scholarly journals Loss of Bone Mineral Density Associated with Age in Male Rats Fed on Sunflower Oil Is Avoided by Virgin Olive Oil Intake or Coenzyme Q Supplementation

2017 ◽  
Vol 18 (7) ◽  
pp. 1397 ◽  
Author(s):  
Alfonso Varela-López ◽  
Julio J. Ochoa ◽  
José M. Llamas-Elvira ◽  
Magdalena López-Frías ◽  
Elena Planells ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Olive Oil ◽  
Bone Mineral ◽  
Sunflower Oil ◽  
Coenzyme Q ◽  
Virgin Olive Oil ◽  
Male Rats ◽  
Mineral Density

scholarly journals Bone quality associated with daily intake of coffee: a biochemical, radiographic and histometric study

2010 ◽  
Vol 21 (3) ◽  
pp. 199-204 ◽  
Author(s):  
Suzie Aparecida Lacerda ◽  
Renata Inahara Matuoka ◽  
Rander Moreira Macedo ◽  
Sergio Olavo Petenusci ◽  
Alessandra Aparecida Campos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Quality ◽  
Bone Mineral ◽  
Bone Repair ◽  
Daily Intake ◽  
Male Rats ◽  
Lower Amount ◽  
Caffeine Intake ◽  
Mineral Density ◽  
Coffee Intake

Caffeine induces loss of calcium and influences the normal development of bone. This study investigated the effects of coffee on bone metabolism in rats by biochemical measurement of calcium, bone densitometry and histometry. Male rats, born of female treated daily with coffee and with coffee intake since born, were anesthetized, subjected to extraction of the upper right incisor, and sacrificed 7, 21 and 42 days after surgery. Blood and urine samples were taken, and their maxilla radiographed and processed to obtain 5-µm-thick semi-serial sections stained with hematoxylin and eosin. The volume and bone quality were estimated using an image-analysis software. The results showed significantly greater amount of calcium in the plasma (9.40 ± 1.73 versus 9.80 ± 2.05 mg%) and urine (1.00 ± 0.50 versus 1.25 ± 0.70 mg/24 h) and significantly less amount in bone (90.0 ± 1.94 versus 86.0 ± 2.12 mg/mg bone), reduced bone mineral density (1.05 ± 0.11 versus 0.65 ± 0.15 mmAL), and lower amount of bone (76.19 ± 1.6 versus 53.41 ± 2.1 %) (ANOVA; p≤0.01) in animals treated with coffee sacrificed after 42 days. It may be concluded that coffee/caffeine intake caused serious adverse effects on calcium metabolism in rats, including increased levels of calcium in the urine and plasma, decreased bone mineral density and lower volume of bone, thus delaying the bone repair process.

scholarly journals Heart Histopathology and Mitochondrial Ultrastructure in Aged Rats Fed for 24 Months on Different Unsaturated Fats (Virgin Olive Oil, Sunflower Oil or Fish Oil) and Affected by Different Longevity

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2390 ◽  
Author(s):  
Navarro-Hortal ◽  
Ramírez-Tortosa ◽  
Varela-López ◽  
Romero-Márquez ◽  
Ochoa ◽  
...  
Keyword(s):  
Fish Oil ◽  
Olive Oil ◽  
Sunflower Oil ◽  
Coenzyme Q ◽  
Virgin Olive Oil ◽  
Decisive Role ◽  
Ultrastructural Level ◽  
Dietary Lipids ◽  
Dietary Fats ◽  
Oil Sunflower

Diet plays a decisive role in heart physiology, with lipids having especial importance in pathology prevention and development. This study aimed to investigate how dietary lipids varying in lipid profile (virgin olive oil, sunflower oil or fish oil) affected the heart of rats during aging. Heart histopathology, mitochondrial morphometry, and oxidative status were assessed. Typical histopathological features associated with aging, such as valvular lesions, endomyocardical hyperplasia, or papillary muscle calcification, were found at a low extent in all the experimental groups. The most relevant finding was that inflammation registered by fish oil group was lower compared to the other treatments. At the ultrastructural level, heart mitochondrial area, perimeter, and aspect ratio were higher in fish oil-fed rats than in those fed on sunflower oil. Concerning oxidative stress markers, there were differences only in coenzyme Q levels and catalase activity, lower in sunflower oil-fed animals compared with those fed on fish oil. In summary, dietary intake for a long period on dietary fats with different fatty acids profile led to differences in some aspects associated with the aging process at the heart. Fish oil seems to be the fat most protective of heart during aging.

scholarly journals Aromatase Inhibition Impairs Skeletal Modeling and Decreases Bone Mineral Density in Growing Male Rats*

Endocrinology ◽  
1997 ◽  
Vol 138 (6) ◽  
pp. 2301-2307 ◽  
Author(s):  
D. Vanderschueren ◽  
E. Van Herck ◽  
J. Nijs ◽  
A. G. H. Ederveen ◽  
R. De Coster ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Male Rats ◽  
Mineral Density ◽  
Aromatase Inhibition

The effect of testosterone itself and in combination with letrozole on bone mineral density in male rats

2018 ◽  
Vol 37 (4) ◽  
pp. 668-675 ◽  
Author(s):  
Forough Saki ◽  
Seyed Reza Kasaee ◽  
Faezeh Sadeghian ◽  
Pedram Talezadeh ◽  
Gholam Hossein Ranjbar Omrani
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Male Rats ◽  
Mineral Density

scholarly journals Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis

2019 ◽  
Vol 75 (5) ◽  
pp. 821-825 ◽  
Author(s):  
Yang Liu ◽  
Meigui You ◽  
Jianwei Shen ◽  
Yaping Xu ◽  
Lin Li ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Frailty Index ◽  
Male Rats ◽  
Bending Test ◽  
Fischer 344 Rats ◽  
Aging Male ◽  
Mineral Density ◽  
Fischer 344

Abstract The research and development of pharmaceutical intervention is insufficient for the frail older adults, especially in preclinical stage for the frail individuals with osteoporosis. Garlic exerts an antiosteoporotic effect and its vital component allicin could protect organisms against aging. The present study aimed to investigate the effect of long-term intragastric administration of allicin (low dose of 4 mg·kg−1·d−1; middle dose of 8 mg·kg−1·d−1; high dose of 16 mg·kg−1·d−1) on frailty with osteoporosis in aging male Fischer 344 rats. Frailty was assessed with a 27-item frailty index based on quantifying health-related deficits in adult male rats varied from 13 to 21 months and in control rats from 6 to 9 months. Osteoporosis was appraised by bone mineral density detected by dual-energy X-ray absorptiometry, biomechanical properties measured by a three-point bending test, and bone metabolic analysis using ELISA. Allicin could attenuate frailty index scores by reducing the accumulation of health deficits in aging male Fischer 344 rats. Meanwhile, allicin could protect against senile osteoporosis, and the underlying mechanism may involve in increasing low bone turnover through elevation of both bone formation and bone resorption, and subsequently lead to increase of bone mineral density, contributing to reversing deleterious bone biomechanical features associated with aging. The present study reveals firstly that long-term oral administration with allicin attenuated frailty with osteoporosis during the process of aging, which provides a preclinical evidence for intervention of frailty.

scholarly journals Fried Sunflower Oil intake affects Bone Quality, in Growing Rats

2019 ◽  
Vol 7 (1) ◽  
pp. 52-65 ◽  
Author(s):  
ELISA VANESA MACRI ◽  
CECILIA RAMOS ◽  
CLARISA BOZZINI ◽  
VALERIA ZAGO ◽  
SILVIA GIACOMINO ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Sunflower Oil ◽  
Control Diet ◽  
Weight Ratio ◽  
Density Lipoprotein ◽  
Body Growth ◽  
Male Rats ◽  
Mineral Density ◽  
Geometrical Properties ◽  
Growing Rats

The effect of consuming a diet containing sunflower oil, which was repeatedly used to fry potatoes, on bone mass and biomechanical competence in growing rats, was investigated. Male Wistar rats (21±1 days old) (n=34) were assigned at weaning to one of three diet groups for 8 weeks: those fed a control diet (C; n=10), a sunflower oil (SFO; n=12) diet or a SFO diet which was repeatedly heated (SFOx; n=12); both mixed with a commercial rat chow at weight ratio of 13% (w/w). Zoometrics, food intake, serum fatty acids composition and lipid profile, total skeleton bone mineral density (BMD), bone mineral content (BMC), and femur biomechanical competence were assessed. Animals fed SFOx diet had altered body growth and showed both increased serum total cholesterol (T-chol) and non-high-density lipoprotein cholesterol (non-HDL-chol). SFOx rats also showed marked differences in BMC, their femur and tibiae had the lowest structural and geometrical properties, but material properties were unchanged. This study showed that growing male rats consuming a SFOx diet adversely affected their body growth, and lipid metabolism. Additionally their BMC and bone biomechanical properties were also altered due to modifications in bone geometric design.

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