scholarly journals The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

2018 ◽  
Vol 19 (9) ◽  
pp. 2729 ◽  
Author(s):  
Chung-Yi Chen ◽  
Chiu-Li Kao ◽  
Chi-Ming Liu
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Epigallocatechin Gallate ◽  
Caffeic Acid Phenethyl Ester ◽  
Host Immune System ◽  
Tlr4 Signaling ◽  
Tlr4 Signaling Pathway ◽  
Bioactive Phytochemicals ◽  
Anti Inflammatory

Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune system. TLR triggering leads to the induction of pro-inflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity. Recently, an increasing number studies have shown the link between TLRs and cancer. Among them, the toll-like receptor 4 (TLR4) signaling pathway is associated with inflammatory response and cancer progression. Dietary phytochemicals are potential modulators of immunological status with various pharmacological properties including anti-cancer, anti-oxidant and anti-inflammatory. Curcumin, 6-gingerol, 6-shogaol, 1-dehydro-10-gingerdione, epigallocatechin gallate (EGCG), luteolin, quercetin, resveratrol, caffeic acid phenethyl ester, xanthohumol, genistein, berberine, and sulforaphane can inhibit TLR4 activation. The aim of the present review is to describe the role of the TLR4 signaling pathway between inflammatory response and cancer progression. We further introduce bioactive phytochemicals with potential anti-inflammation and chemoprevention by inhibiting TLR activation.

Anti-inflammatory action of Athyrium multidentatum extract suppresses the LPS-induced TLR4 signaling pathway

2018 ◽  
Vol 217 ◽  
pp. 220-227 ◽  
Author(s):  
Xiong-Zhe Han ◽  
Rui Ma ◽  
Qi Chen ◽  
Xin Jin ◽  
Yuan-Zhe Jin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tlr4 Signaling ◽  
Tlr4 Signaling Pathway ◽  
Anti Inflammatory ◽  
Inflammatory Action

scholarly journals Glycyrrhizin Ameliorates Radiation Enteritis in Mice Accompanied by the Regulation of the HMGB1/TLR4 Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Xiao-min Zhang ◽  
Xiao Hu ◽  
Jin-ying Ou ◽  
Shan-shan Chen ◽  
Ling-hui Nie ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Inflammatory Cytokines ◽  
Molecular Mechanisms ◽  
Radiation Enteritis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Intestinal Damage ◽  
Tlr4 Signaling ◽  
Pelvic Malignancies ◽  
Tlr4 Signaling Pathway ◽  
Anti Inflammatory

Radiation enteritis is a common side effect of radiotherapy for abdominal and pelvic malignancies, which can lead to a decrease in patients’ tolerance to radiotherapy and the quality of life. It has been demonstrated that glycyrrhizin (GL) possesses significant anti-inflammatory activity. However, little is known about its anti-inflammatory effect in radiation enteritis. In the present study, we aimed to investigate the potential anti-inflammatory effects of GL on radiation enteritis and elucidate the possible underlying molecular mechanisms involved. The C57BL/6 mice were subjected to 6.5 Gy abdominal X-ray irradiation to establish a model of radiation enteritis. Hematoxylin and eosin staining was performed to analyze the pathological changes in the jejunum. The expression of TNF-α in the jejunum was analyzed by immunochemistry. The levels of inflammatory cytokines, such as TNF-α, IL-6, IL-1β, and HMGB1 in the serum were determined by enzyme-linked immunosorbent assay. The intestinal absorption capacity was tested using the D-xylose absorption assay. The levels of HMGB1 and TLR4 were analyzed by western blotting and immunofluorescence staining. We found that GL significantly alleviated the intestinal damage and reduced the levels of inflammatory cytokines, such as TNF-α, IL-6, IL-1β, and HMGB1 levels. Furthermore, the HMGB1/TLR4 signaling pathway was significantly downregulated by GL treatment. In conclusion, these findings indicate that GL has a protective effect against radiation enteritis through the inhibition of the intestinal damage and the inflammatory responses, as well as the HMGB1/TLR4 signaling pathway. Thereby, GL might be a potential therapeutic agent for the treatment of radiation enteritis.

scholarly journals TLR4-Mediated Blunting of Inflammatory Responses to Eccentric Exercise in Young Women

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Rodrigo Fernandez-Gonzalo ◽  
José A. De Paz ◽  
Paula Rodriguez-Miguelez ◽  
María J. Cuevas ◽  
Javier González-Gallego
Keyword(s):  
Inflammatory Response ◽  
Training Program ◽  
Signaling Pathway ◽  
Young Women ◽  
Eccentric Exercise ◽  
Inflammatory Responses ◽  
Control Group ◽  
Eccentric Training ◽  
Tlr4 Signaling ◽  
Tlr4 Signaling Pathway

This study assessed the inflammatory response mediated by the toll-like receptor 4 (TLR4) signaling pathway after acute eccentric exercise before and after an eccentric training program in women. Twenty women performed two acute eccentric bouts using a squat machine over a ~9 week interval. The training group (TG) carried out an eccentric training program during 6 weeks, while the control group (CG) did not follow any training. Protein content of markers involved in the TLR4-mediated activation of several nuclear transcription factors, such as nuclear factorκB (NF-κB), and interferon regulatory transcription factor 3 (IRF3), was analyzed. The inflammatory response after the first acute bout was similar between TG and CG, showing an upregulation of all the markers analyzed, with the exception of IRF3. After the second bout, the upregulation of TLR4 signaling pathway was blunted in TG, but not in CG, through both the myeloid differentiation factor 88- and toll/interleukin-1 receptor domain containing adapter inducing interferon-β-dependent pathways. These results highlight the role of the TLR4 in controlling the exercise-induced inflammatory response in young women. More importantly, these data suggest eccentric training may help to prevent TLR4 activation principally through NF-κB, and perhaps IRF3, downstream signaling in this population.

Sign in / Sign up

Export Citation Format

Share Document