scholarly journals DNA Modified with Boron–Metal Cluster Complexes [M(C2B9H11)2]—Synthesis, Properties, and Applications

2018 ◽  
Vol 19 (11) ◽  
pp. 3501 ◽  
Author(s):  
Agnieszka Olejniczak ◽  
Barbara Nawrot ◽  
Zbigniew Leśnikowski
Keyword(s):  
Nucleic Acids ◽  
Metal Cluster ◽  
Building Blocks ◽  
Molecular Wires ◽  
Molecular Structures ◽  
Metal Centers ◽  
Cluster Complexes ◽  
Boron Cluster ◽  
Nucleic Acid Therapeutics ◽  
Synthesis Properties

Together with tremendous progress in biotechnology, nucleic acids, while retaining their status as “molecules of life”, are becoming “molecular wires”, materials for the construction of molecular structures at the junction between the biological and abiotic worlds. Herein, we present an overview of the approaches for incorporating metal centers into nucleic acids based on metal–boron cluster complexes (metallacarboranes) as the metal carriers. The methods are modular and versatile, allowing practical access to innovative metal-containing DNA for various applications, such as nucleic acid therapeutics, electrochemical biosensors, infrared-sensitive probes, and building blocks for nanoconstruction.

Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

Nanoscale ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 103-114 ◽  
Author(s):  
Damian Kaniowski ◽  
Katarzyna Ebenryter-Olbinska ◽  
Katarzyna Kulik ◽  
Slawomir Janczak ◽  
Anna Maciaszek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nucleic Acids ◽  
Gene Expression Regulation ◽  
Therapeutic Potential ◽  
Building Blocks ◽  
New Materials ◽  
Boron Cluster ◽  
Boron Clusters ◽  
Functional Nanoparticles ◽  
Dual Action

The building blocks based on boron cluster spanning two short DNA adapters assemble into functional nanoparticles due to the formation of DNA helices. They offer dual-action therapeutic potential, e.g., in the BNCT and gene expression regulation.

Factors Affecting Molecular Self-Assembly and Its Mechanism

2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Molecular Structures ◽  
Polymer Science ◽  
New Approach ◽  
Factors Affecting ◽  
Dna Structures ◽  
Self Assembling ◽  
Wide Range

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.

Infrared spectroscopy of unsupported metal cluster complexes using multiple photon dissociation

1986 ◽  
Vol 85 (2) ◽  
pp. 1198-1199 ◽  
Author(s):  
M. R. Zakin ◽  
R. O. Brickman ◽  
D. M. Cox ◽  
K. C. Reichmann ◽  
D. J. Trevor ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Metal Cluster ◽  
Cluster Complexes

The chemistry of metal cluster complexes.

Polyhedron ◽  
1991 ◽  
Vol 10 (17) ◽  
pp. 2085-2086
Author(s):  
Cotton Simon
Keyword(s):  
Metal Cluster ◽  
Cluster Complexes

Cage Opening of a Carborane Ligand by Metal Cluster Complexes

2016 ◽  
Vol 22 (19) ◽  
pp. 6501-6504 ◽  
Author(s):  
Richard D. Adams ◽  
Joseph Kiprotich ◽  
Dmitry V. Peryshkov ◽  
Yuen Onn Wong
Keyword(s):  
Metal Cluster ◽  
Cluster Complexes ◽  
Carborane Ligand

scholarly journals Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1342 ◽  
Author(s):  
Aaron Alford ◽  
Brenna Tucker ◽  
Veronika Kozlovskaya ◽  
Jun Chen ◽  
Nirzari Gupta ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Defense Mechanisms ◽  
The Body ◽  
Stimuli Responsive ◽  
Triggered Release ◽  
Quadruplex Dna ◽  
Nucleic Acid Therapeutics ◽  
Wide Range ◽  
G Quadruplex ◽  
Hydrogel Capsules

Nucleic acid therapeutics have the potential to be the most effective disease treatment strategy due to their intrinsic precision and selectivity for coding highly specific biological processes. However, freely administered nucleic acids of any type are quickly destroyed or rendered inert by a host of defense mechanisms in the body. In this work, we address the challenge of using nucleic acids as drugs by preparing stimuli responsive poly(methacrylic acid)/poly(N-vinylpyrrolidone) (PMAA/PVPON)n multilayer hydrogel capsules loaded with ~7 kDa G-quadruplex DNA. The capsules are shown to release their DNA cargo on demand in response to both enzymatic and ultrasound (US)-triggered degradation. The unique structure adopted by the G-quadruplex is essential to its biological function and we show that the controlled release from the microcapsules preserves the basket conformation of the oligonucleotide used in our studies. We also show that the (PMAA/PVPON) multilayer hydrogel capsules can encapsulate and release ~450 kDa double stranded DNA. The encapsulation and release approaches for both oligonucleotides in multilayer hydrogel microcapsules developed here can be applied to create methodologies for new therapeutic strategies involving the controlled delivery of sensitive biomolecules. Our study provides a promising methodology for the design of effective carriers for DNA vaccines and medicines for a wide range of immunotherapies, cancer therapy and/or tissue regeneration therapies in the future.

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