scholarly journals Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils

2016 ◽  
Vol 17 (12) ◽  
pp. 1971 ◽  
Author(s):  
Gangling Chen ◽  
Xinyi Ye ◽  
Jiangwei Zhang ◽  
Tingli Tang ◽  
Lin Li ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ischemic Postconditioning ◽  
Remote Ischemic Postconditioning ◽  
Nadph Oxidase Activation ◽  
Kinase Pathway

Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats

2011 ◽  
Vol 1372 ◽  
pp. 92-102 ◽  
Author(s):  
Tiziana Genovese ◽  
Emanuela Mazzon ◽  
Irene Paterniti ◽  
Emanuela Esposito ◽  
Placido Bramanti ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Nadph Oxidase ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury ◽  
Nadph Oxidase Activation

scholarly journals Remote Ischemic Postconditioning Protects against Myocardial Ischemia-Reperfusion Injury by Inhibition of the RAGE-HMGB1 Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xiangming Wang ◽  
Junhong Wang ◽  
Tiantian Tu ◽  
Zakaria Iyan ◽  
Deeraj Mungun ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ischemic Postconditioning ◽  
Control Group ◽  
Mice Model ◽  
Remote Ischemic Postconditioning ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion

Background. The aim of the present study was to observe the effect of RAGE-HMGB1 signal pathway on remote ischemic postconditioning in mice with myocardial ischemia reperfusion injury. Methods. Mice model of MIRI was established and randomly divided into three groups: control group, ischemia reperfusion group, and remote ischemic postconditioning group. Infarction size was detected by Evans blue and TTC staining. Cardiac function was detected by echocardiography measurement. The protein levels of RAGE, HMGB1, P-AKT, and ERK1/2 were detected by Western blot 120 min following reperfusion. Results. RIPostC could decrease the infarct size and increase LVEF and FS compared with I/R group. Two hours after myocardial ischemia reperfusion, the levels of RAGE and HMGB1 were significantly decreased in RIPostC group compared with those in I/R group. The level of p-AKT was significantly higher in the RIPostC group than in the I/R group. LY294002 significantly attenuated RIPostC-increased levels of Akt phosphorylation. Conclusion. RIPostC may inhibit the expression of RAGE and HMGB1 and activate PI3K/Akt signaling pathway to extenuate ischemic reperfusion injury in mice. It could further suppress the oxidative stress, have antiapoptosis effect, and reduce inflammatory reaction, but this effect has certain timeliness.

scholarly journals Protective effect of ischemic postconditioning on ischemia reperfusion injury in steatotic rat livers

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Jia-Xing He ◽  
Ke Wang ◽  
Shuai Zhou ◽  
Xiong-Chao Fang ◽  
Bo Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Ischemic Postconditioning ◽  
Rat Livers
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