scholarly journals Developing LRP1 Agonists into a Therapeutic Strategy in Acute Myocardial Infarction

2019 ◽  
Vol 20 (3) ◽  
pp. 544 ◽  
Author(s):  
Nicola Potere ◽  
Marco Del Buono ◽  
Giampaolo Niccoli ◽  
Filippo Crea ◽  
Stefano Toldo ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ischemia Reperfusion ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Therapeutic Window ◽  
Naturally Occurring ◽  
Survival Pathways ◽  
Density Lipoprotein Receptor ◽  
Reperfusion Injury Salvage Kinase

Cardioprotection refers to a strategy aimed at enhancing survival pathways in the injured yet salvageable myocardium following ischemia-reperfusion. Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional receptor that can be targeted following reperfusion, to induce a cardioprotective signaling through the activation of the reperfusion injury salvage kinase (RISK) pathway. The data from preclinical studies with non-selective and selective LRP1 agonists are promising, showing a large therapeutic window for intervention to reduce infarct size after ischemia-reperfusion. A pilot clinical trial with plasma derived α1-antitrypsin (AAT), a naturally occurring LRP1 agonist, supports the translational value of LRP1 as a novel therapeutic target for cardioprotection. A phase I study with a selective LRP1 agonist has been completed showing no toxicity. These findings may open the way to early phase clinical studies with pharmacologic LRP1 activation in patients with acute myocardial infarction (AMI).

Clinical Significance of the Antibody against Oxidized Low-Density Lipoprotein in Acute Myocardial Infarction

Cardiology ◽  
2002 ◽  
Vol 98 (1-2) ◽  
pp. 13-17 ◽  
Author(s):  
Teruo Inoue ◽  
Isao Yaguchi ◽  
Toshihiko Uchida ◽  
Hirotoshi Kamishirado ◽  
Shiro Nakahara ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Clinical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein

Changes in plasma lipids and low-density lipoprotein peak particle size during and after acute myocardial infarction

2002 ◽  
Vol 89 (4) ◽  
pp. 460-462 ◽  
Author(s):  
Carlo M Barbagallo ◽  
Manfredi Rizzo ◽  
Angelo B Cefalù ◽  
Davide Noto ◽  
Antonio Scimeca ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Particle Size ◽  
Plasma Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density

scholarly journals Protein C Deficiency in a Patient of Acute Myocardial Infarction

1970 ◽  
Vol 3 (1) ◽  
pp. 34-35 ◽  
Author(s):  
Tamzeed Ahmed ◽  
Mahbub Mansur
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Protein C ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Oxidase Inhibitor ◽  
Coronary Angiogram ◽  
Protein C Deficiency ◽  
Xanthine Oxidase Inhibitor

A 42-year old male presented with acute myocardial infarction with no discernable risk factors; he never smoked; did not suffer from diabetes and had a well controlled blood pressure with single medication; plasma concentration of total cholesterol was on the upper normal limit, high and low density lipoprotein, cholesterol and triglyceride being normal. In addition to a single antihypertensive he received Allupurinol (Xanthine Oxidase inhibitor) for hyperuricaemia. Coronary angiogram revealed ectatic epicardial coronary arteries. The patient developed deep vein thrombosis of right leg after four days of the coronary angiogram. Coagulation analysis revealed protein C deficiency. The recognition of protein C deficiency as a risk factor for myocardial infarction is important as anticoagulators prevent further thrombotic events whereas inhibitors of platelet aggregation are ineffective. Ibrahim Med. Coll. J. 2009; 3(1): 34-35 Key words: myocardial infarction, risk factors, protein C deficiency, anticoagulation.   doi: 10.3329/imcj.v3i1.2918

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