scholarly journals The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer

2018 ◽  
Vol 19 (6) ◽  
pp. 1695 ◽  
Author(s):  
Katherine Hughes ◽  
Christine Watson
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Involution

scholarly journals Mammary gland adipocytes in lactation cycle, obesity and breast cancer

2021 ◽  
Author(s):  
Georgia Colleluori ◽  
Jessica Perugini ◽  
Giorgio Barbatelli ◽  
Saverio Cinti
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Epithelial Cells ◽  
Close Association ◽  
Critical Role ◽  
Exocrine Gland ◽  
Plastic Properties ◽  
Lactation Cycle ◽  
Gland Development

AbstractThe mammary gland (MG) is an exocrine gland present in female mammals responsible for the production and secretion of milk during the process of lactation. It is mainly composed by epithelial cells and adipocytes. Among the features that make the MG unique there are 1) its highly plastic properties displayed during pregnancy, lactation and involution (all steps belonging to the lactation cycle) and 2) its requirement to grow in close association with adipocytes which are absolutely necessary to ensure MG’s proper development at puberty and remodeling during the lactation cycle. Although MG adipocytes play such a critical role for the gland development, most of the studies have focused on its epithelial component only, leaving the role of the neighboring adipocytes largely unexplored. In this review we aim to describe evidences regarding MG’s adipocytes role and properties in physiologic conditions (gland development and lactation cycle), obesity and breast cancer, emphasizing the existing gaps in the literature which deserve further investigation.

scholarly journals Zinc Signaling in the Mammary Gland: For Better and for Worse

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1204
Author(s):  
Moumita Chakraborty ◽  
Michal Hershfinkel
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Cancer Progression ◽  
Cellular Level ◽  
Normal Mammary Gland ◽  
Dna And Rna ◽  
Dna And Rna Synthesis ◽  
Zinc Signaling ◽  
Epithelial Physiology

Zinc (Zn2+) plays an essential role in epithelial physiology. Among its many effects, most prominent is its action to accelerate cell proliferation, thereby modulating wound healing. It also mediates affects in the gastrointestinal system, in the testes, and in secretory organs, including the pancreas, salivary, and prostate glands. On the cellular level, Zn2+ is involved in protein folding, DNA, and RNA synthesis, and in the function of numerous enzymes. In the mammary gland, Zn2+ accumulation in maternal milk is essential for supporting infant growth during the neonatal period. Importantly, Zn2+ signaling also has direct roles in controlling mammary gland development or, alternatively, involution. During breast cancer progression, accumulation or redistribution of Zn2+ occurs in the mammary gland, with aberrant Zn2+ signaling observed in the malignant cells. Here, we review the current understanding of the role of in Zn2+ the mammary gland, and the proteins controlling cellular Zn2+ homeostasis and signaling, including Zn2+ transporters and the Gq-coupled Zn2+ sensing receptor, ZnR/GPR39. Significant advances in our understanding of Zn2+ signaling in the normal mammary gland as well as in the context of breast cancer provides new avenues for identification of specific targets for breast cancer therapy.

scholarly journals Role of Prolactin, Growth Hormone and Insulin-Like Growth Factor 1 in Mammary Gland Involution in the Dairy Cow

2002 ◽  
Vol 85 (3) ◽  
pp. 507-513 ◽  
Author(s):  
P.A. Accorsi ◽  
B. Pacioni ◽  
C. Pezzi ◽  
M. Forni ◽  
D.J. Flint ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Mammary Gland ◽  
Growth Factor ◽  
Dairy Cow ◽  
Insulin Like Growth Factor ◽  
Mammary Gland Involution

Mammary stem cells: the root of breast cancer?

2004 ◽  
Vol 7 (9) ◽  
Author(s):  
H. A. Coppock ◽  
R. B. Clarke
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Gland ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Differentiated Cells ◽  
Mammary Stem ◽  
Tissue Specific Stem Cells ◽  
Prevention And Therapy

Tissue-specific stem cells play a key role in organ homoeostasis. They are relatively well characterized in systems which undergo constant proliferation and production of differentiated cells, including the haemopoietic system, skin and intestine. However, little is known about the role and regulation of stem cells in the mammary gland. This review briefly summarizes the current understanding of the role of breast-specific stem cells in normal and cancerous tissues, and how this may identify new targets for breast cancer prevention and therapy.

Lifelong exposure to n-3 PUFA affects pubertal mammary gland development

2014 ◽  
Vol 39 (6) ◽  
pp. 699-706 ◽  
Author(s):  
Breanne M. Anderson ◽  
Mira B. MacLennan ◽  
Lyn M. Hillyer ◽  
David W.L. Ma
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dietary Fat ◽  
Mammary Gland Development ◽  
Morphological Development ◽  
Terminal End Buds ◽  
Gland Development

There is growing evidence that early developmental periods may importantly influence future breast cancer risk. Also, there is great interest in the role of dietary fat in breast cancer risk, but the role of dietary fat during pubertal mammary gland development remains poorly understood. This study investigated the effect of n-3 polyunsaturated fatty acids (PUFA) using complementary dietary and genetic approaches to examine the effect of lifelong exposure of n-3 PUFA or n-6 PUFA (control) on mammary gland development and fatty acid composition. n-3 PUFA from both diet and genetics were enriched in mammary glands as early as 3 weeks of age. Parameters related to mammary gland development, including number of terminal end buds (TEB), percent coverage of ductal tree, and infiltration of TEB, were influenced by n-3 PUFA at 3 and 4 weeks of age. Overall, findings suggest that n-3 PUFA incorporation into the mammary gland early in life plays a role in the morphological development of the mammary gland during puberty.

scholarly journals Role of JNK in Mammary Gland Development and Breast Cancer

2011 ◽  
Vol 72 (2) ◽  
pp. 472-481 ◽  
Author(s):  
Cristina Cellurale ◽  
Nomeda Girnius ◽  
Feng Jiang ◽  
Julie Cavanagh-Kyros ◽  
Shaolei Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development

scholarly journals The Mammary Gland Carcinogens: The Role of Metal Compounds and Organic Solvents

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Stephen Juma Mulware
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Organic Solvents ◽  
Redox Regulation ◽  
Dna Hypermethylation ◽  
Brca1 And Brca2 ◽  
Metal Compounds ◽  
Breast Physiology ◽  
Fat Depot

The increased rate of breast cancer incidences especially among postmenopausal women has been reported in recent decades. Despite the fact that women who inherited mutations in the BRCA1 and BRCA2 genes have a high risk of developing breast cancer, studies have also shown that significant exposure to certain metal compounds and organic solvents also increases the risks of mammary gland carcinogenesis. While physiological properties govern the uptake, intracellular distribution, and binding of metal compounds, their interaction with proteins seems to be the most relevant process for metal carcinogenicity than biding to DNA. The four most predominant mechanisms for metal carcinogenicity include (1) interference with cellular redox regulation and induction of oxidative stress, (2) inhibition of major DNA repair, (3) deregulation of cell proliferation, and (4) epigenetic inactivation of genes by DNA hypermethylation. On the other hand, most organic solvents are highly lipophilic and are biotransformed mainly in the liver and the kidney through a series of oxidative and reductive reactions, some of which result in bioactivation. The breast physiology, notably the parenchyma, is embedded in a fat depot capable of storing lipophilic xenobiotics. This paper reviews the role of metal compounds and organic solvents in breast cancer development.

scholarly journals PMCA2 regulates apoptosis during mammary gland involution and predicts outcome in breast cancer

2010 ◽  
Vol 107 (25) ◽  
pp. 11405-11410 ◽  
Author(s):  
J. VanHouten ◽  
C. Sullivan ◽  
C. Bazinet ◽  
T. Ryoo ◽  
R. Camp ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Involution

scholarly journals Abstract 5114: The role of amphiregulin in mammary gland development and breast cancer

2018 ◽  
Author(s):  
Serena Mao ◽  
Minji Park ◽  
Ramon Cabrera ◽  
John Christin ◽  
George Karagiannis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development
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