scholarly journals Alterations of Signaling Pathways Related to the Immune System in Breast Cancer: New Perspectives in Patient Management

2018 ◽  
Vol 19 (9) ◽  
pp. 2733 ◽  
Author(s):  
Andrea Nicolini ◽  
Paola Ferrari ◽  
Lucrezia Diodati ◽  
Angelo Carpi
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Signaling Pathways ◽  
Cancer Patients ◽  
Immune Evasion ◽  
Experimental Studies ◽  
New Drugs ◽  
Breast Cancer Patients ◽  
Tumor Initiating Cells ◽  
Immune Manipulation

In recent years, immune manipulation for cancer treatment, including breast cancer, has been increasingly gaining consent, and many attempts have been made, mainly by either strengthening the immune response (IR) or by inhibiting immune evasion. Therefore, elucidating the related mechanisms is of importance due to the potential to improve the management of cancer patients by immunotherapy. This review article summarized some recent experimental studies, which have discovered novel alterations of signaling pathways related to the immune system in breast cancer. These altered signaling pathways have been grouped according to the general biological mechanism involved: tumor-initiating cells (TICs), cancer stem cells (CSCs), immune evasion, tumor growth and progression, prediction of clinical outcome and prediction of response, or resistance to chemotherapy. These altered pathways related to the immune system open clinical opportunities for the prognosis or treatment of patients. Many of these pathways are related to the origin of breast cancer and immune evasion. We recommended development of new drugs which act on these molecular pathways, and the designing of clinical trials to be carried out mainly in breast cancer patients who required adjuvant treatment.

scholarly journals Hyperactivated Signaling Pathways of Chemokine RANTES/CCL5 in Osteopathies of Jawbone in Breast Cancer Patients–-Case Report and Research

2014 ◽  
Vol 8 ◽  
pp. BCBCR.S15119 ◽  
Author(s):  
Johann Lechner ◽  
Volker Von Baehr
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Immune System ◽  
Signaling Pathways ◽  
Cancer Patients ◽  
The Other ◽  
Breast Cancer Patients ◽  
Immune Mediators ◽  
Healthy Control ◽  
Rantes Production

Background Hollow spaces in the jawbone have been defined as fatty degenerative osteonecrosis of jawbone (FDOJ) and have been linked with a dysregulated immune system. Little is known about the underlying relationship. Objectives Samples of FDOJ were analyzed to assess expression of cytokines which can play a role in the pathogenesis of breast cancer (MaCa). Material and Methods Samples of FDOJ extracted from 23 patients with MaCa and 19 healthy control jawbone samples were analyzed for 7 immune messengers. Results RANTES was found to be highly overexpressed in disease samples. No change was observed in expression levels of the other immune mediators. Discussion This data provides a compelling confirmation that FDOJ produces high levels of RANTES, a cytokine implicated in MaCa and metastasis. Levels detected in FDOJ are five-fold higher than that previously reported for MaCa tissue suggesting its role as a cytokine source in MaCa. Conclusion We thus hypothesize that FDOJ may serve as an expeditor of MaCa progression, through RANTES production.

Influence of physical activity on the immune system in breast cancer patients during chemotherapy

2018 ◽  
Vol 144 (3) ◽  
pp. 579-586 ◽  
Author(s):  
Thorsten Schmidt ◽  
Walter Jonat ◽  
Daniela Wesch ◽  
Hans-Heinrich Oberg ◽  
Sabine Adam-Klages ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Immune System ◽  
Cancer Patients ◽  
Breast Cancer Patients

Multidimensional visualization for the immune system state presentation in breast cancer patients

2015 ◽  
Author(s):  
M. Stakheyeva ◽  
D. Eidenzon ◽  
N. Cherdyntseva ◽  
E. Slonimskaya ◽  
E. Cherdyntsev
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Cancer Patients ◽  
System State ◽  
Breast Cancer Patients ◽  
Multidimensional Visualization

Mechanisms of immune evasion in triple-negative breast cancer patients.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 1096-1096
Author(s):  
Javier Ignacio Orozco ◽  
Ayla O. Manughian-Peter ◽  
Matthew P. Salomon ◽  
Steven O'Day ◽  
Dave S. B. Hoon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Triple Negative Breast Cancer ◽  
Immune Evasion ◽  
Triple Negative ◽  
Breast Cancer Patients

The effect of diet changes on the immune system of breast cancer patients

1993 ◽  
Vol 93 (9) ◽  
pp. A29 ◽  
Author(s):  
B.K Garritson ◽  
A Nikaein ◽  
M.A Gorman ◽  
G.N Peters ◽  
C King ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Cancer Patients ◽  
Breast Cancer Patients

FEATURES

2018 ◽  
Vol 22 (06) ◽  
pp. 16-39
Keyword(s):  
Breast Cancer ◽  
Artificial Intelligence ◽  
Cancer Research ◽  
Immune System ◽  
Cancer Patients ◽  
Molecular Diagnostics ◽  
Multidisciplinary Team ◽  
Clinical Utility ◽  
Breast Cancer Patients ◽  
Exercise Regime

Artificial Intelligence: saving lives and securing the future. The best pill for cancer patients: An exercise regime. Across the divide: Multidisciplinary team to achieve better outcomes for breast cancer patients. The state of cancer research in Asia. Clinical utility of and access to cancer molecular diagnostics in Asia. Reprogramming the immune system against cancer.

scholarly journals An Immune Model to Predict Prognosis of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Based on Support Vector Machine

2021 ◽  
Vol 11 ◽  
Author(s):  
Mozhi Wang ◽  
Zhiyuan Pang ◽  
Yusong Wang ◽  
Mingke Cui ◽  
Litong Yao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Support Vector Machine ◽  
Immune System ◽  
T Cell ◽  
Neoadjuvant Chemotherapy ◽  
Prediction Model ◽  
Cancer Patients ◽  
Immune Status ◽  
Support Vector ◽  
Breast Cancer Patients

Tumor microenvironment has been increasingly proved to be crucial during the development of breast cancer. The theory about the conversion of cold and hot tumor attracted the attention to the influences of traditional therapeutic strategies on immune system. Various genetic models have been constructed, although the relation between immune system and local microenvironment still remains unclear. In this study, we tested and collected the immune index of 262 breast cancer patients before and after neoadjuvant chemotherapy. Five indexes were selected and analyzed to form the prediction model, including the ratio values between after and before neoadjuvant chemotherapy of CD4+/CD8+ T cell ratio; lymphosum of T, B, and natural killer (NK) cells; CD3+CD8+ cytotoxic T cell percent; CD16+CD56+ NK cell absolute value; and CD3+CD4+ helper T cell percent. Interestingly, these characters are both the ratio value of immune status after neoadjuvant chemotherapy to the baseline. Then the prediction model was constructed by support vector machine (accuracy rate = 75.71%, area under curve = 0.793). Beyond the prognostic effect and prediction significance, the study instead emphasized the importance of immune status in traditional systemic therapies. The result provided new evidence that the dynamic change of immune status during neoadjuvant chemotherapy should be paid more attention.

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