scholarly journals A Novel Discovery: Holistic Efficacy at the Special Organ Level of Pungent Flavored Compounds from Pungent Traditional Chinese Medicine

2019 ◽  
Vol 20 (3) ◽  
pp. 752 ◽  
Author(s):  
Zhao Chen ◽  
Yanfeng Cao ◽  
Yanling Zhang ◽  
Yanjiang Qiao
Keyword(s):  
Cardiovascular Diseases ◽  
Liver Diseases ◽  
Skin Diseases ◽  
Gastrointestinal Diseases ◽  
Vital Role ◽  
The Body ◽  
Body Parts ◽  
Systems Pharmacology ◽  
Systematic Strategy ◽  
Organ Level

Pungent traditional Chinese medicines (TCMs) play a vital role in the clinical treatment of hepatobiliary disease, gastrointestinal diseases, cardiovascular diseases, diabetes, skin diseases and so on. Pungent TCMs have a vastness of pungent flavored (with pungent taste or smell) compounds. To elucidate the molecular mechanism of pungent flavored compounds in treating cardiovascular diseases (CVDs) and liver diseases, five pungent TCMs with the action of blood-activating and stasis-resolving (BASR) were selected. Here, an integrated systems pharmacology approach is presented for illustrating the molecular correlations between pungent flavored compounds and their holistic efficacy at the special organ level. First, we identified target proteins that are associated with pungent flavored compounds and found that these targets were functionally related to CVDs and liver diseases. Then, based on the phenotype that directly links human genes to the body parts they affect, we clustered target modules associated with pungent flavored compounds into liver and heart organs. We applied systems-based analysis to introduce a pungent flavored compound-target-pathway-organ network that clarifies mechanisms of pungent substances treating cardiovascular diseases and liver diseases by acting on the heart/liver organ. The systems pharmacology also suggests a novel systematic strategy for rational drug development from pungent TCMs in treating cardiovascular disease and associated liver diseases.

scholarly journals Positive and negative aspects of sauna bathing – current knowledge status

2021 ◽  
Vol 11 (9) ◽  
pp. 497-503
Author(s):  
Mateusz Sobczyk ◽  
Paulina Oleksa ◽  
Piotr Wójcik ◽  
Daria Żuraw ◽  
Monika Rogowska ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Skin Diseases ◽  
Musculoskeletal Diseases ◽  
Current Knowledge ◽  
Physical Exertion ◽  
The Body ◽  
Historical Outline ◽  
Sauna Bathing ◽  
Recreational Services ◽  
Health Promoting

Introduction: Sauna bathing as a health-promoting activity has been known to mankind for millennia. Sauna session, which consists of alternate overheating and then rapidly cooling the body, has a beneficial effect on the health of the body confirmed by scientific research. In the last few decades, sauna bathing has become more available due to the growing market of recreational services such as water parks and sauna parks. Regular use of sauna bathing reduces the risk of cardiovascular diseases, musculoskeletal disorders, mental stress, accelerates the process of regeneration after physical exertion, as well as increases resistance to the harmful effects of certain environmental factors. Despite the health benefits known for many years, the physiological mechanisms occurring in the body during sauna sessions still remain unknown. Sauna bathing treatments can be an effective complement to the process of treatment and rehabilitation of patients with cardiovascular diseases, musculoskeletal diseases, respiratory tract diseases, skin diseases and many others. Material and methods: A literature analysis on sauna bathing was carried out within the Pubmed and Google scholar platforms. The following keywords were used in search: sauna bathing, infrared sauna, cardiovascular diseases.  Purpose of the work: The aim of the following analysis is to present a historical outline of the use of sauna bathing, the health aspect, risks and the assumptions and indicating an important need for further research into the effects of sauna bathing on the body.

scholarly journals RELATIONSHIP BETWEEN POOR DIGESTION AND DISEASE IN PERSPECTIVE OF GRECOARAB MEDICINE

2020 ◽  
pp. 46-47
Author(s):  
Tasfiya Hakeem Ansari ◽  
Mohd. Zulkifle
Keyword(s):  
Skin Diseases ◽  
Well Being ◽  
Relevant Information ◽  
Vital Role ◽  
The Body ◽  
Classical Literature ◽  
Broad Term ◽  
Extensive Stage ◽  
Mental Well Being ◽  
The Relationship

Ingested food undergoes extensive stage-wise processing inside the body so that it can provide nourishment to the tissues. This stage-wise processing of food in Greco-Arab medicine is known as digestion. Innate heat plays a vital role in digestion. In Greco-Arab medicine, digestion is a broad term that includes digestion as well as the metabolism of food. Physicians like Galen, Rhazes and Avicenna, etc. believed that good digestion plays a key role in corporal and mental well being. In the classical literature of Greco-Arab medicine various diseases are described that are caused by poor digestion. Several skin diseases like acne as well as mental diseases like depression etc. are related to poor digestion. This relationship between poor digestion and disease is attributed to the production of morbid matter. Relevant literary material is collected from the classical literature of Greco-Arab medicine. Present work is an attempt to analyze and systematize the relevant information regarding the relationship between poor digestion and disease.

scholarly journals Influence of Fabric Parameterso Wicking Behaviour of Polyester/Lycra Knitted Fabrics

2019 ◽  
Vol 9 (1) ◽  
pp. 3864-3867
Keyword(s):  
Cross Section ◽  
Moisture Transport ◽  
Skin Diseases ◽  
Cotton Fabrics ◽  
Vital Role ◽  
The Body ◽  
Loop Length ◽  
Knitted Fabrics ◽  
Transport Behavior ◽  
Single Jersey

Wicking is one of the important properties of fabrics which decide its utility. The sweat generated in the body should be absorbed by the fabric as otherwise it may lead to skin diseases. It is advised that cotton fabrics should be worn net to the skin in order to get comfort to the wearer. This article is concerned with wicking which plays a vital role in determining comfort and moisture transport behavior of fabric and also into find out the effect of four parameters of single jersey, rib and pique knitted structures on the wickability. Parameters taken for the study were polyester cross-section, lycra denier used, plated structure and loop length.

scholarly journals Alcohol Induced Liver Cirrhosis and its Treatment

2020 ◽  
Vol 7 (2) ◽  
pp. 61-70
Author(s):  
Mohit Gururan
Keyword(s):  
Liver Cirrhosis ◽  
Liver Diseases ◽  
Vital Role ◽  
The Body ◽  
Severe Liver ◽  
Chronic Alcohol Consumption ◽  
Alcoholic Liver Diseases ◽  
Disease Factor ◽  
Over Time ◽  
Complex Organ

The advent of liver diseases globally contributes to a major burden in terms of mortality rate and disease factor. The liver, which is a major complex organ, plays a vital role in the metabolism of the body. The diseases associated with the consumption of alcohol such as cirrhosis and cancer that can be diagnosed through various pathological and cytopathological methods. This review insights how the normally functioning liver cells become vulnerable and lead to the onset of various fatal disorders if left untreated. The alcohol, unlike other drinks, is directly absorbed from the stomach into the bloodstream and is further metabolized by the hepatocytes. The products of alcohol breakdown, such as aldehyde, are toxic to hepatocytes and thus cause liver injury, in cases of chronic alcohol consumption. This injury to the hepatocytes evolves over time and leads to liver cirrhosis. The only cure for severe liver cirrhosis is a transplant of the liver. On the whole, the widespread consumption of alcohol, its making, and effects on the hepatocytes on chronic consumption, which leads to alcoholic liver diseases reviewed.

scholarly journals Pattern of Skin Diseases at Upazilla Level

2017 ◽  
Vol 6 (1) ◽  
pp. 8-11
Author(s):  
Abu Jafar Md Shahidul Hoq ◽  
Gazi Md Matiur Rahman ◽  
Fahmida Sultana ◽  
Mahmudul Hasan
Keyword(s):  
Health Care ◽  
Bacterial Infections ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Personal Characteristics ◽  
Vital Role ◽  
The Body ◽  
Polymorphic Light Eruption ◽  
Primary Health ◽  
Primary Health Care Settings

Skin the largest organ in the human body plays a vital role in one's health care. This anatomical barrier regulates the body temperature and interface with the environment for protecting the body against pathogens. The type of skin problems varies in different geographical areas, climate, economic and other factors including personal characteristics such as age and sex. The pattern of skin diseases varies from one area to another and across different parts within the same country. A retrospective study was done among patient attending Upazilla health complex, South Matlab OPD during the period January 2014 to 31 Dec 2014. To determine the pattern of skin diseases seen in a rural upazilla community. All patients attending the Skin & VD outpatient department were included in this study. All those with dermatological complaints were examined in detail, brief relevant history was elicited and clinical diagnosis was made by a consultant dermatologist.  Patient of Skin diseases comprised 8984 (12 % of total 74870 patients at OPD). The most common age group was 11-20 years (36.06%). Infective disorders were found in 62% and non-infective disorders in 32%, of all the dermatological cases. Fungal infections (48.20%) were the most common among infective dermatoses, whereas bacterial infections were 2nd in position. Among the non-infective dermatoses, eczemas were the most common (33.54%) followed by urticaria (23.78%).  In our study, higher prevalence of infective dermatoses especially fungal infections was more common at rural upazilla level. Since the placement of dermatologists at Upazilla Health Complexes, non-infective dermatoses were also identified in great numbers e.g. Urticaria, Psoriasis, Lichen planus, Pityriasisalba Polymorphic Light Eruption, and vitiligo. These patients were diagnosed, treated and followed up regularly at primary health care settings. CBMJ 2017 January: Vol. 06 No. 01 P: 08-11

scholarly journals Capsaicin: Plants of the Genus Capsicum and Positive Effect of Oriental Spice on Skin Health

2021 ◽  
pp. 1-11
Author(s):  
Shahnai Basharat ◽  
Syed Amir Gilani ◽  
Faiza Iftikhar ◽  
Mian Anjum Murtaza ◽  
Ayesha Basharat ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Transient Receptor Potential ◽  
Skin Diseases ◽  
Positive Impact ◽  
Receptor Potential ◽  
Vital Role ◽  
Nerve Fibers ◽  
The Body ◽  
Transient Receptor ◽  
Chili Peppers

<b><i>Background:</i></b> Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in <i>Capsicum</i> fruits. <b><i>Summary:</i></b> Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. <b><i>Key Messages:</i></b> Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome.

Formulation, Design and Development of Niosome Based Topical Gel for Skin Cancer

2017 ◽  
Vol 2 (3) ◽  
Keyword(s):  
Skin Cancer ◽  
Drug Release ◽  
Hemorrhagic Cystitis ◽  
The Body ◽  
Cancer Drug ◽  
Inversion Method ◽  
Body Parts ◽  
Basal Cells ◽  
Formulation Design ◽  
Topical Gel

Melanoma is the most dangerous type of skin cancer in which mostly damaged unpaired DNA starts mutating abnormally and staged an unprecedented proliferation of epithelial skin to form a malignant tumor. In epidemics of skin, pigment-forming melanocytes of basal cells start depleting and form uneven black or brown moles. Melanoma can further spread all over the body parts and could become hard to detect. In USA Melanoma kills an estimated 10,130 people annually. This challenge can be succumbed by using the certain anti-cancer drug. In this study design, cyclophosphamide were used as a model drug. But it has own limitation like mild to moderate use may cause severe cytopenia, hemorrhagic cystitis, neutropenia, alopecia and GI disturbance. This is a promising challenge, which is caused due to the increasing in plasma drug concentration above therapeutic level and due to no rate limiting steps involved in formulation design. In this study, we tried to modify drug release up to threefold and extended the release of drug by preparing and designing niosome based topical gel. In the presence of Dichloromethane, Span60 and cholesterol, the initial niosomes were prepared using vacuum evaporator. The optimum percentage drug entrapment efficacy, zeta potential, particle size was found to be 72.16%, 6.19mV, 1.67µm.Prepared niosomes were further characterized using TEM analyzer. The optimum batch of niosomes was selected and incorporated into topical gel preparation. Cold inversion method and Poloxamer -188 and HPMC as core polymers, were used to prepare cyclophosphamide niosome based topical gel. The formula was designed using Design expert 7.0.0 software and Box-Behnken Design model was selected. Almost all the evaluation parameters were studied and reported. The MTT shows good % cell growth inhibition by prepared niosome based gel against of A375 cell line. The drug release was extended up to 20th hours. Further as per ICH Q1A (R2), guideline 6 month stability studies were performed. The results were satisfactory and indicating a good formulation approach design was achieved for Melanoma treatment.

Re-imagining Reproduction: Unsettling Metaphors in the History of Imperial Science and Commercial Surrogacy in India

Somatechnics ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 88-103 ◽  
Author(s):  
Kalindi Vora
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
The Body ◽  
Body Parts ◽  
Colonial History ◽  
Women's Bodies ◽  
Commercial Surrogacy ◽  
Art Practices ◽  
History Of ◽  
Travel Industry

This paper provides an analysis of how cultural notions of the body and kinship conveyed through Western medical technologies and practices in Assisted Reproductive Technologies (ART) bring together India's colonial history and its economic development through outsourcing, globalisation and instrumentalised notions of the reproductive body in transnational commercial surrogacy. Essential to this industry is the concept of the disembodied uterus that has arisen in scientific and medical practice, which allows for the logic of the ‘gestational carrier’ as a functional role in ART practices, and therefore in transnational medical fertility travel to India. Highlighting the instrumentalisation of the uterus as an alienable component of a body and subject – and therefore of women's bodies in surrogacy – helps elucidate some of the material and political stakes that accompany the growth of the fertility travel industry in India, where histories of privilege and difference converge. I conclude that the metaphors we use to structure our understanding of bodies and body parts impact how we imagine appropriate roles for people and their bodies in ways that are still deeply entangled with imperial histories of science, and these histories shape the contemporary disparities found in access to medical and legal protections among participants in transnational surrogacy arrangements.

Deadlift Recognition and Application based on Multiple Modalities using Recurrent Neural Network

2020 ◽  
Vol 2020 (17) ◽  
pp. 2-1-2-6
Author(s):  
Shih-Wei Sun ◽  
Ting-Chen Mou ◽  
Pao-Chi Chang
Keyword(s):  
Neural Network ◽  
Recurrent Neural Network ◽  
Network Structure ◽  
Inertial Sensors ◽  
Body Movement ◽  
The Body ◽  
Body Parts ◽  
Multimodal Sensing ◽  
Multiple Devices ◽  
Neural Network Structure

To improve the workout efficiency and to provide the body movement suggestions to users in a “smart gym” environment, we propose to use a depth camera for capturing a user’s body parts and mount multiple inertial sensors on the body parts of a user to generate deadlift behavior models generated by a recurrent neural network structure. The contribution of this paper is trifold: 1) The multimodal sensing signals obtained from multiple devices are fused for generating the deadlift behavior classifiers, 2) the recurrent neural network structure can analyze the information from the synchronized skeletal and inertial sensing data, and 3) a Vaplab dataset is generated for evaluating the deadlift behaviors recognizing capability in the proposed method.

Our Bodies, Whose Property?

2013 ◽  
Author(s):  
Anne Phillips
Keyword(s):  
Labor Markets ◽  
Personal Autonomy ◽  
The Body ◽  
Body Parts ◽  
Complex Issue ◽  
Human Organs ◽  
Property Owners ◽  
The Common ◽  
The Difference ◽  
The Right

No one wants to be treated like an object, regarded as an item of property, or put up for sale. Yet many people frame personal autonomy in terms of self-ownership, representing themselves as property owners with the right to do as they wish with their bodies. Others do not use the language of property, but are similarly insistent on the rights of free individuals to decide for themselves whether to engage in commercial transactions for sex, reproduction, or organ sales. Drawing on analyses of rape, surrogacy, and markets in human organs, this book challenges notions of freedom based on ownership of our bodies and argues against the normalization of markets in bodily services and parts. The book explores the risks associated with metaphors of property and the reasons why the commodification of the body remains problematic. The book asks what is wrong with thinking of oneself as the owner of one's body? What is wrong with making our bodies available for rent or sale? What, if anything, is the difference between markets in sex, reproduction, or human body parts, and the other markets we commonly applaud? The book contends that body markets occupy the outer edges of a continuum that is, in some way, a feature of all labor markets. But it also emphasizes that we all have bodies, and considers the implications of this otherwise banal fact for equality. Bodies remind us of shared vulnerability, alerting us to the common experience of living as embodied beings in the same world. Examining the complex issue of body exceptionalism, the book demonstrates that treating the body as property makes human equality harder to comprehend.

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