scholarly journals Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study

2017 ◽  
Vol 18 (8) ◽  
pp. 1690 ◽  
Author(s):  
Josune Olza ◽  
Azahara Rupérez ◽  
Mercedes Gil-Campos ◽  
Rosaura Leis ◽  
Ramón Cañete ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Leptin Receptor ◽  
Case Control Study ◽  
Receptor Gene ◽  
Case Control ◽  
Gene Variant ◽  
Obese Children ◽  
Control Study

scholarly journals Leptin receptor gene polymorphisms c.668A>G and c.1968G>C in Sudanese women with preeclampsia: a case-control study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Amira Saad ◽  
Ishag Adam ◽  
Salah Eldin G. Elzaki ◽  
Hiba A. Awooda ◽  
Hamdan Z. Hamdan
Keyword(s):  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Case Control Study ◽  
Receptor Gene ◽  
Case Control ◽  
Receptor Gene Polymorphisms ◽  
Control Study

Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain

2006 ◽  
Vol 21 (8) ◽  
pp. 605-612 ◽  
Author(s):  
Olga Portolés ◽  
José Vicente Sorlí ◽  
Francesc Francés ◽  
Oscar Coltell ◽  
Jose I. González ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Leptin Receptor ◽  
Case Control Study ◽  
Receptor Gene ◽  
Gene Promoter ◽  
Population Based ◽  
Case Control ◽  
Obesity Risk ◽  
Control Study

scholarly journals Association between insulin resistance and left ventricular hypertrophy in asymptomatic, Black, sub-Saharan African, hypertensive patients: a case–control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bernard Kianu Phanzu ◽  
Aliocha Nkodila Natuhoyila ◽  
Eleuthère Kintoki Vita ◽  
Jean-René M’Buyamba Kabangu ◽  
Benjamin Longo-Mbenza
Keyword(s):  
Insulin Resistance ◽  
Logistic Regression ◽  
Ventricular Hypertrophy ◽  
Case Control Study ◽  
Case Control ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Independent Variables ◽  
Sub Saharan ◽  
Control Study

Abstract Background Conflicting information exists regarding the association between insulin resistance (IR) and left ventricular hypertrophy (LVH). We described the associations between obesity, fasting insulinemia, homeostasis model assessment of insulin resistance (HOMA-IR), and LVH in Black patients with essential hypertension. Methods A case–control study was conducted at the Centre Médical de Kinshasa (CMK), the Democratic Republic of the Congo, between January and December 2019. Cases and controls were hypertensive patients with and without LVH, respectively. The relationships between obesity indices, physical inactivity, glucose metabolism and lipid disorder parameters, and LVH were assessed using linear and logistic regression analyses in simple and univariate exploratory analyses, respectively. When differences were observed between LVH and independent variables, the effects of potential confounders were studied through the use of multiple linear regression and in conditional logistic regression in multivariate analyses. The coefficients of determination (R2), adjusted odds ratios (aORs), and their 95% confidence intervals (95% CIs) were calculated to determine associations between LVH and the independent variables. Results Eighty-eight LVH cases (52 men) were compared against 132 controls (81 men). Variation in left ventricular mass (LVM) could be predicted by the following variables: age (19%), duration of hypertension (31.3%), body mass index (BMI, 44.4%), waist circumference (WC, 42.5%), glycemia (20%), insulinemia (44.8%), and HOMA-IR (43.7%). Hypertension duration, BMI, insulinemia, and HOMA-IR explained 68.3% of LVM variability in the multiple linear regression analysis. In the logistic regression model, obesity increased the risk of LVH by threefold [aOR 2.8; 95% CI (1.06–7.4); p = 0.038], and IR increased the risk of LVH by eightfold [aOR 8.4; 95 (3.7–15.7); p < 0.001]. Conclusion Obesity and IR appear to be the primary predictors of LVH in Black sub-Saharan African hypertensive patients. The comprehensive management of cardiovascular risk factors should be emphasized, with particular attention paid to obesity and IR. A prospective population-based study of Black sub-Saharan individuals that includes the use of serial imaging remains essential to better understand subclinical LV deterioration over time and to confirm the role played by IR in Black sub-Saharan individuals with hypertension.

scholarly journals Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Daniel Nilsson ◽  
Anand Kumar Andiappan ◽  
Christer Halldén ◽  
Wang De Yun ◽  
Torbjörn Säll ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Receptor Gene ◽  
Case Control ◽  
Toll Like Receptor ◽  
Receptor Gene Polymorphisms ◽  
Control Study

scholarly journals Brain Iron Overload, Insulin Resistance, and Cognitive Performance in Obese Subjects: A Preliminary MRI Case-Control Study

Diabetes Care ◽  
2014 ◽  
Vol 37 (11) ◽  
pp. 3076-3083 ◽  
Author(s):  
Gerard Blasco ◽  
Josep Puig ◽  
Josep Daunis-i-Estadella ◽  
Xavier Molina ◽  
Gemma Xifra ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Iron Overload ◽  
Cognitive Performance ◽  
Case Control Study ◽  
Case Control ◽  
Brain Iron ◽  
Obese Subjects ◽  
Control Study
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