scholarly journals A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities

2017 ◽  
Vol 18 (4) ◽  
pp. 757 ◽  
Author(s):  
Ping Wu ◽  
Qin Liang ◽  
Pei Feng ◽  
Chunyan Li ◽  
Chunguang Yang ◽  
...  
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Delivery System ◽  
Anti Inflammatory ◽  
Analgesic Activities

A statistical approach to the development of a transdermal delivery system for ondansetron

2010 ◽  
Vol 399 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
Yasuko Obata ◽  
Yuriko Ashitaka ◽  
Shingo Kikuchi ◽  
Koichi Isowa ◽  
Kozo Takayama
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Statistical Approach ◽  
Transdermal Delivery System

scholarly journals Development and In vitro Evaluation of Betahistine Adhesive-Type Transdermal Delivery System

2011 ◽  
Vol 9 (6) ◽  
Author(s):  
Ashish A Heda ◽  
Aravind R Sonawane ◽  
Gautam H Naranje ◽  
Vijay G Somani ◽  
Prashant K Puranik
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Delivery System ◽  
Adhesive Type

Transdermal Delivery Of Macromolecules Using Nanolipid Carriers

2021 ◽  
Vol 27 ◽  
Author(s):  
Sana Kalave ◽  
Bappaditya Chatterjee ◽  
Parth Shah ◽  
Ambikanandan Misra
Keyword(s):  
Delivery System ◽  
Transdermal Delivery ◽  
Low Frequency ◽  
Nanostructured Lipid Carriers ◽  
Skin Damage ◽  
Low Frequency Ultrasound ◽  
Transdermal Delivery System ◽  
Nanolipid Carriers ◽  
Transport Of Macromolecules ◽  
Frequency Ultrasound

: Skin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancement in macromolecules' transdermal delivery occurred in recent years. Scientists have opted for liposomes, the use of electroporation or, low-frequency ultrasound techniques. Some of these have shown better delivery of macromolecules at clinically beneficial rates. These physical technologies involve complex mechanisms, which may irreversibly incur skin damage. Majorly, two types of lipid-based formulations, including Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) are widely investigated as a transdermal delivery system. In this review, the concepts, mechanisms, and applications of Nanostructured Lipid Carriers that are considered feasible for transporting macromolecules via transdermal delivery system are thoroughly reviewed and presented along with their clinical perspective.

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