scholarly journals Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis?

2018 ◽  
Vol 19 (6) ◽  
pp. 1820 ◽  
Author(s):  
Witold Kolber ◽  
Paulina Dumnicka ◽  
Małgorzata Maraj ◽  
Beata Kuśnierz-Cabala ◽  
Piotr Ceranowicz ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Interleukin 6 ◽  
Automatic Measurement ◽  
Prediction Of Complications

INTERLEUKIN 6 AND CRP IN THE PREDICTION THE SEVERITY IN PATIENTS OF ACUTE PANCREATITIS

2015 ◽  
pp. 29-35
Author(s):  
Van Xung Nguyen ◽  
Van Huy Tran
Keyword(s):  
Acute Pancreatitis ◽  
Key Words ◽  
Interleukin 6 ◽  
Accuracy Rate ◽  
Background Data ◽  
Single Marker ◽  
Key Words Interleukin 6

Background: Data about the value of interleukin 6 and CRP in the prediction of severity of acute pancreatitis (AP) is still limited. This study is aimed at assessing the values of interleukin 6 and CRP in the prediction the severity of AP. Patients and methods: 55 patients with AP were enrolled. Interleukin was measured at 2 times: the 1st and the 3rd days. Results: IL-6 level day 1 in severe AP (168.86 ± 70.65 pg/ml) was significantly higher than in mild AP (89.54 ± 28.81 pg/ml) and IL-6 day 3 in severe AP (58.64 ± 20.77 pg/ml) significantly higher than mild AP (29.73 ± 14.88 pg/ml). concerning the prediction of severity of AP, IL-6 in day 1 (with cut-off 113.36 pg/ml) had the sensitivity 81.25% and the specificity 84.64%, PPV 68.4% and NPV 91.7%, accuracy rate 88.8%, AUC 0.888 and respectively in day 3 (with cut-off 41.38 pg/ml were 87.5%; 87.18%; 73.7%; 4.4%; 86.7%; 0.867. The values in prediction of severity were significantly higher when combining IL 6 and CRP in compare with the single marker. Conclusion: Combining Interleukin 6 and CRP may have a good value in the prediction of the severity of AP. Key words: Interleukin 6, CRP, acute pancreatitis, severity.

scholarly journals Pancreas-Specific ARID1A Deficiency Promotes Acinar-to-Ductal Metaplasia and Elevates Interleukin-6 Expression in Experimental Pancreatitis Model

2021 ◽  
Author(s):  
Liming Zhang ◽  
Zhaoyun Li ◽  
Yong Zhou ◽  
Jie Zhu ◽  
Chong Jin ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Epigenetic Regulation ◽  
Interleukin 6 ◽  
Ex Vivo ◽  
Acinar Cells ◽  
Genetically Engineered ◽  
Ductal Cells ◽  
Inflammatory Conditions ◽  
Acinar To Ductal Metaplasia

Abstract Background: Although role of ARID1A in pancreatic homeostasis and tumorigenesis has been recently described using genetically engineered mouse (GEM) models, whether ARID1A plays a role in pancreatic inflammation and regeneration remains to be explored.Methods: Pancreas-specific Arid1a-deficient GEM model (Arid1adef) was generated by Ela1-Cre/ERT2 mice crossing with Arid1afl/fl mice and characterized histologically. In physiological and inflammatory conditions, serum amylase and lipase activity were measured to investigate effects of Arid1a deficiency on pancreatic secretion function. Histology analysis of pancreas was used to evaluate pancreatic lesions and recovery. Ex vivo primary acinar cell culture was employed to study acinar-to-ductal metaplasia (ADM) process. In HPNE cells, ARID1A knockdown and histone acetyltransferases inhibitors were used to explore epigenetic regulation on interleukin-6 (IL6) expression. Chromatin immunoprecipitation (ChIP) and quantitative real-time PCR were performed to analyze on IL6 promoters.Results: Arid1a deficiency promoted formation of ductal cysts characterized as silenced acinar genes and activated duct genes. Arid1a-deficient acinar cells were more inclined to trans-differentiation to ductal cells in cerulein-induced acute pancreatitis (AP) model. Expression analysis of proinflammatory cytokines reveals that ARID1A deficiency led to increased IL-6 expression in mice acinar cells and HPNE cells. ARID1A-associated histone acetylation partially involved in epigenetic regulation of IL-6. Conclusion: These results demonstrate ARID1A is involved in cerulein-induced AP development by mediating pro-inflammatory cytokines IL-6 and suggest that ARID1A-containing SWI/SNF complex is an epigenetic regulator of acute pancreatitis.

ABSENCE OF ENDOGENOUS INTERLEUKIN-6 ENHANCES THE INFLAMMATORY RESPONSE DURING ACUTE PANCREATITIS INDUCED BY CERULEIN IN MICE

Cytokine ◽  
2002 ◽  
Vol 18 (5) ◽  
pp. 274-285 ◽  
Author(s):  
Salvatore Cuzzocrea ◽  
Emanuela Mazzon ◽  
Laura Dugo ◽  
Tommaso Centorrino ◽  
Antonio Ciccolo ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Interleukin 6

Serum interleukin-6, interleukin-8, andβ 2-Microglobulin in early assessment of severity of acute pancreatitis comparison with serum C-reactive protein

1995 ◽  
Vol 40 (11) ◽  
pp. 2341-2348 ◽  
Author(s):  
Raffaele Pezzilli ◽  
Paola Billi ◽  
Rita Miniero ◽  
Manuela Fiocchi ◽  
Onda Cappelletti ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Interleukin 6 ◽  
Interleukin 8 ◽  
C Reactive Protein ◽  
Early Assessment ◽  
Reactive Protein
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