences that occur in ASD. We then integrated this knowledge with the literature on evidence-based speech-language intervention practices for autistic children. Results In ASD, structural differences include altered patterns of cortical growth and myelination. Functional differences occur at all brain levels, from lateralization of cortical functions to the rhythmic activations of single neurons. Neuronal oscillations, in particular, could help explain disrupted language development by elucidating the timing differences that contribute to altered functional connectivity, complex information processing, and speech parsing. Findings related to implicit statistical learning, explicit task learning, multisensory integration, and reinforcement in ASD are also discussed. Conclusions Consideration of the neural differences in autistic children provides additional scientific support for current recommended language intervention practices. Recommendations consistent with these neurological findings include the use of short, simple utterances; repetition of syntactic structures using varied vocabulary; pause time; visual supports; and individualized sensory modifications.

scholarly journals Gene variations in autism spectrum disorder are associated with alteration of gut microbiota, metabolites and cytokines

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-16
Author(s):  
Zhi Liu ◽  
Xuhua Mao ◽  
Zhou Dan ◽  
Yang Pei ◽  
Rui Xu ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiota ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Gut Microbiome-Based Analysis of Lipid A Biosynthesis in Individuals with Autism Spectrum Disorder: An In Silico Evaluation

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 688
Author(s):  
Abdulkadir Yusif Maigoro ◽  
Soojin Lee
Keyword(s):  
Autism Spectrum Disorder ◽  
Gut Microbiome ◽  
In Silico ◽  
Lipid A ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Synthesis Rate ◽  
Special Focus ◽  
Control Subjects ◽  
Gastrointestinal Problems

The link between autism spectrum disorder (ASD) and the gut microbiome has received much attention, with special focus on gut–brain-axis immunological imbalances. Gastrointestinal problems are one of the major symptoms of ASD and are thought to be related to immune dysregulation. Therefore, in silico analysis was performed on mined data from 36 individuals with ASD and 21 control subjects, with an emphasis on lipid A endotoxin-producing bacteria and their lipopolysaccharide (LPS) metabolic pathways. Analysis of enzyme distribution among the 15 most abundant genera in both groups revealed that almost all these genera utilized five early-stage enzymes responsible for catalyzing the nine conserved lipid A synthesis steps. However, Haemophilus and Escherichia, which were significantly more abundant in individuals with ASD than in the control subjects, possess a complete set of essential lipid A synthesis enzymes. Furthermore, the 10 genera with the greatest increase in individuals with ASD showed high potential for producing late-stage lipid A products. Collectively, these results suggested that the synthesis rate of immunogenic LPS end products is likely to increase in individuals with ASD, which may be related to their gastrointestinal symptoms and elevated inflammatory conditions.

scholarly journals Means of psychomotor and cognitive recovery for children with autism spectrum disorder

2015 ◽  
Vol 5 (2) ◽  
pp. 49-54
Author(s):  
Paul Ichim ◽  
Iuliana Barna ◽  
Mircea Dragu
Keyword(s):  
Autism Spectrum Disorder ◽  
Social Integration ◽  
Deviant Behavior ◽  
Alternative Therapy ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Multisystemic Therapy ◽  
Spectrum Disorder ◽  
International Assessments ◽  
Autistic People

According to some international assessments, the rate of autism spectrum disorder cases is 1 to 68 children. There are approximately 67 million autistic people in the worlds, and 4 out of 5 children are boys.The alarmingly increasing rate, as well as the impossibility to prevent this disorder, as its causes are not completely clear, the diversity of its symptoms, the precarious social integration and the big number of ineffectual therapies are the key elements that have determined us to pursue this research. The aim of this study is that of demonstrating that the multisystemic therapy (MST) in water and the cognitive therapy play an important role in the multidisciplinary process of recovering and integrating the autistic children in society. Keywords: autism, deviant behavior, alternative therapy, psychomotor education.

scholarly journals Requirements for the teacher-therapist of persons with autism spectrum disorder – challenges for the new specialisation

1970 ◽  
Author(s):  
Joanna Buława-Halasz
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Autistic People ◽  
Adam Mickiewicz

Joanna Buława-Halasz, Requirements for the teacher-therapist of persons with autism spectrum disorder – challenges for the new specialisation. Interdisciplinary Contexts of Special Pedagogy, no. 27, Poznań 2019. Pp. 335–349. Adam Mickiewicz University Press. ISSN 2300-391X. e-ISSN 2658-283X. DOI: https://doi.org/ 10.14746/ikps.2019.27.15 The text concerns the introduced standards for educating teachers-therapists of persons with autism spectrum disorder. This new specialisation in special pedagogy is meant to respond to the needs of autistic people, but its form is not fully responsive to real needs in this area.

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