scholarly journals Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

2018 ◽  
Vol 19 (8) ◽  
pp. 2321 ◽  
Author(s):  
Chong Xue ◽  
Huanyu Lu ◽  
Ying Liu ◽  
Jianbin Zhang ◽  
Jiye Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chinese Medicine ◽  
Cold Stress ◽  
Ferulic Acid ◽  
Heat Production ◽  
Cold Environment ◽  
Stress Injury ◽  
Cold Acclimatization ◽  
Prevention And Treatment ◽  
Radix Aconiti

Trans-ferulic acid-4-β-glucoside (C16H20O9, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.

The effect of jute coats on the heat losses of two breeds of sheep exposed to different environments

1967 ◽  
Vol 9 (4) ◽  
pp. 483-490 ◽  
Author(s):  
A. J. F. Webster ◽  
C. Park
Keyword(s):  
Cold Stress ◽  
Heat Production ◽  
Heat Losses ◽  
Cold Environment ◽  
British Isles ◽  
Wind Speeds ◽  
External Insulation ◽  
Different Types ◽  
Grazing Sheep

Experiments were carried out to measure the effects of wearing jute coats on the heat production and external insulation of Blackface and Cheviot sheep during exposure to different types of cold environment. The results showed that wearing coats did not appreciably increase external insulation in cold conditions at wind speeds up to 10 mph when the fleece was dry. In cold, wet and windy conditions, wearing coats prevented moisture from penetrating the fleece of the sheep so that external insulation was 25–27 units when the sheep were wearing coats, but only 15–18 units when they were not.It has been shown that few environments likely to occur in Britain constitute a cold stress for grazing sheep if their external insulation is above 25 units. Wind and rain reduced the external insulation of sheep with full winter fleeces below this value only when they were not wearing coats. It is concluded, therefore, that jute coats have a considerable value in ameliorating the effects of cold stresses of the type likely to be encountered by hill sheep wintered out of doors in the British Isles.

Dietary supplementation of ferulic acid improves performance and alleviates oxidative stress of lambs in a cold environment

2019 ◽  
Vol 99 (4) ◽  
pp. 705-712 ◽  
Author(s):  
Yuan Wang ◽  
Wenwen Wang ◽  
Ruifang Wang ◽  
Ziqi Meng ◽  
Yuanxiao Duan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ferulic Acid ◽  
Growth Performance ◽  
Average Daily Gain ◽  
Dietary Supplementation ◽  
Neutral Detergent Fiber ◽  
Cold Environment ◽  
Plasma Glutathione Peroxidase ◽  
Mda Content ◽  
Dietary Treatments

Ferulic acid (FA) has been regarded as an antioxidant in domestic animals’ feed. This study was to investigate whether dietary FA supplementation could improve growth performance by decreasing oxidative stress of lambs in cold environment. Thirty-two 3-mo-old crossbred male lambs (Dorper × Small-tail Han sheep; 30.49 ± 0.46 kg) were randomly assigned into one of the following dietary treatments: CON (control, no FA), FA80 (80 mg FA kg−1of diet), FA400 (400 mg FA kg−1of diet), and FA2000 (2000 mg FA kg−1of diet). Lambs fed the FA80 had higher (P < 0.05) average daily gain and lower (P < 0.05) feed efficiency than those fed CON and FA2000. The dry matter, organic matter, and neutral detergent fiber apparent digestibility was lower (P < 0.05) for FA2000 lambs than for lambs from other treatments. Serum total protein and albumin concentrations were greater (P < 0.05) for FA80 group than other groups. Lambs fed FA80 had higher (P < 0.05) plasma glutathione peroxidase and catalase activities and lower (P < 0.05) malondialdehyde (MDA) content than lambs fed CON. However, FA2000 group showed higher (P < 0.05) plasma MDA content than CON group. In conclusion, dietary supplementation of 80 mg FA kg−1diet could improve growth performance by decreasing oxidative stress of lambs in cold environment.

scholarly journals Crosstalk between MicroRNA and Oxidative Stress in Primary Open-Angle Glaucoma

2021 ◽  
Vol 22 (5) ◽  
pp. 2421
Author(s):  
Saray Tabak ◽  
Sofia Schreiber-Avissar ◽  
Elie Beit-Yannai
Keyword(s):  
Oxidative Stress ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Additional Treatment ◽  
Type I ◽  
Open Angle ◽  
Outflow Resistance ◽  
Stress Injury

Reactive oxygen species (ROS) plays a key role in the pathogenesis of primary open-angle glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular meshwork (TM) cells, inducing apoptosis of the retinal ganglion cells (RGC), deteriorating the optic nerve head, and leading to blindness. Aqueous humor (AH) outflow resistance and intraocular pressure (IOP) elevation contribute to disease progression. Nevertheless, despite the existence of pharmacological and surgical treatments, there is room for the development of additional treatment approaches. The following review is aimed at investigating the role of different microRNAs (miRNAs) in the expression of genes and proteins involved in the regulation of inflammatory and degenerative processes, focusing on the delicate balance of synthesis and deposition of extracellular matrix (ECM) regulated by chronic oxidative stress in POAG related tissues. The neutralizing activity of a couple of miRNAs was described, suggesting effective downregulation of pro-inflammatory and pro-fibrotic signaling pathways, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), transforming growth factor-beta 2 (TGF-β2), Wnt/β-Catenin, and PI3K/AKT. In addition, with regards to the elevated IOP in many POAG patients due to increased outflow resistance, Collagen type I degradation was stimulated by some miRNAs and prevented ECM deposition in TM cells. Mitochondrial dysfunction as a consequence of oxidative stress was suppressed following exposure to different miRNAs. In contrast, increased oxidative damage by inhibiting the mTOR signaling pathway was described as part of the action of selected miRNAs. Summarizing, specific miRNAs may be promising therapeutic targets for lowering or preventing oxidative stress injury in POAG patients.

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