scholarly journals Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair

2017 ◽  
Vol 18 (10) ◽  
pp. 2149 ◽  
Author(s):  
Dominik André-Lévigne ◽  
Ali Modarressi ◽  
Michael Pepper ◽  
Brigitte Pittet-Cuénod
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Repair ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cutaneous Wound ◽  
Key Players

Reactive oxygen species: Key players in the anticancer effects of apigenin?

2022 ◽  
Author(s):  
Omolola R. Oyenihi ◽  
Ayodeji B. Oyenihi ◽  
Toyin D. Alabi ◽  
Oluwatosin G. Tade ◽  
Anne A. Adeyanju ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Anticancer Effects ◽  
Key Players

scholarly journals IgG-aggregates rapidly up-regulate FcgRI expression at the surface of human neutrophils in a FcgRII-dependent fashion: A crucial role for FcgRI in the generation of reactive oxygen species

2020 ◽  
Author(s):  
Sandrine Huot ◽  
Cynthia Laflamme ◽  
Paul R. Fortin ◽  
Eric Boilard ◽  
Marc Pouliot
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Cells ◽  
Immune Complexes ◽  
Tissue Damage ◽  
Reactive Oxygen ◽  
Surface Expression ◽  
Human Neutrophils ◽  
Ros Production ◽  
Oxygen Species ◽  
Key Players

AbstractAutoimmune complexes are an important feature of several autoimmune diseases such as lupus, as they contribute to tissue damage through the activation of immune cells. Neutrophils, key players in lupus, interact with immune complexes through Fc gamma receptors (FcgR). Incubation of neutrophils with aggregated-IgGs caused degranulation and increased the surface expression of FcgRI within minutes in a concentration-dependent fashion. After 30 min, IgG aggregates (1 mg/ml) up-regulated FcgRI by 4.95 ± 0.45-fold. FcgRI-positive neutrophils reached 67.24% ± 6.88% on HA-IgGs stimulated neutrophils, from 3.12% ± 1.62% in non-stimulated cells, ranking IgG-aggregates among the most potent known agonists. FcgRIIa, and possibly FcgRIIIa, appeared to mediate this up-regulation. Also, FcgRI-dependent signaling proved necessary for reactive oxygen species (ROS) production in response to IgG-aggregates. Finally, combinations of bacterial materials with aggregates dramatically boosted ROS production. This work suggests FcgRI as an essential component in the response of human neutrophils to immune complexes leading to the production of ROS, which may help explain how neutrophils contribute to tissue damage associated with immune complex-associated diseases, such as lupus.

scholarly journals Author response: Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair

2017 ◽  
Author(s):  
Danny LeBert ◽  
Jayne M Squirrell ◽  
Chrissy Freisinger ◽  
Julie Rindy ◽  
Netta Golenberg ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Repair ◽  
Reactive Oxygen ◽  
Author Response ◽  
Oxygen Species

scholarly journals Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment

2019 ◽  
Vol 20 (19) ◽  
pp. 4810 ◽  
Author(s):  
Sergio Di Meo ◽  
Gaetana Napolitano ◽  
Paola Venditti
Keyword(s):  
Reactive Oxygen Species ◽  
Tissue Injury ◽  
Biological Systems ◽  
Reactive Oxygen ◽  
Biological Macromolecules ◽  
Oxygen Species ◽  
Antioxidant Treatment ◽  
Key Players

From their discovery in biological systems, reactive oxygen species (ROS) have been considered key players in tissue injury for their capacity to oxidize biological macromolecules [...]

scholarly journals Defense against Reactive Oxygen Species during Gastric Wound Repair is Mediated by the Cystine‐Glutamate xCT Transporter in Response to Injury

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Emma L Teal ◽  
Jayati L Chakrabarti ◽  
Nina Steele ◽  
Jennifer Hawkins ◽  
Nambirajan Sundaram ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Repair ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Danny LeBert ◽  
Jayne M Squirrell ◽  
Chrissy Freisinger ◽  
Julie Rindy ◽  
Netta Golenberg ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Repair ◽  
Tissue Injury ◽  
Second Harmonic ◽  
Reactive Oxygen ◽  
Leading Edge ◽  
Time Lapse ◽  
Oxygen Species ◽  
Burn Wound ◽  
Early Wound

Tissue injury leads to early wound-associated reactive oxygen species (ROS) production that mediate tissue regeneration. To identify mechanisms that function downstream of redox signals that modulate regeneration, a vimentin reporter of mesenchymal cells was generated by driving GFP from the vimentin promoter in zebrafish. Early redox signaling mediated vimentin reporter activity at the wound margin. Moreover, both ROS and vimentin were necessary for collagen production and reorganization into projections at the leading edge of the wound. Second harmonic generation time-lapse imaging revealed that the collagen projections were associated with dynamic epithelial extensions at the wound edge during wound repair. Perturbing collagen organization by burn wound disrupted epithelial projections and subsequent wound healing. Taken together our findings suggest that ROS and vimentin integrate early wound signals to orchestrate the formation of collagen-based projections that guide regenerative growth during efficient wound repair.

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species
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