scholarly journals Classical Risk Factors and Inflammatory Biomarkers: One of the Missing Biological Links between Cardiovascular Disease and Major Depressive Disorder

2018 ◽  
Vol 19 (6) ◽  
pp. 1740 ◽  
Author(s):  
Thomas Baghai ◽  
Gabriella Varallo-Bedarida ◽  
Christoph Born ◽  
Sibylle Häfner ◽  
Cornelius Schüle ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Inflammatory Biomarkers ◽  
Major Depressive

scholarly journals The Association Between Major Depressive Disorder in Childhood and Risk Factors for Cardiovascular Disease in Adolescence

2014 ◽  
Vol 76 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Jonathan Rottenberg ◽  
Ilya Yaroslavsky ◽  
Robert M. Carney ◽  
Kenneth E. Freedland ◽  
Charles J. George ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive

Risk factors for dementia are not associated with cognitive dysfunction in young people with major depressive disorder

2019 ◽  
Vol 245 ◽  
pp. 140-144 ◽  
Author(s):  
Markus Donix ◽  
Robert Haussmann ◽  
Franziska Helling ◽  
Anne Zweiniger ◽  
Annett Werner ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Young People ◽  
Depressive Disorder ◽  
Cognitive Dysfunction ◽  
Major Depressive

scholarly journals An Underlying Common Factor, Influenced by Genetics and Unique Environment, Explains the Covariation Between Major Depressive Disorder, Generalized Anxiety Disorder, and Burnout: A Swedish Twin Study

2016 ◽  
Vol 19 (6) ◽  
pp. 619-627 ◽  
Author(s):  
Lisa Mather ◽  
Victoria Blom ◽  
Gunnar Bergström ◽  
Pia Svedberg
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Anxiety Disorder ◽  
Environmental Factors ◽  
Depressive Disorder ◽  
Generalized Anxiety Disorder ◽  
Common Factor ◽  
Generalized Anxiety ◽  
Major Depressive ◽  
Common Pathway

Depression and anxiety are highly comorbid due to shared genetic risk factors, but less is known about whether burnout shares these risk factors. We aimed to examine whether the covariation between major depressive disorder (MDD), generalized anxiety disorder (GAD), and burnout is explained by common genetic and/or environmental factors. This cross-sectional study included 25,378 Swedish twins responding to a survey in 2005–2006. Structural equation models were used to analyze whether the trait variances and covariances were due to additive genetics, non-additive genetics, shared environment, and unique environment. Univariate analyses tested sex limitation models and multivariate analysis tested Cholesky, independent pathway, and common pathway models. The phenotypic correlations were 0.71 (0.69–0.74) between MDD and GAD, 0.58 (0.56–0.60) between MDD and burnout, and 0.53 (0.50–0.56) between GAD and burnout. Heritabilities were 45% for MDD, 49% for GAD, and 38% for burnout; no statistically significant sex differences were found. A common pathway model was chosen as the final model. The common factor was influenced by genetics (58%) and unique environment (42%), and explained 77% of the variation in MDD, 69% in GAD, and 44% in burnout. GAD and burnout had additive genetic factors unique to the phenotypes (11% each), while MDD did not. Unique environment explained 23% of the variability in MDD, 20% in GAD, and 45% in burnout. In conclusion, the covariation was explained by an underlying common factor, largely influenced by genetics. Burnout was to a large degree influenced by unique environmental factors not shared with MDD and GAD.

scholarly journals Incidence and Risk Factors for Suicide Attempts in Patients Diagnosed with Major Depressive Disorder

2020 ◽  
Vol Volume 13 ◽  
pp. 1147-1157
Author(s):  
Angélica Gonçalves Peter ◽  
Mariane Lopez Molina ◽  
Taiane de Azevedo Cardoso ◽  
Thaíse Campos Mondin ◽  
Ricardo Azevedo da Silva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicide Attempts ◽  
Major Depressive ◽  
Risk Factors For Suicide

scholarly journals Risk factors for further sick leave among Japanese workers returning to work after an episode of major depressive disorder: a prospective follow-up study over 1 year

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e029705 ◽  
Author(s):  
Hikaru Hori ◽  
Asuka Katsuki ◽  
Kiyokazu Atake ◽  
Reiji Yoshimura ◽  
Jun Nakamura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sick Leave ◽  
Social Adaptation ◽  
Major Depressive ◽  
Japanese Workers ◽  
Scale Scores ◽  
Returning To Work

ObjectivesWe aimed to investigate the risk factors for further sick leave episodes among Japanese workers returning to work after time off with a major depressive disorder.DesignA prospective study with 1 year of follow-up.ParticipantsWe recruited 103 workers who had returned to work after taking sick leave with a major depressive disorder. Adjusted HRs with 95% CIs were calculated using Cox proportional hazard models to examine the risk of further sick leave.ResultsIn the adjusted analysis, we show that Social Adaptation Self-evaluation Scale scores (HR 0.95; p=0.019), 3-back correct response rate (N-back test) (HR 0.97; p<0.001) and benzodiazepine dosage (diazepam equivalent) (HR1.07; p=0.014) were associated with further episodes of sick leave.ConclusionsPoorer social and cognitive functioning, together with higher diazepam dosages, were associated with an increased likelihood of additional sick leave.

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