scholarly journals Strawberry-Tree Honey Induces Growth Inhibition of Human Colon Cancer Cells and Increases ROS Generation: A Comparison with Manuka Honey

2017 ◽  
Vol 18 (3) ◽  
pp. 613 ◽  
Author(s):  
Sadia Afrin ◽  
Tamara Forbes-Hernandez ◽  
Massimiliano Gasparrini ◽  
Stefano Bompadre ◽  
José Quiles ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Colon ◽  
Ros Generation ◽  
Colon Cancer Cells ◽  
Manuka Honey ◽  
Human Colon Cancer ◽  
Strawberry Tree ◽  
Human Colon Cancer Cells

Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation

2014 ◽  
Vol 5 (8) ◽  
pp. 1909-1914 ◽  
Author(s):  
Lijuan Sun ◽  
Cheng Luo ◽  
Jiankang Liu
Keyword(s):  
Oxidative Stress ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Ros Generation ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Normal Cells ◽  
Human Colon Cancer Cells

Cancer cells are usually under higher levels of oxidative stress compared to normal cells.

AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells

Life Sciences ◽  
2012 ◽  
Vol 91 (15-16) ◽  
pp. 789-799 ◽  
Author(s):  
P. Venkatesan ◽  
Sujit K. Bhutia ◽  
Abhay K. Singh ◽  
Swadesh K. Das ◽  
Rupesh Dash ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals c-Src–Mediated Phosphorylation of NoxA1 and Tks4 Induces the Reactive Oxygen Species (ROS)–Dependent Formation of Functional Invadopodia in Human Colon Cancer Cells

2010 ◽  
Vol 21 (23) ◽  
pp. 4287-4298 ◽  
Author(s):  
Davide Gianni ◽  
Nicolas Taulet ◽  
Céline DerMardirossian ◽  
Gary M. Bokoch
Keyword(s):  
Reactive Oxygen Species ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Ros Generation ◽  
Oxygen Species ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells ◽  
Invadopodia Formation

The NADPH oxidase family, consisting of Nox1-5 and Duox1-2, catalyzes the regulated formation of reactive oxygen species (ROS). Highly expressed in the colon, Nox1 needs the organizer subunit NoxO1 and the activator subunit NoxA1 for its activity. The tyrosine kinase c-Src is necessary for the formation of invadopodia, phosphotyrosine-rich structures which degrade the extracellular matrix (ECM). Many Src substrates are invadopodia components, including the novel Nox1 organizer Tks4 and Tks5 proteins. Nox1-dependent ROS generation is necessary for the maintenance of functional invadopodia in human colon cancer cells. However, the signals and the molecular machinery involved in the redox-dependent regulation of invadopodia formation remain unclear. Here, we show that the interaction of NoxA1 and Tks proteins is dependent on Src activity. Interestingly, the abolishment of Src-mediated phosphorylation of Tyr110 on NoxA1 and of Tyr508 on Tks4 blocks their binding and decreases Nox1-dependent ROS generation. The contemporary presence of Tks4 and NoxA1 unphosphorylable mutants blocks SrcYF-induced invadopodia formation and ECM degradation, while the overexpression of Tks4 and NoxA1 phosphomimetic mutants rescues this phenotype. Taken together, these results elucidate the role of c-Src activity on the formation of invadopodia and may provide insight into the mechanisms of tumor formation in colon cancers.

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