scholarly journals Liposomal Encapsulation for Systemic Delivery of Propranolol via Transdermal Iontophoresis Improves Bone Microarchitecture in Ovariectomized Rats

2017 ◽  
Vol 18 (4) ◽  
pp. 822 ◽  
Author(s):  
Benjamin Teong ◽  
Shyh Kuo ◽  
Wei-Hsin Tsai ◽  
Mei-Ling Ho ◽  
Chung-Hwan Chen ◽  
...  
Keyword(s):  
Bone Microarchitecture ◽  
Ovariectomized Rats ◽  
Systemic Delivery ◽  
Transdermal Iontophoresis

scholarly journals Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Ying-Ju Chen ◽  
Shun-Ping Wang ◽  
Fu-Chou Cheng ◽  
Pei-Yu Hsu ◽  
Yu-Fen Li ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Femoral Head ◽  
Bone Microarchitecture ◽  
Ovariectomized Rats

scholarly journals Sevelamer Restores Bone Volume and Improves Bone Microarchitecture and Strength in Aged Ovariectomized Rats

Endocrinology ◽  
2008 ◽  
Vol 149 (12) ◽  
pp. 6092-6102 ◽  
Author(s):  
T. Kuber Sampath ◽  
Petra Simic ◽  
Sarah Moreno ◽  
Nikolay Bukanov ◽  
Natasa Draca ◽  
...  
Keyword(s):  
Bone Microarchitecture ◽  
Bone Volume ◽  
Ovariectomized Rats

scholarly journals Effect of Mesenchymal Stem Cells and Platelet-Rich Plasma on the Bone Healing of Ovariectomized Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Bo Wei ◽  
Chengshuo Huang ◽  
Mingyan Zhao ◽  
Peng Li ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Platelet Rich Plasma ◽  
Bone Microarchitecture ◽  
Bone Defects ◽  
Ovariectomized Rats ◽  
Marker Genes ◽  
Osteoporotic Bone ◽  
Specific Marker ◽  
Allogeneic Bone

We evaluated the efficacy of platelet-rich plasma (PRP) in combination with allogeneic bone marrow mesenchymal stem cells (BMSCs) for the treatment of osteoporotic bone defects in an ovariectomized rat model. By day 42 after injury, in vivo microcomputed tomography (micro-CT) imaging revealed that bone defects of control rats and ovariectomized rats treated with PRP and BMSCs were completely repaired, whereas those of ovariectomized rats treated with PRP or BMSCs alone exhibited slower healing. Histological data were consistent with these results. We also assessed changes to bone trabeculae in the proximal tibial growth plate. In ovariectomized rats treated with PRP or with a combination of PRP and BMSCs, the trabecular connectivity densities (Conn.D), bone volume ratios (BV/TV), and numbers (Tb.N) in the defect areas increased significantly from day 7 to day 42. These results indicate that PRP treatment enhances bone microarchitecture in osteoporosis. Moreover, expression levels of osteogenesis-specific marker genes including RUNX2, OSX, and OPN were significantly upregulated in rats treated with PRP and BMSCs compared to those of other groups. Thus, we conclude that treatment with PRP combined with BMSCs significantly promotes healing of osteoporotic bone defects. This study provides an alternative strategy for the treatment of osteoporotic bone loss.

scholarly journals Beneficial Effects of Total Phenylethanoid Glycoside Fraction Isolated from Cistanche deserticola on Bone Microstructure in Ovariectomized Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Lingling Yang ◽  
Shuqin Ding ◽  
Bo Zhang ◽  
Jingjing Liu ◽  
Yanhong Dong ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Bone Microarchitecture ◽  
Bone Microstructure ◽  
Akt Signaling ◽  
Hplc Method ◽  
Ovariectomized Rats ◽  
Mineral Density ◽  
Phenylethanoid Glycoside ◽  
Beneficial Effects ◽  
Ovx Rats

The present study was designed to estimate the antiosteoporotic activity of total phenylethanoid glycoside fraction isolated from C. deserticola (CDP) on rats induced by ovariectomy (OVX) as well as the related mechanisms. After 3 months of oral administration, the decreased bone mineral density, serum Ca, and P in OVX rats were recovered and the deteriorated trabecular bone microarchitecture was partly improved by CDP (60, 120, and 240 mg/kg) intervention, the activities of bone resorption markers were downregulated, and the bioactive of the bone formation index was upregulated; meanwhile, the content of MDA was declined, and GSH was increased by CDP treatment. Compositionally, 8 phenylethanoid glycoside compounds were identified in CDP, with the total contents quantified as 50.3% by using the HPLC method. Mechanistically, CDP declined the levels of TRAF6, RANKL, and RANK, thus suppressing RANKL/RANK/TRAF6-induced activation of downstream NF-κB and PI3K/AKT signaling pathways and ultimately preventing activities of the key osteoclastogenic proteins of NFAT2 and c-Fos. All of the above data implied that CDP exhibited beneficial effects on bone microstructure in ovariectomized rats, and these effects may be related to the NF-κB and PI3K/AKT signaling pathways which were triggered by the binding of RANKL, RANK, and TRAF6.

scholarly journals Effects of Spaceflight on Bone Microarchitecture in the Axial and Appendicular Skeleton in Growing Ovariectomized Rats

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Jessica A. Keune ◽  
Adam J. Branscum ◽  
Urszula T. Iwaniec ◽  
Russell T. Turner
Keyword(s):  
Bone Microarchitecture ◽  
Ovariectomized Rats ◽  
Appendicular Skeleton

Effects of treadmill running on bone microarchitecture in ovariectomized rats

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S90
Author(s):  
K. Tamakoshi ◽  
A. Minematsu ◽  
Y. Nishii
Keyword(s):  
Bone Microarchitecture ◽  
Treadmill Running ◽  
Ovariectomized Rats

Effect of swimming exercise on three-dimensional trabecular bone microarchitecture in ovariectomized rats

2015 ◽  
Vol 119 (9) ◽  
pp. 990-997 ◽  
Author(s):  
Yong-In Ju ◽  
Teruki Sone ◽  
Kazuhiro Ohnaru ◽  
Kensuke Tanaka ◽  
Masao Fukunaga
Keyword(s):  
Bone Mass ◽  
Trabecular Bone ◽  
Bone Microarchitecture ◽  
Weight Bearing ◽  
Three Dimensional ◽  
Ovariectomized Rats ◽  
Swimming Exercise ◽  
Mineral Density ◽  
Geometrical Properties ◽  
Ovx Rats

Swimming is generally considered ineffective for increasing bone mass in humans, at least compared with weight-bearing sports. However, swimming exercise has sometimes been shown to have a strong positive effect on bone mass in small animals. This study investigated the effects of swimming on bone mass, strength, and microarchitecture in ovariectomized (OVX) rats. OVX or sham operations were performed on 18-wk-old female Fisher 344 rats. Rats were randomly divided into four groups: sham sedentary (Sham-CON), sham swimming exercised (Sham-SWI), OVX sedentary (OVX-CON), and OVX swimming exercised (OVX-SWI). Rats in exercise groups performed swimming in a water bath for 60 min/day, 5 days/wk, for 12 wk. Bone mineral density (BMD) in right femurs was analyzed using dual-energy X-ray absorptiometry. Three-dimensional trabecular architecture at the distal femoral metaphysis was analyzed using microcomputed tomography (μCT). Geometrical properties of diaphyseal cortical bone were evaluated in the midfemoral region using μCT. The biomechanical properties of femurs were analyzed using three-point bending. Femoral BMD was significantly decreased following ovariectomy. This change was suppressed by swimming. Trabecular bone thickness, number, and connectivity were decreased by ovariectomy, whereas structure model index (i.e., ratio of rod-like to plate-like trabeculae) increased. These changes were also suppressed by swimming exercise. Femurs displayed greater cortical width and maximum load in SWI groups than in CON groups. Together, these results demonstrate that swimming exercise drastically alleviated both OVX-induced decreases in bone mass and mechanical strength and the deterioration of trabecular microarchitecture in rat models of osteoporosis.

(−)-Epigallocatechin-3-gallate improves bone microarchitecture in ovariectomized rats

2013 ◽  
Vol 20 (6) ◽  
pp. 687-694 ◽  
Author(s):  
Chung-Hwan Chen ◽  
Lin Kang ◽  
Ru-Wei Lin ◽  
Yin-Chih Fu ◽  
Yi-Shan Lin ◽  
...  
Keyword(s):  
Bone Microarchitecture ◽  
Ovariectomized Rats
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